Gut bacteria boost? new trial tests probiotics to help immunotherapy fight stubborn colorectal cancer
NCT ID NCT06865521
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests whether adding Akkermansia probiotics to standard immunotherapy and chemotherapy can safely help patients with advanced colorectal cancer that hasn't responded to prior treatments. The trial enrolls 22 adults whose tumors are MSS/pMMR type, which typically don't respond well to immunotherapy alone. Researchers will monitor side effects and measure tumor shrinkage, as well as changes in gut bacteria.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Akkermansia probiotics (Songke) combined with anti-PD-1 monoclonal antibody and standard treatments (chemotherapy, TKI, or bevacizumab)
- What this could lead to
- If it works, this could point toward a way to make immunotherapy more effective for hard-to-treat colorectal cancers.
- What could go wrong
- This is a very early, small (22 people) single-center trial with no control group. The probiotics may not improve outcomes, and side effects from the combination are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Colorectal Cancer, West China Hospital
Chengdu, Sichuan, 610041, China
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Colorectal Cancer, West China Hospital
Chengdu, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a registry make endoscopic procedures safer and more effective?
- A new clue in the fight against colorectal cancer recurrence?
- Can two immune boosters outsmart Chemo-Resistant colon cancer?
- Can a Two-Pronged attack shrink Hard-to-Treat colorectal tumors?
- Can a Two-Drug attack shrink Hard-to-Treat colorectal tumors?