Heart disorder

This trial is testing an experimental treatment called FKC289 for people with primary AL amyloidosis that has relapsed or not responded to standard care. FKC289 uses a patient's own immune cells, engineered to recognize and attack the abnormal plasma cells that produce the harmfu…

This trial tests whether adding a blood-filtering device, called hemoadsorption, to the heart-lung machine can reduce harmful inflammation in children undergoing complex open-heart surgery. The device is designed to remove inflammatory proteins, known as cytokines, from the blood…

This study tests whether high-intensity interval training (HIIT) can improve cardiovascular health in adults who had surgery to repair coarctation of the aorta, a narrowing of the main artery. Participants are randomly assigned to do HIIT at home, HIIT in a supervised clinic, or …

This study compares two pacing methods in 80 people with heart failure and a specific heart block. One method uses a lead placed in the left bundle branch area; the other adds a second lead in the left ventricle. Each participant will try both methods for six months to see which …

This trial explores whether a single, low-dose radiation treatment to the heart can improve pumping function in people with advanced or end-stage heart failure. The study includes 20 adults with severe heart failure who are not eligible for a transplant or mechanical heart pump. …

This study tests the long-term safety and effectiveness of an investigational drug called danicamtiv in adults with symptomatic genetic or familial dilated cardiomyopathy (DCM), a condition where the heart muscle weakens and enlarges. Participants who completed a prior 24-week st…

This trial tests whether specific care strategies used in the intensive care unit after cardiac arrest can improve neurological recovery and survival. Adults who remain comatose after their heartbeat is restored will be cared for using either head elevation or a near-supine posit…

This trial is testing the best timing for opening additional blocked arteries in people who have had a severe type of heart attack (STEMI) with multiple blocked vessels. After the main blocked artery is opened, participants are randomly assigned to have the other blockages treate…

This phase 3 trial investigates whether adding acetazolamide—a drug often used for altitude sickness—to standard diuretics can improve fluid removal in people with heart failure who experience sudden fluid buildup. Participants take the medication for up to five days while being …

This trial asks whether people with heart failure who take SGLT-2 inhibitors (like dapagliflozin or empagliflozin) should continue the medication right up to cardiac surgery, rather than stopping it three days before as currently recommended. The study will compare outcomes like …

This trial investigates whether using a temporary heart pump (microaxial flow pump) right after opening a blocked artery improves survival in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. It also tests whether advanced monitor…

This trial tests whether a heart procedure called pulsed field ablation can be guided using only ultrasound, avoiding the use of X-rays (fluoroscopy), in people with paroxysmal atrial fibrillation. The study compares the success of completely isolating the pulmonary veins—a key s…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This phase II trial is testing whether a combination of selinexor, daratumumab, and dexamethasone (called XDd) can help people with advanced light-chain cardiac amyloidosis, a condition where abnormal proteins build up in the heart. The study aims to see if the regimen can achiev…

This trial tests a 1-month nurse-led program designed to help older adults with coronary heart disease and frailty reduce their daily sitting time. Participants are randomly assigned to either the program or a control group, and the program uses education, goal setting, self-moni…

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial tests whether a newer pacing method, called left bundle branch area pacing, is better than the standard right ventricular pacing for adults with permanent atrial fibrillation and a need for a pacemaker. The goal is to see if the newer technique reduces the risk of deat…

This trial investigates whether guanfacine or cromolyn sodium—two drugs already approved for other conditions—can improve physical functioning and reduce symptoms like fatigue, brain fog, and gastrointestinal issues in adults with postural orthostatic tachycardia syndrome (POTS).…

This phase 3 trial is testing whether an experimental drug called elecoglipron can reduce serious heart failure events, such as hospitalizations or urgent visits, in adults with heart failure with preserved or mildly reduced ejection fraction. Participants will receive either ele…

This trial tests whether starting a temporary balloon pump in the aorta before the standard artery-opening procedure (angioplasty) can improve outcomes for people who arrive at the hospital 4 to 12 hours after a major heart attack. Half of the participants will receive the balloo…

This study tests the long-term safety and tolerability of acoramidis, an oral medication that stabilizes the transthyretin protein, in people newly diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition that can lead to heart failure. Participants who complete…

This trial tests whether using a portable ultrasound device during coronary artery bypass surgery can improve outcomes by letting surgeons see blood flow through the new grafts in real time. About 380 adults scheduled for elective bypass surgery will be randomly assigned to eithe…

This trial investigates whether a minimally invasive procedure called mitral valve TEER, added to standard medical therapy, improves outcomes for heart failure patients whose mitral valve leakage becomes severe only during exercise. Participants are randomly assigned to receive e…

This trial is testing a new device called MRace to repair a leaky mitral valve in people with severe functional mitral regurgitation, a condition where the valve doesn't close properly, causing blood to flow backward. The device is placed through a vein in the leg and guided to t…

This study tests a new device called MRace, designed to repair severe mitral regurgitation—a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The device is implanted through a vein in the leg, avoiding open-heart surgery, and is aim…

This study tests a new device called MRace, designed to repair a leaky mitral valve in the heart without open surgery. The device is placed through a vein in the leg and guided to the heart to help the valve close properly. The trial will include up to 15 people with severe mitra…

This trial asks whether starting dialysis early—within 6 hours—in patients with cardiogenic shock and fluid overload can reduce deaths in the hospital compared to waiting until it's clearly needed. It enrolls adults in intensive care with severe heart pump failure and signs of ex…

This trial tests whether repairing a leaky mitral valve early, using a minimally invasive clip procedure, can help people with heart failure and reduced pumping function tolerate and benefit from standard heart failure medications. Participants are randomly assigned to receive th…

This trial is testing a new mechanical heart pump called the DuoCor 2, designed to support both sides of the heart in people with advanced heart failure. The study will enroll 64 patients who are severely ill and need circulatory support. The main goal is to see if the device hel…

This early-stage trial will test a single dose of a new drug called LY3971297 in 90 people with two types of heart failure: preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). The main goal is to see if the drug is safe and what side effects occur. Particip…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…

This study follows people with moderate to severe pulmonary regurgitation or stenosis who receive the PULSTA transcatheter pulmonary valve, a less invasive option for replacing a faulty heart valve. Researchers will track how well the valve works over time, measuring improvements…

This phase 3 trial is testing whether an experimental drug called BHB-1893 works better than the standard beta-blocker metoprolol for adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), a condition where the heart muscle thickens and blocks blood flow. The stu…

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

This study tests a new laser system designed to vaporize plaque in blocked coronary arteries before doctors place a stent. The trial compares the new laser device to an existing one in about 218 people with severe heart artery narrowing. The main goal is to see if the new system …

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial tests whether a smartphone app that uses light to measure heart rhythm can reliably detect when atrial fibrillation (AF) spontaneously returns to a normal heartbeat. About 200 adults with AF scheduled for an electrical cardioversion will either receive standard care or…

This phase 2 trial is testing an investigational drug called QLS4131 in people newly diagnosed with AL amyloidosis, a condition where abnormal proteins build up in organs and cause damage. QLS4131 is a trispecific antibody designed to target and eliminate the plasma cells produci…

This trial tests whether ezetimibe, a common cholesterol-lowering medication, can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who undergo catheter ablation. Half of the 120 participants will take ezetimibe daily for six months after the…

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This study tests the long-term safety and effectiveness of an experimental oral drug called S-606001 in adults with late-onset Pompe disease, a genetic condition that causes progressive muscle weakness. Participants who completed a prior S-606001 study can join, and they will rec…

This study tests an experimental drug called elranatamab in people newly diagnosed with AL amyloidosis who have not yet had treatment. The drug helps the body's immune cells find and destroy the abnormal cells causing the disease. Researchers want to see if it can produce deep re…

This study looks at two ways to treat atrial fibrillation (a common heart rhythm problem) in people aged 78 and older. One approach uses a procedure called catheter ablation to fix the heart's electrical signals, while the other uses medications to control heart rate or rhythm. R…

This trial tests whether a minimally invasive heart bypass surgery, done through a small incision on the left side of the chest, helps frail adults aged 60 and older recover better than the traditional approach of opening the breastbone. Participants are randomly assigned to one …

This trial tests whether combining two advanced heart-mapping technologies can make ablation for ventricular tachycardia (VT) more accurate and effective. The approach merges a non-invasive 3D electrical map of the heart with detailed scar imaging from an MRI, aiming to better ta…

