Large intestine disorder

This trial tests an experimental oral vaccine, WRSs2, designed to protect against Shigella sonnei, a common cause of severe diarrhea. Healthy adults aged 18-49 receive either the vaccine or a placebo, then are later exposed to the live bacteria in a controlled setting to see if t…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This trial is testing whether adding anakinra, a drug used for arthritis, to standard chemoradiotherapy is safe for people with rectal cancer. The study will include about 12 patients and will use a dose-escalation design to find the highest tolerable dose of capecitabine when co…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This pilot study is testing whether a dietary supplement made from the tinder fungus can safely ease gut symptoms in adults with mild-to-moderate ulcerative colitis or Crohn's disease. Participants will drink the supplement and be monitored for changes in symptoms, inflammation m…

This phase II trial is testing whether argon plasma coagulation (APC) can safely and effectively treat high-grade anal lesions (AIN 2/3) in HIV-positive men who have sex with men. APC uses ionized argon gas to deliver a controlled electrical current that destroys abnormal cells. …

This phase II trial is investigating whether giving the drug bevacizumab directly into the liver's main artery, alongside standard chemotherapy, can shrink liver tumors in people with colorectal cancer that has spread only to the liver. The study enrolls patients whose cancer pro…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This trial is testing whether an experimental drug called JS015, when combined with standard chemotherapy or immunotherapy, is safe and effective for people with advanced solid tumors that have not responded to prior treatment. The study includes patients with certain cancers lik…

This early-stage trial is testing an experimental drug called AMG 355, given alone or together with the immunotherapy Keytruda, in 77 adults with advanced solid tumors (like lung, colon, stomach, or melanoma) that have not responded to standard treatments. The main goals are to c…

This trial tests whether a simple clip-and-floss traction device can speed up the removal of large colon polyps using a technique called endoscopic submucosal dissection (ESD). About 280 people scheduled for ESD will be randomly assigned to receive either the traction device or s…

This study looks at people who undergo laparoscopic surgery for suspected appendicitis but are found to have a normal appendix. It compares two approaches: removing the appendix anyway (routine appendectomy) or leaving it in place. The goal is to see which approach leads to fewer…

This trial asks whether adding the antibody drugs bevacizumab and/or cetuximab to standard chemotherapy can help people with metastatic colorectal cancer live longer. Participants receive one of several treatment combinations, and researchers compare overall survival and progress…

This phase II trial is testing whether a cancer vaccine called PolyPEPI1018, when combined with the immunotherapy drug atezolizumab, can help people with a specific type of metastatic colorectal cancer that has not responded to previous treatments. The study enrolls adults with m…

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery to remove the …

This trial is testing whether a prebiotic supplement called 2'-FL, found in human milk, can safely ease gut symptoms in young people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Participants, aged 11 to 25, are in remission and already …

This study compares two bowel cleansing solutions, Golytely and SUPREP, for colon cancer screening in people with diabetes. Researchers want to see which one cleans the colon better and is easier to tolerate. About 80 participants will be randomly assigned to one of the two preps…

This trial tests an experimental virus-based therapy called JX-594 (Pexa-Vec) in people with advanced colorectal cancer that has not responded to standard treatments. The virus is designed to infect and kill cancer cells while also stimulating the immune system. It is given alone…

This study tests a new fluorescent clip that glows under special light to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to receive either the clip or a standard dye injection before surgery. The g…

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

This study tests whether a collagen plug soaked with a lab-made growth factor (rhPDGF-BB) can safely help heal complex anal fistulas—abnormal tunnels between the rectum and skin. The plug is implanted during a procedure, and the growth factor is meant to boost tissue repair. The …

This trial investigates whether drinking pomegranate juice for 12 weeks can reduce gut inflammation in people with Crohn's disease or ulcerative colitis who are in remission. Participants will drink either pomegranate juice or a placebo beverage twice daily, and researchers will …

This trial tests a personalized treatment plan for people with advanced colorectal cancer that has spread to the liver and stopped responding to standard treatments. The approach combines a liver-directed chemotherapy (HAIC), a targeted therapy (fruquintinib or cetuximab), and an…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing. Results will help determine if further testin…

This trial tests whether giving the chemotherapy drugs raltitrexed and oxaliplatin every two weeks is as effective and less toxic than the standard every-three-week schedule in people with metastatic colorectal cancer who have not had prior chemotherapy. Some participants also re…

This study tests whether a specific diet, called the IBD-AID, can improve symptoms of inflammatory bowel disease (IBD) by changing the bacteria in the gut. Participants aged 15 and older with IBD will follow the diet for 8 weeks, with guidance from study staff and cooking classes…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This phase 2 trial tested a combination of three drugs—encorafenib, binimetinib, and cetuximab—in 95 patients with a specific type of advanced colorectal cancer (BRAF V600E mutation) who had not received prior treatment for their metastatic disease. The goal was to see how many p…

This early-stage trial tests a treatment called Anti-CEA CAR-T, which uses a patient's own immune cells modified to recognize and attack cancer cells that carry a protein called CEA. The study enrolls about 110 adults with advanced colorectal, gastric, or other solid tumors that …

This trial compares two common ways to remove an inflamed appendix: open surgery (one larger cut) and laparoscopic surgery (several small cuts). The goal is to see which approach leads to fewer complications after the operation. About 832 people with acute appendicitis are taking…

This trial investigates a type of immunotherapy called CAR-T cells that are designed to recognize and attack cancer cells carrying a protein called CEA. The study includes adults with advanced gastric, colon, rectal, esophageal, or pancreatic cancer who have not responded to at l…

This pilot study tests a mobile app called PREHapp that guides people through exercises and health tips before colon cancer surgery. The goal is to see if the app is easy to use and whether it helps with recovery, such as walking ability and fewer complications after the operatio…

This study tracks 282 adults with moderate-to-severe ulcerative colitis who are taking mirikizumab as part of their routine care. Researchers will measure how many achieve clinical remission at 12 weeks and endoscopic remission at 24 and 52 weeks, along with changes in symptoms a…

People with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer and need regular colonoscopies to catch early warning signs. This study compares two techniques—narrow-band imaging (a special light) and an artificial intelligence (AI) system—to see which finds…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This early-stage trial tests a new type of cell therapy called CEA-targeted CAR-T for people with advanced colorectal, esophageal, stomach, or pancreatic cancers that have stopped responding to standard treatments. The therapy involves taking a patient's own immune cells, enginee…

This trial compares two ways to seal the base of the appendix during keyhole surgery: a single surgical clip versus traditional suture ligatures. The goal is to see which method leads to fewer complications, shorter hospital stays, and lower costs. Adults scheduled for laparoscop…

This phase 3 trial studies whether adding pelvic reirradiation to chemotherapy before surgery can help more patients with locally recurrent rectal cancer achieve complete tumor removal. The study enrolls 58 adults who have had prior pelvic radiation and now face a recurrence. Par…

This early-phase trial tests a modified virus called JX-594 (Pexa-Vec) in people with advanced colorectal cancer that has not responded to standard treatments. The virus is designed to infect and kill cancer cells while also stimulating the immune system. The main goal is to chec…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This trial compares two antibiotic regimens given after surgery for a ruptured appendix in children. One group receives piperacillin/tazobactam, the other receives ceftriaxone plus metronidazole. The goal is to see which treatment leads to a shorter hospital stay and fewer compli…

This early-stage trial is testing a combination of two lab-made antibodies in people with advanced solid tumors that have not responded to standard treatments. One antibody (LDP) aims to reactivate the immune system against cancer, while the other (CDP1) blocks a growth signal on…

This study tests a new drug called CDP1, which is a biosimilar (a close copy) of the approved cancer drug cetuximab. The trial enrolls adults with advanced colorectal cancer or head and neck squamous cell carcinoma that has not responded to prior treatments. Researchers compare h…

This trial tests a temporary device called CG-100 that is placed inside the intestine during colorectal cancer surgery. The device is designed to protect the surgical connection while it heals, potentially reducing leaks and other complications. The study includes adults aged 22 …

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This phase 2 trial is testing whether a combination of chemotherapy (mFOLFOX6), a targeted therapy (bevacizumab), and an immunotherapy (PD-1 inhibitor) can help people with a specific type of locally advanced colorectal cancer called microsatellite stable (MSS). Unlike other colo…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This study tested fecal microbiota transplantation (FMT) from different donors to treat ulcerative colitis, a type of inflammatory bowel disease. Researchers gave 102 patients a one-time colonoscopic infusion of fresh fecal bacteria from healthy donors. The goal was to see if don…

