Congestive heart failure

This trial is testing an experimental drug called HS235 in obese adults who have both pulmonary hypertension and heart failure with preserved ejection fraction. The study aims to see if the drug is safe, how it moves through the body, and whether it can improve heart and lung fun…

This study tests a new heart pump called BrioVAD for people with severe heart failure that doesn't get better with standard treatments. The pump uses magnetic levitation to help the heart pump blood. About 780 adults will get either the BrioVAD or an existing pump to see if the n…

This study tests whether opening blood vessels (vasodilation) or removing fluid (diuretics) is better for treating sudden fluid buildup in the lungs from heart failure. About 1,100 adults with severe shortness of breath and low oxygen levels will receive one of three treatments i…

This study tests a device that creates a small opening between the heart's upper chambers to relieve pressure in people with chronic heart failure. Unlike other shunts, this one leaves no permanent implant behind. The trial will compare the device to a sham procedure in 700 patie…

This study tests a new device that creates a small passage in the heart to relieve pressure, without leaving a permanent implant. It is for 350 people with heart failure and reduced pumping ability. The goal is to see if it reduces deaths, need for a heart pump or transplant, and…

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This study tests a small device called C-MIC that is implanted without open-heart surgery to help people with heart failure. It includes 22 adults with weak heart pumping (ejection fraction between 25% and 50%) despite standard medications. The device delivers microcurrents to th…

This trial tests whether a gentle electrical stimulation applied to the ear—a technique called low-level transcutaneous vagus nerve stimulation—can help older adults with systolic heart failure. The study will compare daily one-hour sessions of real stimulation versus a sham (ina…

This phase 3 trial studies whether patients with acute decompensated heart failure who are already taking an SGLT2 inhibitor like empagliflozin should continue it during hospitalization. About 536 participants will either keep taking empagliflozin or switch to a placebo while in …

This study tests whether the drug vericiguat can help children with heart failure caused by a weak left heart chamber. About 342 children aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks. The main goal is to see if the drug lowers a key heart stre…

This clinical trial is testing an experimental drug called CRD-4730 in people with heart failure with reduced ejection fraction (HFrEF), a condition where the heart's main pumping chamber is weak. The drug works by blocking a protein called CaMKII, which is thought to contribute …

This Phase 3 study tests whether adding vicadrostat to the standard drug empagliflozin helps adults with chronic heart failure and a weak heart pump (ejection fraction below 40%). About 4200 participants will take either vicadrostat or a placebo, plus empagliflozin, once daily fo…

This study tests whether adding vicadrostat to the standard medicine empagliflozin helps people with heart failure who have a preserved ejection fraction (heart pumps normally but is stiff). About 6000 adults with symptoms will take either vicadrostat plus empagliflozin or a plac…

This study tests a small implanted device that sends gentle electrical signals to strengthen heart contractions in people with heart failure whose hearts still pump fairly well (ejection fraction 40-70%). Researchers will compare the device to a sham (inactive) implant in 1,500 p…

This study tests whether sending doctors a reminder about IV iron guidelines helps heart failure patients with iron deficiency get the recommended treatment. About 3,000 hospitalized adults with heart failure and low iron will be included. Doctors in the intervention group receiv…

This study tests a new medicine called CDR132L in 200 people with a type of heart failure where the heart is stiff and thickened. The goal is to see if it can improve heart structure and function. Participants will receive either the study drug or a placebo by chance, and the stu…

This study compares a newer pacing method (Left Bundle Branch Area Pacing) with the standard cardiac resynchronization therapy for people with heart failure. About 850 adults with moderate to severe heart failure will take part. The goal is to see if the newer method reduces deat…

This study tests a device called Aortix, a small pump placed in the main artery, to help remove excess fluid in people hospitalized with acute heart failure who are not responding well to diuretic medications. About 320 participants will be randomly assigned to receive either the…

This study tests whether a pacemaker programmed to each person's needs can improve symptoms and outcomes for people with a common type of heart failure (HFpEF). About 700 adults with heart failure but normal pumping strength will receive either personalized pacing or minimal/no p…

This study tests a device that stimulates the diaphragm in time with the heartbeat to help people with heart failure. Researchers will see if it improves heart function, exercise ability, and quality of life. About 270 participants will receive the device plus standard care, or s…

This study tests an investigational drug called omecamtiv mecarbil in 1,800 adults with severe heart failure and a very weak heart pump. The goal is to see if it can lower the risk of heart failure worsening, hospitalization, need for a heart pump or transplant, or death. Partici…

This study tests a device that automatically measures foot swelling in people with chronic heart failure. The device sends alerts to healthcare teams if swelling increases, which could signal worsening heart failure. About 1,500 participants will use the device at home for at lea…

This study compares a low-carbohydrate ketogenic diet to a low-fat mixed diet in people with heart failure with preserved ejection fraction who also have diabetes, prediabetes, metabolic syndrome, or obesity. The goal is to see whether the ketogenic diet can improve exercise tole…

This study tests whether lumacaftor, a drug used for cystic fibrosis, can improve blood flow to the brain and thinking abilities in people with stable heart failure and reduced pumping function. About 60 participants will receive either lumacaftor or a placebo for one month. The …

This study tests a new medicine called NNC0487-0111 in about 5,600 people who have both heart failure and obesity. Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug reduces the risk of heart failure worsening, hospitalization,…

This trial tests a temporary heart pump called the CorVad system in people with severe right heart failure that does not improve with standard medications. The pump is placed through a blood vessel to help the right ventricle pump blood, giving the heart a chance to recover or br…

This study tests whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard rate for patients with advanced kidney disease hospitalized due to severe fluid overload. Participants are randomly assigned to receive either a…

This study tests whether an electronic alert in a patient's medical record can prompt doctors to prescribe guideline-recommended heart failure medications that are not yet being used. The trial includes 5,000 adults with heart failure and a reduced ejection fraction (≤40%) seen a…

This study tests two simple tools to improve medication use in people with heart failure with reduced ejection fraction (HFrEF). One tool is a short animated video and checklist sent to patients before a clinic visit to encourage them to discuss their medications. The other is an…

This phase 3 trial tests whether finerenone, a non-steroidal mineralocorticoid receptor antagonist, can reduce cardiovascular death and heart failure events in patients with heart failure and reduced ejection fraction who cannot tolerate or are not eligible for standard steroidal…

This phase 2 trial tests whether an investigational drug called activin ligand-trap, combined with exercise training, can improve exercise capacity and cognitive function in 48 adults with heart failure with preserved ejection fraction (HFpEF). Participants will receive either th…

This study tests a special pacemaker setting called SyncAV, used with left bundle branch area pacing, in people with heart failure and a heart block. The goal is to see if this setting can improve the heart's electrical timing and pumping strength. About 50 adults who already nee…

