Heart disorder

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent A…

This study will follow 30 people with Alagille syndrome who are taking odevixibat in their daily lives. The goal is to see how safe the drug is over the long term by tracking any side effects. It is not testing if the drug works, but rather monitoring its real-world safety.

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This phase 2 trial tests an oral drug called Aom0304 in adults with hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. The study includes people with both obstructive and non-obstructive forms. Participants receive different doses of Aom0304 for …

This study aimed to see if a short course of the heart medication amiodarone could prevent atrial fibrillation (an irregular heartbeat) in adults after heart surgery. About 1 in 3 patients experience this complication. However, the study was withdrawn before enrolling any partici…

This trial compares a new temporary heart pump called VentriCure with standard ECMO support in people with coronary artery disease undergoing high-risk angioplasty. The study includes 220 patients whose hearts are weak or who have severe heart failure. The goal is to see if Ventr…

This platform trial will enroll 1,000 adults with heart failure to test several different treatments at the same time. Participants are randomly assigned to either an experimental intervention or standard care. The main goal is to see if these treatments can prevent death or hosp…

This early-stage study tests a new treatment called HiCM-188, made from stem cells that become heart muscle cells. It is given as a single injection into the heart during bypass surgery in 12 adults with severe heart failure. The main goal is to check safety and see if it improve…

This study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…

This study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…

This study tests a 'nudge' program—including text reminders, a medication calendar, and an action plan—to help 84 adults with atrial fibrillation take their blood thinners consistently. Participants will watch an educational video, create a daily pill-taking routine, and receive …

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This early trial tests a new device called Anchord that repairs leaky mitral valves without open-heart surgery. It will include 5 people with severe valve leakage who are too high-risk for standard surgery. The goal is to see if the device is safe and can reduce the leak, improvi…

This study tests a wearable device that tracks heart rate, breathing, activity, and fluid buildup in people recently hospitalized for heart failure. 800 participants will either get standard care or standard care plus the device for 90 days. The goal is to see if early alerts fro…

This early-stage study tests whether it is safe to take nitroglycerin spray (used for chest pain) together with an experimental drug called nurandociguat (designed to help kidneys) in 36 adults with stable coronary artery disease. Both drugs widen blood vessels, so the main conce…

This study tests whether metformin, a standard diabetes medicine, can improve heart function in people who have received a mechanical heart pump (LVAD) for severe heart failure. Researchers will give metformin or a placebo to 108 patients for 12 months and check heart function, b…

This study tests whether providing home-delivered low-sodium meals and short-term dietary counseling helps older veterans with heart failure recover better after a hospital stay. About 1,400 veterans aged 60 and older will be randomly assigned to receive either the meals plus cou…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study tests whether community health workers (CHWs) can help people with rheumatic heart disease (RHD) take their monthly antibiotic shots consistently. The trial will enroll about 308 participants in Brazil and Timor-Leste, including adults and children with RHD and their c…

This study tests whether the diabetes drug ertugliflozin, started within 72 hours of a first heart attack, can improve heart function in people with type 2 diabetes. About 476 adults will be randomly assigned to take the drug or receive standard care. Researchers will measure cha…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This study tests a new technique called PWI-Box, which uses a device named GeminiS to isolate the pulmonary veins and treat atrial fibrillation (AF) during open-heart surgery. About 200 adults with AF who are already scheduled for heart surgery via sternotomy will take part. The …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests a new device called the X-Clip, which is used to repair a leaky mitral valve without open-heart surgery. The device is inserted through a blood vessel and clips the valve to help it close better. The trial will include 15 adults with moderate-to-severe or severe …

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study tests a new device that uses extreme cold to destroy small areas of heart tissue causing a dangerous fast heartbeat called ventricular tachycardia. The trial will include 100 adults with this condition who have not responded to medication. Researchers will check if the…

This study tests whether special force feedback instruments, used with the da Vinci surgical robot, can safely and effectively repair leaky mitral valves. The trial includes 30 adults with moderate-to-severe mitral regurgitation. Researchers will check for major complications and…

This study compares two ways to guide stent placement during emergency treatment for a severe type of heart attack (STEMI). About 2,500 patients will be randomly assigned to receive either standard X-ray guidance or ultrasound guidance (IVUS) during the procedure. The goal is to …

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study tests whether adding a preventive procedure called pulmonary vein isolation (PVI) to the standard ablation for typical atrial flutter can reduce the risk of heart-related hospital visits, stroke, or death. The trial enrolls adults aged 55 and older with an enlarged lef…

This registry will follow 500 people with symptomatic atrial fibrillation who are scheduled for a heart ablation using the Globe Pulsed Field System. The goal is to see how well the device controls the heart rhythm over 12 months and to track any major side effects within the fir…

This early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…

This study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …

This study tests whether using detailed PET-CT scans to guide where a pacemaker lead is placed can improve heart function in 20 people with heart failure. Participants will receive a standard pacemaker, but the lead position will be chosen based on scan data. The goal is to see i…

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This trial tests whether a new scoring system, called the Biological Congestion Score (BCS), can help doctors better manage diuretic medications in people with chronic heart failure. The BCS combines four blood biomarkers with clinical information to estimate fluid congestion and…

This study tests a new device called the VERAFEYE System, which creates a 3D model of the heart to guide doctors during catheter ablation for paroxysmal atrial fibrillation (a type of irregular heartbeat). About 100 adults who are already scheduled for ablation will have the proc…

This study looks at 240 adults having a major heart attack (STEMI) when the standard emergency procedure to open the blocked artery is expected to be delayed by over an hour. Half will get a clot-busting drug (tenecteplase) right away, followed by the procedure within 2-24 hours.…

This study compares a moderate statin (pitavastatin) combined with ezetimibe against high-intensity statins (atorvastatin or rosuvastatin) in patients aged 75+ with coronary artery disease who need a stent. The goal is to see if the combo is just as good at preventing heart attac…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This study looks at a special stent (a small mesh tube) coated with a drug called sirolimus, used to open blocked heart arteries. Researchers will follow 300 adults who received this stent during a standard heart procedure to see how safe and effective it is over 5 years. The mai…

This study tests whether measuring sodium in urine can help doctors give the right amount of diuretics (water pills) to people hospitalized with worsening heart failure. About 260 adults will be split into two groups: one gets standard care, the other gets treatment guided by uri…

This trial tests whether adding extra ablation lines to the standard pulsed-field ablation procedure helps people with long-standing atrial fibrillation (AF) stay in normal heart rhythm. 430 participants with AF lasting 1-3 years will be randomly assigned to receive either standa…

This study tests whether a non-invasive ear stimulation, called low-level tragus stimulation, can reduce inflammation and early heart rhythm problems after pulsed field ablation for atrial fibrillation. Forty-six adults with atrial fibrillation will receive either active or sham …

This study looks at a device called ShortCut that splits old heart valve leaflets before placing a new valve inside it. The goal is to keep the arteries open and prevent blockages. About 150 people with aortic stenosis who are at risk for this complication will take part. Researc…

This study tests whether using a computer simulation (virtual stenting) before placing stents in heart arteries can lead to better outcomes than the usual method guided by X-ray images alone. About 1,472 adults with coronary artery disease will be randomly assigned to either the …

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests a catheter-based procedure called Varipulse to treat paroxysmal atrial fibrillation (irregular heartbeat that comes and goes). Researchers want to see how well it works long-term when combined with different types of sedation. About 300 adults aged 18-80 with sym…

