Congestive heart failure

This study tests whether regular video calls with a nurse can help people with heart failure manage their condition better than audio-only calls. About 140 adults with heart failure will be randomly assigned to receive either video or audio calls at 7, 30, 60, 180, and 365 days a…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study tested a bedside device called the Reprieve Decongestion Management System in 100 hospitalized patients with acute decompensated heart failure. The device automatically adjusts the dose of a diuretic (furosemide) and saline based on the patient's real-time urine output…

This study tested whether the drug sotagliflozin can improve heart function in people with a type of heart failure called HFpEF who do not have diabetes. Eighty-eight participants took either the drug or a placebo for six months. Researchers used heart scans and exercise tests to…

This study tests a structured transitional care program for people with heart failure. The program includes discharge education, phone follow-ups, and home care support for three months after leaving the hospital. Researchers want to see if it helps reduce depression, improve con…

This study tested a new drug called R2R01 in 33 people with worsening heart failure. Participants received either R2R01 or a placebo alongside their usual treatments. The goal was to see if the drug is safe and helps reduce fluid buildup in the heart.

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested whether adding sacubitril-valsartan to standard care helps people with heart failure (with preserved pumping ability) and a leaky mitral valve. 84 participants were randomly assigned to get the drug or standard care alone. Researchers measured heart function and…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This study looked at whether a type of diabetes medicine called SGLT2 inhibitors can help people with severe heart failure who also have a mechanical heart pump (LVAD). Researchers measured changes in heart size, weight, and kidney function over 6 months in 32 adults. The goal wa…

This completed study in 180 heart failure patients compared the effects of taking Entresto alone versus Entresto plus a second drug (empagliflozin) on mitral valve function and heart pumping ability. Participants had heart failure with reduced ejection fraction and some degree of…

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study tested whether using a smartphone app and phone calls to monitor patients after a heart failure hospital stay helps doctors safely increase their medications. 66 adults with chronic heart failure and low ejection fraction were split into two groups: one received usual …

This study tested a mobile app designed to help people with heart failure monitor their blood pressure, weight, and heart rate daily. The app also tracks symptoms and medications, sharing the data with doctors to guide treatment. Researchers wanted to see if using the app leads t…

This study tested a new drug called JTT-861 in 314 adults with chronic heart failure and reduced pumping ability. Participants took either the drug or a placebo once daily for 12 weeks, alongside their usual heart medications. The goal was to see if the drug improves heart functi…

This study tested whether the drug sacubitril/valsartan can improve heart function in people with heart failure who are on chronic hemodialysis. 52 patients were split into two groups: one received the drug, the other standard care. Researchers measured changes in heart ultrasoun…

This study tested whether a slow-release form of the beta-blocker carvedilol can improve heart function in people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff. 63 adults with high blood pressure and signs…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …

This study tested whether the diabetes drug ertugliflozin can reduce fluid buildup in the skin and tissues of people with heart failure. 28 adults with reduced heart function took the drug or a placebo for one month each. Researchers measured skin water and sodium content to see …

This early study tested a single injection of HM2002, a circular RNA, given directly into the heart muscle during bypass surgery. Only 3 people with heart failure took part. The main goal was to check safety, not to prove it works. The study is complete, but results are not yet a…

This study tested a new drug called AC01 in 58 adults with heart failure and reduced pumping ability. The goal was to check safety and how the body processes the drug. Participants received either AC01 or a placebo in increasing doses. The study is complete, but results are not y…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…

This study looked at 200 people with both heart failure and permanent atrial fibrillation. Participants received either a standard defibrillator (ICD) or one that also paces both lower heart chambers (CRT/ICD). The goal was to see if the extra pacing reduces heart size and improv…

This study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study looked at the safety of using levosimendan over a longer period in people who have both pulmonary hypertension and heart failure with preserved ejection fraction. 35 patients who had already been in a related study received the drug and were monitored for side effects.…