This early-stage trial is testing an experimental drug called HJB647 in 12 adults with stable chronic heart failure and reduced pumping ability. The study aims to check the drug's safety and how the body processes it at two different doses. Participants will receive both the drug…

This phase 3 trial tests whether Qishen Yiqi Dripping Pills, a traditional Chinese herbal medicine, can improve exercise ability and quality of life in people with chronic heart failure caused by coronary heart disease. The study enrolls adults aged 18 to 80 with reduced heart pu…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs (pulmonary hypertension) in people with heart failure. The goal is to see if it can reduce serious heart events like hospitalizations or death. About 750 adults with stable heart f…

This trial tests whether a structured physical rehabilitation and exercise program can help older adults (age 60+) who have been hospitalized for heart failure with preserved ejection fraction (HFpEF). Participants will receive a progressive, multi-domain rehab intervention after…

This phase 3 trial tests whether maridebart cafraglutide (MariTide) can reduce heart failure events like hospitalizations and urgent visits in people with obesity and a specific type of heart failure (preserved or mildly reduced ejection fraction). About 5,056 participants will r…

This study looks at whether changing from standard heart failure medications to a newer drug (sacubitril-valsartan) can improve the health and daily life of people with heart failure in rural Tanzania. About 298 adults with heart failure will be switched to the new drug and follo…

This study tests whether a small wireless sensor placed in the pulmonary artery can help doctors better manage medications for people with heart failure and a leaky mitral valve. The sensor constantly measures pressure inside the heart, giving doctors real-time data to adjust tre…

This study tests the long-term safety of finerenone, a medicine that may help the heart pump better by reducing inflammation and scarring. It is for children from birth to 18 years old with heart failure and a weak left ventricle. All participants will take finerenone along with …

This study tests a device called Barostim that is implanted in the body to stimulate blood pressure sensors, which may help the heart work better. It involves 58 adults with heart failure who are already on the best available medications. The goal is to see if the device improves…

This study tests whether a drug called enavogliflozin can prevent major heart problems or worsening heart failure in people who have had a heart valve replacement (TAVR) and still have heart failure. About 1,040 participants will receive either the drug or a placebo, in addition …

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study is testing a new device called the BrioVAD, a mechanical heart pump for people with severe, advanced heart failure that doesn't get better with standard treatments. The goal is to see if the pump is safe and helps people live longer and feel better. About 60 adults wit…

This study looks at whether the diabetes drug dapagliflozin can improve how well the right side of the heart works after off-pump coronary bypass surgery. Researchers will measure heart function in 72 patients with weak hearts before and after 6 months of taking the drug. The goa…

This phase 3 study tests whether finerenone, a drug that blocks inflammation and scarring in the heart, can improve heart function in children aged 6 months to 18 years with heart failure and left ventricular systolic dysfunction. About 111 participants will receive either finere…

This study tests a new medicine called ADR-002K in 50 people with heart failure caused by blocked heart arteries who are scheduled for bypass surgery. The goal is to see if the drug can prevent heart-related events and improve heart function over two years. Participants must have…

This study is testing whether potassium nitrate, alone or combined with two supplements (propionyl-L-carnitine and nicotinamide riboside), can improve exercise endurance in people with a type of heart failure called HFpEF. About 53 participants will take these agents and undergo …

This study looks at whether adding a low dose of digoxin to usual heart failure treatments helps people feel better and live well after a recent hospital visit for worsening heart failure. About 120 adults with weak heart pumping function will take digoxin or continue their curre…

This study tests a new drug called CK-4021586 (ulacamten) in 60 adults with a type of heart failure where the heart pumps normally but is stiff (HFpEF). Participants take the drug or a placebo for 12 weeks to see if it is safe and how it affects heart function. The goal is to fin…

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or …

This study tests whether a carefully controlled high-fat diet can improve heart function in people with a specific type of heart failure (non-ischemic dilated cardiomyopathy). Researchers believe that switching the heart's fuel source back to fats may help it pump more effectivel…

This study tests whether adding Qishen Yiqi Dropping Pills, a Chinese herbal medicine, to standard therapy can improve exercise ability and quality of life in 120 adults with severe pulmonary hypertension. Participants will be randomly assigned to receive either the herbal pills …

This study tests a new pacing method called left bundle branch area pacing for people with heart failure whose heart pumps less blood than normal (ejection fraction 50% or lower). It is for patients who cannot get standard pacing or need a backup option. The goal is to see if thi…

This study tests whether a high-protein DASH diet, resistance exercise, or both can help people with heart failure and reduced ejection fraction maintain or increase muscle mass. About 100 adults over age 30 with stable heart failure will take part. The goal is to see if these li…

This study tests whether taking selenium and coenzyme Q10 (CoQ10) supplements can reduce heart failure-related hospital visits and deaths. About 1,100 adults with chronic heart failure will receive either the supplements or a placebo alongside their usual care. The goal is to see…

This study tests whether telemedicine follow-up helps doctors adjust heart failure medications more effectively than standard in-person visits. Eighty adults with newly diagnosed heart failure with reduced ejection fraction will be randomly assigned to either remote monitoring or…

This study tests whether adding empagliflozin (a diabetes drug) to standard carvedilol treatment can prevent liver decompensation events and death in 400 adults with cirrhosis and left ventricular diastolic dysfunction (stiff heart). Participants will receive either empagliflozin…

This study tests a new heart pacing method (LOT-CRT) against the standard one (BiVP) in 86 heart failure patients with a specific type of heart block. The goal is to see if the new method better preserves heart pumping function. Participants will be followed for at least 6 months…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and i…

This study tests a small device implanted in the heart that measures pressure and creates a small opening to help blood flow. It is for people with chronic heart failure whose heart pumps weakly (ejection fraction 40% or less) and who still have symptoms despite standard treatmen…

This study looks at whether people hospitalized for acute heart failure can safely drink as much as they want instead of limiting fluids. About 420 participants will be randomly assigned to either a strict 1.5 liters per day limit or a thirst-driven liberal intake. Researchers wi…

This study tests whether replacing unhealthy gut bacteria with healthy donor bacteria (via capsules) is safe and doable for people with chronic heart failure. About 40 adults with stable heart failure will take the capsules and be monitored for side effects and adherence. The goa…

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can lower vein pressure in adults with a failing Fontan circulation. About 27 participants will take the drug or a placebo for 3 months. The goal is to see if it helps the heart pump blood more ea…

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with severe coronary artery disease and a weak heart pump. The goal is to see which approach better prevents death, stroke, heart attacks, or repeat procedures over 5 years. Par…

