Congestive heart failure
MONDO:0005009Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.
Also known as: CHF, cardiac failure, congestive, congestive heart disease, failure, congestive heart, heart failure, congestive
750 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Could continuing a common heart drug before surgery save lives?
Disease control Not yet recruitingThis trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like …
Phase: PHASE4 • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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Can a new pill ease the burden of heart failure with preserved pumping?
Disease control Not yet recruitingThis phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either ele…
Phase: PHASE3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Can a valve fix unlock better heart failure drugs?
Disease control Not yet recruitingThis trial tests whether repairing a leaky mitral valve early, using a minimally invasive clip procedure, can help people with heart failure and reduced pumping function tolerate and benefit from standard heart failure medications. Participants are randomly assigned to receive th…
Phase: NA • Sponsor: University Medical Center Mainz • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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New heart failure drug enters first human safety trial
Disease control Not yet recruitingThis early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…
Phase: PHASE1 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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One pill to rule them all: new study aims to simplify heart failure treatment
Disease control Not yet recruitingThis study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…
Phase: PHASE3 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Iron and folic acid: a simple pill that could ease anemia and heart symptoms?
Disease control Not yet recruitingThis observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…
Sponsor: Alcea • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Can a diabetes drug help heart failure patients walk farther?
Disease control Not yet recruitingThis trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can improve physical function in adults with heart failure and obesity. Participants will receive either tirzepatide or a placebo for six months, while continuing their usual heart failure…
Phase: PHASE3 • Sponsor: Shahid Beheshti University of Medical Sciences • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Smartphone apps and wearables could transform heart recovery
Disease control Not yet recruitingThis study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…
Phase: NA • Sponsor: University of Illinois at Chicago • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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New pill could help failing hearts pump better
Disease control Not yet recruitingThis study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…
Phase: PHASE2 • Sponsor: AnaCardio AB • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Heart rehab goes hybrid: can a mix of home and clinic sessions boost adherence?
Disease control Not yet recruitingThis trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…
Phase: NA • Sponsor: University of the State of Santa Catarina • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Exercise as medicine: can a tailored workout program reduce hospital visits for heart failure patients?
Disease control Not yet recruitingThis trial tests whether a year-long, supervised exercise program — including aerobic, resistance, and breathing exercises — can improve outcomes for people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either usual care or usu…
Phase: NA • Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Can a phone app replace cardiac rehab? a new trial puts digital heart care to the test
Disease control Not yet recruitingThis pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…
Phase: NA • Sponsor: Yonsei University • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Can a smart sensor keep heart failure patients out of the hospital?
Disease control Not yet recruitingThis study tests whether using a real-time continuous glucose monitor (CGM) can improve blood sugar control and reduce hospital readmissions in people with type 2 diabetes and acute heart failure. Researchers will follow 140 adults during their hospital stay and for three months …
Phase: NA • Sponsor: Emory University • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Virtual heart team aims to close medication gap for veterans with heart failure
Disease control Not yet recruitingThis study tests whether a virtual team of clinical pharmacists and cardiologists can help doctors prescribe the right heart failure medications for Veterans. Many patients do not receive all recommended drugs at effective doses after a hospital stay. The team reviews patient rec…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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New heart pump could offer lifeline for advanced heart failure patients
