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Heart failure drug probed for hidden benefit on lung pressure

NCT ID NCT07814482

Disease control Sponsor: Aswan University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are studying whether sacubitril-valsartan, a standard heart failure drug, can lower estimated pulmonary artery systolic pressure in people with reduced ejection fraction heart failure. The trial enrolls adults with an ejection fraction of 40% or less. Participants receive the drug, and researchers use echocardiograms to track changes in lung blood pressure and compare different doses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sacubitril-valsartan, a heart failure drug
What this could lead to
If it works, this could help doctors understand whether sacubitril-valsartan eases high lung blood pressure in heart failure patients, possibly guiding treatment choices.
What could go wrong
This is a small Phase 1 study with 59 people, so results may not apply broadly. The drug is already used for heart failure, but its effect on lung pressure is not proven, and side effects like low blood pressure or kidney problems can occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

59 people

The number who actually took part.

Started

Jul 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged more than 18 years . * Diagnosed with HFrEF defined as those with an EF ≤40% . Exclusion Criteria: * Patients \< 18 years old * Patients with severe renal disease (i.e., estimated glomerular filtration rate according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation ≤30 mL/min/1.73 m2), * Patients with moderate-severe liver disease (i.e., a Child-Pugh score ≥7), * Patients with severe chronic obstructive pulmonary disease (i.e., Global Initiative for ---Chronic Obstructive Lung Disease class ≥3), History of acute pulmonary embolism * History of prior heart surgery with pericardial incision. * Pregnancy and lactation.

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Conditions

The condition(s) this trial relates to.

systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PASP

Contacts and locations

Locations

  • Faculty of medicine- Aswan university

    Aswān, Egypt

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