This study will enroll 30,000 adults in China with atrial fibrillation (a type of irregular heartbeat) that hasn't improved with medication. They will receive a new type of catheter treatment called pulse-field ablation. Researchers will track their health for up to 10 years to s…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can improve quality of life and exercise ability in elderly patients with a common type of heart failure (HFpEF). Fifty adults aged 60 and older will receive either the transplant or a …

This study tests a drug called pelacarsen in people who recently had a heart attack and have high levels of Lp(a), a type of fat in the blood that raises heart risk. The goal is to see if the drug can safely lower Lp(a) levels and improve heart health. About 240 adults in the US …

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This study will follow up to 250 adults who receive the KONECT RESILIA device, which replaces both the aortic valve and the ascending aorta in one surgery. The goal is to see how safe and effective the device is in real-world use. Participants must have a diseased aortic valve an…

This study tests whether customizing ventilator settings during heart bypass surgery can lower the risk of lung complications like pneumonia or respiratory failure. Researchers will compare a standard approach with one that adjusts settings based on lung mechanics. Eighty adults …

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests whether a structured heart-health program can improve heart outcomes in 800 cancer survivors who have heart problems or high heart risk. The program includes exercise, nutrition advice, stress support, and risk-factor management over 12 months. Researchers will c…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This study compares two supervised treadmill exercise programs for people recovering from coronary artery disease or a heart procedure. One group does high-intensity interval training (HIIT) — short, hard efforts with rest periods — while the other does moderate-intensity continu…

This study compares a stepwise blood-thinning approach to the standard method in 424 patients with atrial fibrillation who are at high risk for stroke and need a heart device like a pacemaker. The stepwise plan involves stopping the blood thinner one day before surgery and restar…

This study tests whether a newer drug, Vernakalant, works better than the standard Amiodarone for treating atrial fibrillation (irregular heartbeat) that often occurs after heart surgery. About 50 adults who recently had heart surgery will receive one of the two drugs. The main g…

This study looks at whether a common heart valve procedure called TAVI is safe when done in hospitals that don't have heart surgery available on-site. About 600 people with severe aortic stenosis will be randomly assigned to have TAVI either with or without surgical backup. The g…

This study tests whether adding a Chinese herbal medicine called Qidan Xiaoke Granules to standard heart drugs can reduce major heart problems like heart attacks or repeat procedures in people who have had a stent placed. About 164 adults with coronary artery disease will take th…

This study will compare a newer, less invasive heart procedure called hybrid revascularization to standard coronary artery bypass grafting (CABG) in over 1,000 people with multiple blocked heart arteries. The hybrid approach combines a small incision to graft a key artery with st…

This early study tests a new device called the SATURN TS TMVR System, which is implanted through a catheter to replace the mitral valve in people with severe mitral regurgitation. Up to 15 patients who are too high-risk for open-heart surgery will be enrolled. The goal is to see …

This study tests a non-invasive radiation treatment called STAR for people with a dangerous fast heart rhythm caused by heart scarring. Instead of using medications or a catheter procedure, a single targeted dose of radiation is delivered to the scarred area. The goal is to see i…

This study looks at whether adding a small amount of salt (3 grams daily) to the diet can help people with chronic heart failure who have low blood sodium levels. Researchers will compare salt pills to a placebo in 30 adults over three months. The goal is to see if salt improves …

This early study tests whether the drug CAEL-101/anselamimab can bind to and shrink abnormal protein deposits (amyloid) in people with AL amyloidoma. Five adults with measurable amyloid deposits will receive the drug and be monitored for up to 72 weeks. The goal is to see if the …

This study compares two approaches for people with heart failure and narrowed heart arteries: a stent procedure plus guideline-directed medications versus medications alone. About 1,150 participants will be followed for at least two years to see which group has fewer major heart …

This early-stage trial tests a single dose of a gene therapy called NVC-001 in 21 adults with a genetic form of dilated cardiomyopathy (LMNA mutation). The therapy uses a harmless virus to deliver a modified gene into heart cells, aiming to protect the heart muscle. The main goal…

This study tests whether Baduanjin, a gentle traditional Chinese exercise, helps people recover after heart bypass or stent surgery. Researchers will track 310 adults for up to a year to see if it lowers the risk of heart attacks, chest pain, or the need for more procedures. The …

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study looks at whether moderate treadmill walking can improve how children aged 4 to 6 with surgically corrected acyanotic congenital heart disease walk, balance, and move. Eighty children will take part, with some doing treadmill sessions four times a week for 10 weeks. Res…

This study tests a procedure called pulmonary artery denervation (PADN) for people with heart failure whose heart pumps normally but is stiff. The procedure uses a catheter to burn nerves in the lung artery, which may help the heart work better. About 310 participants will either…

This pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…

This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac r…

This study tests a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in 1,000 people with both resistant hypertension and multivessel coronary artery disease. Participants will undergo the procedure during a planned heart stent op…

This study tests whether using a patient's genetic information to choose anti-platelet drugs can lower bleeding risks compared to standard care. About 1,760 high-risk patients receiving a heart stent will be assigned to either a personalized drug plan or usual therapy. The goal i…

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This study tests whether a new catheter ablation system using pulsed field energy can better control persistent atrial fibrillation (AF) by targeting low-voltage areas in the heart and isolating the superior vena cava, in addition to standard pulmonary vein isolation. About 618 a…

This study will test whether taking ginger supplements for two months can lower inflammation and oxidative stress in people with coronary artery disease. Fifty adults with confirmed heart disease will be randomly assigned to receive either ginger extract or a placebo. Researchers…

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This study looks at whether taking royal jelly and propolis (natural bee products) for two months can lower inflammation and improve heart health in 50 adults with coronary artery disease. Participants will be randomly assigned to receive the supplements or a placebo, and researc…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests a new approach for women with chest pain who don't have blocked arteries. Doctors will use special tests to find the exact cause of the pain, then give each woman a personalized treatment plan. The goal is to see if this tailored approach improves symptoms and qu…

This study compares 1 month versus the standard 6 months of dual antiplatelet therapy (two blood thinners) in people who had a balloon procedure for small coronary artery disease. About 1,484 adults with stable angina or silent ischemia will be randomly assigned to either short o…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover better after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months. The goal is to see if these me…

This study tests three different ways to remove excess fluid in people with worsening heart failure. Participants will receive intravenous furosemide alone, or combined with either acetazolamide or hydrochlorothiazide. The goal is to see which combination works best and is safest…

This study tests a new way to treat atrial fibrillation (AFib), a condition where the heart beats irregularly. Doctors will use pulsed field ablation (PFA) instead of heat or cold to create scars in the heart and block bad signals. They will also use a special 3D ultrasound syste…

This study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests a new way to treat atrial fibrillation (AFib) using short electrical pulses instead of heat. The goal is to block abnormal heart signals in a specific area called the mitral isthmus. Thirty adults with AFib will receive this treatment during a standard procedure …

This study tests whether adding extra ablation to standard treatment can help people with persistent atrial fibrillation (a type of irregular heartbeat). About 350 adults will be randomly assigned to receive either standard ablation or standard ablation plus isolation of the left…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study tests a new device (Sphere-9 catheter and Affera system) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in 260 adults who have had a heart attack. Participants must have had repeated episodes despite medication or a defibrillator. The goal is to see …

This study tests a new use of low-intensity focused ultrasound (LIFU) to calm nerve signals that can trigger dangerous heart rhythms after a heart attack. About 100 adults who recently had a severe heart attack will receive either real or fake ultrasound sessions during and for a…

