Heart disorder

This study tests whether regular video calls with a nurse can help people with heart failure manage their condition better than audio-only calls. About 140 adults with heart failure will be randomly assigned to receive either video or audio calls at 7, 30, 60, 180, and 365 days a…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests a single dose of ravulizumab given before heart surgery to see if it can prevent kidney damage and serious kidney problems in people with chronic kidney disease. About 736 adults will take part. The goal is to reduce the risk of major kidney events within 90 days…

This study tests whether a web-based coaching program called CardioFit can help people with coronary artery disease become more physically active. Participants use a secure website to create personalized exercise plans with guidance from an online coach. The trial compares Cardio…

This study tests a device that freezes small areas of heart tissue to treat paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. About 200 people with AFib that hasn't responded to medication will receive the procedure. Researchers will track safe…

This study tested whether starting ECMO (a heart-lung bypass machine) right at the location of a cardiac arrest, rather than waiting until the patient reaches the hospital, could improve survival with good brain function. Researchers enrolled 65 adults with refractory cardiac arr…

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study looked at 100 people with hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers compared different surgical techniques—removing part of the thickened heart muscle alone or combined with repairing the mitral valve—to…

This study tested whether using ultrasound inside the heart arteries (IVUS) to guide stent placement works better than standard X-ray guidance for people with a blockage in the left main coronary artery. About 800 patients were randomly assigned to one of the two methods and foll…

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This trial tests whether a personalized physical activity plan can help children aged 5–18 with congenital heart disease increase their exercise capacity and daily activity levels. The plan is designed with input from parents, teachers, and a pediatric cardiologist to address saf…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study tested a bedside device called the Reprieve Decongestion Management System in 100 hospitalized patients with acute decompensated heart failure. The device automatically adjusts the dose of a diuretic (furosemide) and saline based on the patient's real-time urine output…

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study investigates whether a home-based cardiac rehabilitation program, tailored to each patient's readiness to change, can improve self-care, quality of life, and confidence in people with heart failure. The program involves home visits and phone counseling over 12 weeks. R…

This study tested whether the drug sotagliflozin can improve heart function in people with a type of heart failure called HFpEF who do not have diabetes. Eighty-eight participants took either the drug or a placebo for six months. Researchers used heart scans and exercise tests to…

This completed trial tested whether giving epinephrine and verapamil directly into the heart arteries could help restore blood flow in heart attack patients whose vessels remain blocked despite standard treatment. 104 adults with ST-elevation heart attacks were enrolled. The stud…

This study looked at 9 people with atrial fibrillation (AFib) that came back after an initial cryoballoon ablation. It compared two repeat ablation methods: another cryoballoon procedure versus radiofrequency ablation guided by a high-fidelity mapping system (Rhythmia). Participa…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study tested whether sending personalized text messages about lifestyle changes could improve heart health in 700 people who had a stent placed for coronary artery disease. Half received 4 texts per week for 24 weeks, while the other half got standard care. Researchers measu…

This study tested whether atorvastatin, a cholesterol-lowering drug, can protect the heart in breast cancer patients receiving doxorubicin-based chemotherapy. 44 women with newly diagnosed breast cancer took atorvastatin daily for 3 months alongside their chemo. Researchers measu…

This early-phase trial tested a combination of three drugs—daratumumab, ixazomib, and dexamethasone—in 21 people with AL amyloidosis, a rare disease where abnormal protein builds up in organs. The main goal was to find the safest dose and check for side effects. Researchers also …

This study tests whether motivational interviewing—a supportive, goal-oriented counseling approach—can help people who have had a heart stent adopt and maintain healthier habits. Participants receive one-on-one coaching sessions and reminder texts over three months, while researc…

This study tests a structured transitional care program for people with heart failure. The program includes discharge education, phone follow-ups, and home care support for three months after leaving the hospital. Researchers want to see if it helps reduce depression, improve con…

This study tested a new drug called R2R01 in 33 people with worsening heart failure. Participants received either R2R01 or a placebo alongside their usual treatments. The goal was to see if the drug is safe and helps reduce fluid buildup in the heart.

