Congestive heart failure

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…

This study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…

This pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…

This study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…

This study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …

This trial tests whether a new scoring system, called the Biological Congestion Score (BCS), can help doctors better manage diuretic medications in people with chronic heart failure. The BCS combines four blood biomarkers with clinical information to estimate fluid congestion and…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can improve quality of life and exercise ability in elderly patients with a common type of heart failure (HFpEF). Fifty adults aged 60 and older will receive either the transplant or a …

This study looks at whether adding a small amount of salt (3 grams daily) to the diet can help people with chronic heart failure who have low blood sodium levels. Researchers will compare salt pills to a placebo in 30 adults over three months. The goal is to see if salt improves …

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either…

This pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests three different ways to remove excess fluid in people with worsening heart failure. Participants will receive intravenous furosemide alone, or combined with either acetazolamide or hydrochlorothiazide. The goal is to see which combination works best and is safest…

This study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…

This study tests a four-month digital program designed to help people with chronic heart failure take their medications as prescribed. The program includes personalized planning, motivational counseling, and symptom tracking. Researchers will enroll 870 adults in Pakistan who hav…

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted for heart failure will be randomly assigned to either…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…

This study will test whether tirzepatide (Mounjaro), a drug used for diabetes and weight loss, can help people with obesity-related heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in blood volume and body fat in 50 participants over 15 mon…

This study tests whether people hospitalized for acute heart failure can be discharged early and continue treatment at home using a subcutaneous injection of furosemide (a diuretic) instead of staying in the hospital for standard IV diuretics. About 250 adults will be randomly as…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…

This study tests a small device called an interatrial shunt that is placed in the heart to relieve pressure. It involves 15 adults with advanced heart failure and reduced pumping ability. Researchers will use advanced heart scans and exercise tests to see if the device improves h…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study tests whether giving doctors daily readings of a patient's peripheral venous pressure (a simple vein pressure measurement) can help heart failure patients get out of the hospital faster and avoid coming back. Researchers will compare 600 patients who get this extra inf…

This study tests a special pacing method for people with heart failure and a type of heart block. The goal is to see if pacing a specific area of the heart can improve heart function and quality of life. About 120 adults with heart failure and reduced pumping ability will partici…

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimiz…

This study tests whether dapagliflozin, a drug already used for diabetes, can improve heart function in people hospitalized with acute heart failure. About 188 participants will take the drug or not for three months, and doctors will use special ultrasound imaging to measure chan…

This study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…

This study tests whether using a special ultrasound score (DUCS) to guide diuretic dosing can improve outcomes for people hospitalized with acute heart failure. About 128 adults with heart failure and fluid buildup will be randomly assigned to either standard care or ultrasound-g…

This study tests a new adjustable cooler for storing donor hearts during transport to the transplant hospital. The cooler aims to keep the heart at a steady temperature, reduce waste, and lower costs compared to the current standard device. About 80 adults receiving a heart trans…

This study tests whether sending doctors a reminder about IV iron guidelines helps heart failure patients with iron deficiency get the recommended treatment. About 3,000 hospitalized adults with heart failure and low iron will be included. Doctors in the intervention group receiv…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs (pulmonary hypertension) in people with heart failure. The goal is to see if it can reduce serious heart events like hospitalizations or death. About 750 adults with stable heart f…

This study tests if a mouthpiece worn during sleep can help people with both heart failure and obstructive sleep apnea. The device keeps the airway open, which may reduce stress on the heart and improve quality of life. 328 participants will use either the real device or a sham o…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This phase 2 trial tests whether an investigational drug called activin ligand-trap, combined with exercise training, can improve exercise capacity and cognitive function in 48 adults with heart failure with preserved ejection fraction (HFpEF). Participants will receive either th…

This study looks at how well the drug Jardiance works compared to other standard heart failure treatments in Chinese patients with a specific type of heart failure (HFrEF). Researchers will track about 5,000 adults to see which treatment better prevents heart failure hospitalizat…

This study tests whether adding HeartLogic diagnostic alerts to usual care can reduce hospitalizations and improve quality of life for people with chronic heart failure and low ejection fraction. About 135 adults with a prior heart failure event will be enrolled. The approach use…