This study tested a drug called sacubitril-valsartan in 60 adults with heart failure and a weak heart pump. The goal was to see if the drug could lower the chance of major heart problems like heart attack, stroke, or death, and improve how well the heart pumps blood. Participants…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested a 12-week cardiac rehabilitation program in 65 elderly patients (70+) with heart failure. The program included strength and aerobic exercises twice a week. Researchers measured changes in movement, heart function, and fitness. The goal was to see if exercise can…

This study looked at whether a drug called sacubitril/valsartan helps African American patients with a certain type of heart failure (reduced ejection fraction). Researchers wanted to see if it lowers the chance of death or hospital visits for heart problems. Over 6,500 African A…

This completed study monitored 1200 Japanese patients with chronic heart failure who were prescribed JARDIANCE® (empagliflozin) for the first time. Researchers tracked side effects, deaths, and hospitalizations over the long term to see how the drug performs in everyday use. The …

This study tested a single injection of special stem cells (Rexlemestrocel-L) into the heart for people with chronic heart failure. The goal was to see if it could reduce serious heart events like hospitalizations or death. The trial involved 565 adults and compared the stem cell…

This completed study tested a breathing machine strategy that uses lung pressure measurements to guide settings, aiming to protect the right side of the heart in patients with acute respiratory distress syndrome (ARDS). Forty adults on ventilators for less than 72 hours were incl…

This completed study tested a device that uses ultrasound to calm overactive nerves near the kidneys (renal denervation) in 6 people with chronic heart failure. The goal was to see if it is safe and can improve heart function by reducing sympathetic nerve activity. Because it was…

This study looked at whether the drug vericiguat can help reverse harmful changes in the heart's shape and function in people with heart failure. Researchers used advanced ultrasound techniques to measure heart size and pumping ability in 40 participants. The goal was to see if v…

This study tested two methods of giving the diuretic furosemide (a water pill) to 50 people with sudden heart failure in the emergency department. Half received the drug as a single injection (bolus), the other half as a slow drip (continuous infusion). Researchers measured urine…

This study tested whether a drug called sacubitril-valsartan (Entresto) can improve early signs of heart failure in people with HIV. The 39 participants had well-controlled HIV but showed subtle heart changes on scans. The goal was to see if the drug could reduce inflammation and…

This trial tested a device called Barostim neo that stimulates nerves to help control blood pressure in people with advanced heart failure. Over 1,000 participants received either the device or standard medical care. The goal was to see if the device could reduce heart-related de…

This study tested whether a single dose of dantrolene, a muscle relaxant, could reduce the risk of dangerous heart rhythms in 68 people with structural heart disease who were scheduled for a procedure to treat ventricular tachycardia. Participants received either dantrolene or a …

This study tested a new device called the Doraya Catheter in 25 hospitalized heart failure patients whose bodies were not responding well to standard water pills (diuretics). The goal was to see if the catheter could safely and effectively remove excess fluid. The study focused o…

This study tested whether a structured discharge education session using the 'teach-back' method—where patients repeat instructions in their own words—could help heart failure patients better understand their condition and self-care routines. The goal was to reduce 30-day hospita…

This study tested a new medicine called AZD5462 in 375 adults with stable chronic heart failure. The goal was to see if the drug could improve how well the heart pumps blood. Participants continued their usual heart failure medications while receiving either AZD5462 or a placebo.…

This study compares two types of ablation (pulsed-field vs cryoballoon) for treating atrial fibrillation in people with heart failure and reduced pumping function. Researchers looked back at 700 patients who had their first ablation to see which method works better and is safer. …

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested a small device that delivers gentle electrical currents to the heart in 70 people with severe heart failure. Participants received either the device plus standard medications or medications alone. The main goal was to see if the device improved the heart's pumpi…

This study tested two types of exercise training—high-intensity interval training (HIIT) and moderate continuous training (MICT)—against standard physical activity advice in 188 people who had a heart attack. The goal was to see which approach best improves fitness and reduces he…