This trial investigates whether adding a dietary supplement called sodium nucleinate to standard FOLFOX chemotherapy helps people with metastatic colorectal cancer (cancer that has spread). Participants are randomly assigned to receive either the supplement or a placebo alongside…

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This large phase III trial studied whether adding the targeted drug cetuximab to standard chemotherapy after surgery helps prevent cancer from coming back in patients with stage III colon cancer. Over 3,300 patients took part, and the study focused on those with a specific geneti…

This trial compares two types of oral nutritional supplements given to colorectal cancer patients before surgery. One group receives standard high-protein drinks, while the other gets immunonutrition drinks enriched with arginine, nucleotides, vitamin D, and omega-3 fatty acids. …

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This completed study looked at whether adding an immune-boosting drug called thymalfasin to standard chemoradiotherapy and a PD-1 inhibitor could help shrink advanced rectal tumors before surgery. Researchers studied 47 patients with stage II/III mid-low rectal cancer. The main g…

This study tests whether a combination of three drugs—cisplatin, nivolumab, and temozolomide—can shrink tumors in people with advanced colorectal cancer that has not responded to other treatments. The cancer must be a specific type called MMR-proficient. The trial involves 18 par…

This study tested whether taking tempeh powder (a source of isoflavones) and vitamin D3 daily for 8 weeks could improve vitamin D levels, reduce inflammation, and boost quality of life in people with inflammatory bowel disease (IBD). Fifty adults with ulcerative colitis or Crohn'…

This trial tests whether a program of exercise, nutrition advice, and psychological support—started four weeks before surgery and continued afterward—can reduce complications in people having colon cancer surgery. Participants are adults over 40 with non-metastatic colon cancer w…

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it takes hold in the body. Participants received either MB310 or a placebo, and researchers monitored side effects…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This study compared two common surgeries for perianal fistula—a painful tunnel near the anus. One hundred adults were split into two groups: one received the LIFT procedure (which aims to preserve muscle control) and the other received fistulotomy with a seton (a thread placed in…

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested whether a 20-minute arm cycling exercise, done twice daily for five days, could improve lung function and recovery in 60 elderly patients after colon cancer surgery. Participants also received standard physical therapy. The goal was to see if the arm exercise co…

This study tested whether adding the arthritis drug Celebrex to an experimental chemo drug called EPO906 could reduce severe diarrhea in people with advanced colorectal cancer. The trial enrolled 75 patients who had already tried other treatments. The first phase found the safest…

This study tested two different ways of stitching the belly wall closed after colorectal cancer surgery to see which one better prevents the wound from bursting open. Forty adults having open surgery were randomly assigned to either an interrupted 'figure-of-X' stitch or a contin…

This study tested two surgical methods for treating a type of anal fistula called transsphincteric anal fistula. Forty adults were randomly assigned to receive either the standard LIFT procedure or a modified version that approaches the fistula from the side. Researchers measured…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study tested whether adding bevacizumab to a powerful four-drug chemotherapy regimen (FOLFOXIRI) could shrink liver tumors in people with colorectal cancer that had spread only to the liver and could not be removed surgically. The goal was to see if more patients could then …

This study tested whether adding the anti-inflammatory drug celecoxib to standard FOLFOX chemotherapy helps prevent cancer from returning in people with stage III colon cancer after surgery. Over 2,500 participants were randomly assigned to receive either celecoxib or a placebo a…

This study tested whether injecting a special dye (ICG) during laparoscopic colorectal cancer surgery helps surgeons see blood flow and choose a safer spot to cut. Over 560 adults took part, with half getting the dye and half relying on the surgeon's usual judgment. The main goal…

This study tested a temporary device called Colovac 2 in 24 people undergoing colon cancer surgery. The device is placed inside the bowel to protect the surgical connection while it heals, potentially avoiding the need for a temporary stoma. Researchers checked if the device stay…

This registry followed 152 patients with colorectal cancer that had spread mainly to the liver. Doctors used tiny beads called LifePearl Microspheres loaded with the chemotherapy drug irinotecan, delivered directly to the liver's blood supply. The goal was to see how and when thi…

This study tested whether placing a temporary drain in the pelvis after rectal cancer surgery reduces the risk of serious infections like leaks or abscesses. About 500 patients were randomly assigned to receive a drain or not. The main goal was to see if drainage lowered pelvic s…

This study looked at the long-term safety of vedolizumab, a biologic drug given by IV, in 59 children with ulcerative colitis or Crohn's disease. Participants had already completed a previous study and continued treatment to monitor for side effects. The goal was to see if the dr…

This registry followed 500 adults with colorectal cancer that spread to the liver. All were treated with a microwave ablation device that uses heat to destroy tumors. The goal was to see how well the device controls tumors locally over 12 months and to track any side effects. The…

This study tested a drug called ustekinumab in 112 children with moderate-to-severe ulcerative colitis, a condition causing inflammation in the colon. The goal was to see if the drug could reduce symptoms like diarrhea and bleeding and help the colon heal. Children first received…

This phase 3 trial tested whether adding two months of Folfirinox chemotherapy before standard radiation and chemo could help more patients with early-stage rectal cancer avoid major surgery. 218 adults with small, low-lying tumors were enrolled. The goal was to see if more patie…

This study compared two low-volume laxatives used to clean the colon before a colonoscopy: one liter of polyethylene glycol with ascorbate (PEG1A) and sodium picosulfate with magnesium citrate (PSCM). The goal was to see which one provides a higher quality colon cleansing, which …

This early-phase trial tested a combination of two drugs (MEK162 and mFOLFIRI) in 25 adults with advanced RAS-positive colorectal cancer that had stopped responding to standard treatment. The main goal was to find the safest dose and check for side effects. Researchers also looke…

This early-stage study tested a new antibody drug (similar to cetuximab) in 18 people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to check safety and how the drug moves through the body. Participants received one of two do…

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This early-stage study tested a custom-made yeast vaccine designed to train the immune system to recognize and attack leftover cancer cells. Five adults with various cancers (like colorectal, breast, or lung) who had completed initial treatment received the vaccine. The goal was …

This study tested a treatment plan for locally advanced rectal cancer that uses a short course of radiation followed by chemotherapy, aiming to avoid surgery. 39 patients were enrolled. The goal was to see if the cancer could be completely controlled without an operation, using a…

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from cont…

This study tested a new way to reconnect the colon after removing a cancerous section using a robot. The technique uses a special double purse-string stitch and a single stapler. Thirty-nine patients with sigmoid colon cancer were included, and the study looked at how well the te…

This study tested whether adding fenofibrate, a drug typically used for high cholesterol, to the standard treatment mesalamine can improve symptoms and quality of life in people with mild-to-moderate ulcerative colitis. The trial enrolled 60 adults and measured changes in disease…

This early-phase study tested a new drug, HBM1020, in 17 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. The drug was given by IV every three weeks. Because this is a Phase 1 trial, i…

This study tested a device called Colovac+ in 27 adults having surgery for colorectal cancer. The device is placed inside the bowel to protect the surgical connection and keep stool away while it heals. The goal was to see if it is safe and effective, and whether it could help pa…

This study tested whether people with ulcerative colitis can use a home stool test to catch inflammation early and prevent symptom flares. Over 700 adults in remission used a smartphone-based test kit to measure calprotectin levels. The goal was to see if this proactive monitorin…

This early-phase study tested the safety of combining the immunotherapy drug pembrolizumab with precise, high-dose radiation (SBRT) to the liver in 15 adults with colorectal cancer that had spread only to the liver. The goal was to see if this combination could prevent the cancer…

This study tested whether a daily bath with a traditional Chinese herbal mixture called Tongyangxiao can help surgical wounds heal faster after anal fistula surgery. 115 patients used either the herbal bath or a standard antiseptic bath for 14 days after surgery. Researchers meas…

This study compared two methods for removing non-cancerous colon polyps that are 10-19 mm in size: cold snare (no heat) and hot snare (uses heat). 216 adults undergoing colonoscopy were randomly assigned to one method. The goal was to see if cold snare is as effective and safe as…

This study tested a new two-drug combination (encorafenib and cetuximab) against standard treatments in 107 Chinese patients with a specific genetic mutation (BRAF V600E) that makes colorectal cancer harder to treat. The goal was to see if the new combo could slow cancer growth b…

This study tested a treatment for people with colorectal cancer that spread to the liver and had not responded to at least two prior therapies. The treatment combined a strong chemotherapy cocktail delivered directly to the liver (FOLFOXIRI via hepatic arterial infusion) with an …

