Could a single pill transform heart failure care for underserved patients?
NCT ID NCT06029712
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tested a 'polypill' that combines four heart failure medications into one capsule, aiming to make it easier for patients to stick with their treatment. The trial included 35 adults with heart failure and reduced ejection fraction, some of whom also had HIV. Researchers measured adherence by pill count and questionnaires to see if the polypill improved medication-taking compared to standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Heart failure polypill (combination of beta blocker, SGLT2i, MRA, and ACE/ARB/ARNI)
What this could lead to
If successful, this polypill could make it easier for people with heart failure to take their life-saving medications, potentially improving adherence and health outcomes.
What could go wrong
This is a small pilot study with only 35 participants, so results may not apply to everyone. The polypill is hand-packed, which may not be scalable or practical for widespread use.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Zuckerberg San Francisco General Hospital
San Francisco, California, 94110, United States