This study looked at health records of 1,249 heart failure patients in Portugal to compare two types of medication: sacubitril/valsartan versus older drugs called ACE inhibitors or ARBs. The goal was to see which treatment better prevents heart failure hospitalizations or death f…

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This study collected data from 2,400 adults in China with chronic heart failure to see how well the drug vericiguat works compared to standard treatments. Researchers tracked deaths, hospital stays, and side effects over 12 months. The goal is to understand if vericiguat helps co…

This study tested two common blood pressure medications—amlodipine and metoprolol—in 50 adults with heart failure with preserved ejection fraction (HFpEF) and hypertension. Participants took each drug for a period, and researchers measured their home blood pressure readings. The …

This study tested whether a step-by-step plan for using diuretics (water pills) is better and safer than usual care for people hospitalized with worsening chronic heart failure. The trial involved 299 adults and compared a structured protocol using furosemide and hydrochlorothiaz…

This study tested whether providing medically tailored meals to people with heart failure could improve their diet quality. Sixty participants received heart-healthy meals delivered to their homes for 12 weeks. The main goal was to see if their diet scores improved by the end of …

This completed Phase 3 trial tested a web application called SmartHF in 225 adults with heart failure and reduced ejection fraction. The app analyzes patient data and gives personalized medication recommendations that patients can share with their doctor. The goal was to see if u…

This early-stage study tested a new drug called CDR132L in 28 people with stable heart failure caused by reduced blood flow to the heart. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and research…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested whether probenecid, a medicine usually used for gout, can improve heart function and exercise ability in veterans with heart failure. About 99 veterans with a specific type of heart failure took probenecid twice daily for 180 days. Researchers measured changes i…

This pilot study tested a 'polypill' that combines four heart failure medications into one capsule, aiming to make it easier for patients to stick with their treatment. The trial included 35 adults with heart failure and reduced ejection fraction, some of whom also had HIV. Resea…

This study looked at whether the drug vericiguat can help people who have had a heart attack or unstable angina and also have a weak heart (ejection fraction below 45%). The main goal was to see if it lowers the chance of dying from heart problems or being hospitalized for heart …

This study tested a remote monitoring system called Seerlinq HeartCore in 330 heart failure patients. Participants used a device at home to measure heart function and report symptoms. The goal was to see if this approach could reduce hospitalizations and deaths over 6 months. The…

This large phase 3 trial tested the drug vericiguat in over 6,000 adults with chronic heart failure and a weakened heart pump. Participants took a daily pill or a placebo to see if the drug could lower the chance of dying from heart problems or being hospitalized for heart failur…

This study tested whether using cardiac MRI to guide ablation (a procedure that destroys small areas of heart tissue) can improve outcomes for people with ventricular tachycardia, a dangerous fast heart rhythm. 104 adults with structural heart disease were randomly assigned to on…

This completed study tested whether empagliflozin, a diabetes drug, can improve heart structure and function in 50 non-diabetic patients with heart failure with preserved ejection fraction. Participants took either empagliflozin or a placebo daily. Researchers measured heart stre…

This study tested whether a weekly injection of semaglutide (2.4 mg) can improve heart failure symptoms and reduce body weight in 617 people with obesity-related heart failure with preserved ejection fraction and type 2 diabetes. Participants received either semaglutide or a plac…

This study looked at whether a clinic led by a heart failure nurse could help patients with heart failure get the right medications after getting an implantable defibrillator (ICD) or cardiac resynchronization therapy (CRT). The goal was to see if this approach improved heart fun…

This study tested whether a single daily pill containing three heart failure drugs could help people with reduced ejection fraction, especially those with low income or from minority groups. 212 adults took either the polypill or standard separate medications. The goal was to see…

This completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in …

This Phase 2 trial tested the drug tovinontrine (CRD-750) against a placebo in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug safely lowers a key heart stress marker called NT-proBNP over 12 weeks. The study is complete, and res…