This phase 2 study tested the immunotherapy drug prolgolimab in 30 people with a specific type of colorectal cancer (MSI/dMMR) that had not spread. Participants received the drug for 6 months before planned surgery. The main goal was to see if the cancer completely disappeared in…

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like infliximab or vedolizumab helps people with moderate to severe ulcerative colitis achieve endoscopic remission (healing of the gut lining). The trial enrolled 438 adults…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…

This study tested a newer, less invasive surgery called ETAP (done through the anus) against standard laparoscopic surgery (done through the belly) for low rectal cancer. 226 adults took part. The goal was to see if ETAP is as good at removing all cancer while possibly leading to…

This phase II trial tested the immunotherapy drug nivolumab (Opdivo) in 35 adults with advanced colorectal cancer that has a specific marker (class II expression) and is microsatellite stable, a type that usually does not respond to immunotherapy. The goal was to see if the drug …

This trial tested a new method called underwater ESD for removing large, flat colon polyps. Instead of using gas to inflate the colon, doctors fill it with saline water. The goal was to see if this reduces complications like bleeding or perforation and improves complete removal. …

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested a drug called axitinib against a placebo in 52 people with advanced colorectal cancer that had spread to the liver and stopped responding to chemotherapy. The goal was to see if axitinib could help control the cancer and to test a special ultrasound technique th…

This study compared two surgical methods for treating a burst section of the colon caused by diverticulitis, a condition that leads to severe abdominal infection. 102 adults with this infection were randomly assigned to either a traditional two-step surgery (Hartmann procedure) o…

This study compared two ways to close skin after colorectal cancer surgery: a tissue adhesive (skin bond) and traditional skin stapling. Researchers looked at wound infection rates within 30 days, pain, and cost in 304 patients. The goal was to see if skin bond leads to fewer inf…

This study tested a new drug called TAK-676, alone and with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to check safety and find the highest dose that causes few side effects. The study also looked at how well …

This study tested giving chemotherapy before a less invasive surgery for early rectal cancer. The goal was to see if this approach could allow patients to keep their rectum instead of needing major surgery. 58 people took part, and the treatment was considered successful if at le…

This completed trial tested whether a mix of 43 plant polyphenols can counteract health damage from environmental pollutants. 98 adults took either the polyphenol supplement or a placebo for a period. Researchers measured changes in gut health, inflammation, and blood markers to …

This study looked at 180 people with rectal cancer that had spread to lymph nodes in the pelvis. One group received a three-drug chemotherapy regimen (FOLFOXIRI) followed by surgery to remove the affected lymph nodes. The other group got standard chemoradiotherapy before surgery.…

This phase 3 trial tested whether a surgical procedure called laparotomy plus heated chemotherapy (HIPEC) could improve outcomes for colorectal cancer patients at high risk of cancer spreading in the abdomen. 150 patients who had already undergone surgery and chemotherapy were ra…

This study tested whether a device that uses light to monitor blood flow (photoplethysmography) could help doctors manage fluids better during colorectal surgery. The goal was to reduce complications after surgery. 160 adults having colorectal surgery took part. The approach is n…

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested a new method called underwater endoscopic submucosal dissection (UESD) for removing large colon growths. Instead of using gas to inflate the colon, the doctor fills it with saline (salt water) to improve visibility and make the procedure easier. The trial involv…

This study looked at whether a high-protein drink with added arginine can reduce problems like infections and slow bowel movement after colorectal surgery. It included 44 adults who were malnourished or at risk of malnutrition before their operation. Participants received either …

This completed Phase 2 trial tested whether a special DNA-based test could predict how well patients with stomach or rectal cancer respond to immunotherapy (tislelizumab) combined with chemotherapy and/or radiation. 189 adults with advanced cancer participated. The goal was to se…

This early-phase study tested a personalized immunotherapy (iNeo-Vac-P01) in 6 patients with stage III colorectal or non-small cell lung cancer who had already completed surgery and standard adjuvant therapy. The vaccine was designed to target unique neoantigens from each patient…

This study looked at whether adding metformin, a common diabetes medicine, to standard chemo and radiation therapy could help people with locally advanced rectal cancer. 60 adults with stage T3 or T4 rectal cancer took part. The main goal was to see if the combination led to a co…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested a new cancer drug called ERAS-007, given by mouth, together with other targeted therapies in 101 people with advanced colorectal or pancreatic cancers that have certain gene changes. The main goals were to check safety, find the best dose, and see how the drugs …

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic condition causing inflammation in the colon. 85 participants received either donor or their own stool via tubes and enemas. The goal was to see if donor transplant…

This study looked back at medical records of 81 people with severe ulcerative colitis to see if starting upadacitinib early works better than using it after other treatments fail. Researchers checked how many avoided surgery and achieved remission within 12 weeks. The goal is to …

This study tested an experimental pill called MORF-057 in 39 adults with moderate to severe ulcerative colitis. The drug aims to reduce gut inflammation by blocking a specific protein. Researchers measured changes in colon tissue health and symptom scores after 12 weeks of treatm…

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 people with a specific type of advanced colon cancer that had spread. The goal was to see if the combo could shrink tumors or stop them from growing. Participants took palbociclib pills and received ce…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This study tested a 15-day diet called UC-TREAT, rich in high-fiber foods, fermented foods, and berries, in 36 adults—some healthy and some with quiescent (inactive) ulcerative colitis. Researchers measured changes in gut bacteria, digestive symptoms, and diet acceptability. The …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tested whether physiotherapist-led pelvic floor and bowel training could improve bowel function in people who had ileo-anal pouch surgery for ulcerative colitis or familial adenomatous polyposis. Fifty-three participants were randomly assigned to either the behavioural…

This study tested a two-step approach for people with metastatic colorectal cancer that doesn't respond well to standard treatments. First, patients received a drug called temozolomide to make their tumors more genetically unstable. Then, they received the immunotherapy drug pemb…

This study tested a traditional Chinese medicine formula called modified Si Ni San in 32 adults who had colorectal polyps removed. The goal was to see if the herbal treatment could improve gut bacteria balance and reduce inflammation better than standard probiotics. Results may h…

This study tested a combination of two treatments (regorafenib and FOLFIRINOX) in 13 people with a type of advanced colorectal cancer that has a specific gene change (RAS mutation). The main goal was to see if the combination was safe and tolerable. The study also looked at how l…

This trial tested a new approach for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Doctors removed immune cells from patients' tumors, used CRISPR gene editing to disable a gene called CISH, and then infused the modified cells b…

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. T…

This study tested a drug called romiplostim in 165 adults with gastrointestinal, pancreatic, or colorectal cancer who were receiving chemotherapy. The goal was to see if romiplostim could prevent low platelet counts (thrombocytopenia) that often force doctors to delay or reduce c…

This study looked at 20 children with Hirschsprung disease, a condition where part of the bowel lacks nerve cells, causing severe constipation. Researchers compared two surgical methods—Swenson and Soave—to see which one had shorter operation time and better daily bowel movements…

This study tested whether a prebiotic called 2'-fucosyllactose can help people with mild-to-moderate ulcerative colitis. 38 adults took the prebiotic or a placebo for four weeks, then switched. Researchers measured symptoms, gut bacteria, and inflammation markers. The goal was to…

This study tested the drug tislelizumab given before surgery in 33 people with early-stage colorectal cancer that has specific genetic changes (MSI-H or dMMR). The goal was to see if the drug could shrink or eliminate tumors before surgical removal. The trial has completed, and r…

This phase 2 trial tested whether adding the immunotherapy drug nivolumab to standard chemotherapy could help people with a specific type of metastatic colorectal cancer (MSS/pMMR). Eighty participants received either the combination or chemotherapy alone. The main goal was to se…

This phase II trial tested a combination of three drugs—TAS-102, irinotecan, and bevacizumab—in 42 people with advanced colorectal cancer that had spread or couldn't be removed. The goal was to see if this mix could slow tumor growth better than standard treatments. Participants …

This phase II trial tested two different drug combinations in 240 people with advanced HER2-positive colorectal cancer that had spread and could not be removed by surgery. One group received the antibodies trastuzumab and pertuzumab, while the other received cetuximab (an antibod…

This study tested a web-based telemonitoring system called TECCU for people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis). 290 participants in Spain were randomly assigned to use the app or receive usual care. The goal was to see if th…

