Scientists squeeze and release heart failure patients to uncover exercise secrets

NCT ID NCT05764564

Completed Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how applying positive or negative pressure around the body affects exercise in people with heart failure with preserved ejection fraction. 27 participants, including healthy volunteers and heart failure patients, were tested non-invasively and some invasively. The goal was to measure changes in cardiac output, heart rate, and other factors during exercise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors understand how body pressure changes affect exercise capacity in heart failure patients, potentially guiding future treatments.
What could go wrong: This is a small, early-phase study (27 participants) focused on understanding mechanisms, not testing a treatment. Results may not apply to all heart failure patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE, DIASTOLIC

Contacts and locations

Locations

Duke University Medical Center

Durham, North Carolina, 27710, United States

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