This study looked at whether giving ulinastatin during heart surgery can lower the chance of lung complications like infections or breathing failure. Researchers analyzed data from over 4,500 patients and also used computer models to understand how the drug works. The results sug…

This Phase 2 study tested the safety and effectiveness of tovinontrine, an experimental drug, compared to a placebo in 303 adults with chronic heart failure with preserved ejection fraction. The main goal was to see if tovinontrine could lower a key biomarker (NT-proBNP) in the b…

This study looked at the safest way to start two heart failure drugs (ARNi and SGLT2i) in 62 adults with a weak heart pump. Researchers compared starting both drugs at the same time versus starting one drug first and adding the other later. The goal was to see which method caused…

This study looked at the safety of the drug sacubitril/valsartan in Japanese children with heart failure. Eight children who had already been in a previous trial took the drug to see if any side effects occurred. The goal was to gather more safety information and provide the drug…

This completed phase 4 trial tested whether vericiguat, a drug already approved for heart failure, can improve blood vessel function, reduce inflammation, and enhance quality of life in 26 people with heart failure with reduced ejection fraction. Participants received either veri…

This study tested whether starting the heart failure drug vericiguat at a 5 mg dose (instead of the usual 2.5 mg) is safe and tolerable. 106 adults with chronic heart failure with reduced ejection fraction took the 5 mg tablet daily for about two weeks. The goal was to see if ski…

This completed trial tested whether ozone therapy can help people with heart failure and reduced ejection fraction. Sixty participants received ozone infusions twice a week for two months. Researchers measured coronary flow reserve, exercise capacity, and heart function before an…

This study tested whether a special clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure took part over 12 weeks. The clinic aimed to improve medication use, health status, and heart function.

This pilot study tested a device that stimulates the diaphragm in time with the heartbeat to see if it can improve heart function in people with heart failure. 35 participants with reduced ejection fraction received the implant. The study checked for safety and changes in heart s…

This completed study looked at 60 adults with acute decompensated heart failure and kidney impairment. Researchers compared three intravenous heart medications—levosimendan, dobutamine, and milrinone—to see which one improved heart and kidney function best. The goal was to find t…

This completed study tested whether special alerts in electronic health records and referrals to pharmacists could help doctors prescribe guideline-recommended heart failure medications more often. Over 4,300 patients with heart failure and reduced ejection fraction took part. Th…

This study tested whether a patient's own bone marrow cells, processed and delivered into the heart muscle, could help people with chronic heart failure. 125 participants were randomly assigned to receive either the cell therapy or a sham procedure. The main goal was to see if th…

This study tested a pacemaker feature called AutoAdapt that automatically adjusts timing settings to help the heart pump better. It involved 198 people with heart failure who needed a special pacemaker. The goal was to see if this smart feature improves symptoms, reduces hospital…

This completed study looked at whether the diabetes drug empagliflozin (Jardiance) can help repair heart damage in diabetic patients who had a major heart attack. 200 participants took either 10 mg or 25 mg of the drug daily for 6 months. Researchers measured changes in heart siz…

This study looked at data from 500 people in Germany who started taking vericiguat for chronic heart failure with reduced ejection fraction. Researchers wanted to see how well the drug works outside of clinical trials, in routine medical care. They tracked deaths and hospitalizat…

This study tested whether a special heart scan (SPECT) can predict which people with severe chronic heart failure will improve after getting a cardiac resynchronization therapy device. The scan uses a radioactive tracer to measure nerve activity in the heart. Researchers enrolled…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

Heart failure is a serious condition with high death and rehospitalization rates. This study tested whether using a blood marker called ST2 to guide treatment could reduce hospital readmissions within one month. Researchers compared standard care with a strategy that adjusts medi…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study tested whether a special type of heart MRI, called T1 mapping, can accurately diagnose cardiac amyloidosis—a condition where abnormal proteins build up in the heart muscle. Researchers studied 112 older adults with heart failure and thickened heart walls. They compared…