Disease control Not yet recruitingThis trial tests a device called the Corheart 6, a left ventricular assist system that helps pump blood in people with advanced left ventricular heart failure. The study includes 100 adults aged 18 to 75 with severe heart failure symptoms despite optimal medical therapy. The main…
Phase: NA • Sponsor: Shenzhen Core Medical Technology CO.,LTD. • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Tailored HIIT may boost fitness in stubborn heart failure
Disease control Not yet recruitingThis study tests whether a personalized high-intensity interval training (HIIT) program can improve exercise capacity and quality of life in people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either a 24-week HIIT plan tailor…
Phase: NA • Sponsor: Peking University Third Hospital • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Heart failure care gets a Check-Up: study tests if sharing guidelines boosts treatment
Disease control Not yet recruitingThis study looks at whether giving doctors—and sometimes patients—personalized reports on recommended heart failure treatments helps more people get the right medications. It involves adults with heart failure and reduced ejection fraction (HFrEF) in the Netherlands. The goal is …
Sponsor: Jasper Brugts MD PhD • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Heart failure drug aims to boost daily living and cut hospital visits
Disease control Not yet recruitingThis trial investigates whether vericiguat, added to standard treatment, can improve quality of life and reduce hospitalizations in adults with heart failure and reduced ejection fraction. Participants receive either vericiguat or a placebo for six months, and their health status…
Phase: PHASE4 • Sponsor: National Institute of Cardiovascular Diseases, Pakistan • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New digital coaching aims to keep heart failure patients out of hospital
Disease control Not yet recruitingThis study tests a four-month digital program designed to help people with chronic heart failure take their medications as prescribed. The program includes personalized planning, motivational counseling, and symptom tracking. Researchers will enroll 870 adults in Pakistan who hav…
Phase: NA • Sponsor: Universiti Putra Malaysia • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Tiny heart implant aims to unclog lungs and save lives in advanced heart failure
Disease control Not yet recruitingThis study tests a small, hourglass-shaped device implanted in the heart's upper chambers to lower pressure and reduce fluid buildup in the lungs. It is for people with advanced heart failure whose heart pumps weakly (ejection fraction 40% or less). The trial randomly assigns som…
Phase: NA • Sponsor: V-Wave Ltd • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Smarter heart pacing could cut hospital stays for heart failure patients
Disease control Not yet recruitingThis study tests a newer, more natural pacing method for people with heart failure and electrical problems in the heart. The approach uses the heart's own conduction system to improve coordination between chambers. Researchers will track patients for two years to see if this meth…
Sponsor: University of Pecs • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Smartwatches may help heart patients avoid hospital readmission
Disease control Not yet recruitingThis study tests whether wearable devices like smartwatches and ECG straps can help doctors remotely manage patients with both heart failure and atrial fibrillation. Participants use the devices to send real-time health data to their care team, who adjust medications and treatmen…
Phase: NA • Sponsor: Beijing Anzhen Hospital • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Heart failure hope: gut bacteria and drug combo tested in seniors
Disease control Not yet recruitingThis study tests whether adding a combination of an SGLT-2 inhibitor (henagliflozin) and a probiotic to standard heart failure treatment can improve heart function and quality of life in people over 60 with a specific type of heart failure called HFpEF. The trial randomly assigns…
Phase: PHASE1, PHASE2 • Sponsor: The First Affiliated Hospital of Air Force Medicial University • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Vein pressure check could slash hospital stays for heart failure patients
Disease control Not yet recruitingThis study tests whether giving doctors daily readings of a patient's peripheral venous pressure (a simple vein pressure measurement) can help heart failure patients get out of the hospital faster and avoid coming back. Researchers will compare 600 patients who get this extra inf…
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Nurse coaching may help heart failure patients avoid hospital visits by mastering fluid control
Disease control Not yet recruitingThis trial tests a nurse-led program designed to help people with chronic heart failure better manage fluid buildup—a common cause of hospital readmission. The program includes education, emotional support, and practical skills like daily weighing and salt restriction. Researcher…
Phase: NA • Sponsor: The Third Xiangya Hospital of Central South University • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Could a single iron infusion ease heart failure in seniors?
