New pill aims to drain fluid in stubborn heart failure swelling
NCT ID NCT05615363
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an experimental drug called OPC-131461 in 157 people with congestive heart failure who still had fluid buildup despite taking standard water pills. Participants received different doses of the drug or a placebo daily for 14 days. The main goal was to see if the drug helped reduce body weight, a sign of fluid loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- OPC-131461
- What this could lead to
- If it works, this could offer a new option to help heart failure patients shed excess fluid when standard diuretics aren't enough.
- What could go wrong
- This is an early Phase 2 trial with only 157 participants, so results may not hold up in larger studies. The drug may cause side effects or fail to improve symptoms meaningfully.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Harasanshin Hospital
Fukuoka, Japan