This study tests whether a three-drug combination (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and symptoms in 50 people with advanced HFpEF, a type of heart failure where the heart is stiff but pumps normally. Participants will receive either the tripl…

This study tests whether a digital remote-management platform can help doctors better adjust heart failure medications after patients leave the hospital. About 252 adults with heart failure and reduced pumping function will use the platform to report symptoms and vital signs, wit…

This study tests whether taking a daily selenium supplement (200 micrograms) can reduce hospitalizations and heart-related deaths in people with heart failure. Selenium is a nutrient important for heart health, and low levels are common in Northern Europe. The trial will include …

This study follows 30 children aged 1 to 17 with chronic heart failure who are taking Entresto for the first time. Researchers will monitor for side effects like low blood pressure, high potassium, kidney problems, and dehydration over 52 weeks. The goal is to understand how safe…

This study tests whether using urine sodium levels to adjust diuretic doses helps people with acute heart failure recover faster and live longer. About 556 adults hospitalized with acute heart failure will receive either standard care or a tailored diuretic plan. The goal is to s…

This early-stage trial tests a new drug called VS-041 in 42 people aged 50 and older who have a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The main goals are to check if the drug is safe and to measure changes in certain blood markers linked to…

This study looks at whether people whose heart failure has improved can safely cut back on some of their daily medications. Participants will either continue all four standard drugs or gradually reduce to just two under close monitoring. The goal is to see if heart function stays…

This study compares two types of heart pacing—conduction system pacing and standard biventricular resynchronization—in 320 adults with heart failure and wide QRS. The goal is to see which method better reduces the risk of death, heart transplant, or hospitalization for heart fail…

This study tests whether adding macitentan to the standard drug dapagliflozin improves outcomes for people with heart failure and a specific type of high blood pressure in the lungs. 64 adults in South Korea will take either the combo or dapagliflozin alone for 24 weeks. Research…

This study tests a device that filters out overactive immune cells from the blood to reduce inflammation in patients with severe heart failure and worsening kidney function. Twenty ICU patients will receive 4-hour treatments daily for up to 6 days. The goal is to see if it safely…

This study tests a new remote monitoring system called SmartSignalHF in 1132 adults with heart failure who have an implanted heart device (ICD or CRT-D). The goal is to see if this system can reduce deaths and hospital stays over 12 months compared to standard care. Participants …

This study looks at whether a special heart device called cardiac contractility modulation (CCM) can help people with heart failure live longer and avoid hospital stays. About 4,200 people with advanced heart failure will either get the device or standard care. The goal is to see…

This trial tests whether doing a coronary angiogram (a special X-ray of the heart arteries) within 2 hours of diagnosis is better than waiting until the patient's heart failure symptoms improve. The study includes 780 adults with a type of heart attack called NSTEMI who also have…

This study tests whether a one-year program led by heart failure nurses, using online training and a mobile app, can reduce repeat hospital stays and improve quality of life for people with heart failure. About 200 adults who were recently hospitalized for worsening heart failure…

This study tests a procedure that uses a catheter to treat a nerve in the body, aiming to improve symptoms in people with a type of heart failure called HFpEF. About 150 participants will be enrolled to see if the procedure is safe and effective. The goal is to help patients feel…

This study tests a potential new medicine called CDR132L in 200 people with heart failure and an enlarged heart. Participants receive either CDR132L or a placebo by IV every 4 weeks for 48 weeks. The goal is to see if the drug can improve heart structure and function.

This study looks at whether combining two common diabetes drugs (GLP-1 agonists and SGLT2 inhibitors) can improve heart function and artery health in people with type 2 diabetes who are at high risk for heart problems. About 240 adults will be split into four groups, each receivi…

This study tests whether a home-based cardiac rehabilitation program using wearable devices and remote monitoring can improve exercise capacity in adults with chronic heart failure. Researchers will compare the home program to standard in-hospital rehab. The goal is to see if the…

This study tests whether adding the drug vericiguat to standard heart failure treatment can reduce hospital stays and deaths in people with severe, decompensated heart failure. About 130 participants will be randomly assigned to get vericiguat or a placebo, and researchers will t…

This study looks at whether a personalized home exercise program can improve heart and kidney function in adults aged 18-75 who have both chronic heart failure and kidney problems (cardiorenal syndrome). Sixty participants will either receive standard medication alone or medicati…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study aims to find out which type of specialist pacemaker works best for people with heart failure and a delay in how the heart's lower chambers beat together. Sixty participants will be randomly assigned to one of three pacing methods and followed for six months. Researcher…

This study looks at whether a special type of pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after having their aortic valve replaced. The trial will include 360 adults who have a new, persistent heart block…

This study tests whether social prescribing—connecting patients to community resources for issues like housing, income, or loneliness—can help women with heart failure better adhere to their medications and improve their quality of life. Researchers will enroll 200 women across f…

This early-stage trial tests a patch made from stem cells that is implanted onto the heart to help it pump better. It is for people with severe heart failure who cannot have a heart transplant. The study will check if the patch is safe and if it improves heart function and sympto…

This study tests a device called the Revivent System, which places small implants on the outside of the heart to reshape it and improve its pumping ability. About 135 people with heart failure and a damaged left ventricle will be randomly assigned to get the device plus standard …

This study tests two ways to manage atrial fibrillation in people with heart failure: using a procedure called catheter ablation to restore normal rhythm, or using medications to control heart rate. About 84 participants will be randomly assigned to one of these approaches. The g…

This study tests whether using a simple bedside ultrasound to measure fluid levels can help doctors give the right amount of medication to heart failure patients. The goal is to reduce hospital readmissions within 30 days and prevent kidney damage. About 588 adults hospitalized w…

This study tests a multidisciplinary clinic that provides heart failure patients with educational videos, a self-management kit, and follow-up phone calls after hospital discharge. The goal is to reduce 30-day readmission rates and improve patient satisfaction. The trial enrolls …

This study looks at whether the drug vericiguat can help repair the hearts of adults with stable heart failure with reduced ejection fraction (HFrEF). Researchers will compare people taking vericiguat plus standard care to those on standard care alone, measuring changes in heart …

This study tests if using two devices together can help people with advanced heart failure. Participants get a CardioMems sensor to monitor heart pressure and later a BaroStim device to regulate blood pressure. The goal is to improve symptoms, walking ability, and reduce hospital…

This early study tests a device called ContraBand™, which is implanted in the lung arteries to reduce pressure on the heart. The goal is to see if it's safe and can improve exercise ability and symptoms in people with left-sided heart failure. About 55 adults with moderate to sev…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study is testing a wearable system called Sensinel CPM to see if it can help people with chronic heart failure avoid hospital visits and reduce healthcare costs. About 1200 participants with moderate to severe heart failure will use the device, and their results will be comp…