Disease control Not yet recruitingThis study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, reduce hospitalizations, and boost quality of life in adults aged 65 and older who have heart failure with preserved ejection fraction and iron deficiency. Participants receive…
Phase: PHASE4 • Sponsor: Duke University • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Heart pump may help High-Risk patients get Life-Saving artery treatment
Disease control Not yet recruitingThis study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…
Phase: NA • Sponsor: China National Center for Cardiovascular Diseases • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Smartwatch study aims to keep heart failure patients out of hospital
Disease control Not yet recruitingThis study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…
Phase: NA • Sponsor: Beijing Anzhen Hospital • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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New tool aims to help heart failure patients get the right meds
Disease control Not yet recruitingThis study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…
Phase: NA • Sponsor: University of British Columbia • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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Can heart failure patients ditch their pills? new study aims to find out
Disease control Not yet recruitingThis pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…
Phase: PHASE4 • Sponsor: Kyungsub Song • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Heart failure drug vericiguat faces new test in tricuspid regurgitation patients
Disease control Not yet recruitingThis study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…
Phase: PHASE4 • Sponsor: Daejeon St. Mary's hospital • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New study to see if heart procedure beats standard care for AF and heart failure
Disease control Not yet recruitingThis study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …
Phase: NA • Sponsor: Tulane University • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New blood test score could personalize heart failure diuretic use
Disease control Not yet recruitingThis trial tests whether a new scoring system, called the Biological Congestion Score (BCS), can help doctors better manage diuretic medications in people with chronic heart failure. The BCS combines four blood biomarkers with clinical information to estimate fluid congestion and…
Phase: NA • Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Weight-Loss drug mounjaro could keep hearts in rhythm after ablation
Disease control Not yet recruitingThis study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…
Phase: PHASE4 • Sponsor: Yunlong Wang • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Could a gut bacteria transplant ease heart failure in seniors?
Disease control Not yet recruitingThis study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can improve quality of life and exercise ability in elderly patients with a common type of heart failure (HFpEF). Fifty adults aged 60 and older will receive either the transplant or a …
Phase: PHASE1, PHASE2 • Sponsor: The First Affiliated Hospital of Air Force Medicial University • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Salt pills for heart failure? new study investigates
Disease control Not yet recruitingThis study looks at whether adding a small amount of salt (3 grams daily) to the diet can help people with chronic heart failure who have low blood sodium levels. Researchers will compare salt pills to a placebo in 30 adults over three months. The goal is to see if salt improves …
Phase: NA • Sponsor: Wroclaw Medical University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Stents plus drugs vs. drugs alone: which is better for heart failure?
Disease control Not yet recruitingThis study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …
Phase: NA • Sponsor: Nanjing First Hospital, Nanjing Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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New procedure targets nerves to treat stubborn heart failure
Disease control Not yet recruitingThis study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either…
Phase: NA • Sponsor: Nanjing First Hospital, Nanjing Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Heart pump auto mode tested in High-Risk procedure
Disease control Not yet recruitingThis pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…
Phase: NA • Sponsor: Rayyan Hemetsberger • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Pacemaker upgrade could ease stiff heart failure
Disease control Not yet recruitingThis pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…
Phase: NA • Sponsor: BackBeat Medical Inc • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New study aims to improve fluid removal in heart failure patients
Disease control Not yet recruitingThis study tests three different ways to remove excess fluid in people with worsening heart failure. Participants will receive intravenous furosemide alone, or combined with either acetazolamide or hydrochlorothiazide. The goal is to see which combination works best and is safest…
Phase: PHASE4 • Sponsor: Lucrecia Maria Burgos • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Can a pill reverse heart scarring? new study aims to find out
Disease control Not yet recruitingThis study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…
Phase: PHASE4 • Sponsor: China National Center for Cardiovascular Diseases • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Simple bedside checks may cut heart failure hospital stays by a full day
Disease control Not yet recruitingThis study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted for heart failure will be randomly assigned to either…
Phase: NA • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New hope for heart patients: drug may cut death risk after valve surgery
Disease control Not yet recruitingThis study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…
Phase: PHASE3 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Could mounjaro ease heart failure in obesity? new trial investigates
Disease control Not yet recruitingThis study will test whether tirzepatide (Mounjaro), a drug used for diabetes and weight loss, can help people with obesity-related heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in blood volume and body fat in 50 participants over 15 mon…
Phase: PHASE4 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Heart failure patients could go home sooner with injectable diuretic
Disease control Not yet recruitingThis study tests whether people hospitalized for acute heart failure can be discharged early and continue treatment at home using a subcutaneous injection of furosemide (a diuretic) instead of staying in the hospital for standard IV diuretics. About 250 adults will be randomly as…
Phase: PHASE3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New clinic aims to tackle heart failure and meth addiction together
Disease control Not yet recruitingThis pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Can a blood pressure pill help heart failure patients get the meds they need?