This phase 2 trial tested whether combining two drugs, sorafenib and irinotecan, works better than either drug alone in people with advanced colorectal cancer that has a KRAS mutation and has stopped responding to all standard treatments. The study enrolled 173 participants acros…

This study tested whether a Medtronic pump and Codman catheter can safely deliver chemotherapy directly to the liver in 35 people with colorectal cancer or bile duct cancer that spread to the liver. The main goal was to check safety, including liver side effects and need for sten…

This study tested a combination of the targeted drug cetuximab with a strong chemotherapy cocktail (FOLFIRINOX) as a first treatment for people whose colorectal cancer had spread and could not be removed by surgery. The goal was to see if this mix could shrink tumors better than …

This early-phase study tested a new drug called SHR-A1811 in 101 people with advanced stomach or colorectal cancers that have a specific protein called HER2. The main goals were to check the drug's safety, find the best dose, and see early signs of tumor shrinkage. Participants h…

This study tested a combination of two drugs, sorafenib and irinotecan, in 64 adults with metastatic colorectal cancer that has a K-RAS mutation and has progressed after prior treatment. The goal was to see if the combination could control the disease and to check for side effect…

This study tested whether more intense chemotherapy combinations could shrink liver tumors in people with colorectal cancer that cannot be fully removed by surgery. 124 participants received either standard two-drug chemo or one of three stronger regimens. The goal was to see if …

This study looked at whether the drug dexmedetomidine, given during laparoscopic surgery for rectal or sigmoid colon cancer, can protect the lungs of patients aged 60 and older. The trial included 64 participants and measured oxygen levels and other breathing indicators. The goal…

This early-phase study tests two experimental drugs, BI 765049 and ezabenlimab, in adults with advanced solid tumors like colorectal, lung, and pancreatic cancer. The main goal is to find the highest safe dose of BI 765049 alone and in combination with ezabenlimab. Participants r…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This study tested a new robotic surgery method called natural orifice specimen extraction surgery (NOSES) for middle rectal cancer. In this approach, the removed tumor is taken out through the anus instead of a large abdominal cut. The study involved 150 patients and compared NOS…

This early-phase trial tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, and lung cancers) that had stopped responding to standard treatments. SNB-101 is a nanoparticle version of SN-38, the active part of a common chemotherapy dru…

This study tested whether rutin, a natural compound found in plants, can help people with ulcerative colitis. 60 adults took rutin tablets or a placebo for 30 days. The goal was to see if rutin reduces gut inflammation and improves symptoms like diarrhea and abdominal pain.

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitore…

This study tested two experimental drugs (BI 754111 and BI 754091) that help the immune system attack cancer. It included 172 adults with advanced solid tumors, including non-small cell lung cancer that had returned after prior treatment. The first part found the safest dose, and…

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This study compared two procedures for removing large, flat colon polyps (over 25 mm) in 360 adults. One method, ESD, removes the polyp in one piece but has higher risks and costs. The other, EMR, removes it in pieces but is safer and cheaper. The goal was to see which leads to f…

This Phase 3 study tested the drug FTD/TPI (a chemotherapy pill) against a placebo in 243 people who had surgery for colorectal cancer but still had cancer DNA in their blood. The goal was to see if the drug could prevent the cancer from coming back. Participants took the drug or…

This early-phase trial tested a new drug called CUE-102 in 42 adults with certain advanced cancers (colorectal, gastric, pancreatic, or ovarian) that had returned or spread despite prior treatments. The drug is designed to help the immune system attack cancer cells that carry a s…

This study tests whether intestinal ultrasound can accurately detect pouchitis—inflammation of the internal pouch created after ulcerative colitis surgery. Adults who have had this surgery will receive an ultrasound, and the results will be compared to the standard pouchoscopy wi…

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This trial evaluates an AI-based software tool designed to assist doctors in interpreting colonoscopy images. Using previously collected images and biopsy results from over a thousand patients, the study checks how accurately the AI classifies colorectal lesions as cancerous, pre…

This study investigates whether a protein called FGF19, normally found in the intestine and gallbladder, appears at higher levels in the blood of people with breast or colorectal cancer compared to healthy individuals. Researchers will measure FGF19 and related markers in fasting…

This study tests whether a combination of serial C-reactive protein blood tests and targeted CT scans can safely identify which rectal cancer patients can skip a temporary ileostomy after laparoscopic low anterior resection. Anastomotic leakage is a serious complication, and a pr…

This study tests whether a new imaging tracer called 18F-PSMA-1007 can better detect liver metastases in people with colorectal cancer. Participants receive an injection of the tracer and then undergo a PET/CT scan. The goal is to see if this method finds the same liver lesions a…

This study tests whether a software called ColoMaia II can help doctors find abnormal growths (polyps) in the colon during a routine colonoscopy. About 600 adults aged 40 to 80 having a screening or diagnostic colonoscopy will be randomly assigned to have the procedure with or wi…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study looked at whether measuring a protein called calprotectin in the blood can help diagnose acute appendicitis. Researchers compared 74 patients with abdominal pain, some with confirmed appendicitis and others with non-specific pain. They measured calprotectin levels and …

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This early-phase trial tested a radioactive tracer called 68Ga-NODAGA-SNA009 in 12 people with colorectal cancer. The tracer targets a protein (GPA33) found on cancer cells and is used with PET scans to see where the cancer is in the body. The main goals were to check safety and …

This study tested whether an artificial intelligence system called CAD EYE can accurately predict if colon polyps are cancerous during a screening colonoscopy. Researchers compared the AI's predictions to the doctor's judgment and the final lab results. The goal is to see if AI c…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This study looked at 416 people who had left-sided colon surgery. A few days after surgery, each person got both a CT scan and an endoscopy to check for leaks where the colon was reconnected. The goal was to see which test is more accurate at finding these leaks. Results help doc…

This study tested whether using artificial intelligence (AI) during colonoscopy helps find more polyps in people with Lynch syndrome, a genetic condition that raises colon cancer risk. One hundred participants each had two colonoscopies back-to-back, with the second using either …

This study tested an artificial intelligence (AI) tool that helps doctors diagnose colorectal polyps during a colonoscopy. The AI analyzes images from a special high-magnification endoscope to predict whether a polyp is cancerous or not. The goal is to improve accuracy and reduce…

This study looked at a new test called OSNA to find free cancer cells in the belly fluid of 108 people with stomach or colon cancer who had no visible spread. The goal was to see if OSNA could detect cancer cells better than the usual lab method. If successful, this could help do…

This completed trial tested whether a 3D imaging device helps doctors more accurately classify colon polyps and adenomas during colonoscopy compared to standard 2D imaging. 460 adults with colorectal polyps were randomly assigned to either 3D or 2D imaging before polyp removal. T…

This study tested a new laser-based device (AccuMeasure) to measure the size of colon polyps during a colonoscopy. Accurate polyp size is important because it helps doctors decide how often patients need follow-up screenings to prevent colorectal cancer. The study involved 138 ad…

This study looked at three screening methods—colonoscopy, colon capsule endoscopy, and a fecal immunochemical test (FIT)—to detect colorectal cancer or advanced growths in people aged 45 and older who have a first-degree relative with colorectal cancer. The goal was to see if the…

This study tested whether an AI tool (GI Genius) helps doctors find more polyps during colonoscopy in people aged 50-74 who had a previous polyp. Over 1,100 participants were randomly assigned to either AI-assisted or standard colonoscopy. The main goal was to see if AI increases…

This study looked at whether offering a blood test for colorectal cancer screening would be accepted by average-risk patients in Appalachian outpatient clinics. Over 200 participants were given the option of a standard screening method or a blood-based test called Shield. The goa…

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps a…

This trial tests whether giving children with autoimmune diseases (like inflammatory bowel disease or rheumatologic conditions) an extra booster dose of the flu vaccine improves their immune response compared to a single dose. These children take immunosuppressive medications tha…

This study tests whether a remotely-delivered patient navigation program helps more rural adults complete colonoscopy screening for colorectal cancer. Participants aged 45-75 who are due for a colonoscopy receive either navigation support from a trained lay navigator or an educat…

This study tests whether giving general practitioners a list of patients who have not completed colorectal cancer screening encourages those patients to get screened. Over 48,000 patients aged 50-74 are involved, and their doctors either receive the list or do not. The goal is to…

This study tested whether personalized reminders (like texts or emails) could encourage more people to return their at-home stool test kits for colon cancer screening. Over 2,100 adults aged 45 to 75 who had not yet returned their kit took part. The goal was to see if these gentl…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study looked at whether mailing free stool tests (FIT kits) to people's homes could increase colorectal cancer screening rates. Over 4,300 adults aged 45-75 who were at average risk took part. The goal was to make screening easier for those who might otherwise skip it, espec…

