HPV vaccine in healthy donors could help fight cancer
NCT ID NCT06508138
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests an HPV vaccine series in healthy relatives of patients with advanced HPV-related cancer. The goal is to generate HPV-specific white blood cells that can be collected and used in a bone marrow transplant or donor lymphocyte infusion for the patient. The study focuses on safety and immune response in the donors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HPV vaccine series (pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine and TA-HPV vaccinia virus)
- What this could lead to
- If successful, this approach could help treat patients with advanced HPV-related cancers by using vaccinated donor immune cells.
- What could go wrong
- This is a very early phase 1 trial with only 24 healthy donors, so safety and immune response are still being tested. The linked recipient trial is also early, and the treatment may not work or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21287, United States
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