This study tested whether an AI-powered smart stethoscope can accurately detect structural heart disease in over 6,600 students aged 10-18 in China. Trained staff used the device to listen to heart sounds, and the AI flagged potential issues. Students with positive results, plus …

This study tested a new MRI technique using a contrast agent called mangafodipir to measure how well heart cells take up manganese, which reflects cell function. It included 44 participants: healthy volunteers and people with heart failure with preserved ejection fraction caused …

This study looked at whether taking extra ultrasound images during a standard stress echocardiogram can help doctors figure out if chest pain or shortness of breath is caused by a stiff heart (heart failure with preserved ejection fraction, or HFpEF). Researchers enrolled 30 peop…

This study tested a new contrast agent called NH002 in 36 adults with heart disease. The agent is used during heart ultrasound to make the heart's chambers and borders clearer. The main goal was to check safety by monitoring vital signs, heart activity, and allergic reactions aft…

This study aimed to create better diagnostic tools for a type of heart failure called heart failure with preserved ejection fraction (HFpEF), which is common in older adults but hard to diagnose. Researchers tested a combination of five blood markers in 91 participants to see if …

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

This study tested whether a low-salt, heart-healthy diet (DASH diet) can prevent heart failure in veterans with high blood pressure and metabolic syndrome. 71 veterans received counseling and some also got tailored messages via smartphone or email. The goal was to see if the diet…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study tests whether starting cardiopulmonary rehabilitation (exercise and breathing training) early in the hospital helps people with acute decompensated heart failure recover faster. About 40 adults who are stable enough will take part. The goal is to see if early rehab imp…

This study tested whether using a device that electrically stimulates the thigh muscles at home, for 4 weeks after a hospital stay, could help people with heart failure walk farther and feel stronger. Only 8 people took part, so the results are very early. The goal is to find a s…

This study tested whether metformin, a standard diabetes drug, could help older adults with a specific type of heart failure (HFpEF) feel better and move more easily. Over 20 weeks, 86 participants took either metformin or a placebo. Researchers measured exercise capacity, qualit…

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study tested whether adding leg compression to standard diuretic treatment helps people hospitalized with heart failure and severe fluid buildup. 106 adults received either diuretics alone or diuretics plus leg compression for up to 72 hours. Researchers measured changes in …

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study tested whether a home-based exercise program is practical for people with chronic heart failure who have just been hospitalized. Thirty patients were taught exercises by a physiotherapist and did them at home for 12 weeks. The goal was to see how many completed the pro…

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study looked at whether high-intensity interval training (short bursts of hard exercise) is better than moderate continuous exercise for people with heart failure. Researchers measured nerve activity, blood vessel function, and muscle health in 35 participants. The goal was …

This study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…

This study tested whether colchicine, an anti-inflammatory drug, can lower inflammation in people with a specific type of heart failure called HFpEF. 42 adults with heart failure symptoms and signs of inflammation took part. The goal was to see if colchicine could reduce markers …

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…

This study tested whether an extended-release version of the diuretic torsemide works better than the standard immediate-release form for reducing overactive bladder symptoms in people with chronic heart failure. Twenty-four participants took each version for four weeks, tracking…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested a 12-week exercise program designed for people with both congestive heart failure and knee osteoarthritis. 94 adults took part, with half doing low-impact aerobic and strength exercises and the other half receiving standard care. The goal was to see if the tailo…

This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter can reduce the need for morphine after heart surgery via sternotomy. 160 adults undergoing various heart surgeries were enrolled. The goal w…

This study tested a gentle electrical stimulation of a nerve in the ear (called tVNS) to see if it could reduce inflammation and improve heart function and exercise ability in people with a type of heart failure called HFpEF. 52 adults with HFpEF received either the real stimulat…

This study tested whether a very high dose of the diuretic bumetanide can remove more fluid than standard doses of furosemide in people hospitalized with worsening heart failure. Twenty patients received either the ultra-high dose or the usual dose over 24 hours. The goal was to …

