Can a higher starting dose of vericiguat speed up heart failure treatment?

NCT ID NCT06195930

Completed Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether starting the heart failure drug vericiguat at a 5 mg dose (instead of the usual 2.5 mg) is safe and tolerable. 106 adults with chronic heart failure with reduced ejection fraction took the 5 mg tablet daily for about two weeks. The goal was to see if skipping the lower starting step could help patients reach the target 10 mg dose faster without serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vericiguat
What this could lead to: If successful, this could allow people with chronic heart failure to skip a lower starting dose and reach the effective target dose faster.
What could go wrong: This is a small, short-term safety study (106 participants, 4 weeks). It does not test long-term benefits or risks, and participants may experience side effects like low blood pressure or dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION

Contacts and locations

Locations

ASST Papa Giovanni XXIII

Bergamo, Lombardy, 24127, Italy
ASST Spedali Civili di Brescia

Brescia, Lombardy, 25123, Italy
Advanced Cardiovascular, LLC - Alexander City

Alexander City, Alabama, 35010, United States
Ascension Saint Agnes Heart Care

Baltimore, Maryland, 21229, United States
CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina

CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina
Capio Citykliniken - Hjartmottagning

Lund, 222 21, Sweden
Centro de Investigacion y Prevencion Cardiovascular | Sede Recoleta

Buenos Aires, Ciudad Auton. de Buenos Aires, C1119ACN, Argentina
Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina

Santa Fe, S3000FWO, Argentina
Centrum Medyczne Zdrowa

Krakow, 31-216, Poland
Chear Center LLC

New York, New York, 10455, United States
Clinical Best Solutions Sp. Z O.O. Sp.K.

Lublin, 20-011, Poland
Clinical Best Solutions Sp. Z O.O. Sp.K.

Warsaw, 00-710, Poland
Complex Rendelo Med Zrt.

Székesfehérvár, 8000, Hungary
Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos

Rosario, Santa Fe Province, S2000DEJ, Argentina
Coromed Smo Kft

Pécs, 7623, Hungary
Eszak-Pesti Centrumkorhaz-Honvedkorhaz

Budapest, 1134, Hungary
Fondazione IRCCS Policlinico San Matteo

Pavia, Lombardy, 27100, Italy
Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department

Santiago de Compostela, A Coruña, 15706, Spain
Hospital Clínico Universitario de Valencia

Valencia, 46010, Spain
Hospital Ramon y Cajal | Cardiology - Research Unit

Madrid, 28034, Spain
Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology Department

Barcelona, 08907, Spain
Hospital del Mar | Cardiology Department

Barcelona, 08003, Spain
Hospital la Paz

Madrid, 28046, Spain
IRCCS Centro Cardiologico Monzino

Milan, Lombardy, 20138, Italy
IRMED Osrodek Badan Klinicznych

Piotrkow Trybunalski, 97-300, Poland
Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina

Corrientes, 3400, Argentina
Karolinska Universitetssjukhuset

Stockholm, 17176, Sweden
Malopolskie Centrum Sercowo-Naczyniowe PAKS

Chrzanów, 32-500, Poland
NZOZ "Twoja Przychodnia" Sp. z o.o.

Lublin, 20-857, Poland
Reid Physician Associates | Cardiology Department

Richmond, Indiana, 47374, United States
Semmelweis Egyetem Belgyógyaszati és Haematológiai Klinika, Kardiológia

Budapest, 1088, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz

Kaposvár, 7400, Hungary
St. Louis Heart & Vascular, PC

St Louis, Missouri, 63136, United States
Tolna Varmegyei Balassa Janos Korhaz

Szekszárd, 7100, Hungary
Vita Longa Sp. z o.o.

Katowice, 40-748, Poland

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