Can a higher starting dose of vericiguat speed up heart failure treatment?
NCT ID NCT06195930
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether starting the heart failure drug vericiguat at a 5 mg dose (instead of the usual 2.5 mg) is safe and tolerable. 106 adults with chronic heart failure with reduced ejection fraction took the 5 mg tablet daily for about two weeks. The goal was to see if skipping the lower starting step could help patients reach the target 10 mg dose faster without serious side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
vericiguat
What this could lead to
If successful, this could allow people with chronic heart failure to skip a lower starting dose and reach the effective target dose faster.
What could go wrong
This is a small, short-term safety study (106 participants, 4 weeks). It does not test long-term benefits or risks, and participants may experience side effects like low blood pressure or dizziness.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ASST Papa Giovanni XXIII
Bergamo, Lombardy, 24127, Italy
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ASST Spedali Civili di Brescia
Brescia, Lombardy, 25123, Italy
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Advanced Cardiovascular, LLC - Alexander City
Alexander City, Alabama, 35010, United States
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Ascension Saint Agnes Heart Care
Baltimore, Maryland, 21229, United States
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CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina
CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina
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Capio Citykliniken - Hjartmottagning
Lund, 222 21, Sweden
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Centro de Investigacion y Prevencion Cardiovascular | Sede Recoleta
Buenos Aires, Ciudad Auton. de Buenos Aires, C1119ACN, Argentina
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Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina
Santa Fe, S3000FWO, Argentina
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Centrum Medyczne Zdrowa
Krakow, 31-216, Poland
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Chear Center LLC
New York, New York, 10455, United States
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Clinical Best Solutions Sp. Z O.O. Sp.K.
Lublin, 20-011, Poland
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Clinical Best Solutions Sp. Z O.O. Sp.K.
Warsaw, 00-710, Poland
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Complex Rendelo Med Zrt.
Székesfehérvár, 8000, Hungary
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Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos
Rosario, Santa Fe Province, S2000DEJ, Argentina
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Coromed Smo Kft
Pécs, 7623, Hungary
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Eszak-Pesti Centrumkorhaz-Honvedkorhaz
Budapest, 1134, Hungary
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Fondazione IRCCS Policlinico San Matteo
Pavia, Lombardy, 27100, Italy
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Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department
Santiago de Compostela, A Coruña, 15706, Spain
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Hospital Clínico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Ramon y Cajal | Cardiology - Research Unit
Madrid, 28034, Spain
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Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology Department
Barcelona, 08907, Spain
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Hospital del Mar | Cardiology Department
Barcelona, 08003, Spain
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Hospital la Paz
Madrid, 28046, Spain
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IRCCS Centro Cardiologico Monzino
Milan, Lombardy, 20138, Italy
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IRMED Osrodek Badan Klinicznych
Piotrkow Trybunalski, 97-300, Poland
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Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina
Corrientes, 3400, Argentina
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Karolinska Universitetssjukhuset
Stockholm, 17176, Sweden
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Malopolskie Centrum Sercowo-Naczyniowe PAKS
Chrzanów, 32-500, Poland
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NZOZ "Twoja Przychodnia" Sp. z o.o.
Lublin, 20-857, Poland
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Reid Physician Associates | Cardiology Department
Richmond, Indiana, 47374, United States
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Semmelweis Egyetem Belgyógyaszati és Haematológiai Klinika, Kardiológia
Budapest, 1088, Hungary
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Somogy Varmegyei Kaposi Mor Oktato Korhaz
Kaposvár, 7400, Hungary
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St. Louis Heart & Vascular, PC
St Louis, Missouri, 63136, United States
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Tolna Varmegyei Balassa Janos Korhaz
Szekszárd, 7100, Hungary
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Vita Longa Sp. z o.o.
Katowice, 40-748, Poland