Drug combo shows promise for tough cancers

NCT ID NCT02856425

Completed Disease control Sponsor: Gustave Roussy, Cancer Campus, Grand Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested a combination of two drugs—pembrolizumab (an immunotherapy) and nintedanib (a drug that blocks blood vessel growth)—in 196 adults with advanced solid tumors that had worsened after standard treatment. The main goal was to find the safest dose of nintedanib when given with pembrolizumab. The study aimed to see if this combination could be better tolerated and more effective than either drug alone.

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Conditions

The condition(s) this trial relates to.

cervical cancer childhood kidney cell carcinoma colorectal adenocarcinoma gastric adenocarcinoma gastroesophageal adenocarcinoma hepatocellular carcinoma mesothelioma non-small cell lung carcinoma thymic carcinoma urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PATIENTS WITH ANY ADVANCED SOLID TUMORS

Contacts and locations

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Locations

Centre Léon Bérard

Lyon, 69008, France
Gustave Roussy

Villejuif, Val De Marne, 94805, France
Hôpital Bichat

Paris, 75018, France
IUCT--O

Toulouse, 31059, France
Institut Bergonié

Bordeaux, 33000, France