This trial investigates whether a daily dose of alpha-lipoic acid, a vitamin-like antioxidant, can lower the risk of major heart problems in people with chronic heart failure caused by coronary artery disease. Researchers will compare the supplement against a placebo in over 1,50…

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This study is testing two ways to perform a repeat ablation procedure in people with atrial fibrillation (an irregular heartbeat) that has returned after a first treatment. Both approaches use pulsed-field ablation to isolate the pulmonary veins, but one also adds ablation of the…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This trial tests whether adding a minimally invasive mitral valve repair (transcatheter edge-to-edge repair, or TEER) to standard catheter ablation improves outcomes for people with both atrial functional mitral regurgitation and atrial fibrillation. Participants are randomly ass…

This trial tests whether a virtual world-based cardiac rehabilitation program can improve heart health and participation compared to standard in-person rehab. The program, called Destination Cardiac Rehab, is a 3D interactive telehealth option that patients can use from home. Res…

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This trial tests whether dapagliflozin, a drug used for diabetes, can improve blood flow in the tiny vessels of the heart in people with angina (chest pain) but no blocked coronary arteries. Participants will take either dapagliflozin or a placebo daily for 180 days. The study me…

This trial tests whether tirzepatide, a weekly injection used for diabetes and weight loss, can improve physical function in adults with heart failure and obesity. Participants will receive either tirzepatide or a placebo for six months, while continuing their usual heart failure…

This trial compares two standard IV medicines—verapamil and metoprolol—to see which controls rapid heart rate better in adults with atrial fibrillation who are otherwise stable. Patients receive one of the drugs in the emergency department, and their heart rate, blood pressure, a…

This trial tests whether a catheter-based procedure called transcatheter edge-to-edge repair (TEER) can improve outcomes in people with atrial functional mitral regurgitation, a condition where the heart's left atrium enlarges and causes the mitral valve to leak. The study will e…

This study tests whether adding mobile health tools—like smartphone apps, connected scales, blood pressure monitors, and activity trackers—to standard cardiac rehab helps heart patients monitor their health and stick to healthy habits at home. The trial enrolls adults who have ha…

This trial compares two ways of giving tranexamic acid, a drug that reduces bleeding, to adults undergoing off-pump coronary artery bypass surgery. Half receive the drug as a pill before surgery, while the other half get it through an IV during surgery. The goal is to see if the …

This phase 3 trial is testing an investigational drug called abelacimab in about 2,500 people with atrial fibrillation (an irregular heartbeat) who are at high risk for stroke but cannot take standard oral blood thinners. Participants will receive either abelacimab or a placebo, …

This trial asks whether people with severe aortic stenosis can safely go home the same day after a minimally invasive heart valve replacement (TAVI) instead of staying in the hospital. About 764 patients who are stable six hours after the procedure will be randomly assigned to ei…

This trial tests whether wearing a portable heart monitor for two weeks after a TAVI procedure can reduce the risk of sudden death, dangerous heart rhythms, or stroke within the following year. People who have had a successful TAVI and show certain electrical abnormalities on the…

This trial tests an investigational medicine called ATR 1072 in adults with PRKAG2 syndrome, a genetic condition that causes abnormal heart muscle thickening and rhythm problems. The drug is designed to reduce the activity of the faulty PRKAG2 gene. Researchers are evaluating its…

This study tests a new device (Sphere-9 catheter and Affera system) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in 260 adults who have had a heart attack. Participants must have had repeated episodes despite medication or a defibrillator. The goal is to see …

This trial tests whether heart attack patients who have had complete artery-opening procedures can safely stop aspirin after 3-6 months and continue with only a P2Y12 inhibitor. The goal is to see if this approach reduces bleeding problems without increasing the risk of another h…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This trial tests whether angiotensin receptor blockers (ARBs), a type of blood pressure medication, can reduce the risk of death or heart failure in people who have had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis and still have a thickened heart mus…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This trial is testing a new device called the Crea Aortic Valve, a replacement heart valve that can be implanted through a catheter without open-heart surgery. It is designed for people aged 60 and older with severe aortic stenosis—a narrowing of the heart's main valve—who are co…

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This trial tests whether a lab-grown, tissue-engineered blood vessel can be safely used as a bypass graft in people with coronary artery disease undergoing heart bypass surgery. Ten participants will receive the artificial vessel alongside a standard graft, and researchers will m…

This trial investigates whether a high-protein diet, with or without an HMB supplement, can improve muscle mass, strength, and physical function in people with heart failure. Participants are randomly assigned to one of three groups: a standard-protein diet, a high-protein diet, …

This trial tests whether adding eccentric cycling—a type of exercise where muscles lengthen under tension—to standard cardiac rehabilitation can improve recovery in people who have had a heart attack. Eccentric exercise may allow higher muscle loads with less cardiovascular deman…

This trial tests whether adding extra ablation lines to the standard pulsed-field ablation procedure helps people with long-standing atrial fibrillation (AF) stay in normal heart rhythm. 430 participants with AF lasting 1-3 years will be randomly assigned to receive either standa…

This study tests whether a best-practices checklist can help emergency doctors manage acute heart failure more effectively. The checklist guides assessment, treatment, and decisions about whether to admit or discharge patients. Researchers are introducing the checklist in four la…

This trial tests whether a procedure called pulsed field ablation can safely treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. About 30 people with frequent premature heartbeats or ventricular tachycardia will receive the treatment using a special…

This trial tests whether a year-long, supervised exercise program — including aerobic, resistance, and breathing exercises — can improve outcomes for people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either usual care or usu…

This trial tests whether an AI system can help doctors choose better ventilator settings for children (ages 1 month to 18 years) in the pediatric ICU who need a breathing machine. Half of the children will receive standard care, while the other half will have their ventilator adj…

This trial tests a new suture system designed to close a patent foramen ovale (PFO), a small hole in the heart that can increase stroke risk. Researchers will compare the new device to an existing occluder in about 244 adults aged 18 to 65 with moderate-to-large PFOs. The goal is…

This trial tests whether a nurse-led education program can improve self-care knowledge in people with heart failure in Rwanda. About 400 participants from three district hospitals will receive illustrated flip-book teaching and a simplified handout. The study measures changes in …

This trial tests whether a mechanical, spring-driven device called FreedomEDGE® can safely and effectively deliver daratumumab, a standard treatment for multiple myeloma and amyloidosis. Currently, nurses give these injections by hand, which can be physically demanding. About 100…

This trial tests whether a 9-month program called STEP COACH can help people with coronary artery disease stay physically active after completing cardiac rehab. Participants use their own smartwatch or smartphone to track steps and receive coaching on increasing both step volume …

This pilot study is testing whether a smartphone app called HeartMate can help people with heart disease manage their condition from home. Over six weeks, participants use the app for daily heart checks, guided exercise, breathing training, and a mind program, with weekly coachin…

This trial investigates whether a new pulsed field ablation system can safely and effectively treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The system uses short electrical pulses to destroy tiny areas of heart tissue causing the abnormal rh…

This study tests a new device called the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System for people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is placed through a catheter, avoiding open-hear…

This trial tests whether a personalized exercise program before heart surgery can improve physical fitness in adults with congenital heart disease. Participants are randomly assigned to either usual care or a 6-week prehabilitation plan with aerobic, breathing, and strength exerc…

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The…

This trial tests whether adding tirzepatide (Mounjaro) to a structured lifestyle program reduces the return of atrial fibrillation within a year after catheter ablation in obese patients. About 710 participants with symptomatic AF and a BMI of 28 or higher (or 24 with other risk …

This study tests whether a virtual team of clinical pharmacists and cardiologists can help doctors prescribe the right heart failure medications for Veterans. Many patients do not receive all recommended drugs at effective doses after a hospital stay. The team reviews patient rec…

This study looks at how well a device can close a common heart hole called a ventricular septal defect (VSD) in children aged 6 months to 18 years. Instead of open-heart surgery, doctors use a small tube to place a device that plugs the hole. The goal is to see if this method is …

This study looks at whether eating a daily serving of peanut butter at breakfast can improve blood sugar control, thinking skills, and heart health in middle-aged adults with prediabetes. Participants will either add peanut butter to their first meal or stick with their usual die…

This study tests a device called the Globe Pulsed Field System, which uses short bursts of electric energy to destroy tiny areas of heart tissue that cause abnormal rhythms in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). The tria…