This study looked at whether giving extra help and information to spouses of colorectal cancer patients could get them to complete a simple at-home screening test (FIT). About 60 people took part. The goal was to find out what stops them from screening and if a tailored approach …

This study looked at whether taking omeprazole (a heartburn drug) and low-dose aspirin together could help prevent colorectal polyps in people at high risk. Twenty-one adults with a history of multiple polyps took both pills daily for 25-45 days. Researchers collected tissue samp…

This phase 3 trial compared colonoscopy with annual fecal occult blood tests for colorectal cancer screening in nearly 5,000 healthy adults aged 50-69. The goal was to see which method finds more early tumors and has a better balance of benefits and harms. Participants were rando…

This study tested whether taking magnesium supplements could reduce the risk of colorectal cancer in people with a specific genetic makeup. Researchers gave 250 participants either magnesium or a placebo for 12 weeks and measured changes in colon tissue markers linked to cancer d…

This observational study followed 145 adults who received REBYOTA™ to prevent another Clostridioides difficile infection (CDI) after completing antibiotics. Researchers collected information from medical records over 6 months to see how many people stayed infection-free. The goal…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This study tests whether a home-based telerehabilitation program can improve functional capacity and quality of life for patients recovering from colorectal cancer surgery. Fifty-four participants will either follow the digital program or receive a standard booklet. The goal is t…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study looked at 250 children having laparoscopic surgery for appendicitis. It compared using low versus medium gas pressure in the belly during the operation to see if it affects pain the next day. The goal is to find ways to make children more comfortable after surgery.

This study investigates how easy or hard it is for adults with inflammatory bowel disease (IBD) to follow three different eating plans: intermittent fasting, the Mediterranean diet, and the low FODMAP diet. Researchers will interview participants to understand what helps or hinde…

This trial compares two bowel-cleansing agents—lactulose and polyethylene glycol (PEG)—to see which provides a cleaner colon for colonoscopy. About 450 adults aged 18–79 scheduled for a screening colonoscopy will be randomly assigned to one of the two preparations. The study meas…

This study tests whether morning light therapy can improve sleep timing and reduce symptoms in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Sixty-eight adults with active IBD symptoms will either use a light therapy device at hom…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This trial compares two approaches to a nerve block (TAP block) for pain after colorectal cancer surgery. One group receives the standard numbing drug bupivacaine, while the other gets bupivacaine plus dexmedetomidine, a drug that may extend pain relief. The study measures pain s…

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

Many colorectal cancer survivors lose muscle mass and strength after chemotherapy. This study tested whether adding creatine supplements to a 10-week resistance training program could help. Twenty-seven survivors participated, comparing those who took creatine with those who only…

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a web app called PrehabPal designed to help frail adults aged 65 and older prepare for colon cancer surgery. The app creates a personalized prehabilitation program and offers coaching. Researchers compared it to standard written instructions in 132 participants …

This study tested whether a self-regulation hypnotic intervention could help reduce pain and anxiety during brachytherapy for rectal cancer. Fifty-two adults were randomly assigned to receive either hypnosis training or standard care with pain and anxiety medication. Researchers …

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested whether silkworm pupa tablets can improve nutrition and reduce frailty in people who had surgery for stomach, colorectal, esophageal, or pancreatic cancer. 120 participants took the tablets for 3 months. Researchers measured weight, frailty, muscle mass, and qua…

This study tested whether the Paula Method of muscle exercises can help people who have bowel control problems after rectal cancer surgery. 62 adults who had surgery and still had symptoms took part. The exercises aim to strengthen muscles naturally without drugs or surgery.

This study tested whether psyllium husk, a type of fiber supplement, can reduce bowel symptoms and improve quality of life in people who had rectal cancer surgery. 24 participants who had ongoing bowel issues after surgery took psyllium husk. The goal was to see if it helps with …

This study tested whether a temporary stent placed inside the bowel could replace a traditional ileostomy (a bag outside the body) after rectal cancer surgery. 570 patients at high risk for leaks were randomly assigned to either the stent or ileostomy. The goal was to see if the …

This study looked at whether doing special exercises before colorectal cancer surgery (called prehabilitation) helps patients recover better compared to standard care. Over 700 adults scheduled for surgery took part. The main goal was to see if the exercise group had better physi…

This study tested whether using a cold therapy device on the belly after appendix removal helps control pain in children ages 7 and older. Half the kids got the cold pack plus usual care, the other half got usual care alone. Researchers measured pain scores, morphine use, and hos…

This study tested whether two nurse phone calls during the first three cycles of chemotherapy could improve the emotional state and quality of life of patients with breast, colon, or rectal cancer. 274 patients were randomly assigned to receive either standard care or standard ca…

This study tested a web-based support program for people with colorectal cancer undergoing treatment. The program provided information and tips on physical, emotional, and daily-life challenges. Researchers measured whether it helped reduce symptoms and improve quality of life co…

This study tested whether an education and support program can help family caregivers of cancer patients feel more confident and less anxious. About 484 caregivers and patients took part. Researchers compared different types of support to see which worked best.

This study tested whether a probiotic called Lactobacillus rhamnosus GG can reduce inflammation and PTSD symptoms in veterans. Researchers enrolled 383 veterans with PTSD and gut issues, giving them either the probiotic or a placebo. The goal was to see if calming inflammation in…

This study tested a newer, gentler type of keyhole surgery for removing the appendix. It uses lower gas pressure and smaller instruments than standard laparoscopy. Fifty adults with uncomplicated appendicitis took part, and the researchers measured their pain, recovery time, and …

This study looked at whether mindfulness exercises can lower stress and improve communication between patients with liver disease and their doctors. 56 adults took part, answering surveys about their stress, anxiety, and how well they felt they could share decisions with their he…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study looked at whether chewing gum after colorectal surgery can help reduce nausea, vomiting, and get the bowels working again sooner. 84 adults who had laparoscopic colorectal surgery took part. The idea is that chewing tricks the body into thinking it's eating, which may …

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

This study tested an online educational program for cancer patients receiving chemotherapy. The program included video sessions, peer discussions, and digital materials to help with symptom management and emotional coping. Researchers compared 212 patients who used the program to…

This early-phase study tested whether TUDCA, a bile acid supplement, is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults took TUDCA for 6 weeks while researchers measured changes in cell stress markers from colon biopsies. The goal…

This phase II trial tested a concentrated plant dietary supplement (made from foods like taro, rice, and carrots) in 30 people with gastrointestinal cancers who had diarrhea from chemotherapy. Participants received the supplement alongside standard anti-diarrheal treatment. The g…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study compared two types of nerve blocks (TAP and ESPB) to standard pain medication (tramadol) for people with acute appendicitis in the emergency department. The goal was to see if these blocks could reduce pain before surgery and lower the need for opioids. The trial inclu…

This pilot study tested whether offering free, personalized legal services to people with advanced colorectal cancer could help reduce stress, financial worries, and improve quality of life. Twenty participants received help from a nonprofit legal organization for six months. Res…

This study tested whether taking N-Acetylcysteine before chemotherapy could reduce nerve damage in colorectal cancer patients receiving oxaliplatin. 46 participants received either N-Acetylcysteine or a placebo before each chemo session. The goal was to see if the supplement coul…

This study compared two types of nerve blocks (erector spinae plane block vs. transversus abdominis plane block) for pain relief after laparoscopic appendix removal. 72 adults aged 18-50 participated. The goal was to see which block provides better pain control and fewer complica…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study tested a bladder training method called ICCAUT in 400 people who had rectal cancer surgery. The training involves clamping the urinary tube and practicing urinating before the tube is removed. The goal was to see if this reduces the need for a new catheter or incomplet…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This study compared two ways to manage pain during and after colorectal surgery: a TAP block (an injection into the abdominal wall) versus epidural anesthesia (an injection near the spine). About 200 adults having elective colon or rectal surgery for cancer or diverticulitis took…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study tested whether sending personalized text messages could help colorectal cancer survivors eat more whole grains and less refined grains. Forty-six survivors who had finished active treatment received text messages and nutrition materials. The main goal was to see if peo…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study examines national data from Switzerland to understand trends in early-onset colorectal cancer, which affects people under 50. By analyzing surgical cases from 2003 to 2022, researchers aim to see how common this cancer is, where it occurs, and what short-term outcomes …