This study tests a new medicine called NNC0537-1482, designed to potentially treat heart failure. It is the first time this drug is given to humans, so healthy volunteers receive a single injection under the skin to check for safety and how the body processes it. Participants are…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Twenty adults with end-stage heart failure on the transplant waiting list will receive these hearts and take antiviral medication to prevent infection. The goal …

This study tests a newly designed device to hold arterial pressure monitoring lines in place after coronary artery bypass surgery. The goal is to see if it keeps readings more accurate and stable than standard tape, especially when patients move. Sixty adults undergoing bypass su…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This study tested whether giving a low dose of the clot-busting drug tPA directly into the heart arteries, during standard angioplasty, improves blood flow and reduces complications in people having a major heart attack. 210 patients were enrolled. The goal was to see if this app…

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This study tested two different catheters (lattice-tip vs standard irrigated-tip) for a heart procedure called ablation, which treats a fast heartbeat (atrial flutter). 102 adults received the procedure to see which catheter works better and faster with fewer side effects. The go…

This study tested whether starting the drug dapagliflozin during a hospital stay for acute heart failure can reduce the risk of death or worsening heart failure. Over 2,400 adults who were stable after initial treatment were randomly given either dapagliflozin or a placebo. The g…

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study tested whether dapagliflozin (Farxiga), a drug used for diabetes and heart failure, can prevent heart damage caused by anthracycline chemotherapy. 94 adults with cancer took either dapagliflozin or a placebo daily for four months alongside their chemo. Researchers meas…

This study tested a new way to give the heart failure drug furosemide: as a shot under the skin instead of through an IV. Twenty adults with chronic heart failure received both versions to compare how much drug gets into the body. The goal is to see if the shot works well enough …

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tests whether a therapeutic education program helps teenagers and young adults with congenital heart disease transition from pediatric to adult medical care. Participants aged 13 to 25 will either receive the education program or standard follow-up. Researchers will me…

This study tested a new care pathway for people hospitalized with acute heart failure. Instead of a standard hospital stay, some patients were discharged early (within 4 days) and received follow-up care at home from both hospital and private practice teams. The goal was to see i…

This study tested a drug called ALXN2060 (acoramidis) in 25 Japanese patients with a rare heart condition called ATTR-CM, which causes heart failure. The drug is taken as a tablet twice daily. Researchers measured how far patients could walk in 6 minutes and tracked heart-related…

This study tested whether adding vasopressin to the standard drug epinephrine helps more people survive a cardiac arrest that happens outside the hospital. Over 2,400 adults were enrolled. The main goal was to see how many patients were alive when they reached the hospital.

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested whether implanting a new aortic valve (TAVI) without first using a balloon to open the narrowed valve is safer and as effective as the standard procedure with balloon predilatation. 250 adults with severe aortic stenosis who were at high risk for open-heart surg…

This study tested a device called ShortCut that splits the leaflets of a failing artificial heart valve before placing a new valve inside it. The goal was to prevent the old leaflets from blocking the coronary arteries, which can cause a heart attack. Eight people at risk for thi…

This study tested a new drug called aficamten against the standard medicine metoprolol in 175 adults with a heart condition that makes the heart muscle thick and blocks blood flow. The goal was to see which drug better improves exercise ability and symptoms like shortness of brea…

This study tested whether adding sacubitril-valsartan to standard care helps people with heart failure (with preserved pumping ability) and a leaky mitral valve. 84 participants were randomly assigned to get the drug or standard care alone. Researchers measured heart function and…

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested whether breathing air with low and then high oxygen before heart bypass surgery could help protect the heart from damage. 120 adults scheduled for bypass surgery took part. The approach is drug-free and aims to reduce complications after surgery.

