Can a genetic marker make rectal cancer treatment more precise?
NCT ID NCT06210971
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial is testing whether a combination of chemotherapy drugs (liposomal irinotecan and capecitabine) plus radiation, given before surgery, can help people with locally advanced rectal cancer. The treatment plan is personalized based on a genetic marker (UGT1A1) that affects how the body processes the drugs. The main goal is to see if this approach can lead to a complete disappearance of the tumor at the time of surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- liposomal irinotecan and capecitabine combined with radiation therapy
- What this could lead to
- If successful, this approach could increase the chance of eliminating the tumor before surgery, potentially improving outcomes for rectal cancer patients.
- What could go wrong
- This is an early-phase trial with a small number of participants, so results may not be conclusive. The treatment may cause side effects, and the genetic-guided dosing may not improve outcomes as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RECTAL CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hebei Medical University Fourth Hospital
Shijiazhuang, Hebei, 050000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Digital nurse companion: could an app ease the burden of chronic illness?
- Which rectal cancer surgery preserves quality of life better? a study investigates
- AI as a surgical Co-Pilot: predicting difficulty in rectal cancer
- Can AI learn to grade endoscopy quality from video?
- Can precision protons spare rectal cancer patients from harsh side effects?
- A new radiation combo may spare the rectum in early cancer