Heart failure drug combo: start together or one at a time?

NCT ID NCT05989503

Completed Disease control Sponsor: Universidade do Porto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the safest way to start two heart failure drugs (ARNi and SGLT2i) in 62 adults with a weak heart pump. Researchers compared starting both drugs at the same time versus starting one drug first and adding the other later. The goal was to see which method caused fewer side effects like low blood pressure, kidney problems, or hospital visits.

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE WITH REDUCED EJECTION FRACTION

Contacts and locations

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Locations

Centro Hospitalar Universitário São João

Porto, 4200-319, Portugal
Centro Hospitalar Universitário de Santo António

Porto, Porto District, 4099-001, Portugal
Centro Hospitalar Vila Nova de Gaia/Espinho

Porto, 4434-502, Portugal
Faculty of Medicine (FMUP)

Porto, 4200-319, Portugal
Unidade Local de Saúde de Matosinhos - Hospital Pedro Hispano

Porto, Portugal

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