Drug combo shows promise for Hard-to-Treat cancers

NCT ID NCT02856425

First seen Jan 22, 2026 · Last updated May 15, 2026 · Updated 17 times

Summary

This early-phase trial tested a combination of two drugs—pembrolizumab (an immunotherapy) and nintedanib (an anti-angiogenesis drug)—in 196 adults with advanced solid tumors that had worsened after standard treatment. The main goal was to find the safest dose of nintedanib when given with pembrolizumab. The study aimed to see if this combination could be better tolerated and more effective than either drug alone.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Centre Léon Bérard

    Lyon, 69008, France

  • Gustave Roussy

    Villejuif, Val De Marne, 94805, France

  • Hôpital Bichat

    Paris, 75018, France

  • IUCT--O

    Toulouse, 31059, France

  • Institut Bergonié

    Bordeaux, 33000, France

Conditions

Explore the condition pages connected to this study.