Disease control Not yet recruitingThis pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…
Phase: PHASE2, PHASE3 • Sponsor: Ottawa Heart Institute Research Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Heart shunt device aims to boost energy in failing hearts
Disease control Not yet recruitingThis study tests a small device called an interatrial shunt that is placed in the heart to relieve pressure. It involves 15 adults with advanced heart failure and reduced pumping ability. Researchers will use advanced heart scans and exercise tests to see if the device improves h…
Phase: NA • Sponsor: Heinrich-Heine University, Duesseldorf • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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New pacing technique could help heart failure patients with electrical delay
Disease control Not yet recruitingThis study tests a special pacing method for people with heart failure and a type of heart block. The goal is to see if pacing a specific area of the heart can improve heart function and quality of life. About 120 adults with heart failure and reduced pumping ability will partici…
Phase: NA • Sponsor: Seoul National University Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo therapy aims to rescue failing hearts without transplant
Disease control Not yet recruitingThis study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…
Phase: NA • Sponsor: Abiomed Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Can quick drug optimization after heart failure hospitalization save lives in women?
Disease control Not yet recruitingThis study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimiz…
Phase: PHASE4 • Sponsor: IRCCS Policlinico S. Donato • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Could a common diabetes drug mend hearts after failure?
Disease control Not yet recruitingThis study tests whether dapagliflozin, a drug already used for diabetes, can improve heart function in people hospitalized with acute heart failure. About 188 participants will take the drug or not for three months, and doctors will use special ultrasound imaging to measure chan…
Phase: NA • Sponsor: Qilu Hospital of Shandong University • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Heart pump patients: does routine leg tube prevent limb loss?
Disease control Not yet recruitingThis study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…
Phase: NA • Sponsor: Samsung Medical Center • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Ultrasound-Guided diuretic dosing may improve heart failure hospital outcomes
Disease control Not yet recruitingThis study tests whether using a special ultrasound score (DUCS) to guide diuretic dosing can improve outcomes for people hospitalized with acute heart failure. About 128 adults with heart failure and fluid buildup will be randomly assigned to either standard care or ultrasound-g…
Phase: PHASE2, PHASE3 • Sponsor: Hospital de Clinicas de Porto Alegre • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New cooler could keep donor hearts fresher for transplant
Disease control Not yet recruitingThis study tests a new adjustable cooler for storing donor hearts during transport to the transplant hospital. The cooler aims to keep the heart at a steady temperature, reduce waste, and lower costs compared to the current standard device. About 80 adults receiving a heart trans…
Phase: NA • Sponsor: Cedars-Sinai Medical Center • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Simple mouthpiece could ease heart strain in sleep apnea patients
Disease control Not yet recruitingThis study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…
Phase: NA • Sponsor: National University Hospital, Singapore • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Can a common heart drug reverse scarring in stiff heart failure?
Disease control Not yet recruitingThis study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …
Phase: PHASE4 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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5,000-Patient study tests jardiance against standard heart failure drugs in china
Disease control Not yet recruitingThis study looks at how well the drug Jardiance works compared to other standard heart failure treatments in Chinese patients with a specific type of heart failure (HFrEF). Researchers will track about 5,000 adults to see which treatment better prevents heart failure hospitalizat…
Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Smart alerts aim to cut heart failure hospital stays
Disease control Not yet recruitingThis study tests whether adding HeartLogic diagnostic alerts to usual care can reduce hospitalizations and improve quality of life for people with chronic heart failure and low ejection fraction. About 135 adults with a prior heart failure event will be enrolled. The approach use…
Phase: NA • Sponsor: Robert Pickett • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Could zapping a nerve ease heart failure? new trial tests it
Disease control Not yet recruitingThis early-stage trial tests whether a catheter-based procedure that zaps a nerve near the spine can safely help people with heart failure with reduced ejection fraction. Up to 50 patients will be randomly assigned to get the real treatment or a sham procedure, and neither they n…
Phase: NA • Sponsor: Axon Therapies, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Can a common amino acid boost heart function in failure patients?
Disease control Not yet recruitingThis phase 2 trial tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment improves heart function and symptoms. Researchers will enroll 200 stable heart failure patients with low ejection fraction (under 40%). Participants will receive either L…
Phase: PHASE2 • Sponsor: German University in Cairo • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Can a quick dose of dapagliflozin help elderly heart failure patients in the ER?