This trial tests the drug istaroxime in 600 adults with mild to moderate cardiogenic shock caused by acute heart failure. Participants receive a 48-hour IV infusion of istaroxime or a placebo, plus standard care. Researchers measure changes in blood pressure, breathing, and overa…

This study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…

This study compares two drugs, finerenone and spironolactone, in 60 adults with heart failure and diabetic kidney disease who are at high risk for high potassium levels (hyperkalemia). Participants will receive either finerenone daily or spironolactone every other day, plus stand…

This study tests whether adding Vitamin C, Omega-3 fatty acids, lignin, and lactulose to standard care can improve recovery in 108 adults after coronary artery bypass grafting (CABG). Participants will take the supplements daily for 10 weeks starting 15 days after surgery. The go…

This study tests a drug called NL005 in people who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening treatment. The goal is to see if NL005 can reduce permanent heart muscle damage. Participants will receive either NL005 or a placebo daily for …

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This pilot study checks if a bigger trial on low-dose aspirin for people with early, symptom-free coronary artery disease can be done. It will enroll 48 adults with signs of artery narrowing but no symptoms. The main goal is to see if doctors can recruit enough patients and if pa…

This study compares two heart procedures for people with persistent atrial fibrillation (AFib) lasting 6 months to 3 years. One group gets standard pulmonary vein isolation (PVI) ablation, while the other gets PVI plus an extra ablation on the Bachmann bundle. The goal is to see …

This study compares a drug-coated balloon (DCB) to a drug-eluting stent (DES) for treating new blockages in heart arteries. About 1,548 adults with stable or unstable angina, old heart attacks, or silent ischemia will be randomly assigned to one of the two treatments. The main go…

This study tests whether valsartan, a common blood pressure drug, can slow the worsening of atrial functional mitral regurgitation (a leaky heart valve) in 50 adults with normal heart pumping function. Participants take either valsartan or a placebo twice daily for 12 months, wit…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tests a new device called SynFlow Duro, a temporary heart pump for people who go into severe shock after heart surgery. About 60 adults in China will receive the pump to see if it helps their heart recover or keeps them stable until a transplant or permanent device. Th…

This study tests a four-month digital program designed to help people with chronic heart failure take their medications as prescribed. The program includes personalized planning, motivational counseling, and symptom tracking. Researchers will enroll 870 adults in Pakistan who hav…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study tests whether an early, aggressive approach—using a catheter to open and stent high-risk plaques seen on a CT scan—plus medication is better than medication alone for preventing heart problems. About 2,500 people with coronary artery disease will be randomly assigned t…

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. About 320 adults with AF will receive this procedure to see if it safely restores normal heart rhythm for at least a year. The goal is to reduce sympt…

This study follows 30 adults with paroxysmal atrial fibrillation (PAF) who have or will get a special pacemaker. The pacemaker can detect irregular heartbeats early and send a painless pacing pulse to stop them. It also sends data to doctors remotely. Researchers will check how w…

This study tests a new technique called Dynamic Voltage Mapping (DVM) to better identify scar tissue in the heart that causes ventricular tachycardia (VT), a life-threatening heart rhythm. The approach uses catheters to create a personalized electrical map, aiming to guide ablati…

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted for heart failure will be randomly assigned to either…

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This study tests whether the drug finerenone can help people with heart failure who have had a heart valve replacement (TAVI). About 2,800 older adults will be randomly assigned to receive finerenone or a placebo. The goal is to see if the drug lowers the chance of death or worse…

This study looks at how safe and effective the SAPIEN 3 heart valve is for people with a certain type of bicuspid aortic valve stenosis (Type-0). About 170 people in China will be observed after the procedure to track serious problems like death, stroke, or rehospitalization. The…

This study tests whether an external abdominal tourniquet can temporarily block blood flow to the lower body during cardiac arrest, redirecting it to the brain and heart. Researchers will try it on 5 adults with non-traumatic cardiac arrest outside a hospital. The goal is to see …

This study tests whether a potassium binder called Sodium Zirconium Cyclosilicate can help heart failure patients take higher, more effective doses of a standard medication (aldosterone receptor antagonist) without dangerous potassium spikes. About 110 adults over 70 with heart f…

This study tests whether taking a daily probiotic capsule for 12 weeks can reduce the chance of atrial fibrillation (AF) returning in people who have just had a cardioversion (a procedure to restore normal heart rhythm). Fifty-six adults aged 40 and older with persistent AF will …

This study will test whether tirzepatide (Mounjaro), a drug used for diabetes and weight loss, can help people with obesity-related heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in blood volume and body fat in 50 participants over 15 mon…

This study tests whether creating a small opening between the upper heart chambers during mitral valve repair can prevent heart failure symptoms after surgery. Researchers will compare 50 patients who get the extra opening to those who have standard surgery alone. The goal is to …

This study tests a daily injection called elamipretide in 48 people with genetically confirmed Barth syndrome, a rare condition that causes muscle weakness and heart problems. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see if the drug…

This study tests whether drinking a specially designed milk every day for a year can reduce the chance of stents narrowing again and prevent further heart problems in people who have had a first heart attack. About 140 adults who recently had a stent placed will be randomly assig…

This study compares a new heart valve implant (Myval) to standard medication in 778 people aged 65+ with moderate aortic stenosis. The goal is to see if the implant reduces death, stroke, heart failure, and improves quality of life over 2 years. Participants will be randomly assi…

This study compares two CPR methods for newborns with cardiac arrest: a new technique that combines chest compressions with sustained lung inflation versus the standard 3:1 compression-to-ventilation ratio. Researchers will enroll 554 newborns across multiple hospitals to see whi…

This study tests whether people hospitalized for acute heart failure can be discharged early and continue treatment at home using a subcutaneous injection of furosemide (a diuretic) instead of staying in the hospital for standard IV diuretics. About 250 adults will be randomly as…

This study will track 100 people with severe aortic stenosis who receive the Hydra THV heart valve through a less invasive procedure (TAVR). The goal is to see how well the valve works and how safe it is in everyday practice. Participants will be followed for short- and mid-term …

This study tests a new device called the TRiCares Topaz, which replaces the tricuspid heart valve without open surgery. It is for people with severe tricuspid regurgitation (a leaky valve) who still have symptoms despite medication. The study will compare this device to another a…

This study looks at whether heart attack patients with mild artery narrowing can be treated with medication alone instead of getting a stent. About 2,000 people will be randomly assigned to either standard medication or medication plus a stent. The goal is to see if medication al…

This study compares a new stent that releases sirolimus and ascorbic acid (vitamin C) to a standard everolimus-releasing stent in over 2,000 people with coronary artery disease. The goal is to see if the new stent is as good at preventing heart-related complications like death, h…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This study tests whether mirabegron, a drug typically used for overactive bladder, can reduce dangerous heart rhythms in people with heart disease. Twenty adults with an implanted defibrillator and frequent ventricular tachycardia will take the drug for two months. Researchers wi…

This registry follows 1,000 adults with mitral regurgitation who receive the MitraClip G5, a device that repairs the heart valve without open-heart surgery. Researchers will measure how well the procedure reduces valve leakage and improves symptoms like shortness of breath. All d…

This Phase 2 trial tests a new drug called QLS4131, given under the skin, in combination with other medications for people with malignant plasma cell neoplasms like multiple myeloma. The study will compare different drug combinations to see which works best at shrinking tumors an…

This study compares a newer pacing method called Left Bundle Branch Area Pacing (LBBAP) with the standard coronary sinus pacing for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if LBBAP better imp…

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses and blood pressure in 180 participants. The goa…