This pilot study tested whether a mindfulness program could help reduce colorectal cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods and have had a colon polyp. Twenty-four women participated to see if the program was feasible and acceptab…

This study looks at whether obesity, measured by body mass index (BMI), affects the chances of a 'textbook outcome' after minimally invasive surgery for colorectal cancer. A textbook outcome means the surgery went smoothly with no major complications, a short hospital stay, and n…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study looks back at the medical records of over 1,000 people hospitalized with inflammatory bowel disease (IBD) in China. The goal is to understand the features, treatments, and outcomes of patients whose IBD does not respond well to standard therapies. By analyzing real-wor…

This study observes 1006 adults with ulcerative colitis or Crohn's disease in Brazil who are taking or have taken vedolizumab. Researchers will look at how long patients stay on the drug and what other treatments they used before. No new treatment is given—this is just a review o…

This study looks at whether having certain E. coli bacteria in the colon after colorectal cancer surgery is linked to anxiety or depression. Researchers will compare psychiatric symptoms and diagnoses between patients who carry the bacteria and those who do not. The goal is to be…

This study measures the carbon dioxide emissions produced during colonoscopy for colorectal cancer screening, including energy use, equipment, medications, and waste. Researchers will also compare different polypectomy techniques to see which are more eco-friendly. The goal is to…

This study looks at how a surgeon's growing experience with single-incision laparoscopic surgery—a minimally invasive technique using a single small cut—affects short- and long-term results for people with rectal or sigmoid colon cancer. By analyzing past cases from one surgical …

This study looks at people who develop a leak after colorectal cancer surgery. Researchers will track which patients need emergency surgery, die within 90 days, or end up with a permanent stoma. The goal is to find factors that predict these outcomes and help guide future care.

This large Italian study investigates whether a composite measure called 'Textbook Outcome' can serve as a reliable indicator of quality in colorectal cancer surgery. Researchers will analyze data from over 6,000 patients to see if meeting six key criteria—including survival, com…

This study compares how often bowel obstruction occurs after two types of appendix removal surgery: open appendectomy and laparoscopic appendectomy. Fifty people with acute appendicitis will be randomly assigned to one of the two procedures. The goal is to see whether the minimal…

This study aims to create a simple model that uses routine clinical and lab data from the first day after colorectal cancer surgery to predict the risk of anastomotic leakage—a serious complication where the surgical connection leaks. Researchers reviewed records of 117 patients …

This study tests a computerized tool that collects patient information and generates personalized, guideline-based next steps for colorectal cancer screening. It focuses on a large, diverse population of under- and uninsured patients in Dallas. The goal is to improve screening ra…

This study aims to create a mindfulness program designed for couples where one partner has metastatic colorectal cancer. Researchers will interview patients, their partners, and clinicians to understand their needs and preferences for such a program. The goal is to design a progr…

This study compares two ways of doing colonoscopy in people with inflammatory bowel disease (IBD) who are at higher risk for colon cancer. One method takes biopsies only from visible abnormal areas, while the other also takes random biopsies from normal-looking tissue. The goal i…

This study looks at whether a computer-aided diagnosis (CADx) system can help doctors better identify small colorectal polyps (5 mm or smaller) during a colonoscopy. Over 360 doctors will use the system to predict whether polyps are harmless or precancerous. The goal is to see if…

This study investigates whether GHB is truly the most common drug used in chemical submission (drug-facilitated assault) or if its short detection window in blood and urine hides its real prevalence. Researchers will analyze hair samples from adult victims of suspected chemical s…

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This study tested whether a weekly electronic survey could help identify cancer treatment delays and racial differences. About 100 adults with newly diagnosed breast or colorectal cancer who hadn't started treatment yet filled out a short survey each week for 8 weeks. The goal wa…

This study investigates whether having an empty bladder reduces movement of the mesorectum (tissue around the rectum) during radiotherapy for rectal cancer. About 50 adults with rectal cancer receive planning CT scans and weekly CBCT scans under both empty and full bladder condit…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This completed study surveyed over 2,500 appendicitis patients to understand their satisfaction and regret after choosing either surgery or antibiotics. Researchers aim to use this information to design decision-support tools that help future patients make choices aligned with th…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study looks at whether a narrowed inferior mesenteric artery (IMA) — seen on routine CT scans — is linked to a higher chance of anastomotic leakage after rectal cancer surgery. Anastomotic leakage is a serious complication where the surgical connection leaks. The study will …

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cel…

This study followed 110 people with anal cancer to see if PET/CT scans can help doctors monitor the disease after initial treatment. Researchers tracked how long patients stayed cancer-free and measured metabolic activity in tumors. The goal is to find better ways to detect relap…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at whether a new blood test called EPISPOT can predict how well chemotherapy works in people with metastatic colorectal cancer. Researchers measured circulating tumor cells in 168 patients before and during treatment. The goal was to see if early changes in thes…

This study surveyed 231 adults with Lynch syndrome, an inherited condition that raises bowel cancer risk. Researchers wanted to find out how many people follow the UK recommendation of a colonoscopy every two years, and what makes it harder or easier to keep up with these check-u…

This study looked at whether magnetic stimulation of nerves in the lower back can change how the colon moves. It included 30 people: healthy volunteers, and patients with constipation or fecal incontinence. The goal was to understand the effect, not to treat the condition.

This study looked at the safety of Bevacizumab-Pfizer Biosimilar, a drug used to treat colorectal cancer, by analyzing medical records from 1,000 patients in Japan. Researchers focused on side effects like bleeding, high blood pressure, and kidney problems. The goal was to unders…

This study tested whether a theory-based chatbot could increase colorectal cancer screening rates. 500 adults aged 50-75 in Hong Kong were randomly assigned to receive either standard text reminders or a chatbot that provided personalized risk information and screening guidance. …

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study measured how often adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) show signs of eating disorders, including avoidant/restrictive food intake disorder (ARFID). Researchers used questionnaires to assess eating habits and nutritional status…

This study looked at 30 colorectal cancer patients to see if tumor deposits (small clusters of cancer cells found near the main tumor) can help predict survival and whether the cancer spreads to other organs. Researchers tracked overall survival and the appearance of new metastas…

This study tested a new scoring system called CAT-DESIRE to evaluate ulcerative colitis severity using colonoscopy images. Researchers reviewed images from 235 patients to see if the new score is reliable and can predict long-term outcomes. The goal is to provide a simple, accura…

This study looked at how 208 patients with severe diverticulitis were treated at a Brussels hospital network between 2015 and 2024. Researchers wanted to see which treatments doctors chose, such as medication alone, drainage, or different types of surgery. The goal was to underst…

This study looked for leftover cancer DNA in the blood of over 2,000 people who had surgery for stage II or III colorectal cancer. Participants did not receive any new treatment—they just gave blood samples over about 21 months. The goal was to find patients who might be eligible…

This study looked at 590 colorectal cancer patients to develop a risk tool that predicts postoperative delirium—a common complication causing confusion and slower recovery. Researchers combined blood test results (including the TyG index) with patient subtypes to create a scoring…

This study looked at whether an AI computer program could suggest cancer treatments that match what experts recommend. Researchers reviewed medical records of 30 people with stomach, colon, or pancreatic cancer. They entered key details into the AI and compared its suggestions to…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study looked at 140 patients who had colon cancer surgery and chemotherapy at Rouen University Hospital. The goal was to see if living farther from the hospital caused a longer wait to start chemotherapy after surgery. The findings could help improve care for patients who li…

This completed study interviewed 12 patients waiting for either a colonoscopy or a colon capsule endoscopy. The goal was to understand what factors are most important to them when deciding between these two colon tests. Researchers used telephone interviews and analyzed the conve…

This study looked at antibodies in the intestines of 160 people: 80 with Crohn's disease, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. Researchers took blood samples and intestinal biopsies to compare antibody levels in the gut versus the blood. The goal…

This study looked at 366 adults referred for suspected inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal was to find simple, non-invasive markers that can help doctors diagnose IBD more accurately and predict how the disease will progres…

This study examined how differences in the BAFF gene might affect a person's risk of developing ulcerative colitis and how well they respond to the drug vedolizumab. Researchers analyzed genetic samples from 841 people with ulcerative colitis. The goal was to better understand th…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at 150 colorectal cancer patients to see if counting tumor buds in biopsy samples could predict whether cancer has spread to lymph nodes or other organs. Researchers used a special stain to find tumor buds and counted them in the densest area. They then used a c…

This study involved 132 adults with colorectal cancer who had standard surgery (low anterior resection) and a temporary ileostomy (a stoma to divert waste). The goal was to measure major complications after surgery and create a single safety endpoint. This will help doctors compa…

This study tested a new classification system for people whose colorectal cancer has spread only to the liver. Researchers looked at survival rates and compared different patient groups to see if the system helps predict outcomes. The goal is to better identify which patients mig…

This completed study looked at how often joint pain occurs in 71 people with ovarian, colorectal, or lung cancer who were taking the drug bevacizumab. Participants filled out a questionnaire about their joint pain over 6 months. The goal was to better understand this side effect.