This study tests whether using portable air filters at home can improve the health of people with heart failure. Researchers will measure how far participants can walk in six minutes, along with blood pressure and heart-related blood markers. The study involves 255 adults in Indi…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests a telemedicine-based care model for heart failure patients who are frequently readmitted to hospital and cannot join standard rehab. Researchers will provide on-demand video and chat support from cardiologists to general practitioners and community health workers…

This study looks at 140 heart failure patients to see if taking a medicine called ARNI before coming to the hospital leads to better short-term health. Researchers will compare those who were already on ARNI with those who were not, tracking heart and kidney events during the hos…

This study tests whether injecting stem cells from umbilical cords into the heart during bypass surgery can help repair heart muscle and improve function in people with chronic heart failure. About 51 adults with weak hearts (ejection fraction 40% or less) will take part. The goa…

This study is testing a new mechanical heart pump, called the Corheart 6, in 53 people with advanced heart failure. The pump is implanted to help the heart pump blood. Researchers want to see if it is safe and effective at keeping patients alive, either until they can get a heart…

This study tests a device called the eLym System that drains excess fluid from the lymphatic system to treat congestion in people hospitalized with acute decompensated heart failure. The device is placed temporarily for up to 60 hours in a heart catheterization lab. Researchers a…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study tests an experimental drug called HRS-7535 in 225 adults who have both heart failure (with mildly reduced or preserved pumping ability) and obesity. Participants will receive either the drug or a placebo for 36 weeks to see if it helps with weight loss and reduces infl…

This study looks at whether combining a heart procedure called ablation with a 12-week home exercise program can improve how well the body uses oxygen in people with a type of heart failure (HFpEF) and a common heart rhythm problem (atrial fibrillation). About 40 participants wil…

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham ve…

This phase 4 trial tests whether taking ramipril once daily or split into two smaller doses works better for protecting kidney function in 80 adults with chronic kidney disease and heart failure. Over 30 days, researchers will measure changes in blood markers of kidney function, …

This study looks at 100 people with heart failure who need a special pacemaker. Doctors want to see if a heart ultrasound before the procedure can predict which pacing method—left bundle branch pacing or standard biventricular pacing—works better. The goal is to improve how well …

This study tests whether using telemedicine (video or phone check-ins) can help doctors better adjust heart failure medications after patients leave the hospital. About 140 adults with heart failure and reduced pumping ability will be split into two groups: one gets usual care, t…

This Phase 3 trial tests the Reprieve System, a bedside device that automatically adjusts diuretic and saline infusion based on a patient's urine output, to treat acute decompensated heart failure. Researchers will compare it to standard diuretic therapy in 400 hospitalized adult…

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two p…

This study looks at whether adding protein supplements to the diet can prevent muscle wasting in people with heart failure. About 120 adults with heart failure and reduced pumping ability will be randomly assigned to receive no, low, or high doses of protein drinks. The main goal…

This study will compare two groups of people with chronic heart failure: those who receive the Cordella PA Sensor System (an implanted device that monitors pressure in the lung artery) and those who get standard medication alone. Researchers will track about 2,150 participants fo…

This study tests whether giving heart failure patients a debit card to buy fruits, vegetables, and legumes, along with optional health coaching, can reduce emergency visits, hospital stays, and deaths. About 900 adults with congestive heart failure who have had a recent hospital …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This phase 2 trial at Yale University is testing whether the diabetes drug ertugliflozin can help people with chronic heart failure manage fluid buildup better than a standard diuretic (metolazone) or a placebo. Sixty adults on daily diuretics will take one of the three treatment…

This study tests two water pills—acetazolamide and metolazone—added to standard diuretics in 320 adults hospitalized with acute decompensated heart failure. The goal is to see which drug clears fluid buildup faster and more safely, reducing hospital stays and complications. Parti…

This study tests whether the drug sacubitril/valsartan (Entresto) can improve heart function in people who have a prosthetic (artificial) heart valve and heart failure with reduced pumping ability. About 220 adults will either get the drug plus standard care, or standard care alo…

This study tests a newer heart pacing method (His or left bundle branch pacing) against the standard method (biventricular pacing) in over 2,000 adults with heart failure and a weak heart pump. The goal is to see which approach better improves quality of life, reduces hospital st…

This study tests whether a daily oral iron supplement (sucrosomial iron with vitamin C) can improve exercise ability and quality of life in people with chronic heart failure and iron deficiency. About 60 participants will receive either the iron supplement or a placebo for 24 wee…

This early-phase study tests whether injecting lab-grown heart cells (made from human embryonic stem cells) can safely improve heart function in 18 adults with chronic heart damage from a past heart attack. Participants receive one of three doses via a catheter, and researchers m…

This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medic…

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol…

This trial tests whether a quick, painless electrical test called bioimpedance analysis (BIA) can help doctors better manage fluid levels in patients hospitalized with worsening heart failure. 255 participants will be randomly assigned to receive either BIA-guided treatment or st…

This study tests whether a newer pacing method called left bundle branch pacing (LBBP) works better than the standard biventricular pacing for people with chronic heart failure and reduced pumping ability. About 60 adults with heart failure and a specific electrical delay in the …

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This study tests a temporary heart pump called iVAC 2L in 100 patients undergoing high-risk angioplasty. The pump helps stabilize blood flow during the procedure. Researchers will track deaths, heart attacks, strokes, and other complications for up to a year to see if the device …

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This study uses the Swedish Heart Failure Registry to identify people with heart failure and reduced ejection fraction who may need medication adjustments, iron deficiency screening, device therapy, or physiotherapy. Researchers will compare outcomes for 500 patients who receive …

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study is testing whether a digital stethoscope, combined with artificial intelligence, can detect two serious conditions: high blood pressure in the lungs (pulmonary hypertension) and a weak heart pump (low ejection fraction). About 3,850 adults will have their heart sounds …

This study tests a wearable ring that measures blood pressure, comparing it to the standard 24-hour monitor in 100 people with heart failure and reduced pumping ability. The goal is to see if the ring is accurate and easy to use. If successful, it could make blood pressure tracki…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study aims to see if a special MRI done during exercise can help doctors better diagnose and predict outcomes in people with a type of heart failure called HFpEF. Researchers will enroll 400 adults, including those with HFpEF, those with shortness of breath from other causes…

This study looks at whether advanced heart scans (echocardiogram and MRI) can help diagnose a type of heart failure called HFpEF, where the heart is stiff but pumps normally. Standard tests often miss it, leaving many without proper treatment. Researchers will study 40 adults wit…

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study tests whether inhaling a special form of xenon gas during an MRI can help doctors see and measure blood vessel changes in the lungs of people with pulmonary arterial hypertension (PAH). The goal is to find a non-invasive way to diagnose different types of PAH and track…