This study looked at whether doing resistance or aerobic exercise first during a rehab session affects heart function in men with chronic heart failure. Sixty men aged 55-65 with reduced heart pumping ability took part. Researchers measured heart function and quality of life to s…

This study tested a breathing exercise called the active cycle breathing technique in 120 adults who had just had heart surgery. The exercise combines controlled breathing, deep breaths, and huffing or coughing to help clear the lungs and improve breathing. Researchers measured w…

This study looked at whether adding manual lymphatic drainage (a gentle massage technique) to early in-hospital cardiac rehabilitation helps people with acute decompensated heart failure. The goal was to reduce leg swelling and improve physical function. Forty stable hospitalized…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This early study tested a new drug called HRS-9057 in 25 adults with chronic heart failure who still had fluid buildup despite standard diuretics. The drug was given as an injection and compared to tolvaptan pills. The main goal was to check safety and how well the drug removes e…

This study tested whether acupuncture can improve heart function and quality of life in people with chronic heart failure. Fourteen patients received 10 acupuncture sessions over 5 weeks, and each person also served as their own control with a no-treatment period. Researchers mea…

This study tested whether a digital app called KardioPAC could help people in cardiac rehab stay more active and feel better. 43 heart patients used the app alongside standard rehab, or just standard rehab alone. The goal was to see if the app improved exercise habits, blood pres…

This study tested an experimental drug called OPC-131461 in 157 people with congestive heart failure who still had fluid buildup despite taking standard water pills. Participants received different doses of the drug or a placebo daily for 14 days. The main goal was to see if the …

This study tested a device called preCARDIA that temporarily blocks a large vein in the chest to help patients with sudden, severe heart failure. The goal was to see if it is safe and can help remove excess fluid when standard treatments are not working. The study included 60 adu…

This early-stage study tested a new drug called XXB750 in 27 adults with stable heart failure and reduced heart pumping ability. The main goal was to see if the drug is safe and tolerable. Participants received either the drug or a placebo, and researchers monitored for side effe…

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This pilot study tested whether sleep coaching and sleep hygiene training could help people with a common type of heart failure (HFpEF) sleep better and feel better. Ten participants wore activity trackers and kept sleep diaries to see if they could gradually extend their sleep t…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This completed study looked at blood samples from 47 patients in France (part of a larger European study) to find biological markers linked to diastolic heart failure in people with metabolic syndrome. The goal was to confirm earlier findings about these markers. Participants had…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This study looked at a new way of managing chronic heart failure using nurse-led consultations. Researchers reviewed the records of 138 patients to understand how these consultations helped with adjusting medications and monitoring health. The goal was to see if this approach can…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This completed study looked at 26,000 adults with chronic heart failure in France who used a web app for remote monitoring. Researchers compared those who were digitally literate with those who were not, tracking hospitalizations and death rates. The goal was to understand whethe…

This study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs (using the whole body or just one leg) could improve fitness. The study involved 93 adults aged 60…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study looked at how often cardiac amyloidosis occurs in older Tunisian patients with a type of heart failure called HFpEF. Researchers used heart scans and imaging to find cases and identify early warning signs. The goal is to make diagnosis easier and faster for this seriou…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study observed 49 adults hospitalized with acute heart failure to learn how fluid congestion behaves during treatment. Researchers tracked clinical signs, lab tests, and ultrasound measures, then followed patients for a year to see who was readmitted or died. The goal is to …

This study aimed to make heart rate monitors more accurate for people with heart conditions. Researchers collected data from 138 participants, including cardiac patients and athletes, using Fitbit and Polar devices over 13 weeks. The goal was to remove false readings and develop …

This study looked at how common vitamin D deficiency is in people with chronic heart failure and whether giving vitamin D supplements improves their health. 91 adults with heart failure were divided into groups based on their vitamin D levels. Those with severe deficiency were ra…

