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Study reveals hidden risks for polyp regrowth after colonoscopy

NCT ID NCT07445178

Knowledge-focused Sponsor: University of Sao Paulo Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study reviewed the medical records of 255 adults who had colorectal polyps removed during a colonoscopy. The goal was to find out which factors, such as how the polyp was removed or its tissue type, make it more likely to come back. Researchers also tracked any complications from the procedure. The findings can help doctors better predict and prevent polyp recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

255 people

The number who actually took part.

Started

Dec 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of 255 consecutive adult patients (≥18 years) who underwent loop colorectal polypectomy, with or without the use of thermal energy, at a tertiary referral center between 2023 and 2025. Only individuals with available histopathological examination of the resected lesion and who had undergone at least one documented surveillance colonoscopy, allowing evaluation of the previous resection site, were included. Patients who underwent advanced non-loop-based techniques, those without endoscopic follow-up, and cases with incomplete clinical or histological data were excluded, ensuring methodological homogeneity and adequate measurement of outcomes.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years at the time of polypectomy; * Underwent snare polypectomy, with or without the use of thermal energy (cold snare or hot snare), performed during the study period (2023-2025); * Procedure performed at a participating tertiary center, ensuring technical and record standardization; * Availability of histopathological examination of the resected lesion, allowing for adequate histological characterization; * Performance of at least one documented surveillance colonoscopy, with evaluation of the previous resection site; * Adequate recording of clinical and endoscopic variables necessary for analysis (lesion size, location, resection technique, etc.); Exclusion Criteria: * Patients undergoing techniques other than loop polypectomy, such as: Endoscopic submucosal dissection (ESD), advanced mucosal resection not based on conventional loop, primary surgical resection of the lesion; * Absence of follow-up colonoscopy, making it impossible to assess the primary outcome (local recurrence); * Incomplete clinical, endoscopic, or histopathological data that prevent adequate classification of study variables; * Invasive lesions beyond the mucosa (invasive cancer with deep submucosal invasion) that have been referred for immediate surgical treatment without endoscopic follow-up; * Loss to follow-up before the first surveillance colonoscopy.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal adenoma colorectal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colo-rectal cancer

Contacts and locations

Locations

  • Hospital das Clínicas of Ribeirão Preto Medical School

    Ribeirão Preto, São Paulo, 14048-900, Brazil

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