This study will compare norepinephrine and dopamine as the first drug given to adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 512 participants will be randomly assigned to one of the two drugs. The goal is to see which d…

This pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…

This study tests a procedure called renal denervation (RDN) in 20 people with heart failure. Doctors use a thin tube to deliver radiofrequency energy to nerves around the kidney arteries, aiming to reduce stress on the heart. Participants continue their usual heart failure medica…

This study tests whether adjusting diuretic doses based on urine sodium levels improves outcomes for people hospitalized with acute heart failure and severe fluid buildup. About 270 participants will be randomly assigned to either standard care or a strategy where diuretic doses …

This study compares two pacing methods in 80 people with heart failure and a specific heart block. One method uses a lead placed in the left bundle branch area; the other adds a second lead in the left ventricle. Each participant will try both methods for six months to see which …

This pilot study tests a long-acting antibiotic called oritavancin for treating gram-positive heart infections, such as infective endocarditis. The goal is to see if weekly IV doses can replace the usual weeks-long hospital stays and daily antibiotics. The study will enroll 20 ad…

This study tests a new pacing method called anodal biphasic pacing (ABP) in 108 adults who need a heart procedure or have a pacemaker. ABP uses a different electrical waveform that may improve how the heart pumps and reduce problems from standard pacing. Researchers will compare …

This study tests if using only drug-coated balloons is as safe and effective as stenting for treating blocked heart arteries at branch points. About 272 people with chronic coronary syndrome will be randomly assigned to one of the two treatments. Researchers will track deaths, he…

This phase 2 trial tests whether quercetin, a dietary supplement found in many fruits and vegetables, can improve the function of tiny blood vessels in young adults with obesity. Forty participants will take either quercetin or a placebo daily for 30 days. Researchers will measur…

This study looks at whether giving volunteer community responders a small, portable defibrillator (about the size of a chocolate bar) helps them treat people having a cardiac arrest outside the hospital. Around 1,000 volunteers in Singapore will carry the device for up to a year …

This study tests whether high-calorie diets and special nutritional formulas can help underweight children aged 1 to 5 with congenital heart disease gain weight. Seventy-five children will be split into three groups: standard diet, high-calorie diet, or high-calorie diet plus a s…

This study tests whether removing blood clots from heart arteries during emergency treatment can improve long-term heart health. About 6,760 adults having a severe heart attack will be randomly assigned to get standard care or standard care plus clot removal. Researchers will tra…

This study tests a small device called an interatrial shunt that is placed in the heart to relieve pressure. It involves 15 adults with advanced heart failure and reduced pumping ability. Researchers will use advanced heart scans and exercise tests to see if the device improves h…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study looks at how long people should take a combination of two blood thinners (ticagrelor and aspirin) after coronary artery bypass surgery to keep the new vein grafts open. 300 patients will be randomly assigned to take the combination for 3, 6, or 12 months, then switch t…

This study tests whether a medicine given as a nose spray before a heart stent procedure can reduce heart muscle injury or heart attack. About 1800 adults scheduled for elective stent placement will receive either the medicine or a placebo spray. Researchers will measure heart da…

This study tests an experimental drug called elranatamab in people newly diagnosed with AL amyloidosis who have not yet had treatment. The drug helps the body's immune cells find and destroy the abnormal cells causing the disease. Researchers want to see if it can produce deep re…

This study tests a new device called DuoCor 2, which is a mechanical pump that helps both sides of the heart pump blood. It is for people with advanced heart failure in both ventricles who have few other options. The study will enroll 50 adults and measure how many survive for 6 …

This study tests whether giving doctors daily readings of a patient's peripheral venous pressure (a simple vein pressure measurement) can help heart failure patients get out of the hospital faster and avoid coming back. Researchers will compare 600 patients who get this extra inf…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study compares two surgical techniques for coronary artery bypass grafting (CABG). One uses only arteries (total arterial grafting), while the other uses a mix of artery and vein grafts (conventional mixed grafting). The goal is to see which approach keeps grafts open longer…

This study tests whether a drug-coated balloon (DCB) is as safe and effective as a drug-eluting stent (DES) for treating large blockages in heart arteries. About 2,492 patients will be randomly assigned to receive either a balloon or a stent, guided by advanced imaging. The goal …

This study tests a 3-month behavioral coaching program for 232 adults with coronary heart disease who sit a lot. The program includes face-to-face and phone sessions to help them reduce sitting time and increase physical activity. Researchers will measure changes using activity t…

This trial compares two latest-generation heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) in 200 patients with severe aortic stenosis. Participants will be randomly assigned to receive one valve during a standard procedure and followed for one year. The goal is to see which v…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This study tests a device called AngioVac that uses suction to remove infected growths (vegetations) from the right side of the heart in people with infective endocarditis. The trial will enroll 30 adults with large vegetations and track survival, infection clearance, and complic…

This study tests whether AI-generated messages can help doctors improve medication plans for adults with heart failure. About 500 patients will have their doctors receive brief suggestions before appointments. The goal is to see if more patients get the right medications within 3…

This study tests a special pacing method for people with heart failure and a type of heart block. The goal is to see if pacing a specific area of the heart can improve heart function and quality of life. About 120 adults with heart failure and reduced pumping ability will partici…

This study tests whether using only ultrasound (echocardiography) to guide a minimally invasive heart valve replacement is as effective as the standard method that combines X-ray and ultrasound. The goal is to reduce kidney injury from contrast dye and lower radiation exposure. A…

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This study tests whether a drug-coated balloon is as good as or better than a drug-eluting stent for people with multiple blocked heart arteries. About 892 adults with stable heart disease or recent heart attack will be randomly assigned to one of the two treatments. The goal is …

This study tests a new radiation treatment for people with a life-threatening fast heart rhythm called ventricular tachycardia that hasn't been helped by medication or prior procedures. About 24 adults with an implanted defibrillator will receive a single, targeted dose of radiat…

This study will test whether sildenafil, a drug often used for erectile dysfunction, can improve heart function in children aged 1-18 with dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers will measure changes in the heart's pumping ability ove…

This early study tests a new device called the TRICENTO G2 to treat severe tricuspid regurgitation, a condition where a heart valve leaks badly. Ten adults with symptoms like shortness of breath or swelling will get the valve through a minimally invasive procedure. The goal is to…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This trial tests a hybrid exercise program (HyBEST) for people with coronary artery disease. It combines supervised sessions at a center with home workouts using a wearable tracker. The goal is to see if this approach improves exercise capacity, body composition, and quality of l…

This study tests a new method to guide where a pacing lead is placed in the heart's upper chambers during cardiac resynchronization therapy for heart failure. Researchers will use a special catheter to map electrical signals and target a specific area called Bachmann's bundle. Th…

This study tests a special radioactive tracer called [68Ga]Ga-FAPI-46 for PET scans in 40 people with transthyretin cardiac amyloidosis (ATTR-CM), a condition where abnormal proteins build up in the heart. The goal is to see if this scan can measure scar-like activity in the hear…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study will test whether an algorithm that analyzes data from Withings smart scales (weight, body water, and step counts) can accurately detect heart failure. Researchers will look back at data from 9,000 people aged 45 and older in the US. If the algorithm works well, it cou…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study evaluates a simple questionnaire designed to detect decompensated heart failure—a sudden worsening of heart failure—in people aged 55 and older on Réunion Island. Researchers will compare the questionnaire's results with standard heart exams (echocardiogram, ECG, and c…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study looks at 115 children aged 6 months to 5 years who have a hole in the heart (VSD) and need surgery. Doctors want to see if an ultrasound probe placed in the food pipe (TEE) can measure heart pressure as accurately as the standard method using a thin tube (catheter) ins…