This early-stage trial tests whether a catheter-based procedure that zaps a nerve near the spine can safely help people with heart failure with reduced ejection fraction. Up to 50 patients will be randomly assigned to get the real treatment or a sham procedure, and neither they n…

This phase 2 trial tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment improves heart function and symptoms. Researchers will enroll 200 stable heart failure patients with low ejection fraction (under 40%). Participants will receive either L…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study looks at whether starting the drug dapagliflozin within 24 hours of arriving at the emergency room is practical for elderly patients (75+) with acute heart failure. It will involve 144 patients across 6 hospitals, comparing early drug treatment plus a nurse phone call …

This study tests whether an artificial intelligence (AI) system can help doctors manage medications for people with heart failure with reduced ejection fraction (HFrEF). About 1,200 participants from 60 hospitals will be assigned to either AI-guided care or standard care. The goa…

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard heart failure medications can help people with chronic heart failure walk farther and improve heart function. About 150 adults with reduced heart pumping abil…

This study looks at whether reducing the number of kidney function tests during heart failure treatment helps patients reach the best medication doses more safely. About 344 adults with heart failure and reduced ejection fraction will take part. The goal is to improve drug dosing…

This Phase 3 trial will test whether glimepiride, a standard diabetes pill, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 participants will receive either glimepiride …

This Phase 3 trial tests whether a continuous infusion of alprostadil, a drug that widens blood vessels, can help maintain stability in 600 people with advanced heart failure. Participants receive either the drug or a placebo for 6 months. The main goal is to see if the drug redu…

This study looks at whether a 30-minute face-to-face lesson with a nurse can help people with chronic heart failure stay stable and take better care of themselves after being discharged from the hospital. About 118 adults will be randomly assigned to either receive this extra edu…

This study tests whether levosimendan, a drug that strengthens heart contractions without increasing oxygen demand, can help people hospitalized with acute decompensated heart failure. About 332 adults will receive either levosimendan plus standard care or standard care alone. Re…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This study tests whether using a real-time continuous glucose monitor (CGM) can improve blood sugar control and reduce hospital readmissions in people with type 2 diabetes and acute heart failure. Researchers will follow 140 adults during their hospital stay and for three months …

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study looks at whether the drug sacubitril/valsartan (Entresto) can improve the heart's ability to relax in people with heart failure and reduced pumping strength. Researchers will use ultrasound to measure changes after six months of treatment. The study involves 70 adults …

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study tests whether an artificial intelligence (AI) program can help doctors identify a rare heart condition called cardiac amyloidosis on routine echocardiograms. The condition causes protein buildup in the heart muscle, leading to heart failure, and is often missed early o…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study tests whether paramedics can use a lung ultrasound to improve diagnosis of heart failure in patients with breathing trouble. About 1,000 adults with shortness of breath will receive the ultrasound during emergency care. Researchers will compare the paramedic's diagnosi…

This study will check if a fast, bedside heart ultrasound performed by emergency doctors or interpreted by artificial intelligence can accurately detect heart problems in children who already have heart disease. About 200 children aged 0-21 will be included. The results will be c…

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study tests whether a new risk algorithm (FIND HF) can better detect undiagnosed heart failure in people at risk. About 475 adults aged 40+ will have a blood test and heart ultrasound. Researchers will compare how many high-risk vs low-risk people are found to have heart pro…

This study will check how well a heart surgeon's visual estimate of the heart's pumping ability matches the more precise measurement from an ultrasound (TEE) during open-heart surgery. About 70 adults having planned heart surgery with a heart-lung machine will take part. The goal…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether combining breathing exercises with cognitive tasks (like memory games) can improve thinking and daily function in adults with heart failure. 54 participants will be randomly assigned to dual-task breathing training, standard breathing training, or a contr…

This study tests whether an 8-week home telerehabilitation program, with real-time coaching and vital sign monitoring, can improve physical function and reduce frailty in older adults with heart failure. Seventy participants will be randomly assigned to either the telerehab progr…