This completed study looked back at medical records of 500 patients aged 50 or younger diagnosed with colorectal cancer or precancerous growths at a hospital in Shenzhen, China. Researchers compared those with early-stage disease to those with later-stage disease to identify fact…

This study tracked 646 people with complex fistulas (abnormal tunnels) caused by Crohn's disease or other conditions. Researchers observed the standard surgical treatments patients received at their clinics and recorded outcomes like fistula closure and complications. The goal is…

This study looked at 57 patients with rectal cancer to compare surgical outcomes from three different treatment approaches: the RAPIDO protocol (short-course radiation plus chemotherapy), standard long-course radiation with chemotherapy, and surgery alone. Researchers measured th…

This study looked at 200 older adults (65+) having planned surgery for colorectal cancer. Researchers used a frailty test before surgery to see if it could predict complications like infections or longer hospital stays. The goal is to help doctors better plan care and reduce risk…

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This completed Italian study looked at how often children with inactive inflammatory bowel disease (IBD) also have disorders of gut-brain interaction (DGBIs), like irritable bowel syndrome. Researchers used the Rome IV questionnaire to compare 220 children with quiescent IBD to h…

This study measured calprotectin, a protein in stool that signals gut inflammation, in 121 healthy adults aged 22 and older. Participants collected a single stool sample at home and mailed it in. The goal is to establish what level is normal, helping doctors better tell apart inf…

This study reviewed medical records of 966 children diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. Researchers looked at how often children needed surgery and how treatments like immunosuppressants and anti-TNF drugs were used over time. The goal was …

This completed study from China looked at 50 adults with Crohn's disease who were treated with two newer biologic drugs, Ustekinumab and Vedolizumab. The goal was to see how well these drugs control the disease and what factors might predict a good response. By analyzing past med…

This completed observational study looked at 669 Crohn's disease patients to see if finding hidden anal fistulas early with MRI leads to better long-term health. Researchers compared patients who had no symptoms but were found to have fistulas on MRI to those who had symptoms. Th…

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study tested whether using an artificial intelligence system (ENDOAID) together with a small attachment on the colonoscope (Endocuff) helps doctors find more precancerous polyps (adenomas) than using AI alone. Over 1,700 adults aged 45-85 undergoing colonoscopy for screening…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at 120 adults with inflammatory bowel disease (IBD) to see if simple stool tests can tell if the disease is active or in remission, just like a colonoscopy does. Colonoscopy is the current gold standard but is expensive, invasive, and not ideal for frequent chec…

This study looked at whether adding walnuts to your diet can change the bacteria in your gut and reduce signs of colon cancer risk. About 140 people at higher risk for colorectal cancer ate walnuts for a month. Researchers measured changes in gut bacteria, blood markers, and colo…

This study looked at whether using a standardized set of measurements, including patient-reported outcomes, can improve care for people with colorectal cancer. Researchers followed 133 patients over time, collecting data on their health and quality of life. The goal was to see if…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This study looked at 74 people with metastatic colorectal cancer starting their first chemotherapy. Researchers took blood samples early in treatment to measure three markers: CEA, circulating tumor DNA, and total cell-free DNA. The goal was to see if early changes in these marke…

This study followed 56 patients who had surgery for non-metastatic colon cancer to see if the number and type of immune cells in their tumors could predict whether the cancer would come back. Researchers analyzed both blood samples and tumor tissue for various immune markers. The…

This study looked at whether a genetic test called QMPSF can help predict if stage II or III colon cancer will come back after surgery. Researchers analyzed tumor tissue from 401 patients for specific DNA changes. The goal was to see if these genetic markers are linked to cancer …

This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to…

This study looked at 846 people who had a positive stool test for colorectal cancer and needed a follow-up colonoscopy. Researchers wanted to understand how involved patients felt in making decisions about their care and how satisfied they were with the entire screening and treat…

This study looked back at the medical records of 500 people with colorectal cancer from two regions in China. Researchers collected information on patients' backgrounds, lifestyle, and treatments to find patterns that affect survival. The goal was to understand regional differenc…

This completed study looked at 29 patients with a hard-to-treat form of advanced colorectal cancer. The goal was to find new ways to group these patients based on the biology of their tumors. This could help doctors choose more effective treatments in the future. The study did no…

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants h…

This study explored how teenagers and their parents react emotionally and mentally when they learn about genetic risks for conditions like hereditary breast cancer, Lynch syndrome, or high cholesterol. Researchers surveyed 162 participants using questionnaires and interviews to m…

This study tested whether starting a colonoscopy with the patient lying on their back (supine) or on their left side (left-lateral) makes a difference. Researchers measured how long it took to complete the procedure, how much pain patients felt, and how difficult the procedure wa…

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This study looked at how two different diets affect gut bacteria and markers linked to colon cancer risk in 15 African American adults at higher risk. Participants ate a high-fat, animal-based diet and a low-fat, plant-based diet for three weeks each. Researchers measured changes…

This completed study from West China Hospital examined tumor tissue from 100 colorectal cancer patients who had already received immunotherapy. Researchers measured levels of a protein called PHGDH to see if it was linked to how well the patients responded to treatment and how lo…

This study looked for the most effective and practical way to screen for anal high-grade lesions (a precancerous condition) in Thai men who have sex with men and transgender women. Researchers tested different screening methods in 950 participants to see which approach finds the …

This study looked at 36 adults with spina bifida to understand why they often have bowel issues. Researchers took small tissue samples from the colon during a routine scope and measured how the rectum works. The goal was to see if nerve damage affects the gut's lining and nerves,…

This study looked at whether using a special balloon-assisted scope (G-Eye) together with artificial intelligence (CAD-Eye) finds more polyps than a standard colonoscopy with AI alone. About 300 people aged 50-74 who had a positive stool test took part. The goal was to see if the…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at nearly 1,000 cancer survivors to find out which follow-up care model works best for their quality of life and satisfaction. Participants were breast, prostate, or colorectal cancer survivors who had finished active treatment. Researchers compared different ca…

This study looked at 70 adults with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it leads to more complications or longer hospital stays. Researchers measured muscle strength, mass, and physical performance. The goal is to find patien…

This study followed 107 adults newly diagnosed with rectal cancer to see how their symptoms, balance, and quality of life changed over time. Researchers used questionnaires to track bowel issues, emotional distress, and balance problems. The goal was to better understand these ch…

This study tested how different social media messages influence people's plans to get screened for colorectal cancer. Over 2,000 participants completed a 15-minute survey after seeing one of several message types. The goal was to see which messages made people more likely to foll…

This study looked at 100 adults having laparoscopic surgery for colon cancer to see if the amount of oxygen delivered to tissues during the procedure affects the risk of a leak where the bowel is reconnected. Researchers measured oxygen delivery using a non-invasive monitor. The …

This study looked at how people feel and function after a two-step surgery for rectal cancer. Researchers followed 65 patients to measure bowel symptoms and their impact on quality of life one year after the final reconstruction. The goal is to identify which patients may have wo…

This pilot study looked at whether repeated FDG-PET/CT scans can help select patients and evaluate how well a special chemotherapy (PIPAC) works for cancer that has spread to the lining of the abdomen. 34 patients with various abdominal cancers were included. The goal was to see …

This completed study tested a blood test that looks for tiny cancer leftovers after surgery in 175 people with stage II or III colorectal cancer. The goal was to see if the test could identify who really needs chemotherapy. If it works, it could help personalize treatment and avo…

This study followed 704 adults with metastatic colorectal cancer who received regorafenib through a French compassionate-use program. Researchers measured how long patients lived after starting the drug and collected data on tumor characteristics and prior treatments. The goal wa…

This study looked at how a short course of antibiotics changes the nerve and glia cells in the lower gut of 10 healthy adults. Researchers took colon tissue samples before and after antibiotic treatment to count these cells and measure gene activity. The goal was to understand if…