This study tested a computer alert that pops up in doctors' electronic health records to remind them to prescribe recommended heart failure medications. Over 1,100 patients with a specific type of heart failure (reduced ejection fraction) took part across four health systems. The…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study followed 520 French adults with central or mixed sleep apnea to see how a treatment called adaptive servo-ventilation (ASV) improved their sleep quality. Participants used a breathing device that adjusts pressure in real time. The goal was to measure changes in sleep q…

This completed study looked at whether clinical decision support systems (CDSS) built into electronic health records help doctors better follow guidelines for chronic heart failure. Researchers analyzed data from over 66,000 patients in Russia, checking if the system increased us…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study with over 1,000 participants looked at whether patient surveys and interviews can help doctors spot changes in heart failure. Researchers also collected blood samples to explore links between biology and quality of life. The goal was to see if these tools are…

This study used blood and urine samples from 236 Japanese patients with chronic heart failure to see how biomarkers like BNP change during treatment with sacubitril valsartan or enalapril. Researchers looked for links between biomarker changes and improvements in heart failure sy…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at over 31,000 cancer patients to see if an AI-enhanced electrocardiogram (ECG) could predict heart damage caused by chemotherapy. Researchers analyzed existing ECGs taken before treatment to see if the AI could identify those at risk. The goal is to develop a s…

This completed study looked at 334 adults with heart failure and reduced pumping ability. Researchers used ultrasound to measure left atrial strain before and after starting sacubitril/valsartan, a drug known to improve survival. The goal was to see if these measurements could pr…

This study looks at how the drug Sacubitril-Valsartan changes heart function in people with heart failure and reduced pumping ability. Researchers used a non-invasive method to measure heart pressure and volume in 117 participants. The goal is to uncover the mechanisms behind the…

This study tested whether artificial intelligence (AI) could predict a person's risk of developing a specific type of heart failure (HFrEF) up to 5 years in the future, using only a standard ECG. Researchers analyzed data from over 286,000 adults in China and the US. The goal was…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This study looked at 623 adults with heart failure or high blood pressure in the lungs to see how well different tests measure pressure inside the heart. Doctors used both non-invasive ultrasound (echocardiogram) and invasive catheter measurements to check for elevated filling pr…

This completed study looked at 60 heart failure patients with reduced pumping function and dangerous heart rhythms. Researchers compared metabolic profiles between those with ischemic (blocked arteries) and non-ischemic (other causes) heart disease. By analyzing blood samples, th…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This completed observational study looked at how often heart failure patients in a French nationwide remote monitoring program were prescribed SGLT2 inhibitors between 2021 and 2024. Researchers analyzed data from over 13,600 adults to see how prescription rates changed over time…

This study tested whether heart failure patients learn more from watching videos or reading text about their condition. 130 patients with heart failure took part. They were randomly assigned to video or text modules, then tested on their knowledge. The goal is to find the best wa…

This study tested a wearable heart monitoring patch in people recovering from a severe heart failure episode. The goal was to see if the patch could collect useful health data at home, making future drug research easier. About 54 adults wore the patch for a few days after leaving…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study looked at how the heart failure drug Entresto (LCZ696) lowers blood pressure and helps the body get rid of salt. 46 stable heart failure patients took part. Researchers measured blood pressure and urine sodium levels to understand the drug's effects.

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study involved 184 adults hospitalized for worsening heart failure. Researchers tracked which heart failure medications were started or adjusted during the hospital stay. The goal was to see if starting these treatments in the hospital, under close monitoring, could lead to …

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at 40 people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but still causes symptoms. Researchers used a special exercise test on a bike to measure how the heart, lungs, and muscles work together during a…

This study tested how well three translation tools—ChatGPT, Google Translate, and UD Talk—handle conversations between doctors and patients in Chinese and Japanese during heart and lung checkups. Researchers compared their accuracy and errors using a scoring system. The goal was …