This study investigates whether two common vaccines—the shingles vaccine (RZV) and an RSV vaccine (RSVPreF3)—can slow the buildup of fatty plaque in the coronary arteries. The trial enrolls adults aged 50 and older who are at risk for cardiovascular events. Participants receive e…

This trial tests a device called the Corheart 6, a left ventricular assist system that helps pump blood in people with advanced left ventricular heart failure. The study includes 100 adults aged 18 to 75 with severe heart failure symptoms despite optimal medical therapy. The main…

This phase 3 trial compares an experimental CAR-T cell therapy, NXC-201, with a standard drug combination (daratumumab plus CyBorD) in people newly diagnosed with AL amyloidosis, a rare condition where abnormal proteins damage organs. Participants receive either a single infusion…

This trial tests whether adding a 3D holographic visualization tool, called EchoPixel Holographic Therapy Guidance, helps doctors perform two common heart procedures more accurately. The procedures are left atrial appendage occlusion (for atrial fibrillation) and mitral valve rep…

This study tests whether a nurse-led discharge education program helps heart failure patients avoid unplanned hospital readmissions within 30 days. The program includes an educational assessment, a discharge session using the teach-back method, and a follow-up phone call. Researc…

This trial compares a minimally invasive surgery that closes off a small heart pouch (the left atrial appendage) to standard blood-thinning medication in people with atrial fibrillation who have a high risk of bleeding. The goal is to see if the surgery can prevent strokes, major…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests whether adding a small amount of saltwater (hypertonic saline) to a standard water pill (furosemide) can help people with heart failure and kidney disease. The goal is to improve fluid removal, reduce hospital readmissions, and lower the risk of death. The trial …

This study tests whether a personalized high-intensity interval training (HIIT) program can improve exercise capacity and quality of life in people with heart failure with preserved ejection fraction (HFpEF). Participants are randomly assigned to either a 24-week HIIT plan tailor…

This study looks at whether giving doctors—and sometimes patients—personalized reports on recommended heart failure treatments helps more people get the right medications. It involves adults with heart failure and reduced ejection fraction (HFrEF) in the Netherlands. The goal is …

This study tests whether giving high-risk heart attack patients personalized education before they leave the hospital can reduce their chances of being readmitted. The education covers disease management, medication adherence, lifestyle changes, and recognizing warning signs. Res…

This trial investigates whether photobiomodulation—applying low-level laser light to the surgical wound—can improve healing and reduce complications after coronary artery bypass grafting (CABG). It compares two methods of harvesting the saphenous vein (the conventional technique …

This trial investigates whether vericiguat, added to standard treatment, can improve quality of life and reduce hospitalizations in adults with heart failure and reduced ejection fraction. Participants receive either vericiguat or a placebo for six months, and their health status…

This study tests whether community health workers (CHWs) can help people with rheumatic heart disease (RHD) take their monthly antibiotic shots consistently. The trial will enroll about 308 participants in Brazil and Timor-Leste, including adults and children with RHD and their c…

This study compares a long-acting antibiotic called dalbavancin to standard therapy for treating infective endocarditis, a serious infection of the heart valves caused by certain bacteria. Dalbavancin is given as one or two intravenous infusions, while standard therapy requires d…

This trial tests whether using a detailed CT scan of the heart's arteries before a procedure to open blockages (PCI) can make the procedure more efficient. About 200 adults with coronary artery disease will be randomly assigned to either have their procedure guided by a pre-plann…

This study tests a four-month digital program designed to help people with chronic heart failure take their medications as prescribed. The program includes personalized planning, motivational counseling, and symptom tracking. Researchers will enroll 870 adults in Pakistan who hav…

This clinical trial is testing a new heart valve replacement system called Encantor, which uses software to guide placement of the valve. The study includes 150 adults with severe aortic stenosis who are candidates for a minimally invasive procedure. Researchers will track how ma…

This study tests a small, hourglass-shaped device implanted in the heart's upper chambers to lower pressure and reduce fluid buildup in the lungs. It is for people with advanced heart failure whose heart pumps weakly (ejection fraction 40% or less). The trial randomly assigns som…

This study tests a newer, more natural pacing method for people with heart failure and electrical problems in the heart. The approach uses the heart's own conduction system to improve coordination between chambers. Researchers will track patients for two years to see if this meth…

Many children with complex congenital heart disease struggle with executive functions like attention, planning, and self-control, which are crucial for school and daily life. This study tests a 12-week program called E-Fit that combines computer-based cognitive training, one-on-o…

This study tests whether wearable devices like smartwatches and ECG straps can help doctors remotely manage patients with both heart failure and atrial fibrillation. Participants use the devices to send real-time health data to their care team, who adjust medications and treatmen…

This trial tests whether a newer balloon-expandable heart valve with intermediate sizes (Myval) is as safe as a standard self-expanding valve (Evolut) in people with severe aortic stenosis whose valve measurements fall in a 'borderline' range. About 600 participants will be rando…

This study tests a new imaging and guidance system called VERAFEYE that creates a 3D model of the heart to help doctors navigate during catheter ablation for atrial fibrillation. About 50 adults with paroxysmal or persistent atrial fibrillation will have their standard ablation p…

This study tests whether pelvic floor muscle training (PFMT) with a handheld biofeedback device can improve erectile function and sexual quality of life in men with functional hypogonadism (low testosterone) and erectile dysfunction. Participants are randomly assigned to PFMT wit…

This study tests whether adding a combination of an SGLT-2 inhibitor (henagliflozin) and a probiotic to standard heart failure treatment can improve heart function and quality of life in people over 60 with a specific type of heart failure called HFpEF. The trial randomly assigns…

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This trial tests a nurse-led program designed to help people with chronic heart failure better manage fluid buildup—a common cause of hospital readmission. The program includes education, emotional support, and practical skills like daily weighing and salt restriction. Researcher…

This trial tests whether filtering a specific inflammatory protein (C-reactive protein, or CRP) from the blood can improve outcomes in people with cardiogenic shock—a life-threatening condition where the heart cannot pump enough blood—after a heart attack. About 50 participants w…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, reduce hospitalizations, and boost quality of life in adults aged 65 and older who have heart failure with preserved ejection fraction and iron deficiency. Participants receive…

This study tests two chemotherapy-free treatments for people newly diagnosed with AL amyloidosis, a rare blood disorder. The choice of treatment depends on whether the patient has a specific genetic change called t(11;14). Those with t(11;14) receive a daily pill called sonrotocl…

This trial investigates whether patients with acute coronary syndrome can safely stop taking aspirin soon after a heart stent procedure and continue with only a potent antiplatelet drug (ticagrelor or prasugrel). The standard approach is to take both aspirin and a P2Y12 inhibitor…

This study is testing a new artificial heart valve, called the TRIFORMIS RESILIA, for people who need their tricuspid valve replaced. The tricuspid valve controls blood flow between two right heart chambers. Researchers will follow 75 adults who receive this valve during surgery …

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This study tests whether adding a drug called inclisiran to standard cholesterol-lowering therapy (statins) helps people who recently had a heart attack or unstable angina lower their LDL ('bad') cholesterol more than statins alone. About 300 adults in Saudi Arabia will receive e…

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in…

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent A…

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This phase 2 trial tests an oral drug called Aom0304 in adults with hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. The study includes people with both obstructive and non-obstructive forms. Participants receive different doses of Aom0304 for …

This trial compares a new temporary heart pump called VentriCure with standard ECMO support in people with coronary artery disease undergoing high-risk angioplasty. The study includes 220 patients whose hearts are weak or who have severe heart failure. The goal is to see if Ventr…

This early-stage study tests a new treatment called HiCM-188, made from stem cells that become heart muscle cells. It is given as a single injection into the heart during bypass surgery in 12 adults with severe heart failure. The main goal is to check safety and see if it improve…

This study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This early trial tests a new device called Anchord that repairs leaky mitral valves without open-heart surgery. It will include 5 people with severe valve leakage who are too high-risk for standard surgery. The goal is to see if the device is safe and can reduce the leak, improvi…

This study tests a wearable device that tracks heart rate, breathing, activity, and fluid buildup in people recently hospitalized for heart failure. 800 participants will either get standard care or standard care plus the device for 90 days. The goal is to see if early alerts fro…