Disease control Not yet recruitingThis study looks at whether starting the drug dapagliflozin within 24 hours of arriving at the emergency room is practical for elderly patients (75+) with acute heart failure. It will involve 144 patients across 6 hospitals, comparing early drug treatment plus a nurse phone call …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Besancon • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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AI takes on heart failure: could it cut hospital stays?
Disease control Not yet recruitingThis study tests whether an artificial intelligence (AI) system can help doctors manage medications for people with heart failure with reduced ejection fraction (HFrEF). About 1,200 participants from 60 hospitals will be assigned to either AI-guided care or standard care. The goa…
Phase: NA • Sponsor: Shanghai Zhongshan Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Lab-grown heart cells injected into failing hearts: a new hope?
Disease control Not yet recruitingThis early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…
Phase: PHASE1, PHASE2 • Sponsor: Heartseed Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Can a smartwatch make virtual heart rehab work better?
Disease control Not yet recruitingThis study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…
Phase: NA • Sponsor: Nova Scotia Health Authority • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Can oxygen chambers boost heart failure treatment?
Disease control Not yet recruitingThis study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard heart failure medications can help people with chronic heart failure walk farther and improve heart function. About 150 adults with reduced heart pumping abil…
Phase: NA • Sponsor: Fujian Medical University • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Heart failure study questions need for frequent kidney checks
Disease control Not yet recruitingThis study looks at whether reducing the number of kidney function tests during heart failure treatment helps patients reach the best medication doses more safely. About 344 adults with heart failure and reduced ejection fraction will take part. The goal is to improve drug dosing…
Phase: NA • Sponsor: University Medical Center Groningen • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Can a common diabetes drug protect the heart? new trial aims to find out
Disease control Not yet recruitingThis Phase 3 trial will test whether glimepiride, a standard diabetes pill, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 participants will receive either glimepiride …
Phase: PHASE3 • Sponsor: Tongji Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New infusion drug aims to keep severe heart failure patients out of hospital
Disease control Not yet recruitingThis Phase 3 trial tests whether a continuous infusion of alprostadil, a drug that widens blood vessels, can help maintain stability in 600 people with advanced heart failure. Participants receive either the drug or a placebo for 6 months. The main goal is to see if the drug redu…
Phase: PHASE3 • Sponsor: Biopeutics Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Simple nurse chat may keep heart patients out of hospital
Disease control Not yet recruitingThis study looks at whether a 30-minute face-to-face lesson with a nurse can help people with chronic heart failure stay stable and take better care of themselves after being discharged from the hospital. About 118 adults will be randomly assigned to either receive this extra edu…
Phase: NA • Sponsor: Azienda Socio Sanitaria Territoriale di Lodi • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New heart failure drug trial aims to ease breathing and save lives
Disease control Not yet recruitingThis study tests whether levosimendan, a drug that strengthens heart contractions without increasing oxygen demand, can help people hospitalized with acute decompensated heart failure. About 332 adults will receive either levosimendan plus standard care or standard care alone. Re…
Phase: PHASE2, PHASE3 • Sponsor: Chittagong Medical College • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Heart failure and AF: which procedure works best?
Disease control Not yet recruitingThis study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…
Phase: PHASE4 • Sponsor: University of British Columbia • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Can a common heart drug improve how the heart relaxes?
Disease control Not yet recruitingThis study looks at whether the drug sacubitril/valsartan (Entresto) can improve the heart's ability to relax in people with heart failure and reduced pumping strength. Researchers will use ultrasound to measure changes after six months of treatment. The study involves 70 adults …
Sponsor: Assiut University • Aim: Disease control
Last updated Jun 26, 2026 13:42 UTC
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Paramedics test handheld ultrasound to spot heart failure in the field
Diagnosis Not yet recruitingThis study tests whether paramedics can use a lung ultrasound to improve diagnosis of heart failure in patients with breathing trouble. About 1,000 adults with shortness of breath will receive the ultrasound during emergency care. Researchers will compare the paramedic's diagnosi…
Phase: NA • Sponsor: Rutgers, The State University of New Jersey • Aim: Diagnosis
Last updated Jul 15, 2026 00:00 UTC
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AI eye on the heart: new tool spots rare amyloidosis earlier
Diagnosis Not yet recruitingThis study tests whether an artificial intelligence (AI) program can help doctors identify a rare heart condition called cardiac amyloidosis on routine echocardiograms. The condition causes protein buildup in the heart muscle, leading to heart failure, and is often missed early o…
Phase: NA • Sponsor: Germans Trias i Pujol Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 13:06 UTC
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Could a simple algorithm spot silent heart failure before it strikes?