This study trains non-expert staff in GP practices to perform quick heart ultrasounds on people 65 and older. The goal is to find hidden heart valve disease or heart failure early, especially in diverse communities. Researchers hope this approach can reduce emergency hospital vis…

This study tests whether ultrasound contrast agents (microbubbles) can estimate pressure inside the heart, potentially replacing invasive catheters. Ten adults with suspected heart disease will receive a standard ultrasound with contrast while also having a catheter for compariso…

This early-phase study tests whether a special PET scan tracer, 18F-fluoroglutamine, can detect pulmonary arterial hypertension (PAH) earlier and more accurately. PAH is a serious disease of the lung's blood vessels that often goes undiagnosed for years. The study will scan 71 ad…

This study looks at whether molecules in saliva can help doctors quickly tell if heart failure is getting worse. Researchers will collect saliva and blood samples from 90 adults with stable or worsening heart failure. The goal is to develop a simple, non-invasive test that could …

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This study tests whether a special breathing exercise program, called inspiratory muscle training, can improve how well the breathing muscles work during exercise in people with heart failure. Researchers will measure blood flow to breathing and leg muscles, and how long particip…

This study tests whether adding inspiratory muscle training (using a device called PowerBreathe) to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. Researchers will measure blood flow and oxygen use in …

This study tests whether combining breathing exercises with mild electrical muscle stimulation can help people hospitalized with worsening heart failure. 135 patients will be split into three groups: one gets both treatments plus standard care, one gets breathing exercises only, …

This study tests whether combining breathing exercises with cognitive tasks (like memory games) can improve thinking and daily function in adults with heart failure. 54 participants will be randomly assigned to dual-task breathing training, standard breathing training, or a contr…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face anxiety, depression, and PTSD, but mental health care is hard to access. The app aims to help them manage these symptoms on their own…

This study tests a wearable suit called AquaPass that removes excess fluid through sweat in people with chronic heart failure and fluid overload. Participants wear the suit for up to 5 hours in a hospital or clinic, alongside their usual medications. The goal is to see if the sui…

This study looks at whether giving intravenous iron (Ferinject) to heart failure patients with low iron can improve their quality of life and walking ability. About 100 hospitalized adults with a specific type of heart failure (HFpEF) will receive either iron infusions plus diet …

This study tests whether a mobile-based telemedicine program—using phone calls and text messages for health education, medication reminders, and lifestyle advice—can improve quality of life in adults with chronic heart failure. About 70 patients in Ethiopia will be split into two…

This study tests whether three 15-minute hypnosis sessions can help people with persistent breathlessness from cancer, COPD, interstitial lung disease, or chronic heart failure feel more in control of their breathing. Researchers will measure changes using a standard questionnair…

This study looks at whether a special type of exercise called eccentric training (where muscles lengthen under tension) can help people with heart failure and reduced pumping ability. Researchers will compare eccentric bike and strength training to standard cardio and strength ex…

This study tests whether increasing the pacemaker rate during light exercise can lower pressure inside the heart for people with heart failure with preserved ejection fraction (HFpEF). Twenty participants will have their heart pressures measured at rest and while cycling, as the …

This study is testing a new group exercise program combined with remote activity monitoring for older adults with heart failure with preserved ejection fraction (HFpEF). The goal is to see if this approach can improve exercise habits, physical function, and quality of life. About…

This study tests a new drug called HRS-1893 in 48 adults with heart failure where the heart pumps normally but is too stiff (heart failure with preserved ejection fraction). The main goal is to check safety and side effects, while also looking at changes in heart stress markers a…

This study tests whether blocking signals from the splanchnic nerve can reduce congestion and improve exercise ability in people with heart failure. About 54 adults with heart failure and reduced pumping function will receive either a nerve-blocking procedure or a sham procedure.…

This study tests whether a daily capsule of potassium nitrate (KNO3) can improve leg muscle power and overall exercise capacity in people with heart failure. 75 adults with reduced heart function will take either KNO3 or a placebo for 6 weeks. Researchers will measure changes in …

This study looks at whether placing stents in blocked heart arteries can improve quality of life for people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart muscle is stiff. About 350 participants will be randomly assigned to receive either…

This study tests whether adjusting a pacemaker's lower heart rate to an individual's optimal level can improve symptoms and quality of life in people with heart failure and bradycardia. Researchers will compare this personalized approach to the standard fixed rate of 60 beats per…

This study looks at whether removing fluid from around the lungs (a procedure called thoracentesis) can reduce shortness of breath in people hospitalized for heart failure. About 216 adults will either get standard heart failure medicines alone or medicines plus the fluid removal…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 participants will take these medications and be tested on how well t…

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can help the heart use energy better. The study involves 12 participants with very weak hearts who are in the hosp…

This study tests whether empagliflozin (a diabetes drug) and potassium nitrate (a supplement) can improve exercise endurance in people with heart failure with preserved ejection fraction (HFpEF). About 53 participants will take one of three combinations of these drugs for a perio…

This study tests whether adjusting the dose of a diuretic (water pill) based on urine sodium levels can improve outcomes for people hospitalized with acute heart failure. Researchers will compare two urine sodium targets against standard care in 600 adults. The goal is to see if …

This study tests whether high-flow oxygen therapy can improve heart function in people with chronic heart failure who have recently had heart surgery. Researchers will compare it to non-invasive ventilation (a breathing machine) in 30 adults. The goal is to see if the oxygen ther…

This study tests a 12-week home-based tai chi program for people with chronic heart failure and their caregivers. Participants learn tai chi through videos and online coaching, aiming to improve heart function and reduce caregiver burden. The trial enrolls 256 sedentary adults wi…

This study tests a digital support program for 240 adults with heart failure. The program, accessed via a secure online portal, aims to help patients feel more in control of their condition and improve their quality of life. Participants use the program for six months, and resear…

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can improve exercise capacity in people with heart failure and chronic inflammation. Sixty participants will be randomly assigned to receive either colchicine or a placebo for three months. Researchers …

This pilot study tests the Reprieve System, a bedside device that automatically adjusts the delivery of a diuretic (furosemide) and saline based on the patient's real-time urine output. The goal is to safely and quickly remove excess fluid from 50 hospitalized adults with acute d…

This study tests three different drugs—empagliflozin, acetazolamide, and metolazone—added to standard water pills (loop diuretics) in 66 adults hospitalized for acute decompensated heart failure. The goal is to see which drug works best at increasing urine output over three days.…

This study is testing whether using mobile health apps and receiving tailored text messages can help people with chronic heart failure take better care of themselves and avoid hospital stays. Researchers will enroll 360 adults with Stage C heart failure and randomly assign them t…