This study tests whether metformin, a standard diabetes medicine, can improve heart function in people who have received a mechanical heart pump (LVAD) for severe heart failure. Researchers will give metformin or a placebo to 108 patients for 12 months and check heart function, b…

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study tests whether the diabetes drug ertugliflozin, started within 72 hours of a first heart attack, can improve heart function in people with type 2 diabetes. About 476 adults will be randomly assigned to take the drug or receive standard care. Researchers will measure cha…

This trial will compare three drugs—dopamine, norepinephrine, and epinephrine—to see which works best for people experiencing a pulmonary hypertensive crisis, a life-threatening spike in blood pressure in the lungs. The study will enroll 75 adults with pulmonary arterial hyperten…

This pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This study tests a new device called the X-Clip, which is used to repair a leaky mitral valve without open-heart surgery. The device is inserted through a blood vessel and clips the valve to help it close better. The trial will include 15 adults with moderate-to-severe or severe …

This study tests whether mazdutide, a weekly injection that helps with weight loss, can slow the buildup of fatty plaque in the heart arteries of 116 overweight or obese adults with coronary heart disease. Participants will receive either the drug or a placebo for 52 weeks, and d…

This study compares two ways to guide stent placement during emergency treatment for a severe type of heart attack (STEMI). About 2,500 patients will be randomly assigned to receive either standard X-ray guidance or ultrasound guidance (IVUS) during the procedure. The goal is to …

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This study tests whether adding a preventive procedure called pulmonary vein isolation (PVI) to the standard ablation for typical atrial flutter can reduce the risk of heart-related hospital visits, stroke, or death. The trial enrolls adults aged 55 and older with an enlarged lef…

This registry will follow 500 people with symptomatic atrial fibrillation who are scheduled for a heart ablation using the Globe Pulsed Field System. The goal is to see how well the device controls the heart rhythm over 12 months and to track any major side effects within the fir…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study tests whether using detailed PET-CT scans to guide where a pacemaker lead is placed can improve heart function in 20 people with heart failure. Participants will receive a standard pacemaker, but the lead position will be chosen based on scan data. The goal is to see i…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This study looks at whether icosapent ethyl, a purified fish oil medication, can reduce inflammation and improve heart structure in people with coronary artery disease. Researchers will follow 420 patients for one year, comparing those who receive standard care plus icosapent eth…

This trial tests whether a new scoring system, called the Biological Congestion Score (BCS), can help doctors better manage diuretic medications in people with chronic heart failure. The BCS combines four blood biomarkers with clinical information to estimate fluid congestion and…

This study looks at 240 adults having a major heart attack (STEMI) when the standard emergency procedure to open the blocked artery is expected to be delayed by over an hour. Half will get a clot-busting drug (tenecteplase) right away, followed by the procedure within 2-24 hours.…

This study compares a moderate statin (pitavastatin) combined with ezetimibe against high-intensity statins (atorvastatin or rosuvastatin) in patients aged 75+ with coronary artery disease who need a stent. The goal is to see if the combo is just as good at preventing heart attac…

This study tests whether measuring sodium in urine can help doctors give the right amount of diuretics (water pills) to people hospitalized with worsening heart failure. About 260 adults will be split into two groups: one gets standard care, the other gets treatment guided by uri…

This study tests whether a non-invasive ear stimulation, called low-level tragus stimulation, can reduce inflammation and early heart rhythm problems after pulsed field ablation for atrial fibrillation. Forty-six adults with atrial fibrillation will receive either active or sham …

This study looks at a device called ShortCut that splits old heart valve leaflets before placing a new valve inside it. The goal is to keep the arteries open and prevent blockages. About 150 people with aortic stenosis who are at risk for this complication will take part. Researc…

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study will enroll 30,000 adults in China with atrial fibrillation (a type of irregular heartbeat) that hasn't improved with medication. They will receive a new type of catheter treatment called pulse-field ablation. Researchers will track their health for up to 10 years to s…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can improve quality of life and exercise ability in elderly patients with a common type of heart failure (HFpEF). Fifty adults aged 60 and older will receive either the transplant or a …

This study tests a drug called pelacarsen in people who recently had a heart attack and have high levels of Lp(a), a type of fat in the blood that raises heart risk. The goal is to see if the drug can safely lower Lp(a) levels and improve heart health. About 240 adults in the US …

This study tests whether customizing ventilator settings during heart bypass surgery can lower the risk of lung complications like pneumonia or respiratory failure. Researchers will compare a standard approach with one that adjusts settings based on lung mechanics. Eighty adults …

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests whether a structured heart-health program can improve heart outcomes in 800 cancer survivors who have heart problems or high heart risk. The program includes exercise, nutrition advice, stress support, and risk-factor management over 12 months. Researchers will c…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This study compares two supervised treadmill exercise programs for people recovering from coronary artery disease or a heart procedure. One group does high-intensity interval training (HIIT) — short, hard efforts with rest periods — while the other does moderate-intensity continu…

This study compares a stepwise blood-thinning approach to the standard method in 424 patients with atrial fibrillation who are at high risk for stroke and need a heart device like a pacemaker. The stepwise plan involves stopping the blood thinner one day before surgery and restar…

This study tests whether a newer drug, Vernakalant, works better than the standard Amiodarone for treating atrial fibrillation (irregular heartbeat) that often occurs after heart surgery. About 50 adults who recently had heart surgery will receive one of the two drugs. The main g…

This study tests whether adding a Chinese herbal medicine called Qidan Xiaoke Granules to standard heart drugs can reduce major heart problems like heart attacks or repeat procedures in people who have had a stent placed. About 164 adults with coronary artery disease will take th…

This study will compare a newer, less invasive heart procedure called hybrid revascularization to standard coronary artery bypass grafting (CABG) in over 1,000 people with multiple blocked heart arteries. The hybrid approach combines a small incision to graft a key artery with st…

This study tests a non-invasive radiation treatment called STAR for people with a dangerous fast heart rhythm caused by heart scarring. Instead of using medications or a catheter procedure, a single targeted dose of radiation is delivered to the scarred area. The goal is to see i…

This study looks at whether adding a small amount of salt (3 grams daily) to the diet can help people with chronic heart failure who have low blood sodium levels. Researchers will compare salt pills to a placebo in 30 adults over three months. The goal is to see if salt improves …

This early study tests whether the drug CAEL-101/anselamimab can bind to and shrink abnormal protein deposits (amyloid) in people with AL amyloidoma. Five adults with measurable amyloid deposits will receive the drug and be monitored for up to 72 weeks. The goal is to see if the …

This study tests whether Baduanjin, a gentle traditional Chinese exercise, helps people recover after heart bypass or stent surgery. Researchers will track 310 adults for up to a year to see if it lowers the risk of heart attacks, chest pain, or the need for more procedures. The …

This study looks at whether starting blood thinners (DOACs) is safe and effective for people who have had a stroke, but also have a history of a brain bleed and an irregular heartbeat (atrial fibrillation). About 852 participants will be randomly assigned to receive either a bloo…

This study looks at whether moderate treadmill walking can improve how children aged 4 to 6 with surgically corrected acyanotic congenital heart disease walk, balance, and move. Eighty children will take part, with some doing treadmill sessions four times a week for 10 weeks. Res…

This pilot study tests two ways of running a temporary heart pump (Impella CP) during a high-risk procedure to open blocked heart arteries in patients with weakened heart muscle. Fifty patients will be randomly assigned to either an automatic mode that adjusts flow or a fixed low…

This study compares two types of pacemaker procedures in adults with heart failure and atrial fibrillation who are not candidates for rhythm control. All participants will receive a heart ablation, then be randomly assigned to either conduction system pacing or standard cardiac r…

This study tests a procedure called renal denervation, which uses a catheter to calm overactive nerves in the kidneys, in 1,000 people with both resistant hypertension and multivessel coronary artery disease. Participants will undergo the procedure during a planned heart stent op…

This study tests whether using a patient's genetic information to choose anti-platelet drugs can lower bleeding risks compared to standard care. About 1,760 high-risk patients receiving a heart stent will be assigned to either a personalized drug plan or usual therapy. The goal i…

This study tests whether a new wire-free imaging method called μFR can help doctors decide which blocked heart arteries need stents after a heart attack. About 350 patients with multiple blocked arteries will be randomly assigned to standard care or μFR-guided treatment. The goal…