This study explores whether an additional CT scan of the heart, taken right after a standard scan for lung clots, can effectively detect blood clots in the left atrial appendage (LAA) in people with atrial fibrillation. Currently, detecting these clots requires a more involved pr…

This study tests whether an artificial intelligence (AI) program can help doctors identify a rare heart condition called cardiac amyloidosis on routine echocardiograms. The condition causes protein buildup in the heart muscle, leading to heart failure, and is often missed early o…

This study will test a new, more accurate blood test (Troponin T high-sensitivity Gen 6) to see if it helps doctors diagnose heart attacks faster. Researchers will compare emergency department visit data from 19,500 patients before and after the test is introduced. The goal is to…

This study will test whether a small, wearable patch that records heart activity for 7 days can find undiagnosed atrial fibrillation (a common heart rhythm problem) in 30,000 Chinese adults aged 60 and older. Participants will wear the patch and then be followed for up to 10 year…

This study explores whether a PET/MR scan using a radioactive tracer called 18F-Florbetaben can detect amyloid deposits—abnormal protein clumps that can damage organs—in people with certain blood disorders. Participants receive a single injection of the tracer followed by a whole…

This study will test whether a deep learning-based image reconstruction method can improve the quality of coronary CT scans. Researchers will look at existing scans from 200 patients who had a CT angiogram for suspected heart disease. Two radiologists will rate the images on a sc…

This pilot study will test whether an AI-assisted ultrasound device can help emergency doctors quickly detect heart failure in patients with symptoms. About 84 adults visiting the ER with signs of heart failure will be enrolled. The goal is to see if this approach is practical an…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study will test whether a faster type of bone scan (CZT-SPECT) can accurately diagnose transthyretin cardiac amyloidosis, a serious heart condition. Researchers will compare the new scan with the standard method in 200 patients. If it works, it could make diagnosis quicker a…

This study tests whether an AI tool called RADAR can help nurses in low-resource settings detect rheumatic heart disease more accurately using echocardiography. The goal is to make screening easier to scale up worldwide. The trial will enroll 62 nurse screeners at participating f…

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This study aims to see if a new method using electrical and mechanical signals from the heart can accurately diagnose valvular heart disease. Researchers will recruit 1,300 adults with and without valve problems to compare the new test against standard echocardiography. If it wor…

This study will see if community pharmacies can effectively screen people aged 65 and older for atrial fibrillation, a heart condition that raises stroke risk. Trained pharmacists will use a small, portable ECG device to record a 30-second heart reading. If the result is abnormal…

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vi…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests whether a computer model can find signs of a heart condition called cardiac amyloidosis in bone scans that were done for other reasons. Researchers will look back at 57 patients' scans to see if the model can correctly identify those with the disease. If it works…

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This study tests whether a noninvasive skin test can accurately diagnose microvascular heart problems in women who have chest pain but clear major arteries. Researchers will compare skin blood vessel function with invasive heart measurements in 60 women. If the skin test works, i…

This study looks at whether a simple blood test done in the ambulance can safely rule out a heart attack in people with chest pain. Many patients are taken to the hospital even though they are not having a heart attack. The test uses a portable device to measure a heart protein c…

This study tests a new way to find a hidden heart condition called cardiac amyloidosis in people with atrial fibrillation (AF). Researchers will use AI to analyze EKGs and CT scans to spot early signs of the disease. About 500 adults with AF and certain warning signs will be spli…

This study tests whether paramedics can use a lung ultrasound to improve diagnosis of heart failure in patients with breathing trouble. About 1,000 adults with shortness of breath will receive the ultrasound during emergency care. Researchers will compare the paramedic's diagnosi…

This study tests advanced CT scans to find dangerous blockages in heart arteries without needing to insert a tube into the heart. About 142 adults with moderate blockages will get two types of CT scans, and results will be compared to the standard invasive test. The goal is to se…

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This study tests whether a special PET-CT scan using a drug called evuzamitide can detect signs of cardiac amyloidosis in people whose standard heart scans were unclear but who have high levels of a blood marker called TAD1. About 25 adults with heart failure or a genetic risk fo…

This study will enroll 5000 adults to see if a one-minute, single-lead ECG, analyzed by machine learning, can detect heart conditions like high blood pressure, heart failure, and diabetes. Participants will have their ECG recorded twice and compared with full medical exams. The g…

This study investigates whether screening older veterans (age 65 and older) who have a higher risk of atrial fibrillation—a condition where the heart beats irregularly—can reduce their chances of stroke, heart failure, or death. Participants selected for screening wear a small, w…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study tests whether colchicine, a drug usually used for gout, can prevent atrial fibrillation (a type of irregular heartbeat) after coronary artery bypass surgery. About 400 adults scheduled for elective bypass will receive either colchicine or a placebo starting 3 days befo…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study tests whether a drug called sotagliflozin can prevent heart, muscle, and fat damage caused by a common type of chemotherapy (anthracycline) in people with newly diagnosed lymphoma. About 60 adults who are scheduled to receive high-dose anthracycline will take either th…

This study looks at whether giving patients and their doctors a polygenic risk score — a genetic test that estimates future risk of coronary heart disease — helps more people start taking statins to prevent heart problems. Researchers will enroll 200 adults aged 40-69 without pri…

This study tests whether taking a low dose of colchicine (0.5 mg) every day for two years after coronary artery bypass grafting (CABG) can prevent the new blood vessel grafts from failing. About 622 adults who just had bypass surgery will be randomly assigned to get either colchi…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study looks at whether 12 virtual health coaching sessions over 16 weeks can help people with heart disease (like heart failure or a heart attack) improve their health, reduce stress, and lower the chance of going back to the hospital. About 70 adults will take part, and the…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study tests whether giving magnesium along with the standard drug metoprolol can quickly lower a dangerously fast heart rate in people with atrial fibrillation or atrial flutter. About 196 adults in the emergency room will receive either magnesium or a placebo, plus metoprol…

This study tests a new type of breathing muscle training for people with heart failure. 108 participants will either do the new breathing exercise, a standard one, or usual care for 8 weeks. Researchers will measure if it improves exercise capacity, breathing strength, and qualit…

This study compares two types of exercise—moderate-intensity aerobic training and high-intensity interval training (HIIT)—in women aged 40-70 with stable heart failure. Over 12 weeks, researchers measure how each program affects functional capacity (e.g., walking distance) and qu…

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether wearing eye masks and/or earplugs at night can improve sleep quality and reduce delirium in 128 patients recovering from coronary artery bypass surgery. Participants will be randomly assigned to use these aids on the first three nights after surgery. Rese…

This study compares two types of nerve blocks—Intertransverse Process Block and M-TAPA—for pain after laparoscopic gallbladder removal. Sixty adults will be randomly assigned to receive one of the blocks. The main goal is to see which block provides better pain relief and reduces…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This study tests if combining arm and leg cycling exercise is better than leg cycling alone for improving fitness and quality of life in people who have had a heart attack. Forty medically stable adults aged 40-70 will exercise three times a week for six weeks. Researchers will m…

This study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…

This study tests whether structured play activities, done with a parent, can reduce anxiety in children with congenital heart disease before their surgery. About 204 children aged 0-12 will be randomly assigned to either receive therapeutic play plus standard care, or standard ca…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. The drink is given three times a day for five days. Researchers will measure changes in heart stress markers and symptoms. The goal is to see if ketones can improve energy for t…