This study tests whether regular yoga practice can improve quality of life and well-being in adults with stable chronic heart failure. Researchers will measure changes in physical and mental health using standard questionnaires. The goal is to see if adding yoga to standard care …

This study looks at whether meeting with a coach, either in person or by video, helps adults with a certain type of heart failure (HFpEF) exercise more regularly. About 300 participants will be split into three groups for 18 months: one with no coach, one with in-person coaching,…

This study looks at whether listening to music during a special exercise test can improve how well the heart and lungs work in people with heart failure. About 40 adults with heart failure will take part. Researchers will measure things like oxygen use and breathing to see if mus…

This study looks at whether shorter or longer sessions of high-intensity interval training (HIIT) work better for people with chronic heart failure. Researchers will measure changes in walking ability, heart function, and quality of life in 45 participants. The goal is to find a …

This study looks at whether a pacemaker can improve exercise ability and quality of life in people with heart failure with preserved ejection fraction (HFpEF) who also have a small heart chamber and a low heart rate during activity. About 30 participants will get a pacemaker and …

This early-stage trial is testing a new drug called NNC0537-1482 in 36 adults with heart failure. The main goal is to check if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo by injection, and neither they nor the doctors will …

This study tests whether combining cognitive training (brain games) with physical exercise can improve thinking, memory, and brain blood flow in people with chronic heart failure. Researchers will enroll 216 men and women aged 50 and older with stable heart failure. Participants …

This study tests whether daily leg heat therapy can help people with heart failure with preserved ejection fraction (HFpEF) exercise longer and feel better. Participants wear water-circulating trousers heated to 42°C for 90 minutes each day at home. The goal is to see if this imp…

This study tests whether a tailored, home-based exercise program (with or without weight loss medications) can improve exercise capacity and quality of life in 120 adults with heart failure with preserved ejection fraction (HFpEF). Participants will follow exercise videos and mee…

This study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for people with heart failure. Participants use the app for education, mindfulness, and physical activity guidance, plus periodic video calls with an exercise physiologist. The goal…

This study tests whether nurse-led education for heart failure patients and their informal caregivers can improve patients' quality of life, self-care, and medication adherence. About 280 patients recently hospitalized for heart failure and their caregivers will receive oral sess…

This study tests whether adding game-like elements and social rewards (like support or friendly competition) can motivate people with a type of heart failure (HFpEF) to walk more. About 270 adults will use a step tracker and be randomly assigned to one of two gamification program…

This study looks at whether two proteins released by a struggling heart can be detected in the blood during acute heart failure. Researchers will measure these proteins in about 500 adults—some with stable or worsening heart failure and some healthy—to see if higher levels relate…

This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes a…

This study collects heart tissue and blood samples from people with advanced heart failure who are receiving a mechanical heart pump (LVAD) or a heart transplant. The samples are compared with healthy donor heart tissue to learn more about the biology of heart disease. The goal i…

This study uses advanced MRI to measure the fat around the heart in people with a type of heart failure called HFpEF. Researchers want to see if the fat's composition, not just its amount, is linked to disease severity. They will also test if a diabetes drug called semaglutide ch…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study compares two ultrasound techniques—2D and 3D speckle-tracking echocardiography—to see which measures heart muscle contraction more accurately in people with heart failure and reduced pumping function. Researchers will enroll 419 patients from seven cardiac rehabilitati…

This study explores barriers to heart failure self-care and care transitions for adults facing social challenges. Researchers will interview patients, caregivers, and community health workers to identify what gets in the way of good care. The goal is to use these insights to desi…

This study looks at whether training doctors on quickly starting and adjusting heart failure medications (called GDMT) during a hospital stay leads to better treatment after discharge. About 438 adults with heart failure and reduced ejection fraction will be observed across multi…

This study looks at why some people with severe heart failure (called HFrEF) see their heart function improve after standard medical therapy, while others do not. Researchers will collect blood samples and imaging data from 1,740 patients in China and follow them for 12 months. T…

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study is testing a special PET scan that uses a tracer called 68Ga-FAPI to look for inflammation and scarring in the hearts of people with a specific type of heart failure (HFpEF). About 35 adults with this condition will get the scan to see how well it works. The goal is to…

This study tests whether ultrasound scans can detect leftover fluid in the lungs and veins of people hospitalized for heart failure. About 580 adults will get scans at several points during their stay, but doctors won't see the results. Researchers will then track who is readmitt…

This study tests new MRI techniques to examine the heart's small blood vessels and scarring in people with a type of heart failure called HFpEF. Researchers will compare scans from healthy volunteers and patients to see if these methods can reveal hidden heart problems. The goal …

This study follows 1,400 Japanese adults with chronic heart failure to see how safe the drug vericiguat is in everyday use. Half will take vericiguat plus standard care, the other half standard care alone. Researchers will track side effects, blood pressure, and heart-related dea…

This study observes 1350 Korean adults with chronic heart failure who are prescribed Verquvo by their doctors. Researchers will track side effects and heart-related events over up to 12 months to see how safe and effective the drug is in everyday use. No experimental treatments a…

This study looks at whether a person's genetic makeup can predict how well they respond to the heart failure drug metoprolol. Researchers will give the drug to 100 people with heart failure and track their heart function and drug levels. The goal is to see if a genetic score can …

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This study is testing a skin patch called MyHeartSentinel that records heart electrical and mechanical signals in people with heart failure. Researchers want to see if the patch can detect early signs of a worsening episode (decompensation) while patients are in the hospital and …

This study looks at 110 patients aged 80 and older who are in the hospital for acute heart failure. Researchers will use ultrasound and blood tests to measure muscle loss (sarcopenia) and see how it affects their recovery over six months. The goal is to find better ways to predic…

This study tests whether pacing the heart to mimic the speed of a workout can improve heart function in people with heart failure. Fifty-two adults with a weak heart and an implanted defibrillator will receive either active pacing or a sham (fake) pacing for 6 weeks. Researchers …

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

This study looks at whether a program called ADAPT, where nurses and social workers call people with heart failure weekly to help manage symptoms and improve well-being, can work outside of a research setting. The program aims to reduce hospital visits and improve quality of life…

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This early-phase study is testing whether omega-3 fatty acids can reduce inflammation in the heart muscle of people with heart failure with preserved ejection fraction (HFpEF). Researchers will use special MRI scans before and after an iron-based infusion to detect changes in inf…

This study examines why fat accumulates in the right ventricle of people with pulmonary arterial hypertension (PAH) and how it affects heart function and exercise ability. Researchers will use MRI and blood tests in 75 adults with PAH to track changes over time. The goal is to be…

