New hope for Stomach-Lining cancer: direct chemo attack
NCT ID NCT06269978
First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This early-phase trial tests whether giving two standard chemotherapy drugs (5FU and oxaliplatin) directly into the abdominal cavity is safe for people with colorectal cancer that has spread only to the peritoneal lining. About 24 adults will receive the drugs through a catheter during a short procedure. The main goals are to find the best dose and check for side effects. If safe, this approach might deliver stronger treatment to the cancer while reducing whole-body side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fluorouracil and oxaliplatin
- What this could lead to
- If this works, it could offer a new way to deliver chemotherapy directly to the abdomen, potentially controlling cancer spread in the peritoneum with fewer side effects.
- What could go wrong
- This is a very early (Phase I) trial with only 24 people, focused on safety and dosing. It may not show strong anti-cancer effects, and there are risks from the drugs and procedures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
-
UT Southwestern/Simmons Cancer Center
Dallas, Texas, 75390, United States
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