This study tests whether using mild electrical pulses on the diaphragm and belly muscles can improve breathing, heart function, and exercise ability in people who recently had a heart artery-opening procedure (angioplasty). 42 adults will receive either standard rehab plus this s…

This study tests two types of exercise—aerobic and resistance—both combined with blood flow restriction (using cuffs on the legs) in 40 people with stable heart failure. The goal is to see which approach better improves muscle oxygen levels, heart stress markers, daily function, …

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study tests an experimental medicine called BAY 3670549 in 360 adults with atrial fibrillation (an irregular heartbeat). Participants receive a single IV dose of the drug or a placebo to see if it can restore normal heart rhythm without needing an electrical shock procedure.…

This study compares deep sedation using a combination of three drugs (dexmedetomidine, remimazolam, and remifentanil) to standard general anaesthesia for patients undergoing a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if deep sedation can…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist air through the nose) can help people with heart failure exercise longer during cardiac rehab. Twenty-eight adults will do two treadmill tests—one with the device and one without—to compare end…

This study will compare two types of nerve blocks—Transversalis Fascia Plane Block and M-TAPA—for controlling pain after laparoscopic inguinal hernia repair. Sixty adults aged 18–65 will be randomly assigned to receive one of the blocks before surgery. Researchers will measure pa…

This study tests whether starting with a higher shock energy (360 J) is better than a standard 200 J for restoring normal heart rhythm in people with atrial fibrillation. About 400 adults will be randomly assigned to one of three groups, including a personalized approach based on…

This study tests whether a 12-week home exercise program, guided by a mobile app and smartwatch, can improve exercise capacity and quality of life in people with a left ventricular assist device (LVAD). About 78 participants who recently got an LVAD and cannot attend hospital reh…

This early study tests whether a special gel, injected into the heart during a procedure to open blocked arteries, can safely reduce injury in people having their first major heart attack. Twenty participants will be randomly assigned to get the gel plus standard care or standard…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study compares two types of nerve blocks to control pain after laparoscopic hysterectomy. Sixty women aged 18-65 will receive either an Intertransverse Process Block or an M-TAPA block. The main goal is to see which block provides better pain relief in the first 24 hours aft…

This study tests different arm exercise routines in 36 adults with heart failure who have an implanted heart device (ICD or CRT). The goal is to see which type of arm workout best improves arm function and overall fitness. Participants will do either high-intensity interval or mo…

This study tests whether playing motion-sensing Nintendo Switch games can help children and teens with congenital heart disease become more physically active. Thirteen participants aged 8-18 will wear activity monitors and follow a 12-week exergame program with coaching and suppo…

This phase 2 trial tests whether mirabegron, a drug currently used for overactive bladder, can reduce symptoms of Postural Orthostatic Tachycardia Syndrome (POTS). Thirty-six adults with confirmed POTS will receive either mirabegron or a placebo. The main goal is to see if the dr…

This study tests a virtual psychological support program called HeartGPS for mothers whose babies are diagnosed with congenital heart disease before birth. About 210 mothers and their infants will take part, with some receiving the program plus usual care and others only usual ca…

This study looks at the best way to give the water-removing medicine furosemide to people hospitalized with acute heart failure and too much fluid in the body. About 436 adults will be randomly assigned to receive the medicine either as a slow continuous infusion or as several in…

This study tests whether combining breathing exercises with cognitive tasks (like memory games) can improve thinking and daily function in adults with heart failure. 54 participants will be randomly assigned to dual-task breathing training, standard breathing training, or a contr…

This study compares two types of exercise—elliptical training and Swiss ball aerobics—to see which better helps people recover after heart bypass surgery (CABG). Researchers will measure improvements in walking ability, heart rate, shortness of breath, and quality of life. The st…

This study tests whether adding a special breathing exercise device (IMT Threshold) to standard rehab can help people recover faster after coronary artery bypass graft surgery. The goal is to reduce time in the hospital and prevent serious breathing complications like pneumonia. …

This study tests whether a structured nursing program—including education, emotional support, and follow-up calls—can help heart bypass patients and their caregivers adapt better during recovery at home. About 40 adults who recently had heart surgery and their primary caregivers …

This study tests whether playing soft music or using a musical mobile can reduce pain and stress in infants when chest tubes are removed after heart surgery. Fifty-four babies aged 2 to 12 months will be randomly assigned to hear music, see a musical mobile, or receive standard c…

This study tests a 10-session program called ViCCY for caregivers of heart failure patients who also have mild to moderate memory problems. About 256 caregivers and 60 patients will take part. The goal is to see if the program improves caregivers' mental health and reduces stress…

This study tests a digital exercise program that adapts in real time to help children aged 6 to 12 recover after congenital heart disease surgery. Kids wear a monitor and get personalized exercise prompts and feedback. Researchers will compare their recovery to children receiving…

This study tests whether an 8-week home telerehabilitation program, with real-time coaching and vital sign monitoring, can improve physical function and reduce frailty in older adults with heart failure. Seventy participants will be randomly assigned to either the telerehab progr…

This study compares two ways to sedate patients during a heart scan and electric shock treatment for atrial fibrillation. Currently, a cardiologist gives mild sedation for the scan, but an anaesthesiologist must give stronger sedation for the shock, causing delays. Researchers wa…

This study tests if a new flexible cable (SuperCable) is better than standard steel wire for closing the breastbone after heart surgery. About 86 adults will be randomly assigned to one method. The goal is to see if SuperCable leads to faster bone healing, less pain, and shorter …

This pilot study tests a non-invasive ear stimulation device (aVNT) in 30 people with Postural Orthostatic Tachycardia Syndrome (POTS). The goal is to see if it can reduce rapid heart rate upon standing, improve blood flow to the brain, and ease other symptoms like brain fog and …

This study tests whether low dose naltrexone (LDN) can reduce fatigue in people with Postural Orthostatic Tachycardia Syndrome (POTS). Eighty participants will receive either LDN or a placebo for 4 months. The goal is to see if LDN improves fatigue and quality of life.

This study tests whether foot massage or kinesio taping can help older adults (65+) move better and feel less afraid of movement after heart surgery. Sixty participants will receive one of the two treatments daily for a week. Researchers will measure mobility, pain, and fear of m…

This study looks at whether a multifunctional baby carrier that rocks, swaddles, and plays white noise can help infants (0-3 months old) feel less pain, sleep better, and have steadier heart rates and oxygen levels after congenital heart surgery. About 52 babies will be randomly …

This study looks at 224 adults with a type of irregular heartbeat called paroxysmal atrial fibrillation who are getting a first-time heart procedure called pulsed-field ablation. Researchers want to see if using conscious sedation (being awake but relaxed) is safer than general a…

This study tests whether a structured medication training program delivered via WhatsApp can help people with heart failure better manage their symptoms and stick to their medication routine. Researchers will compare the training group to a group receiving standard care. The stud…

This study tests whether giving lidocaine through an IV can reduce diaphragm twitching and coughing during a procedure called pulse field ablation for atrial fibrillation. Sixty adults with AFib will be randomly assigned to receive lidocaine or a placebo (saline). The goal is to …

This Phase 1 trial investigates how the drug HRS-9057 is absorbed, processed, and eliminated in healthy men. Six participants receive a single dose, and researchers measure the drug and its breakdown products in blood, urine, and stool. The goal is to understand the drug's behavi…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-o…

This study will observe how the Impella 5.5 heart pump changes the way the heart squeezes and works in adults with end-stage heart failure. Researchers will use ultrasound (echocardiography) to measure heart function before, right after, and 7-14 days after the pump is placed. Th…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This trial is testing a medical device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety in people. Participants will be monitored closely, but the device is not yet proven to treat or cure any condition.