This study tests whether a new catheter ablation system using pulsed field energy can better control persistent atrial fibrillation (AF) by targeting low-voltage areas in the heart and isolating the superior vena cava, in addition to standard pulmonary vein isolation. About 618 a…

This study will test whether taking ginger supplements for two months can lower inflammation and oxidative stress in people with coronary artery disease. Fifty adults with confirmed heart disease will be randomly assigned to receive either ginger extract or a placebo. Researchers…

This pilot study tests a special pacemaker-like device called Moderato Plus in 20 people with high blood pressure and a type of heart failure where the heart pumps normally but is too stiff (HFpEF). The device delivers Cardiac Neuromodulation Therapy to help control blood pressur…

This study looks at whether taking royal jelly and propolis (natural bee products) for two months can lower inflammation and improve heart health in 50 adults with coronary artery disease. Participants will be randomly assigned to receive the supplements or a placebo, and researc…

This study tests a new approach for women with chest pain who don't have blocked arteries. Doctors will use special tests to find the exact cause of the pain, then give each woman a personalized treatment plan. The goal is to see if this tailored approach improves symptoms and qu…

This study compares 1 month versus the standard 6 months of dual antiplatelet therapy (two blood thinners) in people who had a balloon procedure for small coronary artery disease. About 1,484 adults with stable angina or silent ischemia will be randomly assigned to either short o…

This study tests three different ways to remove excess fluid in people with worsening heart failure. Participants will receive intravenous furosemide alone, or combined with either acetazolamide or hydrochlorothiazide. The goal is to see which combination works best and is safest…

This study tests whether adding extra ablation to standard treatment can help people with persistent atrial fibrillation (a type of irregular heartbeat). About 350 adults will be randomly assigned to receive either standard ablation or standard ablation plus isolation of the left…

This study tests whether the drug propranolol can prevent heart injury after breast cancer surgery in women who also have high blood pressure or angina. One hundred participants will either receive propranolol before surgery or standard care. Researchers will measure heart stress…

This study tests whether the drug finerenone can reduce scarring in the heart muscle and improve heart structure and function in people with heart failure. About 104 adults with mild to moderate heart failure will receive either finerenone or a placebo for 6 months. The main goal…

This study tests a drug called NL005 in people who have had a severe type of heart attack (STEMI) and undergone emergency artery-opening treatment. The goal is to see if NL005 can reduce permanent heart muscle damage. Participants will receive either NL005 or a placebo daily for …

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This study compares a drug-coated balloon (DCB) to a drug-eluting stent (DES) for treating new blockages in heart arteries. About 1,548 adults with stable or unstable angina, old heart attacks, or silent ischemia will be randomly assigned to one of the two treatments. The main go…

This study tests whether an external abdominal tourniquet can temporarily block blood flow to the lower body during cardiac arrest, redirecting it to the brain and heart. Researchers will try it on 5 adults with non-traumatic cardiac arrest outside a hospital. The goal is to see …

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This trial tests whether a special ultrasound technique can detect heart muscle ischemia (reduced blood flow) in people with suspected acute coronary syndrome. The approach uses microbubbles that stick to activated immune cells and blood vessel linings, potentially revealing infl…

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This study aims to build a comprehensive prediction rule for diagnosing acute heart failure in the emergency department. It will enroll 560 adults with suspected heart failure or acute shortness of breath. Participants will undergo standard tests, including blood work, lung ultra…

This trial is testing whether an artificial intelligence-enhanced electrocardiogram (AI-ECG) can help doctors quickly and safely identify which people with non-cardiac chest pain are truly low risk. Half of the participants will receive the AI-ECG in addition to standard care, wh…

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether an experimental contrast agent called NH002 can improve the quality of heart ultrasound images in adults with suspected or known heart disease. The agent is given as an injection or infusion and contains tiny microbubbles that help outline the heart's inn…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

This study explores whether the electrical signal measured by a pacemaker or defibrillator during implantation can help identify cardiac amyloidosis — a condition where abnormal proteins build up in the heart. Researchers will enroll 242 adults aged 65 and older who already need …

This trial tests whether an accelerated heart MRI scan, taking only 15 to 20 minutes, can diagnose coronary artery disease as accurately as the standard 45- to 50-minute scan. About 2,000 adults with suspected coronary heart disease will be randomly assigned to receive either the…

This trial tests whether a Doppler ultrasound patch placed on the neck can quickly and accurately detect when a cardiac arrest patient's heart starts beating again during emergency resuscitation. The patch's readings are compared to those from an arterial line, the gold standard …

This study enrolls children and young adults scheduled for heart surgery or catheterization under general anesthesia. Researchers place a forehead sensor that measures tissue oxygen levels and use an algorithm to estimate blood hemoglobin. The goal is to see if this noninvasive m…

This study tests whether an artificial intelligence software, SMD-AFECG, can predict the risk of atrial fibrillation (AF) within the next two hours using data from a single-lead electrocardiogram (ECG). Researchers will analyze nearly 800 ECG recordings from a hospital database, …

This study tests whether an artificial intelligence software called SMD-RVECG can predict the risk of atrial fibrillation with rapid ventricular response (a fast, irregular heart rhythm) within the next two hours. Researchers will analyze 348 existing single-lead electrocardiogra…

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study explores whether specialized eye imaging can identify people with a rare heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). Researchers will use machine learning to analyze eye scans from 500 adults—some with ATTR-CM and others with heart failure bu…

This study evaluates whether a quick blood test for NT-pro-BNP, done in a doctor's office, can help diagnose heart failure earlier in rural areas where specialists are scarce. The test is given to people over 60 with symptoms like shortness of breath or swelling. Researchers will…

This study will test whether an algorithm that analyzes data from Withings smart scales (weight, body water, and step counts) can accurately detect heart failure. Researchers will look back at data from 9,000 people aged 45 and older in the US. If the algorithm works well, it cou…

This study evaluates a simple questionnaire designed to detect decompensated heart failure—a sudden worsening of heart failure—in people aged 55 and older on Réunion Island. Researchers will compare the questionnaire's results with standard heart exams (echocardiogram, ECG, and c…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study looks at 115 children aged 6 months to 5 years who have a hole in the heart (VSD) and need surgery. Doctors want to see if an ultrasound probe placed in the food pipe (TEE) can measure heart pressure as accurately as the standard method using a thin tube (catheter) ins…

This study explores whether an additional CT scan of the heart, taken right after a standard scan for lung clots, can effectively detect blood clots in the left atrial appendage (LAA) in people with atrial fibrillation. Currently, detecting these clots requires a more involved pr…

This study will test whether a small, wearable patch that records heart activity for 7 days can find undiagnosed atrial fibrillation (a common heart rhythm problem) in 30,000 Chinese adults aged 60 and older. Participants will wear the patch and then be followed for up to 10 year…

This study explores whether a PET/MR scan using a radioactive tracer called 18F-Florbetaben can detect amyloid deposits—abnormal protein clumps that can damage organs—in people with certain blood disorders. Participants receive a single injection of the tracer followed by a whole…

This study will test whether a deep learning-based image reconstruction method can improve the quality of coronary CT scans. Researchers will look at existing scans from 200 patients who had a CT angiogram for suspected heart disease. Two radiologists will rate the images on a sc…

This pilot study will test whether an AI-assisted ultrasound device can help emergency doctors quickly detect heart failure in patients with symptoms. About 84 adults visiting the ER with signs of heart failure will be enrolled. The goal is to see if this approach is practical an…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study will test whether a faster type of bone scan (CZT-SPECT) can accurately diagnose transthyretin cardiac amyloidosis, a serious heart condition. Researchers will compare the new scan with the standard method in 200 patients. If it works, it could make diagnosis quicker a…

This study tests whether an AI tool called RADAR can help nurses in low-resource settings detect rheumatic heart disease more accurately using echocardiography. The goal is to make screening easier to scale up worldwide. The trial will enroll 62 nurse screeners at participating f…

This pilot study will test whether breathing controlled amounts of carbon dioxide (CO2) can help doctors see blood flow in the heart using MRI, without needing standard contrast dyes. Thirty adults with known or suspected coronary artery disease will take part. The goal is to che…

This study aims to see if a new method using electrical and mechanical signals from the heart can accurately diagnose valvular heart disease. Researchers will recruit 1,300 adults with and without valve problems to compare the new test against standard echocardiography. If it wor…

