New combo therapy aims to save rectums from surgery
NCT ID NCT06417476
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving either short-course radiation or long-course chemoradiation, followed by a strong chemotherapy cocktail (mFOLFOXIRI), can shrink low rectal tumors enough to avoid radical surgery. About 66 adults with stage T2-4a rectal cancer whose tumor is within 8 cm of the anus will be randomly assigned to one of the two radiation approaches. The main goal is to see how many patients can keep their rectum for at least one year without needing major surgery.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Locations
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651 Dongfeng Road East
Guangzhou, Guangdong, 510060, China