This study will test whether a five-point ultrasound can better predict fluid overload in 200 patients hospitalized with congestive heart failure. Doctors will use the ultrasound results to guide diuretic treatment and track readmission rates over 30 and 90 days. The goal is to s…

This study investigates whether measuring blood flow in the heart's smallest blood vessels (microcirculation) can help predict serious health events within a year after a person is hospitalized for acute myocarditis. Researchers will use a special technique during a standard hear…

This study gathers data from 392 adults with heart failure who need a right heart catheterization. Researchers will use the data to train a machine learning model for a non-invasive device that estimates heart pressure. The goal is to help doctors monitor and treat heart failure …

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study will enroll 100 people who have already had a heart procedure (pulsed field ablation) for atrial fibrillation. Participants will wear a BodyGuardian monitor for a period after the procedure to see if it catches any return of irregular heartbeats. The study also asks pa…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study tests a new home monitoring system called AVATAR-SC that uses a digital avatar to collect voice recordings and symptom questionnaires from heart failure patients. The goal is to see if changes in voice can serve as early warning signs of worsening heart failure. Sixty …

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test a new imaging system called CHORUS IDx in 200 people scheduled for a heart ablation procedure. The system takes pictures inside the heart to help doctors see better during the procedure. The main goal is to check if the device is safe and to collect images th…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This observational study will test whether an artificial intelligence algorithm can accurately detect heart sounds using data from a wearable ECG patch in 50 people with heart failure. Participants will wear the patch and have their heart sounds recorded with a digital stethoscop…

This study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…

This observational study will follow 2,352 adults with coronary heart disease to see how factors like blood sugar, sleep, and heart imaging relate to thinking and memory problems. Participants will take memory tests and undergo scans and blood work during a hospital stay. The goa…

This observational study will follow 200 adults with Brugada Syndrome who need anesthesia for surgery or other procedures. Researchers want to see how often dangerous heart rhythms occur during and up to 30 days after anesthesia. They will also check if certain anesthetic drugs o…

This observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …

This early-stage study will give a small dose of a radioactive-labeled drug called HRS-1893 to 6 healthy men. Researchers will track how the drug is absorbed, broken down, and eliminated through urine and feces. The goal is to understand the drug's path in the body, which is a ke…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study looks at whether a brief training video can boost police officers' confidence and willingness to use an AED (a device that shocks the heart) during cardiac arrest, especially on women. About 30 officers will take surveys before and after watching the video. The goal is…

This study follows 10 Chinese adults who have a specific gene mutation (BAG3) linked to dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Researchers will track changes in heart function, symptoms, and biomarkers over time to better understand how the…

This study looks at 150 people with persistent atrial fibrillation (a type of irregular heartbeat) who are scheduled for a heart procedure called ablation. Researchers want to see if levels of a protein called BDNF in the blood are linked to signs of heart muscle damage (atrial c…

This study looks at 150 adults having coronary bypass surgery to find out how often hidden heart injury occurs. Researchers use a sensitive blood test (troponin) and heart MRI to detect damage that standard tests might miss. The goal is to improve diagnosis and long-term care aft…

This observational study will follow 600 adults with chronic or acute heart failure to see how biomarkers and other factors predict individual responses to standard medications. Participants will have assessments at the start and after 1, 3, and 6 months, with follow-up phone cal…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study looks at whether a digital tool called Luscii is practical and acceptable for people with a rare heart condition called ATTR-CM. About 60 adults in Austria, Germany, and Italy will use a smartphone app and home devices to share health information with their care team. …

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study will collect health information from 3000 people with hypertrophic cardiomyopathy (HCM) across multiple hospitals in China. The goal is to build a comprehensive database to understand how the disease is currently diagnosed and treated, and to identify factors that affe…

This study aims to see if wearable foot-pods (like Stryd) and breathing frequency monitors can accurately measure exercise intensity in people who have had a heart attack in the past 6 months. 24 participants will perform walking tests on flat ground and a treadmill while their o…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study will observe 110 adults having planned heart bypass surgery. Researchers will record settings on the breathing machine during surgery and check if patients develop lung complications like pneumonia or need a breathing tube for too long. No new treatments are given—the …

This study will collect real-world information on the VERAFEYE system, a device that creates 3D images of the heart during procedures to treat atrial fibrillation (an irregular heartbeat) and to close the left atrial appendage (a small pouch in the heart). About 50 adults will ta…

This study will look at medical records from over 2 million adults who had surgery in Sweden between 2021 and 2024. Researchers want to see how common heart failure is in surgical patients and whether it raises the risk of death or other problems after surgery. The goal is to bet…

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study tests a special blood pressure monitor that deflates very slowly, designed for people with a Left Ventricular Assist Device (LVAD). Researchers want to see if patients can use it easily at home and if it helps track their blood pressure accurately. About 50 adults with…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study looks back at medical records of 850 patients aged 80 and older who had a heart stent procedure at a UK hospital over seven years. Researchers will describe the patients' health, age, and frailty, and track complications like heart attack, stroke, or death up to one ye…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study checks whether three common ECG-based methods can accurately locate where abnormal heart rhythms start in adults who had Tetralogy of Fallot repair. Researchers will pace the heart from known spots during a scheduled procedure and compare the predicted location to the …

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will follow 500 people with severe aortic stenosis who need a heart valve replacement. Researchers want to see if a dedicated Heart Valve Unit—a team of heart specialists working together—can reduce confusion, delirium, and memory problems that sometimes happen after t…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study aims to collect blood samples from 450 people, including individuals with autism spectrum disorder (ASD), their relatives, and healthy controls. Researchers will isolate cells from the blood to study genetic factors and biological processes linked to autism. The goal i…

This study will enroll 1000 heart failure patients to see if different types of body fat—around the heart, under the skin, and within muscles—are linked to heart structure and future health events like heart attacks or strokes. Researchers will use CT scans to measure these fat d…

This study aims to see if improving how emergency dispatchers handle calls and model their actions can speed up the detection of cardiac arrest and improve CPR quality. Researchers will study 4,000 people who experience cardiac arrest outside of a hospital. The goal is to learn i…

This study compares two types of heart ablation for people with persistent atrial fibrillation: pulsed field ablation and radiofrequency ablation. The goal is to see which one causes fewer stomach problems after the procedure. Twenty participants will be matched by age and health…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study will compare two common types of heart valves used in TAVI (a procedure to replace a narrowed aortic valve) to see which one sends fewer tiny particles to the brain during the procedure. 80 adults with severe aortic stenosis will be randomly assigned to receive either …

This study will follow 600 adults who have had a stent placed or bypass surgery for coronary artery disease. Researchers will collect medical information, blood samples, and traditional Chinese medicine symptoms over 12 months. Using artificial intelligence, they aim to create a …

This study investigates whether a condition called clonal hematopoiesis of indeterminate potential (CHIP), which is an age-related change in blood cells, is linked to more severe heart damage in people who have had a major heart attack (STEMI). Researchers will test blood samples…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study will compare five different pulsed field ablation systems used to treat atrial fibrillation (an irregular heartbeat). The goal is to see which system causes the fewest tiny clots (microemboli) that travel to the brain during the procedure. One hundred adults with atria…

This study compares how much radiation doctors are exposed to during heart procedures (PCI) when using the left distal wrist versus the right wrist for artery access. About 748 patients scheduled for PCI will take part. The goal is to see if the left wrist approach reduces radiat…

