Stool test may predict gut healing in ulcerative colitis

NCT ID NCT07721441

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Tang-Du Hospital Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study is testing whether a simple stool test can predict if the gut lining is healing in people with moderate-to-severe ulcerative colitis who are starting biologic therapy for the first time. Researchers will measure levels of a protein called calprotectin in stool samples using a new method. The goal is to see if early changes in this protein can tell doctors whether the treatment is working, potentially reducing the need for invasive colonoscopies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fecal calprotectin test using magnetic particle chemiluminescence
What this could lead to: If successful, this could provide a non-invasive way to predict whether biologic therapy is healing the gut lining in ulcerative colitis, potentially reducing the need for frequent colonoscopies.
What could go wrong: This is an observational study, not a treatment trial, so it will not test a new therapy. The results may not apply to all patients or settings.

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Conditions

The condition(s) this trial relates to.

ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ULCERATIVE COLITIS (UC)

Contacts and locations

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Locations

Chongqing General Hospital

Chongqing, Chongqing Municipality, 401121, China
Peking University People's Hospital

Beijing, Beijing Municipality, 100044, China
Qilu Hospital (Qingdao), Shandong University

Qingdao, Shandong, 266035, China
Shengjing Hospital of China Medical University,

Shengyang, Liaoning, 110004, China
Shenzhen Hospital, Southern Medical University

Shenzhen, Guangdong, 518101, China
Tangdu Hospital, Air Force Medical University

Xi’an, Shanxi, 710038, China
The First Affiliated Hospital of Xi'an Medical University

Xi’an, Shanxi, 710077, China
The Second Hospital of Dalian Medical University

Dalian, 116023, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China
Zhongda Hospital, Southeast University

Nanjing, Jiangsu, 210009, China

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