This study looked at 598 people who had surgery to remove colorectal cancer with the goal of curing it. Researchers wanted to understand how often the cancer comes back after five years and where it returns. The goal is to use this information to create better follow-up care plan…

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how well doctors follow guidelines when prescribing antiTNFα drugs and whether the benefits outweigh the risks for both mother and baby. Researchers look…

This study looked at how sustainable laparoscopic appendectomy is by measuring its environmental impact (carbon emissions), cost, and health benefits. Researchers followed 63 patients in Chile who had surgery for acute appendicitis. The goal was to create a single score that comb…

This study gathered real-world videos and images from 600 adults undergoing screening or surveillance colonoscopies. The data will be used to develop and test artificial intelligence systems that can help doctors detect colon polyps. The study is complete and focused on data coll…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study looked at 298 patients who had surgery for rectal cancer that came back in the same area. The goal was to find out how often the cancer returns again and what factors increase that risk. Researchers tracked long-term survival and identified key risk factors to help gui…

This study looks at data from 121 people with metastatic colorectal cancer who received two approved treatments—regorafenib and TAS (with or without bevacizumab)—in different orders. Researchers want to see which sequence works better and how long patients live. Since this is an …

This study reviewed the medical records of 255 adults who had colorectal polyps removed during a colonoscopy. The goal was to find out which factors, such as how the polyp was removed or its tissue type, make it more likely to come back. Researchers also tracked any complications…

This study tested an 11-step community program to help African Americans get screened for colorectal cancer. The program included education, risk assessment, and help with barriers like cost, transportation, and scheduling. 163 participants joined, and the study measured whether …

This pilot study tested whether training primary care doctors in shared decision-making could increase colorectal cancer screening rates. Doctors in quality circles received evidence summaries, decision aids, and stool test kits to help patients choose between colonoscopy and FIT…

This study looked at 143 people in China who had a second surgery after rectal cancer treatment because of a leak or tumor return. Researchers wanted to find out what factors help the surgery succeed and whether patients can regain the ability to poop normally. The goal is to bet…

This study tested a device called Napoleon to help gastroenterology fellows measure colon polyps more accurately during colonoscopies. 46 patients aged 45 and older participated. The goal was to see if using the device improves measurement accuracy compared to just looking, which…

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study looked at whether using a special dye (indocyanine green) during laparoscopic surgery for colon or rectal cancer can help surgeons see blood flow in real time and reduce the risk of a dangerous leak where the bowel is reconnected. Researchers compared 115 patients who …

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study looked at 139 children having a colonoscopy to see how often the CMV virus is found in their gut tissue and blood. Some children had inflammatory bowel disease (Crohn's or colitis) and some did not. The goal was to learn which tests best detect CMV in the gut, helping …

This study looked at 690 rectal cancer patients to see if the size of a specific artery (the middle rectal artery) on MRI scans could help predict whether cancer has spread to nearby lymph nodes. The goal was to create a tool that helps doctors decide if more extensive surgery is…

This study tested whether a program that uses computer algorithms to identify people who are overdue for colorectal cancer screening, combined with a patient navigator to help them schedule and complete the test, could increase screening rates. The study included 385 adults livin…

This study looked at 227 people with colorectal cancer that had spread to the lining of the belly. Researchers wanted to see if waiting longer between chemotherapy and surgery affected how long patients lived without the cancer coming back. The goal is to find the best timing for…

This study tested whether checking the removed tissue during surgery (frozen section) helps ensure all cancer is removed in people with mid or low rectal cancer who had radiation therapy. 99 patients were split into two groups: one had the extra check, the other had standard surg…

This study looked at 3000 cancer patients to see which treatments work best for preventing dangerously low white blood cell counts after chemotherapy. It compared different approaches to see how well they prevent infections and improve quality of life. The goal is to give doctors…

This study tested whether a blood test can find tumor cells or substances released by intestinal polyps. Researchers compared blood samples from 120 people with and without polyps during a colonoscopy. The goal is to see if these markers could help predict or monitor cancer sprea…

This study looked at 80 adults aged 40-60 to see if sitting for long periods slows down gut transit time and changes gut bacteria in ways that could lead to colon polyps. Participants wore activity monitors, ate blue muffins to track digestion time, and provided stool samples. Th…

This completed study analyzed tumor and blood samples from 160 people with esophageal or rectal cancer. Researchers looked for genetic markers in the EGFR signaling pathway that might predict how well a patient responds to chemoradiotherapy given before surgery. The goal is to be…

This study looked at whether eating certain fats (polyunsaturated fatty acids) is linked to colorectal cancer risk. Researchers measured fatty acids in fat tissue and blood samples from 551 people with and without colorectal cancer. The goal was to find reliable biomarkers that c…

This completed study examined whether differences in the IL-7 receptor gene are linked to the risk of developing ulcerative colitis and how well patients respond to the drug vedolizumab. Researchers enrolled 898 people, including those with UC and healthy controls, and analyzed t…

This study observed 193 adults who had emergency laparoscopic appendix surgery for uncomplicated appendicitis. Researchers wanted to see how closely hospitals followed a specific recovery plan called RICA (an ERAS pathway) and whether early discharge within 24 hours was safe and …

This study tested whether a short training video on 'blink features' (visual clues like redness or ulcers) could help medical students and non-gastroenterology trainees better detect cancer in images of colon polyps. 65 participants completed an online survey before and after wat…

This study compared two types of laparoscopic surgery for early-stage colon cancer: conventional colectomy and complete mesocolic excision (CME). Researchers looked at 150 patients in Upper Egypt to see which surgery removed more lymph nodes and caused fewer complications. The go…

This study tested whether offering a simple blood test instead of a colonoscopy or stool test would encourage more people to get screened for colorectal cancer. Researchers enrolled 297 adults aged 45-75 who had previously skipped or refused traditional screening. The goal was to…

This study looked at whether a nurse practitioner can safely monitor people with colorectal cancer who are getting intravenous chemotherapy, compared to a doctor. About 207 adults took part. The goal was to see if the number of serious side effects and quality of life were simila…

This study tested a step-by-step plan for patients who had high C-reactive protein (CRP) levels after surgery for colorectal cancer. High CRP can signal a serious complication called an anastomotic leak, where the surgical connection leaks. The goal was to see if a proactive mana…

This study looked at whether proteins in the blood can help screen for colorectal cancer. Researchers tested blood samples from 350 people aged 50 and older who were already scheduled for a colonoscopy. The goal was to see if certain protein markers could reliably detect advanced…

This study looked at how bevacizumab, a drug used to treat advanced colorectal cancer, affects the stiffness of arteries. Researchers measured artery stiffness in 13 patients before and after 4 months of treatment. The goal was to better understand the drug's cardiovascular side …

This study looked at 236 adults with breast, colorectal, or pancreatic cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to see if patients stayed for treatment or went elsewhere. The goal was to understand what factors influen…

This study tested an educational program to help people in rural areas learn more about colorectal cancer screening. 205 adults aged 45-74 from specific counties in New Hampshire and Vermont took part. Researchers measured changes in knowledge and intentions to get screened befor…

This completed study analyzed data from 1,500 colon cancer patients to see if a new way of classifying lymph node involvement—based on both the number and location of affected nodes and tumor deposits—can better predict survival than the current standard system. Researchers colle…

This study looked back at 765 children with complicated appendicitis treated over ten years. Researchers wanted to see how well laparoscopic surgery works for different types of the condition, including cases with abscess or mass. The goal is to help doctors decide the best treat…

This study looked at how often emergency room doctors in Villavicencio, Colombia, use a tool called the Alvarado score to help diagnose appendicitis. The researchers surveyed 125 doctors to see if they knew about the score, used it, and wrote it down for patients with belly pain.…

This completed study followed over 3,600 people with stage I to III colon cancer who had surgery. The goal was to learn how far cancer spreads to lymph nodes and how much bowel and tissue should be removed for the best outcome. The results could help guide surgeons in the future,…

This study looked at 679 people with colorectal cancer that had spread to the liver. Researchers compared having surgery to remove both the colon and liver tumors at the same time versus having two separate surgeries. The goal was to see which approach led to better survival and …

This study aimed to create a model that predicts whether rectal cancer will come back after treatment. Researchers looked at medical records and inflammation markers from over 2,300 patients with advanced rectal cancer who had chemotherapy or radiation before surgery. The goal wa…

This completed study tested whether an AI system called GI Genius helps doctors spot polyps during colonoscopy. Over 5,000 adults participated. The goal was to see if AI improves detection rates and whether using AI has a lasting learning effect. Results could lead to better colo…