New combo therapy aims to spare lymph nodes and boost rectal cancer outcomes
NCT ID NCT06507371
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This Phase III trial tests whether a modified short-course radiation that spares nearby lymph nodes, combined with chemotherapy (CAPOX) and the immunotherapy drug tislelizumab, works better than standard radiation plus chemotherapy for people with a certain type of rectal cancer (MSS). The study enrolls 170 patients with middle or low rectal cancer who want to avoid permanent colostomy. The main goal is to see if the new approach leads to a complete disappearance of the tumor after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tislelizumab (PD-1 antibody), capecitabine, oxaliplatin, and node-sparing short-course radiotherapy
- What this could lead to
- If successful, this could offer a more effective, less toxic treatment for rectal cancer that avoids damaging healthy lymph nodes and may help more patients avoid permanent colostomy.
- What could go wrong
- This is a Phase III trial, but the combination of immunotherapy and radiation is still experimental. Side effects from chemotherapy and immune-related reactions are possible, and the benefit over standard treatment is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sir Run Run Shao hospital
Hanzhou, Zhejiang, 310016, China
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