Diagnosis Not yet recruitingThis study tests whether a new risk algorithm (FIND HF) can better detect undiagnosed heart failure in people at risk. About 475 adults aged 40+ will have a blood test and heart ultrasound. Researchers will compare how many high-risk vs low-risk people are found to have heart pro…
Sponsor: University of Leeds • Aim: Diagnosis
Last updated Jun 27, 2026 08:14 UTC
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Can a Surgeon's gut feeling match an ultrasound? new study aims to find out
Diagnosis Not yet recruitingThis study will check how well a heart surgeon's visual estimate of the heart's pumping ability matches the more precise measurement from an ultrasound (TEE) during open-heart surgery. About 70 adults having planned heart surgery with a heart-lung machine will take part. The goal…
Sponsor: Ataturk University • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC
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Bedside flu shot for heart patients: a simple strategy to save lives?
Prevention Not yet recruitingThis trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…
Phase: NA • Sponsor: Stephan Baldus • Aim: Prevention
Last updated Jul 25, 2026 00:00 UTC
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Could a common steroid speed heart shock recovery?
Symptom relief Not yet recruitingThis study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…
Phase: PHASE2 • Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Aug 15, 2026 00:00 UTC
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AI therapy coach aims to ease distress in seriously ill seniors
Symptom relief Not yet recruitingThis study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…
Phase: PHASE1 • Sponsor: Rutgers, The State University of New Jersey • Aim: Symptom relief
Last updated Aug 07, 2026 00:00 UTC
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Heart patients get a coach: will it keep them healthier?
Symptom relief Not yet recruitingThis study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…
Phase: NA • Sponsor: Ohio State University • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Heart failure patients may boost fitness with online lifestyle program
Symptom relief Not yet recruitingThis study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…
Phase: NA • Sponsor: Maimónides Biomedical Research Institute of Córdoba • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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Can a community health worker lighten the load for rural caregivers?
Symptom relief Not yet recruitingThis study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Olive oil may boost heart rehab for heart failure patients
Symptom relief Not yet recruitingThis study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…
Phase: NA • Sponsor: Old Dominion University • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Virtual rehab for frail hearts: a new hope for seniors?
Symptom relief Not yet recruitingThis study tests whether an 8-week home telerehabilitation program, with real-time coaching and vital sign monitoring, can improve physical function and reduce frailty in older adults with heart failure. Seventy participants will be randomly assigned to either the telerehab progr…
Phase: NA • Sponsor: University of Salerno • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Heart failure patients get a digital coach: new study tests WhatsApp training for better symptom control
Symptom relief Not yet recruitingThis study tests whether a structured medication training program delivered via WhatsApp can help people with heart failure better manage their symptoms and stick to their medication routine. Researchers will compare the training group to a group receiving standard care. The stud…
Phase: NA • Sponsor: Saglik Bilimleri Universitesi • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Strength before cardio: new exercise strategy tested for heart patients
Symptom relief Not yet recruitingThis study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…
Phase: NA • Sponsor: Northwestern University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Which workout is best for heart failure? new study aims to find out
Symptom relief Not yet recruitingThis study compares two supervised exercise programs—neuromuscular training (focusing on balance and coordination) and resistance training (using weights and bands)—in 40 adults with chronic heart failure. Over 10 weeks, researchers will measure how far participants can walk, the…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Sauna sessions may ease heart failure symptoms and reduce water pills
Symptom relief Not yet recruitingThis study looks at whether adding sauna therapy to standard cardiac rehabilitation can help people with heart failure feel less congested and possibly lower their dose of water pills (diuretics). About 46 adults with heart failure and reduced pumping ability will be randomly ass…
Phase: NA • Sponsor: BAUDRY Guillaume • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Could inflatable leg boots help heart failure patients?