This study tests whether wetting the skin or wearing a water-soaked T-shirt can help people with heart failure stay cooler and reduce stress on the heart during hot, dry conditions. Researchers will expose 88 participants (half with heart failure, half healthy) to simulated heat …

This observational study looks at whether removing excess fluid from the body (diuresis) can reduce sleep apnea severity in adults hospitalized with heart failure. Fifty participants will wear a sleep monitor before and after fluid removal, and researchers will track changes in n…

This study follows 1,000 adults with chronic heart failure to learn what factors influence their health outcomes, such as heart-related death or unplanned hospital visits. Researchers will collect data on genetics, gut bacteria, environment, and other markers. The goal is to bett…

This study looks at whether breathing a low-density helium-oxygen gas mixture can reduce breathlessness and improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF) and obesity. Researchers will measure how much oxygen the body uses during b…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

Researchers at the University of Calgary are testing a new, non-invasive way to assess heart function using a handgrip exercise. The study involves 100 adults, half with heart failure and half without. Participants squeeze a device with maximum force for two minutes while sensors…

This study looks at whether a special heart failure care network can help people who were recently in the hospital for worsening heart failure. About 1000 adults with moderate to severe heart failure will take part at five heart centers in Germany. Half will get extra support fro…

This study is testing whether using a blood test called NTproBNP can help doctors decide the best time to discharge patients hospitalized with worsening heart failure. 750 participants will be randomly assigned to either a biomarker-guided discharge plan or usual care. The goal i…

This study uses advanced MRI scans with a special manganese dye to look at how the heart handles calcium and energy in people with heart failure with preserved ejection fraction (HFpEF). Researchers will compare 40 people with HFpEF (half with type 2 diabetes) and 20 healthy volu…

This study is recruiting 130 people with heart failure with preserved ejection fraction (HFpEF), both obese and non-obese. Researchers will use CT and MRI scans, blood tests, and other checks to see if having more fat around the heart leads to worse heart function. The goal is to…

This study aims to create a digital decision-making aid for older adults with heart failure who are considering getting an implantable cardioverter-defibrillator (ICD). The tool will help patients weigh the benefits of preventing sudden cardiac death against the downsides of the …

This study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…

This study looks at how severe obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and has trouble filling with blood. Researchers will study 250 people with obesity using heart ultrasounds and blood tests to find early signs of heart problems.…

This study follows 500 people with a type of heart failure called HFpEF (heart failure with preserved ejection fraction) for at least 3 years. Researchers want to find out which medical signs or test results can predict serious problems like hospitalization or death. No new treat…

This study aims to find early signs of heart failure in women who had preeclampsia, a pregnancy complication involving high blood pressure. Researchers will use exercise stress tests and heart imaging to compare 250 women with a history of preeclampsia to 250 women with normal pr…

This study is looking at 1,000 people with and without heart failure to better understand the different types of the condition. Researchers will use heart images and blood tests to find patterns that could lead to more personalized treatments. The goal is to improve care for peop…

This study is testing a new device called HemoCept during a standard heart procedure called right heart catheterization. The goal is to see if the device can accurately measure pressure in the heart's blood vessels. About 50 adults with conditions like pulmonary hypertension or h…

This study is collecting information from 20,000 people with chronic heart failure in Russia to understand how they are diagnosed, treated, and monitored. Researchers will look at patient ages, treatments, and hospital visits. The goal is to find gaps in care and improve future t…

This study looks at heart tissue from 180 people with a type of heart failure called HFpEF. Researchers take tiny samples of heart muscle during a routine procedure to find changes in the tissue. The goal is to learn what causes this condition so better treatments can be develope…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

This study looks at how a common diabetes drug (SGLT2 inhibitor) changes the way the heart and muscles use energy from ketones. Researchers want to see if these changes can improve exercise ability and daily function in 30 adults with type 2 diabetes and heart failure. Participan…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study looks at tiny structures inside heart cells called mitochondria in people with heart failure and clogged arteries. Researchers will take small heart tissue samples during bypass surgery and compare them with blood tests. They want to see if damaged mitochondria are lin…

This study will use a mobile MRI truck to screen 600 people in large German cities who have risk factors like diabetes, high blood pressure, or obesity but no heart failure symptoms. The goal is to find out how many have hidden (stage B) heart failure. Results will be compared to…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome by analyzing immune cells from a blood sample. Researchers will compare calcium and inflammation signals in these cells between patients with and without heart probl…

This pilot study is testing whether a 12-week monitored exercise program can improve heart health in veterans with a type of heart failure called HFpEF. Only 4 participants are being enrolled to see if the facility can support a larger study and if exercise shows any benefit with…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks at why postmenopausal women have a higher risk of diastolic heart failure. Researchers will examine heart tissue from 500 patients undergoing cardiac surgery to study how estrogen loss affects heart energy and blood vessel health. The goal is to better understand…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study is testing whether a special wearable device, combined with artificial intelligence, can help people with chronic heart failure avoid hospital visits. About 205 adults will wear the device for six months while their health data is monitored remotely. The goal is to see…

This study aims to develop a way to predict when congestive heart failure suddenly worsens, using data from a non-invasive wearable device. About 60 adults who already have a heart monitor implant will wear the device for up to a year. Researchers will look for patterns in the we…

This study follows 2,000 people with chronic heart failure to see how their physical activity levels relate to hospitalizations and survival. Participants wear a pedometer or smartwatch and answer activity questionnaires every six months. No new treatment is given—the goal is sim…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 participants over time, using heart scans and blood tests to see if certain biomarkers can spot trouble before symptoms …

This study uses magnetic resonance spectroscopy, a special MRI technique, to measure the heart's energy levels without needles or biopsies. Researchers will compare healthy volunteers, people with heart failure, and those with other heart conditions to see if low energy metabolis…

This study is looking at people with pulmonary arterial hypertension (PAH), those with a genetic risk but no disease, and healthy individuals. Researchers aim to find molecular and physical markers that explain why some people get PAH and others stay healthy. The goal is to impro…

This study looks at why people with a type of heart failure (HFpEF) have trouble exercising. Researchers will measure energy use in the heart and leg muscles using special scans. They aim to link these energy problems to how well patients can walk and exercise. The study does not…

This study creates a live registry of up to 40,000 heart failure patients across the Yale New Haven Health System. Researchers will track hospitalizations and use of recommended therapies like beta blockers and ACE inhibitors. The goal is to monitor and improve heart failure care…

This study tests a special MRI that can show how heart cells process energy in people with ischemic heart disease. About 15 adults with chronic heart failure will get this scan along with standard tests. The goal is to see if this new method can tell healthy from damaged heart ti…