This study tests whether a structured medication training program delivered via WhatsApp can help people with heart failure better manage their symptoms and stick to their medication routine. Researchers will compare the training group to a group receiving standard care. The stud…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…

This study compares two supervised exercise programs—neuromuscular training (focusing on balance and coordination) and resistance training (using weights and bands)—in 40 adults with chronic heart failure. Over 10 weeks, researchers will measure how far participants can walk, the…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study looks at whether adding sauna therapy to standard cardiac rehabilitation can help people with heart failure feel less congested and possibly lower their dose of water pills (diuretics). About 46 adults with heart failure and reduced pumping ability will be randomly ass…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether pulsatile compression boots, which rhythmically squeeze the legs, can help patients hospitalized with acute heart failure and leg swelling. The boots aim to move fluid out of the legs, improve circulation, and support heart and kidney function. One hundre…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study tests a personalized system that uses a mobile app and smart wristband to encourage physical activity in 82 adults with heart failure. Participants get custom activity goals, real-time feedback, and motivational support over 12 months. The goal is to see if this approa…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will test whether a five-point ultrasound can better predict fluid overload in 200 patients hospitalized with congestive heart failure. Doctors will use the ultrasound results to guide diuretic treatment and track readmission rates over 30 and 90 days. The goal is to s…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This observational study will follow 600 adults with chronic or acute heart failure to see how biomarkers and other factors predict individual responses to standard medications. Participants will have assessments at the start and after 1, 3, and 6 months, with follow-up phone cal…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study will look at medical records from over 2 million adults who had surgery in Sweden between 2021 and 2024. Researchers want to see how common heart failure is in surgical patients and whether it raises the risk of death or other problems after surgery. The goal is to bet…

This study tests a special blood pressure monitor that deflates very slowly, designed for people with a Left Ventricular Assist Device (LVAD). Researchers want to see if patients can use it easily at home and if it helps track their blood pressure accurately. About 50 adults with…

This observational study will follow 50 people with severe tricuspid regurgitation (a leaky heart valve) and reduced heart function who undergo valve repair using the PASCAL Precision System. The main goal is to see if, 12 months after repair, patients can take higher doses of st…

This study tests a new method to measure central venous pressure (a key heart health indicator) without inserting a catheter. Researchers will use a pressure cuff and Doppler sensor on the forearm of 30 children (ages 0-17) in the intensive care unit. The goal is to see if this n…

This observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in these changes. About 50…

This study will follow 2000 adults hospitalized with acute heart failure in Brazil to learn how they are treated and what happens to them over the next year. Researchers want to see if doctors are using the latest recommended medicines and find out what barriers prevent better ca…

This study tests a simple idea: showing heart failure patients easy-to-understand pictures of how their medications can help them live longer and stay out of the hospital. About 100 adults with heart failure will receive these visual aids along with their usual care. Researchers …

This observational study will enroll 30,000 adults in Denmark to better understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff to fill properly. Researchers will use blood tests, heart imaging, and health rec…

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This early-stage study will test two versions of a drug (AD-118 and AD-1181) in 70 healthy adults to see how they are processed by the body and if they are safe. Participants will receive a single dose of each version under fasting conditions. The study does not aim to treat any …

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study looks at 200 adults with a type of heart failure called HFpEF. Researchers will use medical records and exercise tests to find different patient groups, or phenotypes. The goal is to better understand these groups, not to test any new treatment. Participants will have …

This study will observe 3,000 adults in China with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers will track how many patients are hospitalized for heart failure or die from heart-related causes over time. The goal is to see how effective an…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at 600 people (400 with chronic heart failure and 200 healthy) to find patterns in genes, proteins, and gut bacteria that may predict who gets worse. Researchers will track patients for one year to see who is hospitalized or dies. The goal is to create a better r…

This study looks at why people with heart failure or those taking opioid painkillers develop central sleep apnea (pauses in breathing during sleep). Current treatments don't work well, so researchers will test combinations of breathing machines and medications in 200 Veterans. Th…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study looks at whether a hybrid care model—using telemonitoring, teleconsultations, and online tools—can help patients with type 2 diabetes or chronic heart failure get regular care during health emergencies like pandemics. Researchers will follow 180 patients for one year, …