New heart drug AC01 shows promise in early trial

NCT ID NCT05642507

First seen Oct 31, 2025 · Last updated May 01, 2026 · Updated 23 times

Summary

This study tested a new medicine called AC01 in 58 adults with a type of heart failure where the heart pumps less blood than normal. The goal was to check if the drug is safe and how the body processes it. Participants received either AC01 or a placebo, and researchers monitored side effects, heart function, and drug levels in the blood.

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Contacts and locations

Locations

  • Amsterdam University Medical Centre

    Amsterdam, 1081 HV, Netherlands

  • Azienda Sanitaria Universitaria Integrata

    Trieste, 34149, Italy

  • Erasmus Medical Centre

    Rotterdam, 3015 GD, Netherlands

  • Golden Jubilee National Hospital

    Glasgow, G81 4DY, United Kingdom

  • Karolinska University Hospital

    Stockholm, 171 76, Sweden

  • King's College Hospital

    London, SE5 9RS, United Kingdom

  • Maastricht Heart and Vascular Center

    Maastricht, 6229 HX, Netherlands

  • Ninewells Hospital and Medical School

    Dundee, DD1 9SY, United Kingdom

  • Sahlgrenska University Hospital

    Gothenburg, 413045, Sweden

  • Skånes Universitetssjukhus Lund

    Lund, 222 42, Sweden

  • Spedali Civilia di Brescia

    Brescia, 25123, Italy

  • University Medical Centre Groningen/ICON

    Groningen, 9718 GZ, Netherlands

  • University of Glasgow, Institute of Cardiovascular & Medical Sciences

    Glasgow, G12 8QQ, United Kingdom

Conditions

Explore the condition pages connected to this study.