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This study looked at how applying positive or negative pressure around the body affects exercise in people with heart failure with preserved ejection fraction. 27 participants, including healthy volunteers and heart failure patients, were tested non-invasively and some invasively…

This study looked at medical records of 4,000 heart failure patients to see if combining routine blood tests (like NT-proBNP) with heart scan results (like fat density around the heart) can better predict who is at risk of dying within a year. The goal is to improve personalized …

This completed study gathered information on 254 Mexican patients with heart failure and reduced ejection fraction. Researchers looked at patient characteristics, treatments, and outcomes in real-world settings. The goal was to understand current medical practices and identify ba…

This study looked at how Chinese Americans talk about advance care planning—decisions about end-of-life care—with their families. Researchers interviewed religious leaders, patients with chronic diseases, and family caregivers in Chicago to understand their needs and readiness. T…

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study looked at over 1,000 adults with a type of heart failure called HFpEF, where the heart pumps normally but is too stiff. Researchers measured the fat around the heart using ultrasound and checked how well the heart was working. The goal was to see if more heart fat is l…

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at whether a 6-minute stepper test (ST6) can accurately measure exercise tolerance in people with heart conditions undergoing rehabilitation. Researchers compared the stepper test results with the standard 6-minute walk test and a cardiac stress test in 60 patie…

This study looked at how lactate, a natural substance made by the body, affects heart function in 12 people with chronic heart failure. Researchers gave lactate as an infusion and as a drink, then measured changes in blood flow and heart pressure. The goal was to understand if la…

This study checked how well German hospitals and heart failure clinics follow recommended treatments for people with a certain type of heart failure (HFrEF) after a serious episode. Researchers looked at the care of 899 patients to see if guidelines were being used. The goal was …

This pilot study tested a computer tool that alerts pharmacists when heart failure patients are not taking their medications as directed. Only 3 pharmacists took part, and the goal was to see if the tool was practical and acceptable. Because it was so small, the results are not e…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This completed study in Greece observed 257 adults with heart failure who were prescribed dapagliflozin as part of their routine care. Researchers tracked how long patients stayed on the drug, any changes in their other heart medications, and how their quality of life changed ove…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study tested a clinical decision support tool called PREVENT to help nurses prioritize which patients need homecare most urgently after leaving the hospital. Researchers studied nearly 2,000 adults with conditions like diabetes, heart failure, and lung disease to see if the …

This study analyzed data from nearly 5,000 Japanese patients with chronic heart failure who started taking vericiguat as part of their regular care. Researchers tracked outcomes like hospital stays and deaths over one year to see how the drug performs in everyday practice. The go…

This early-stage study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH kept food diaries and had blood tests to measure carnitine. The goal was to gather information …

This study looked at how people with chronic heart failure or COPD process protein from meals. Researchers measured muscle building, body composition, and gut function in 90 adults aged 45 and older. The goal was to understand why muscle loss happens and how to design better diet…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This early-phase study tested whether giving chloride supplements (lysine chloride) to people with stable heart failure could affect their body's fluid balance. Twenty participants took either the supplement or a placebo three times daily for five days. The goal was to understand…

This study tracked 30 adults with advanced heart failure who received a CardioMEMS implant, a wireless sensor placed in the lung artery to monitor pressure. Patients sent data from home, and doctors used it to guide care. The goal was to see if this approach reduces hospital stay…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This completed study enrolled 164 adults with chronic heart failure, some also with permanent atrial fibrillation. Researchers measured blood markers of inflammation and certain microRNAs (genetic molecules) and used echocardiograms to look at heart structure. The goal was to und…

This study tested whether a 2-week course of a ketone drink could improve how the heart uses energy in 12 people with chronic heart failure. Researchers used PET scans to measure heart fuel consumption and efficiency. The goal was to understand if ketones could be a better energy…

This study tested a clinical decision support tool that helps doctors identify social needs—like food, housing, or transportation—in African American patients with chronic diseases such as diabetes or heart failure. The tool uses a social risk score to flag patients who may need …

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…