This study will see if community pharmacies can effectively screen people aged 65 and older for atrial fibrillation, a heart condition that raises stroke risk. Trained pharmacists will use a small, portable ECG device to record a 30-second heart reading. If the result is abnormal…

This pilot study tests whether a computer-controlled device that delivers precise gas mixtures can safely help identify coronary artery disease in people without known heart problems. Eighty healthy adults aged 45 and older will breathe different gas concentrations while their vi…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests whether a computer model can find signs of a heart condition called cardiac amyloidosis in bone scans that were done for other reasons. Researchers will look back at 57 patients' scans to see if the model can correctly identify those with the disease. If it works…

This study tests whether a simple, 1-minute electrocardiogram (ECG) analyzed by artificial intelligence can accurately detect significant blockages in the heart's arteries. Researchers will compare the AI's predictions against standard imaging tests in 400 adults. If successful, …

This trial tests whether a structured oral hydration plan—drinking at least 1,500 mL of fluid within 12 hours around the procedure—can reduce the risk of contrast-induced acute kidney injury (CI-AKI) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary P…

This trial tests whether cutting out a small fibrous structure called the Ligament of Marshall during minimally invasive heart bypass surgery can prevent new-onset atrial fibrillation (an irregular heartbeat) that often occurs after the operation. The study will include 628 adult…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study investigates whether screening older veterans (age 65 and older) who have a higher risk of atrial fibrillation—a condition where the heart beats irregularly—can reduce their chances of stroke, heart failure, or death. Participants selected for screening wear a small, w…

This study tests an investigational nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. About 750 adults will be randomly assigned to use either the real spray or a placebo at home when symptoms start. Th…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether a special ketone drink can help people hospitalized with acute heart failure. The drink is given three times a day for five days. Researchers will measure changes in heart stress markers and symptoms. The goal is to see if ketones can improve energy for t…

This trial tests whether slow-paced breathing—reducing breaths to 4-7 per minute—can improve heart rate variability, a marker of heart health, in hospitalized heart failure patients. Participants will be randomly assigned to either standard cardiac rehab alone or rehab plus slow-…

This trial tests whether placing a small catheter near the breastbone to deliver local anesthetic can reduce pain after coronary artery bypass surgery. Half of the participants will receive this catheter-based pain relief, while the other half gets standard care. Researchers will…

This study tests whether a mobile health program can help people with heart failure increase their physical activity and stay active. The program includes a smartphone app for goal-setting and self-monitoring, an AI-based health coach trained in motivational interviewing, and occ…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

This study tests an experimental medicine called BAY 3670549 in 360 adults with atrial fibrillation (an irregular heartbeat). Participants receive a single IV dose of the drug or a placebo to see if it can restore normal heart rhythm without needing an electrical shock procedure.…

This trial tests whether an 8-week daily resistance exercise program can reduce chest pain and improve daily function in women who have angina without blocked coronary arteries (ANOCA). Around 76 to 152 women across 13 hospitals in the UK and Netherlands will be randomly assigned…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This trial investigates whether a structured, moderate-intensity cardiac rehabilitation program is safe for people with arrhythmogenic cardiomyopathy who carry high-risk genetic mutations. Participants will be randomly assigned to either the exercise program or standard physical …

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This study tests an 8-week online group program designed to help adults with congenital heart disease become more aware of internal body sensations like breathing, heart rate, and fatigue. The goal is to see if this approach is feasible and acceptable, and whether it can improve …

This study tests whether an 8-week virtual wellness program is practical and helpful for unpaid caregivers of people with advanced heart or lung disease. The program includes personalized exercise, nutrition advice, and stress management, all delivered at home with professional s…

This study compares two ways to sedate patients during a heart scan and electric shock treatment for atrial fibrillation. Currently, a cardiologist gives mild sedation for the scan, but an anaesthesiologist must give stronger sedation for the shock, causing delays. Researchers wa…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study tests whether giving magnesium along with the standard drug metoprolol can quickly lower a dangerously fast heart rate in people with atrial fibrillation or atrial flutter. About 196 adults in the emergency room will receive either magnesium or a placebo, plus metoprol…

This study tests a new type of breathing muscle training for people with heart failure. 108 participants will either do the new breathing exercise, a standard one, or usual care for 8 weeks. Researchers will measure if it improves exercise capacity, breathing strength, and qualit…

This study compares two types of exercise—moderate-intensity aerobic training and high-intensity interval training (HIIT)—in women aged 40-70 with stable heart failure. Over 12 weeks, researchers measure how each program affects functional capacity (e.g., walking distance) and qu…

This study tests whether a 6-month digital education program—with short videos on exercise, healthy eating, and stress management—can improve exercise capacity and quality of life in adults with heart failure and overweight or obesity. Fifty-two participants will be randomly assi…

This study tests whether wearing eye masks and/or earplugs at night can improve sleep quality and reduce delirium in 128 patients recovering from coronary artery bypass surgery. Participants will be randomly assigned to use these aids on the first three nights after surgery. Rese…

This study compares two types of nerve blocks—Intertransverse Process Block and M-TAPA—for pain after laparoscopic gallbladder removal. Sixty adults will be randomly assigned to receive one of the blocks. The main goal is to see which block provides better pain relief and reduces…

This study tests whether injecting a long-acting numbing medicine (bupivacaine) through chest tubes can safely reduce pain and lower the need for strong painkillers after heart bypass surgery. Sixty adults will receive either the numbing medicine or a saltwater placebo whenever t…

This study tests if combining arm and leg cycling exercise is better than leg cycling alone for improving fitness and quality of life in people who have had a heart attack. Forty medically stable adults aged 40-70 will exercise three times a week for six weeks. Researchers will m…

This study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…

This study tests whether structured play activities, done with a parent, can reduce anxiety in children with congenital heart disease before their surgery. About 204 children aged 0-12 will be randomly assigned to either receive therapeutic play plus standard care, or standard ca…

This study tests whether using mild electrical pulses on the diaphragm and belly muscles can improve breathing, heart function, and exercise ability in people who recently had a heart artery-opening procedure (angioplasty). 42 adults will receive either standard rehab plus this s…

This study tests two types of exercise—aerobic and resistance—both combined with blood flow restriction (using cuffs on the legs) in 40 people with stable heart failure. The goal is to see which approach better improves muscle oxygen levels, heart stress markers, daily function, …

This study compares deep sedation using a combination of three drugs (dexmedetomidine, remimazolam, and remifentanil) to standard general anaesthesia for patients undergoing a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if deep sedation can…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist air through the nose) can help people with heart failure exercise longer during cardiac rehab. Twenty-eight adults will do two treadmill tests—one with the device and one without—to compare end…

This study will compare two types of nerve blocks—Transversalis Fascia Plane Block and M-TAPA—for controlling pain after laparoscopic inguinal hernia repair. Sixty adults aged 18–65 will be randomly assigned to receive one of the blocks before surgery. Researchers will measure pa…

This study tests whether starting with a higher shock energy (360 J) is better than a standard 200 J for restoring normal heart rhythm in people with atrial fibrillation. About 400 adults will be randomly assigned to one of three groups, including a personalized approach based on…

This study tests whether a 12-week home exercise program, guided by a mobile app and smartwatch, can improve exercise capacity and quality of life in people with a left ventricular assist device (LVAD). About 78 participants who recently got an LVAD and cannot attend hospital reh…

This early study tests whether a special gel, injected into the heart during a procedure to open blocked arteries, can safely reduce injury in people having their first major heart attack. Twenty participants will be randomly assigned to get the gel plus standard care or standard…

This study compares three pain management approaches for 120 adults undergoing coronary artery bypass surgery: standard painkillers alone, standard plus a parasternal nerve block, or standard plus both parasternal and adductor canal blocks. The goal is to see if adding these nerv…

This study compares two types of nerve blocks to control pain after laparoscopic hysterectomy. Sixty women aged 18-65 will receive either an Intertransverse Process Block or an M-TAPA block. The main goal is to see which block provides better pain relief in the first 24 hours aft…

This study tests whether playing motion-sensing Nintendo Switch games can help children and teens with congenital heart disease become more physically active. Thirteen participants aged 8-18 will wear activity monitors and follow a 12-week exergame program with coaching and suppo…

This study tests a virtual psychological support program called HeartGPS for mothers whose babies are diagnosed with congenital heart disease before birth. About 210 mothers and their infants will take part, with some receiving the program plus usual care and others only usual ca…

This study compares two types of exercise—elliptical training and Swiss ball aerobics—to see which better helps people recover after heart bypass surgery (CABG). Researchers will measure improvements in walking ability, heart rate, shortness of breath, and quality of life. The st…

This study tests a digital exercise program that adapts in real time to help children aged 6 to 12 recover after congenital heart disease surgery. Kids wear a monitor and get personalized exercise prompts and feedback. Researchers will compare their recovery to children receiving…

This study tests whether an 8-week home telerehabilitation program, with real-time coaching and vital sign monitoring, can improve physical function and reduce frailty in older adults with heart failure. Seventy participants will be randomly assigned to either the telerehab progr…

This study tests whether low dose naltrexone (LDN) can reduce fatigue in people with Postural Orthostatic Tachycardia Syndrome (POTS). Eighty participants will receive either LDN or a placebo for 4 months. The goal is to see if LDN improves fatigue and quality of life.

