Ketone drink shows promise for heart energy in small study

NCT ID NCT06398964

Completed Knowledge-focused Sponsor: Aarhus University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a 2-week course of a ketone drink could improve how the heart uses energy in 12 people with chronic heart failure. Researchers used PET scans to measure heart fuel consumption and efficiency. The goal was to understand if ketones could be a better energy source for failing hearts. This is early research, not a proven treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 3-hydroxybutyrate (a ketone body) taken as a drink
What this could lead to: If successful, this could point toward a new way to improve heart energy efficiency in heart failure patients.
What could go wrong: This is a very small, early study with only 12 participants. It is designed to measure effects, not to prove a treatment works. Results may not apply to all heart failure patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH REDUCED EJECTION FRACTION

Contacts and locations

Locations

Aarhus University Hospital

Aarhus, Central Jutland, 8200, Denmark

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