New combo aims to cut rectal cancer treatment time and boost cure rates

NCT ID NCT05673772

Ongoing Disease control Sponsor: Kyungpook National University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests a shorter course of radiation followed by FOLFOX chemotherapy before surgery for locally advanced rectal cancer. About 364 participants will be randomly assigned to either this new regimen or standard chemoradiation. The goal is to see if the shorter approach improves 3-year disease-free survival by targeting cancer cells early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: short-course radiation therapy and FOLFOX chemotherapy (oxaliplatin, leucovorin, 5-FU)
What this could lead to: If successful, this approach could shorten preoperative treatment time and improve long-term survival for people with locally advanced rectal cancer.
What could go wrong: This is a mid-stage trial with 364 participants, so results are not yet proven. The experimental regimen may cause more side effects or not improve outcomes compared to standard chemoradiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Locations

, Korea University Anam Hospital

Seoul, South Korea
Asan Medical Center

Seoul, 05505, South Korea
Catholic University of Korea Incheon St. Mary's Hospital

Incheon, South Korea
Chonnam National University Hwasun Hospital

Gwangju, South Korea
Chungnam National University Hospital

Daejeon, South Korea
Gangnam Severance Hospital

Seoul, South Korea
Gyu seog Choi

Daegu, 702-210, South Korea
Jeonbuk National University Hospital

Jeonju, South Korea
Seoul National University Bundang Hospital

Seoul, South Korea

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