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This trial tests a website called Heart2Heart, created for teens living with congenital heart disease. The site provides health information and interactive tools to help them stay healthy. Researchers want to see if teens will use and enjoy the site, and whether it changes their …

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study aims to build a specialized AI model, called CorAI, for coronary artery disease (CAD). Researchers will collect de-identified medical data from about 640 patients with suspected or confirmed CAD to create a rich dataset. Using this data, they will develop and test CorA…

This study looks at whether a digital tool called Luscii is practical and acceptable for people with a rare heart condition called ATTR-CM. About 60 adults in Austria, Germany, and Italy will use a smartphone app and home devices to share health information with their care team. …

This observational study looks at whether changes in a blood marker called NT-proBNP, measured at the bedside, can reflect how well fluid is being removed in patients hospitalized with acute decompensated heart failure. Participants receive standard care, and researchers track NT…

This study is a large, observational registry in Türkiye that will track the real-world practice and outcomes of a procedure called percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) — a complete blockage of a coronary artery that has been present for at l…

This study investigates whether levels of a protein called neurofilament light chain (NFL) in the blood can predict neurological recovery in people who remain comatose after a cardiac arrest. Researchers will measure NFL at several time points over the first week in the ICU and c…

This study tests whether a non-invasive sensor placed on the back can detect early signs of kidney injury in adults undergoing off-pump coronary artery bypass surgery. Kidney injury is common after such surgery, but current detection relies on blood tests that rise days later. Th…

This study investigates how often muscle relaxants used during general anesthesia remain in the body after surgery, a condition called residual neuromuscular blockade. It will follow 160 adults aged 18-90 who are scheduled for post-anesthesia care unit admission after elective su…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study looks at whether tiny plastic particles in the blood are linked to problems with the heart's small blood vessels. Researchers will measure microplastic levels in 184 people who are already having a heart procedure, and then check their heart vessel function and track t…

This observational study looks at how the blood thinner apixaban is processed in the bodies of Asian patients with atrial fibrillation. Researchers will analyze existing medical records and blood concentration data from about 200 patients to understand how factors like kidney fun…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study tests whether AI-generated avatar videos and a chatbot can better engage older Veterans in cardiovascular clinical trials compared to standard mailed letters. Veterans aged 65 and older with heart conditions will receive either a routine invitation or a link to a websi…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

About one in three people who have open-heart surgery develop an irregular heartbeat called postoperative atrial fibrillation (POAF), which raises the risk of stroke and other complications. This study is testing whether a blood marker called lipoprotein(a), or Lp(a), can identif…

This study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study follows people with Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) over time to learn how the condition progresses and affects daily life. Researchers will collect health data and patient feedback to identify patterns and potential markers of the disease. The goal i…

This study follows 100 adults with myotonic dystrophy (types 1 or 2) for two years to understand how muscle stiffness, daily function, and heart health change over time. Researchers will look back at up to 18 months of past medical records and then track participants with clinic …

This study looks at people whose coronary arteries are abnormally widened (coronary artery ectasia). Researchers want to see if exercise stress tests and certain blood markers can detect when the heart muscle isn't getting enough blood. The goal is to better understand the link b…

This observational study examines how antiplatelet medications affect platelet function in people over 80 with atrial fibrillation who have received a Watchman implant. Researchers will measure various markers of platelet reactivity before and after treatment to see if clotting r…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This trial investigates whether analyzing electrical signals from the heart during pulsed field ablation can tell doctors how well the catheter is touching tissue and whether the resulting scar will be permanent. About 60 people with paroxysmal atrial fibrillation will undergo th…

Septic shock is a life-threatening condition with high mortality. This study investigates whether patients with septic shock have a deficiency of angiotensin II, a hormone that helps regulate blood pressure. Researchers will measure hormone levels in blood and urine samples from …

This study tests two different formulations of an experimental drug called AD-118 in healthy adults aged 19 to 64. Participants receive a single dose of each version in a random order, and researchers measure how the drug moves through the body and check for side effects. The goa…

This study looks at people with obstructive hypertrophic cardiomyopathy — a condition where the heart muscle is abnormally thick and blocks blood flow. Researchers want to see if certain abnormalities in the mitral valve or its supporting structures affect how well the drug mavac…

This study tests whether an artificial intelligence analysis of standard electrocardiograms (ECGs) can track heart muscle recovery in people with atrial fibrillation and mild heart failure who undergo catheter ablation. Researchers will follow 1,000 participants for a year, using…

This study looks at how the stiffness and function of blood vessels change in people newly diagnosed with heart failure. Researchers will measure these factors at the start, after a few weeks of standard medication, and after a cardiac rehab program. All tests are non-invasive an…

This study investigates how often atrial fibrillation (AF), a type of irregular heartbeat, occurs in people with certain blood cancers who are starting a targeted cancer drug called a Bruton's tyrosine kinase inhibitor (BTKI). Researchers will follow 500 participants—400 starting…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This study follows 600 older adults (age 60+) who have had a heart attack to see if aging-related markers in their blood and body can predict future heart problems or death. Researchers collect medical data, blood samples, and heart scans over at least two years. The goal is to b…

This study looks at heart function and rhythm in children and young adults up to age 25 who have had surgery to repair Tetralogy of Fallot, a congenital heart defect. Researchers will use echocardiography, a 12-lead ECG, and Holter monitoring to detect changes such as arrhythmias…

This study looks at how atrial cardiomyopathy—a condition where the heart's upper chambers are damaged—relates to cardiovascular-kidney-metabolic (CKM) syndrome, a cluster of heart, kidney, and metabolic problems. Researchers will use non-invasive tests like ECG, echocardiography…

This study tests a cloud-based tool called ACT+ to help people in Uganda get follow-up care after a positive screening for rheumatic heart disease. Researchers will work with local providers to improve the tool and then see if it increases the number of people who complete a conf…

This study tests a new wearable system called M2VS that measures heart activity (ECG) and blood pressure continuously for 24 hours. Researchers want to see if it works as well as standard monitors like Holter ECG and ambulatory blood pressure monitors. The study involves 20 adult…

This study tests whether wearable devices and artificial intelligence can help personalize the timing of valve replacement in people with moderate to severe aortic stenosis who have no symptoms. Participants wear a smartwatch to track heart rate, activity, and blood pressure, and…

This study looks back at the medical records of 300 people with arrhythmogenic cardiomyopathy who have an implantable cardioverter-defibrillator (ICD) and have had dangerous heart rhythms. Researchers want to count how often ICD-related problems occur, such as lead failure or ina…

This Phase 1 trial investigates how the drug HRS-9057 is absorbed, processed, and eliminated in healthy men. Six participants receive a single dose, and researchers measure the drug and its breakdown products in blood, urine, and stool. The goal is to understand the drug's behavi…

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-o…

This study investigates whether measuring blood flow in the heart's smallest blood vessels (microcirculation) can help predict serious health events within a year after a person is hospitalized for acute myocarditis. Researchers will use a special technique during a standard hear…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study will enroll 100 people who have already had a heart procedure (pulsed field ablation) for atrial fibrillation. Participants will wear a BodyGuardian monitor for a period after the procedure to see if it catches any return of irregular heartbeats. The study also asks pa…

This study tests a new home monitoring system called AVATAR-SC that uses a digital avatar to collect voice recordings and symptom questionnaires from heart failure patients. The goal is to see if changes in voice can serve as early warning signs of worsening heart failure. Sixty …

