New combo therapy shows promise against HPV-Driven cancers
NCT ID NCT03260023
First seen Jan 11, 2026 · Last updated May 16, 2026 · Updated 23 times
Summary
This study tests whether combining two drugs—TG4001 (a vaccine-like therapy) and avelumab (an immunotherapy)—can shrink tumors or slow disease in people with advanced HPV-16 cancers (cervical, anal, penile, vulvar, or vaginal). About 143 adults whose cancer has spread or returned after prior treatment will receive the combo. The goal is to see if the combination works better than avelumab alone, while monitoring safety and side effects.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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CHU Besançon
Besançon, France
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CLCC Georges-François Leclerc
Dijon, France
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Centre Léon Bérard
Lyon, France
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Centre Paul Strauss - ICANS - Institut de cancérologie Strasbourg Europe
Strasbourg, France
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Fundación de Investigación Biomédica Hospital Clínico San Carlos
Madrid, Spain
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Fundación de Investigación biomédica H. 12 de Octubre
Madrid, Spain
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Hopital de la Timone
Marseille, France
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Hospital General de Valencia
Valencia, Spain
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Hospital Virgen de La Victoria
Málaga, Spain
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Hospital Virgen de las Nieves
Granada, Spain
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Hôpital Saint André - CHU de Bordeaux
Bordeaux, France
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Hôpitaux Civils de Colmar - Hôpital Pasteur
Colmar, France
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I.C.O. Gauducheau
Saint-Herblain, France
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I.C.O. Paul Papin
Angers, France
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ICO Badalona - Hospital Germans Trias i Pujol
Badalona, Spain
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Institut Claudius Regaud - IUCT - Oncopole
Toulouse, France
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Institut Curie
Paris, France
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Institut Gustave Roussy
Villejuif, France
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
Conditions
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