This study checks if two Italian questionnaires accurately measure how well people with heart failure care for themselves and how caregivers help. Researchers will enroll 1,000 patients and their caregivers across Italy. The goal is to improve heart failure management by using re…

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study tests a cloud-based tool called ACT+ to help people in Uganda get follow-up care after a positive screening for rheumatic heart disease. Researchers will work with local providers to improve the tool and then see if it increases the number of people who complete a conf…

This study looks at 223 adults hospitalized with acute heart failure to see if changes in urine salt levels (sodium and chloride) can help doctors understand how well the body is getting rid of extra fluid. Participants will have blood and urine tests, heart ultrasounds, and chec…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This study will collect blood samples from 115 adults with cardiac sarcoidosis to look for tiny particles called exosomes that might show whether the disease is active or quiet. The goal is to develop a simple blood test that could help doctors monitor the condition without needi…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This early-stage study will use advanced PET scans to look at how the brain and body work together in people with and without heart disease. Researchers want to see if blood flow and energy use in different organs change during physical or mental stress. The goal is to better und…

This study will use brain electrodes (SEEG) and breathing monitors in 20 adults with drug-resistant epilepsy to map which brain areas control breathing during a challenge. The goal is to understand why some patients experience fatal breathing arrest after seizures (SUDEP). No tre…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study looks at whether a special simulation training program for emergency doctors can help them use heart ultrasound more effectively in patients with acute heart failure. The goal is to see if this training leads to faster treatment with diuretics, which help remove excess…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This observational study will follow 50 people with severe tricuspid regurgitation (a leaky heart valve) and reduced heart function who undergo valve repair using the PASCAL Precision System. The main goal is to see if, 12 months after repair, patients can take higher doses of st…

This study tests a new method to measure central venous pressure (a key heart health indicator) without inserting a catheter. Researchers will use a pressure cuff and Doppler sensor on the forearm of 30 children (ages 0-17) in the intensive care unit. The goal is to see if this n…

This study will examine 250 adults with chest pain but no major blockages in their heart arteries (a condition called INOCA). Researchers will collect cells from the heart's blood vessels during a standard angiogram and track symptoms, activity, and function over one year using q…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study examines whether volunteers alerted by a smartphone app can improve survival for people who have a cardiac arrest outside the hospital. Researchers will compare outcomes for about 5,200 adults who either did or did not receive help from these first responders. The goal…

This study tests a special breastfeeding guideline for infants born with congenital heart disease (CHD). Researchers want to see if the guideline helps more mothers breastfeed directly and reduces stress. About 266 mother-infant pairs will take part across multiple hospitals, wit…

This study will follow 200 people with suspected or confirmed cardiac amyloidosis, a condition where abnormal proteins build up in the heart and cause heart failure. Over two years, participants will undergo heart MRI scans, exercise tests, and blood work at regular visits. The g…

This study will follow 1000 adults in China with severe coronary artery disease who are too high-risk for bypass surgery and need complex angioplasty. Researchers will collect data on their health, procedures, and outcomes for one year to see what factors affect survival and comp…

This study tests a nursing support program for families of children aged 1 to 3 who have had heart surgery. The program includes education and counseling sessions to help parents improve caregiving skills and support their child's growth. Researchers will compare families who rec…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at 128 adults having gallbladder surgery to see if using a low-flow (more eco-friendly) versus normal-flow sevoflurane anesthesia changes heart electrical signals linked to dangerous rhythms. Researchers will measure these signals before, during, and after surger…

This observational study will track 300 adults with advanced heart failure to see how well they follow a four-medication treatment plan. Researchers will also measure quality of life using standard questionnaires. The goal is to understand real-world adherence and identify areas …

This study will collect information on 1,200 emergency intubations across multiple hospitals in Taiwan. Researchers will track how often the tube is placed correctly on the first try and how often serious problems like low oxygen, low blood pressure, or cardiac arrest occur. The …

This study will check if a routine blood measure called mean platelet volume (MPV) can predict acute coronary syndrome (heart attack or unstable angina) in people with metabolic dysfunction-associated steatotic liver disease (MASLD). Researchers will compare MPV levels between 60…

This study looks at how sarcopenia (age-related muscle loss) is connected to fatigue and orthostatic intolerance (dizziness when standing up) in people aged 65 and older. Researchers will compare 90 older adults with and without sarcopenia to see if those with muscle loss experie…

This study looks at how the heart's upper and lower chambers change shape and function after closing a hole called patent ductus arteriosus (PDA) using a catheter-based procedure. It will include 40 people aged 12 and older who are already scheduled for the closure. The goal is t…

This study will measure hormone levels in 100 children aged 1 to 12 who have dilated cardiomyopathy, a condition where the heart is enlarged and weakened. Researchers will collect blood samples to check hormones like thyroid, cortisol, and growth factors, and compare them to heal…

This observational study will follow 3000 patients with severely calcified coronary arteries who undergo a procedure to open the blockages (PCI). Researchers will track outcomes like heart attacks and repeat procedures over time. The goal is to learn which techniques work best in…

This study will use AI-guided CT scans to look for signs of heart disease in 100 former high-intensity athletes, like NFL alumni or Division I players, aged 30 and older. The goal is to find out how common coronary artery disease is in this group and understand the types of plaqu…

This observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The…

This study tests whether showing real-time visual feedback to EMS responders helps them deliver the right amount of air during simulated CPR. 80 rescuers will give breaths to a mannequin with and without feedback, using two different CPR strategies. The goal is to see if feedback…

This study looks at whether adding a special heart function test (coronary function testing) to the standard artery-opening procedure (angioplasty) can better relieve chest pain and improve quality of life. About 450 adults with a significant blockage in a major heart artery will…

This study looks for ways to predict if pericarditis (inflammation of the sac around the heart) will come back. About 10-30% of people have a repeat episode, and half of those have multiple returns. Researchers will use a special PET/CT scan, blood tests, and patient information …

This study tests a clinical decision support tool that helps doctors decide when to refer heart failure patients to palliative care. The tool uses a risk model to predict one-year survival and provides guidance at the point of care. Researchers will enroll 2,260 participants, inc…

This study looks at whether a special breathing maneuver during heart surgery can improve heart and lung function in children with congenital heart disease. About 80 children will be randomly assigned to receive either the maneuver or standard care. The goal is to see if this app…

This study aims to find out how often exocrine pancreatic insufficiency (EPI) occurs in people with Alagille syndrome who have had a liver transplant. About 30 participants aged 7 to 50 will eat a high-fat diet and collect stool samples for lab testing. The results will help doct…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will enroll 144 adults with acute coronary syndrome (heart attack or unstable angina) to see how inflammatory markers (hs-CRP and neutrophil-to-lymphocyte ratio) and cardiac troponin levels relate to heart function measured by echocardiography. Researchers hope to impr…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in these changes. About 50…

This study observes 600 people with aortic stenosis who cannot have a standard TAVI procedure through the leg artery. Instead, doctors will use other access points, like the chest or neck, to replace the heart valve. The goal is to track safety and success rates of these alternat…

This study aims to improve how MRI scans measure blood flow in the heart muscle. Researchers will compare a new, fully quantitative method with the standard semi-quantitative approach in 35 people with possible heart disease. The goal is to develop a more accurate tool for diagno…

This study will test a new type of CT scan (photon counting CT) to see if it can give doctors a clearer picture of the fatty deposits (plaques) inside heart arteries. The goal is to find out if these detailed images can help predict who might have a heart attack or other serious …