This study will look at data from 918 adults who had planned heart surgery to find out why some develop atrial fibrillation, a common and serious irregular heartbeat. The researchers will also examine whether newer anesthesia methods, like a nerve block, might help protect agains…

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study will follow 100 health science students for at least 10 years to understand why some people with very flexible joints (hypermobility) develop chronic pain, fatigue, and other health issues while others do not. Researchers will measure balance, heart rate, and quality o…

This observational study will follow 200 adults with Brugada Syndrome who need anesthesia for surgery or other procedures. Researchers want to see how often dangerous heart rhythms occur during and up to 30 days after anesthesia. They will also check if certain anesthetic drugs o…

This observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …

This early-stage study will give a small dose of a radioactive-labeled drug called HRS-1893 to 6 healthy men. Researchers will track how the drug is absorbed, broken down, and eliminated through urine and feces. The goal is to understand the drug's path in the body, which is a ke…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study looks at whether a brief training video can boost police officers' confidence and willingness to use an AED (a device that shocks the heart) during cardiac arrest, especially on women. About 30 officers will take surveys before and after watching the video. The goal is…

This study follows 10 Chinese adults who have a specific gene mutation (BAG3) linked to dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Researchers will track changes in heart function, symptoms, and biomarkers over time to better understand how the…

This study looks at 150 adults having coronary bypass surgery to find out how often hidden heart injury occurs. Researchers use a sensitive blood test (troponin) and heart MRI to detect damage that standard tests might miss. The goal is to improve diagnosis and long-term care aft…

This study looks at 150 people with persistent atrial fibrillation (a type of irregular heartbeat) who are scheduled for a heart procedure called ablation. Researchers want to see if levels of a protein called BDNF in the blood are linked to signs of heart muscle damage (atrial c…

This observational study will follow 600 adults with chronic or acute heart failure to see how biomarkers and other factors predict individual responses to standard medications. Participants will have assessments at the start and after 1, 3, and 6 months, with follow-up phone cal…

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study will test a new, noninvasive camera called XyCAM CRE that measures blood flow in the back of the eye. Researchers will compare its images with standard eye tests in 350 adults with retinal disorders. The goal is to see if this camera can provide extra information to he…

This study aims to find out how common heart rhythm problems are in people with chronic kidney disease, both those on dialysis and those not yet on dialysis. Researchers will use a simple ECG test to check for abnormal heart rates and electrical changes. The goal is to better und…

This study will collect health information from 3000 people with hypertrophic cardiomyopathy (HCM) across multiple hospitals in China. The goal is to build a comprehensive database to understand how the disease is currently diagnosed and treated, and to identify factors that affe…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study will observe 110 adults having planned heart bypass surgery. Researchers will record settings on the breathing machine during surgery and check if patients develop lung complications like pneumonia or need a breathing tube for too long. No new treatments are given—the …

This study will look at medical records from over 2 million adults who had surgery in Sweden between 2021 and 2024. Researchers want to see how common heart failure is in surgical patients and whether it raises the risk of death or other problems after surgery. The goal is to bet…

This study tests a special blood pressure monitor that deflates very slowly, designed for people with a Left Ventricular Assist Device (LVAD). Researchers want to see if patients can use it easily at home and if it helps track their blood pressure accurately. About 50 adults with…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study looks back at medical records of 850 patients aged 80 and older who had a heart stent procedure at a UK hospital over seven years. Researchers will describe the patients' health, age, and frailty, and track complications like heart attack, stroke, or death up to one ye…

This study will examine how the heart-lung machine used during cardiac surgery changes platelet function and metabolism. Researchers will take blood samples from 100 adult heart surgery patients at several time points. The goal is to link these platelet changes to post-surgery in…

This study checks whether three common ECG-based methods can accurately locate where abnormal heart rhythms start in adults who had Tetralogy of Fallot repair. Researchers will pace the heart from known spots during a scheduled procedure and compare the predicted location to the …

This study will follow 500 people with severe aortic stenosis who need a heart valve replacement. Researchers want to see if a dedicated Heart Valve Unit—a team of heart specialists working together—can reduce confusion, delirium, and memory problems that sometimes happen after t…

This study will enroll 1000 heart failure patients to see if different types of body fat—around the heart, under the skin, and within muscles—are linked to heart structure and future health events like heart attacks or strokes. Researchers will use CT scans to measure these fat d…

This study aims to see if improving how emergency dispatchers handle calls and model their actions can speed up the detection of cardiac arrest and improve CPR quality. Researchers will study 4,000 people who experience cardiac arrest outside of a hospital. The goal is to learn i…

This study compares two types of heart ablation for people with persistent atrial fibrillation: pulsed field ablation and radiofrequency ablation. The goal is to see which one causes fewer stomach problems after the procedure. Twenty participants will be matched by age and health…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study will compare two common types of heart valves used in TAVI (a procedure to replace a narrowed aortic valve) to see which one sends fewer tiny particles to the brain during the procedure. 80 adults with severe aortic stenosis will be randomly assigned to receive either …

This study will follow 600 adults who have had a stent placed or bypass surgery for coronary artery disease. Researchers will collect medical information, blood samples, and traditional Chinese medicine symptoms over 12 months. Using artificial intelligence, they aim to create a …

This study investigates whether a condition called clonal hematopoiesis of indeterminate potential (CHIP), which is an age-related change in blood cells, is linked to more severe heart damage in people who have had a major heart attack (STEMI). Researchers will test blood samples…

This study tests two different computer alerts designed to encourage doctors to refer heart patients to cardiac rehab. About 7,000 adults who had heart surgery or a stent in the past year will take part. The goal is to see if these simple reminders increase the number of people w…

This study will compare five different pulsed field ablation systems used to treat atrial fibrillation (an irregular heartbeat). The goal is to see which system causes the fewest tiny clots (microemboli) that travel to the brain during the procedure. One hundred adults with atria…

This study checks if two Italian questionnaires accurately measure how well people with heart failure care for themselves and how caregivers help. Researchers will enroll 1,000 patients and their caregivers across Italy. The goal is to improve heart failure management by using re…

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study looks at 223 adults hospitalized with acute heart failure to see if changes in urine salt levels (sodium and chloride) can help doctors understand how well the body is getting rid of extra fluid. Participants will have blood and urine tests, heart ultrasounds, and chec…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This early-stage study will use advanced PET scans to look at how the brain and body work together in people with and without heart disease. Researchers want to see if blood flow and energy use in different organs change during physical or mental stress. The goal is to better und…

This study will use brain electrodes (SEEG) and breathing monitors in 20 adults with drug-resistant epilepsy to map which brain areas control breathing during a challenge. The goal is to understand why some patients experience fatal breathing arrest after seizures (SUDEP). No tre…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study looks at 1,000 adults who had planned heart bypass surgery. Researchers will review existing hospital records to see if changes in routine blood tests (like inflammation and kidney markers) in the first hours after surgery can identify patients at higher risk for compl…

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study looks at whether a special simulation training program for emergency doctors can help them use heart ultrasound more effectively in patients with acute heart failure. The goal is to see if this training leads to faster treatment with diuretics, which help remove excess…

This study tests whether using a CT scan to plan a heart stent procedure (PCI) makes it faster, safer, and more effective than the usual approach. About 200 adults with coronary artery disease will either get CT-guided planning or standard care. Researchers will compare procedure…

This study tests a new method to measure central venous pressure (a key heart health indicator) without inserting a catheter. Researchers will use a pressure cuff and Doppler sensor on the forearm of 30 children (ages 0-17) in the intensive care unit. The goal is to see if this n…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study examines whether volunteers alerted by a smartphone app can improve survival for people who have a cardiac arrest outside the hospital. Researchers will compare outcomes for about 5,200 adults who either did or did not receive help from these first responders. The goal…

This study tests a special breastfeeding guideline for infants born with congenital heart disease (CHD). Researchers want to see if the guideline helps more mothers breastfeed directly and reduces stress. About 266 mother-infant pairs will take part across multiple hospitals, wit…

This study will follow 200 people with suspected or confirmed cardiac amyloidosis, a condition where abnormal proteins build up in the heart and cause heart failure. Over two years, participants will undergo heart MRI scans, exercise tests, and blood work at regular visits. The g…

This study tests a nursing support program for families of children aged 1 to 3 who have had heart surgery. The program includes education and counseling sessions to help parents improve caregiving skills and support their child's growth. Researchers will compare families who rec…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…