New pill plus chemo shows promise for Hard-to-Treat colon cancer

NCT ID NCT06106308

Ongoing Disease control Sponsor: Cardiff Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding an experimental drug called onvansertib to standard chemotherapy and bevacizumab can shrink tumors better than chemo alone in people with advanced colorectal cancer that has a KRAS or NRAS mutation. About 110 participants who have not had prior treatment for metastatic disease will receive either the new combination or standard therapy. The study aims to find the most effective dose and see if the combo improves response rates and delays cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Onvansertib (an experimental oral drug) combined with standard chemotherapy (FOLFIRI or FOLFOX) and bevacizumab
What this could lead to: If it works, this could offer a new first-line treatment option for people with a common genetic mutation in metastatic colorectal cancer, potentially improving tumor shrinkage and delaying disease progression.
What could go wrong: This is a mid-stage trial with only 110 participants, so results may not apply to everyone. Adding a new drug to standard chemo could increase side effects, and the benefit over current therapy is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRC KRAS/NRAS MUTATION METASTATIC COLORECTAL CANCER

Contacts and locations

Show contact details

Locations

CCCN

Las Vegas, Nevada, 89119, United States
Cancer & Hematology Centers of Western Michigan - Lemmen-Holton Cancer Pavilion

Grand Rapids, Michigan, 49503, United States
Cancer Center of Kansas

Wichita, Kansas, 67214, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cleveland Clinic Martin Health

Stuart, Florida, 34994, United States
Comprehensive Blood and Cancer Center - Bakersfield

Bakersfield, California, 93309, United States
Fort Wayne Medical Oncology and Hematology

Fort Wayne, Indiana, 46804, United States
Highlands Oncology Group

Springdale, Arkansas, 72762, United States
Inova Schar Cancer Institute

Fairfax, Virginia, 22031, United States
Kaiser Permanente

Honolulu, Hawaii, 96819, United States
Lehigh Valley Health Network

Allentown, Pennsylvania, 18103, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Manhattan Hematology Oncology (MHO) Research Foundation, Inc.

New York, New York, 10016, United States
Mayo Clinic - Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic - Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic Cancer Center

Rochester, Minnesota, 55905, United States
Memorial Cancer Institute

Hollywood, Florida, 33021, United States
Norris Comprehensive Cancer Center

Los Angeles, California, 90089, United States
Oncology Consultants, PA

Houston, Texas, 77024, United States
Orange Coast Memorial Medical Center

Fountain Valley, California, 92708, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
PIH Health

Whittier, California, 90602, United States
Pacific Cancer Medical Center

Anaheim, California, 92801, United States
Saint Luke's Hospital

Kansas City, Missouri, 64111, United States
Sharp Memorial Hospital

San Diego, California, 92123, United States
St. Bernards Medical Center

Jonesboro, Arkansas, 72401, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
The University of Arizona Cancer Center

Tucson, Arizona, 85724, United States
The University of Kansas Cancer Center - Westwood

Westwood, Kansas, 66205, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
Torrance Memorial Physician Network - Cancer Care and Infusion Center

Torrance, California, 90505, United States
Trihealth Kenwood

Cincinnati, Ohio, 45242, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92037, United States
UCLA Department of Medicine-Hematology/Oncology

Los Angeles, California, 90095, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
Utah Cancer Specialists

Salt Lake City, Utah, 84124, United States
VCU Massey Cancer Center

Richmond, Virginia, 23298, United States
Virginia Mason Medical Center

Seattle, Washington, 98101, United States
Washington University School of Medicine Center for Advanced Medicine

St Louis, Missouri, 63110, United States
West Cancer Clinic

Germantown, Tennessee, 38138, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.