Symptom relief Not yet recruitingThis study tests whether pulsatile compression boots, which rhythmically squeeze the legs, can help patients hospitalized with acute heart failure and leg swelling. The boots aim to move fluid out of the legs, improve circulation, and support heart and kidney function. One hundre…
Phase: NA • Sponsor: Odense University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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New tech trial aims to get heart failure patients moving
Symptom relief Not yet recruitingThis study tests a personalized system that uses a mobile app and smart wristband to encourage physical activity in 82 adults with heart failure. Participants get custom activity goals, real-time feedback, and motivational support over 12 months. The goal is to see if this approa…
Phase: NA • Sponsor: Abant Izzet Baysal University • Aim: Symptom relief
Last updated Jun 26, 2026 16:16 UTC
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Bedside blood test may reveal how well heart failure treatment works
Knowledge-focused Not yet recruitingThis observational study looks at whether changes in a blood marker called NT-proBNP, measured at the bedside, can reflect how well fluid is being removed in patients hospitalized with acute decompensated heart failure. Participants receive standard care, and researchers track NT…
Sponsor: Mao Chen • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
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Can a 30-hour e-learning course equip family doctors to deliver better palliative care?
Knowledge-focused Not yet recruitingThis trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…
Phase: NA • Sponsor: University of Coimbra • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Healthy volunteers test two versions of a promising heart failure drug
Knowledge-focused Not yet recruitingThis study tests two different formulations of an experimental drug called AD-118 in healthy adults aged 19 to 64. Participants receive a single dose of each version in a random order, and researchers measure how the drug moves through the body and check for side effects. The goa…
Phase: PHASE1 • Sponsor: Addpharma Inc. • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC
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Stiff arteries may hold key to heart failure progression
Knowledge-focused Not yet recruitingThis study looks at how the stiffness and function of blood vessels change in people newly diagnosed with heart failure. Researchers will measure these factors at the start, after a few weeks of standard medication, and after a cardiac rehab program. All tests are non-invasive an…
Sponsor: Coventry University • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC
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Sound waves could spot stroke dangers early
Knowledge-focused Not yet recruitingThis study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…
Sponsor: Virginia Commonwealth University • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Can a quick ultrasound keep heart failure patients out of the hospital?
Knowledge-focused Not yet recruitingThis study will test whether a five-point ultrasound can better predict fluid overload in 200 patients hospitalized with congestive heart failure. Doctors will use the ultrasound results to guide diuretic treatment and track readmission rates over 30 and 90 days. The goal is to s…
Phase: NA • Sponsor: Boston Medical Center • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Heart failure study aims to tailor treatments using biomarkers
Knowledge-focused Not yet recruitingThis observational study will follow 600 adults with chronic or acute heart failure to see how biomarkers and other factors predict individual responses to standard medications. Participants will have assessments at the start and after 1, 3, and 6 months, with follow-up phone cal…
Sponsor: Maastricht University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Heart failure mystery: 500 patients join hunt for better treatment
Knowledge-focused Not yet recruitingThis study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …
Sponsor: University Of Perugia • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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2.2 million patients: does heart failure raise surgery death risk?
