New combo tackles tough colorectal cancer
NCT ID NCT01715441
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested whether combining two drugs, sorafenib and irinotecan, works better than either drug alone in people with advanced colorectal cancer that has a KRAS mutation and has stopped responding to all standard treatments. The study enrolled 173 participants across multiple centers. The main goal was to see how many patients had their cancer stop growing after two months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sorafenib and irinotecan combination
- What this could lead to
- If successful, this combination could offer a new treatment option for people with a hard-to-treat form of colorectal cancer that has stopped responding to other drugs.
- What could go wrong
- This is a phase 2 trial with a moderate number of participants, so results are not definitive. The combination may not improve outcomes over single drugs and could cause additional side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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C.H.U. de REIMS
Reims, 51092, France
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CHU Charles Nicolle
Rouen, 76038, France
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CRLC Val d'Aurelle-Paul Lamarque
Montpellier, 34298, France
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Centre François Baclesse
Caen, 14076, France
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Centre Léon Bérard
Lyon, 69373, France
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Centre Oscar Lambret
Lille, 59020, France
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Hôpital AVICENNE
Bobigny, 93009, France
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Hôpital LA TIMONE
Marseille, 13365, France
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Institut de Cancérologie de l'Ouest - René Gauducheau
Saint-Herblain, 44805, France