This pilot study at Mayo Clinic will use cardiac MRI scans to examine how the heart's main pumping chamber changes in people with severe mitral regurgitation before and after valve repair surgery. The goal is to see if this approach can help identify patients at risk of developin…

This study looks at whether certain proteins in the blood can predict if someone with chronic heart failure will develop kidney problems (cardiorenal syndrome). Researchers will measure these proteins in 150 adults with heart failure and follow them for one year. The goal is to f…

This study looks at whether pharmacist-led medication checkups and easy-to-understand education can help people with heart failure get the right medicines. It involves 40 patients in Denver who have limited access to care. The goal is to see if this approach is practical and impr…

This study uses a special heart MRI to see if a device called a coronary sinus reducer can improve blood flow in patients with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (small vessel disease). The device is implanted to reroute …

This study looks at whether early heart ultrasound results can predict which patients hospitalized with heart failure will need to return to the hospital or have a higher risk of death. Researchers will measure heart structure and function before starting IV diuretics in 76 adult…

This study tests whether heart failure patients can safely drink as much fluid as they want instead of restricting it. Researchers will compare lung congestion, blood markers, quality of life, and hospital readmissions in 326 participants over time. The goal is to see if liberal …

This study looks at how a specific type of heart failure (left ventricular diastolic dysfunction) affects short-term results after heart surgery, especially in women. Researchers will track 1,000 patients undergoing cardiac surgery, comparing men and women to find differences in …

This study from Stanford University is looking at what happens inside the body when people with heart failure exercise. Researchers will measure thousands of proteins in the blood before and after a single workout, and again after a 12-week cardiac rehab program. By comparing the…

This study looks at how extreme head-down positioning (Trendelenburg) and gas inflation during robotic surgery affect the heart's ability to pump blood. Researchers will monitor 80 patients—some with normal heart function and some with heart failure—using a special probe and brai…

This study looks at how often heart failure with preserved ejection fraction (HFpEF) occurs in people with COPD and how it affects their health over time. Researchers will follow 200 adults aged 50–70 in Russia who are hospitalized with COPD. They will use heart and lung tests to…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This study observes 300 adults in South Korea with chronic heart failure who are prescribed finerenone as part of their usual care. Researchers will track side effects and treatment satisfaction over one year. The goal is to see how safe and effective finerenone is in everyday me…

This study looks at whether acute stress can cause sudden worsening of congestive heart failure. Researchers will monitor 112 heart failure patients who have an implanted device that measures pressure in the lung artery. They will compare pressure readings during stressful and ca…

This study uses artificial intelligence to analyze electrocardiograms (ECGs) and identify people at high risk for developing left ventricular dysfunction, a type of heart muscle weakness. Researchers will then see if giving standard heart medications—like ACE inhibitors, beta-blo…

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This early-phase study is testing whether a drink containing ketones can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days while researchers measure heart efficiency wi…

This study looks at whether simple, non-invasive skin tests can detect early signs of heart disease by measuring how well small blood vessels work. Researchers will study 900 people aged 60-75, comparing skin blood flow measurements with detailed heart scans. The goal is to find …

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart tissue samples from 50 adults to find the best ways to diagnose and treat this condition. Participants must be bet…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This observational study looks at how fitness level relates to bacteria in the mouth and blood flow to muscles. Researchers will collect mouth swabs, saliva, and blood samples, and measure exercise capacity in 70 adults with heart failure, peripheral artery disease, or overweight…

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if…

This study will use cardiac MRI scans to measure heart muscle scarring in 125 people with heart failure and a leaky mitral valve who are scheduled for a MitraClip procedure. Researchers want to see if the amount of scarring predicts how well the heart recovers six months later. P…

This study is creating a registry of 101 adults with chronic heart failure to track their health over time. Researchers will collect data on disease progression and survival at one, five, and ten years after diagnosis. The goal is to better understand how heart failure evolves, n…

This study is tracking 4,000 people in the UK who were recently diagnosed with heart failure and have a weak heart pump (ejection fraction below 50%). Researchers will follow them over time to see how their health changes, what treatments they receive, and how often they are hosp…

This study looks at why some people with heart failure get better with exercise rehab while others don't. Researchers will measure oxygen use during exercise and check tiny molecules in the blood called microRNAs. They hope to find patterns that could one day help design personal…

This study looks at how common depression and mild memory problems are in people hospitalized for chronic heart failure, and whether these issues lead to worse health outcomes. About 300 adults aged 18 to 85 will answer questionnaires about their mood and thinking skills. The goa…

This study is observing 3000 adults with various types of heart failure to learn how the disease develops and progresses. Researchers will collect medical records, blood samples, and imaging data to identify distinct patient groups. The goal is to match the right treatments to th…

This study is looking at children ages 7 to 18 who have been newly diagnosed with high blood pressure. Researchers want to understand how certain hormones in the body, like angiotensin-(1-7), may contribute to damage in the heart, kidneys, and blood vessels. Over two years, they …

This study tests a hospital-wide treatment guide for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the guide helps doctors identify which patients will benefit most from a minimally invasive valve repair procedure calle…

This observational study follows 200 adults with chronic kidney disease and a type of heart failure (HFpEF), some taking SGLT2 inhibitors (flozins) and some not. Researchers will measure arterial stiffness, heart function, and kidney decline over time to see if flozins are linked…

This observational study tests a new device (eMyosound LYRA) that uses sound waves to measure stiffness in the heart and liver. Researchers will compare 150 people—some with heart failure, some with a rare heart condition called ATTR-CM, and some healthy volunteers. The goal is t…

This study follows 1,250 people with a type of heart failure called HFpEF, where the heart doesn't pump blood properly. Researchers will collect routine medical information to better understand why HFpEF develops, find new tests, and learn about life expectancy. No new treatments…

This study looks at what happens when people with a certain type of heart failure (HFpEF) stop taking beta-blockers for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life in 30 participants. The goal is to see if stopping this commo…

This study looks at how hormones and metabolism are involved in pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will measure sex hormone levels, insulin resistance, and test two potential treatments—metformin and ACE-2—in small groups. The goal is to …

This study is testing a new way to measure liver function in adults who have had the Fontan procedure, a surgery for certain heart defects. Researchers will use a dual cholate clearance test (a special blood test) and a heart MRI to see how well the liver is working. They will co…

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…

This pilot study is testing whether wearable devices like smartwatches, blood pressure monitors, and smart scales can help patients recover after a stay in the intensive care unit (ICU). Many ICU survivors face physical and mental challenges, known as Post-Intensive Care Syndrome…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…

This study looks at how blood flow in the heart's small vessels and body composition (muscle vs. fat) affect exercise ability in people with a type of heart failure called HFpEF. Researchers will measure heart blood flow using ultrasound and body composition with a special scale,…