Knowledge-focused Not yet recruitingThis study will look at medical records from over 2 million adults who had surgery in Sweden between 2021 and 2024. Researchers want to see how common heart failure is in surgical patients and whether it raises the risk of death or other problems after surgery. The goal is to bet…
Sponsor: Umeå University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New BP monitor could make life easier for heart pump patients
Knowledge-focused Not yet recruitingThis study tests a special blood pressure monitor that deflates very slowly, designed for people with a Left Ventricular Assist Device (LVAD). Researchers want to see if patients can use it easily at home and if it helps track their blood pressure accurately. About 50 adults with…
Phase: NA • Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Heart valve repair may unlock higher doses of key heart failure drugs
Knowledge-focused Not yet recruitingThis observational study will follow 50 people with severe tricuspid regurgitation (a leaky heart valve) and reduced heart function who undergo valve repair using the PASCAL Precision System. The main goal is to see if, 12 months after repair, patients can take higher doses of st…
Sponsor: Ceric Sàrl • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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No needles needed: new device may measure heart pressure through the arm
Knowledge-focused Not yet recruitingThis study tests a new method to measure central venous pressure (a key heart health indicator) without inserting a catheter. Researchers will use a pressure cuff and Doppler sensor on the forearm of 30 children (ages 0-17) in the intensive care unit. The goal is to see if this n…
Sponsor: Le Bonheur Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Heart fat may melt away after weight loss surgery, study hopes to show
Knowledge-focused Not yet recruitingThis observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The…
Sponsor: Itshak Amsalem • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Hormone Therapy's heart impact under the microscope
Knowledge-focused Not yet recruitingThis study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in these changes. About 50…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Brazil launches massive heart failure study to improve care
Knowledge-focused Not yet recruitingThis study will follow 2000 adults hospitalized with acute heart failure in Brazil to learn how they are treated and what happens to them over the next year. Researchers want to see if doctors are using the latest recommended medicines and find out what barriers prevent better ca…
Sponsor: Hospital do Coracao • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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PICTURES MAY BOOST HEART DRUG ADHERENCE IN NEW STUDY
Knowledge-focused Not yet recruitingThis study tests a simple idea: showing heart failure patients easy-to-understand pictures of how their medications can help them live longer and stay out of the hospital. About 100 adults with heart failure will receive these visual aids along with their usual care. Researchers …
Phase: EARLY_PHASE1 • Sponsor: University of Giessen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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30,000-Person study seeks to unmask hidden heart failure
Knowledge-focused Not yet recruitingThis observational study will enroll 30,000 adults in Denmark to better understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff to fill properly. Researchers will use blood tests, heart imaging, and health rec…
Sponsor: Herlev and Gentofte Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Healthy volunteers needed to test two forms of heart failure medicine
Knowledge-focused Not yet recruitingThis early-stage study will test two versions of a drug (AD-118 and AD-1181) in 70 healthy adults to see how they are processed by the body and if they are safe. Participants will receive a single dose of each version under fasting conditions. The study does not aim to treat any …
Phase: PHASE1 • Sponsor: Addpharma Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Heart failure patients grouped by data, not drugs
Knowledge-focused Not yet recruitingThis study looks at 200 adults with a type of heart failure called HFpEF. Researchers will use medical records and exercise tests to find different patient groups, or phenotypes. The goal is to better understand these groups, not to test any new treatment. Participants will have …
Sponsor: Instituto Politécnico de Leiria • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Jardiance under the microscope: new study tracks heart failure outcomes in china
Knowledge-focused Not yet recruitingThis study will observe 3,000 adults in China with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers will track how many patients are hospitalized for heart failure or die from heart-related causes over time. The goal is to see how effective an…
Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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New study aims to better detect breathing trouble in Non-Communicative ICU patients
Knowledge-focused Not yet recruitingThis study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…
Sponsor: Istinye University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Heart failure study to uncover hidden links to kidney and liver disease
Knowledge-focused Not yet recruitingThis study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…
Sponsor: Russian Scientific Medical Society of Therapists • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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New study aims to decode heart failure using body data
Knowledge-focused Not yet recruitingThis study looks at 600 people (400 with chronic heart failure and 200 healthy) to find patterns in genes, proteins, and gut bacteria that may predict who gets worse. Researchers will track patients for one year to see who is hospitalized or dies. The goal is to create a better r…
Sponsor: Xinjiang Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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New study aims to crack the code on Hard-to-Treat sleep apnea in heart failure
Knowledge-focused Not yet recruitingThis study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…
Phase: PHASE4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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New study explores digital tools to keep care going in crises
Knowledge-focused Not yet recruitingThis study looks at whether a hybrid care model—using telemonitoring, teleconsultations, and online tools—can help patients with type 2 diabetes or chronic heart failure get regular care during health emergencies like pandemics. Researchers will follow 180 patients for one year, …
Phase: NA • Sponsor: Radboud University Medical Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:29 UTC