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This large phase 3 study tested whether milvexian, an oral blood thinner, can reduce the risk of major cardiovascular events like heart attack, stroke, or death in people who recently had an acute coronary syndrome (heart attack or unstable angina). Over 14,000 participants took …

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This study tested a device designed to catch and remove debris that can break loose during transcatheter aortic valve replacement (TAVR), a procedure to replace a narrowed heart valve. The device uses two filters placed in arteries leading to the brain. The trial involved 260 peo…

This study followed 500 people who received the Amplatzer PFO Occluder, a device that closes a small hole in the heart called PFO. Researchers tracked serious complications within 30 days and longer-term issues like stroke or blood clots over 3 years. The goal was to confirm the …

This study looked at whether a type of diabetes medicine called SGLT2 inhibitors can help people with severe heart failure who also have a mechanical heart pump (LVAD). Researchers measured changes in heart size, weight, and kidney function over 6 months in 32 adults. The goal wa…

This study tested whether a half-dose blood thinner (ticagrelor) taken alone after heart stent placement works as well as the standard two-drug therapy in East-Asian patients with chronic coronary syndrome. Sixty participants were randomly assigned to one of three treatment group…

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested whether ticagrelor, a newer antiplatelet drug, reduces heart muscle damage during a procedure called rotational atherectomy, which clears hardened arteries. 180 stable heart patients received either ticagrelor or standard clopidogrel before and after the procedu…

This study tested giving chemotherapy before surgery to children with Wilms tumor, a rare kidney cancer. The goal was to shrink tumors so surgeons could remove less kidney tissue, helping preserve kidney function. 249 children took part, and the approach aimed to reduce the need …

This completed study in 180 heart failure patients compared the effects of taking Entresto alone versus Entresto plus a second drug (empagliflozin) on mitral valve function and heart pumping ability. Participants had heart failure with reduced ejection fraction and some degree of…

This study tested the safety of a drug called maralixibat in 27 infants under 12 months old with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC), two rare liver diseases that cause bile buildup. The drug is given as an oral solution and aims to reduce bi…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This completed study tested a new catheter and generator system designed to treat paroxysmal atrial fibrillation (AFib) — a common heart rhythm problem. The device uses pulsed field ablation (PFA) to target and destroy tiny areas of heart tissue causing the irregular rhythm. 188 …

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study looked at whether adding semaglutide (a drug used for diabetes and weight loss) to the standard heart failure medication dapagliflozin helps people with heart failure who have had a surgical heart valve replacement. 160 participants were split into two groups: one got …

This study looked at over 17,000 people who had a heart attack to compare two blood thinners: prasugrel and ticagrelor. Hospitals switched from ticagrelor to prasugrel in a stepwise way to see which drug better prevents death, another heart attack, or stroke. The goal is to find …

This study tested a remote, virtual cardiology program for people recently hospitalized with worsening heart failure. The program provided education, monitoring, and quick medication adjustments. Researchers compared outcomes like death and repeat heart failure events between tho…

This study tested whether placing the left ventricle lead of a cardiac resynchronization therapy (CRT) device at the heart's latest electrical activation spot improves outcomes. It included 1,000 heart failure patients with bundle branch block. The goal was to see if this targete…

This study tested a new device called Firesorb, a temporary scaffold that slowly releases medicine to keep heart arteries open and then dissolves over time. Researchers compared it to a standard permanent stent in 430 people with coronary artery disease. The goal was to see if th…

This study looked at ways to help children aged 5-20 with rheumatic heart disease take their regular antibiotics. Researchers compared having a case manager alone versus a case manager plus a peer support group. The goal was to see if the simpler approach works just as well to ke…

This pilot study tested whether varenicline (Chantix) helps smokers with coronary heart disease quit better than the standard nicotine patch. Fifty motivated smokers who had a heart-related event were randomly assigned to one of the two treatments for 12 weeks. The main goal was …

This study tested a procedure called radiofrequency catheter ablation in 20 people with Brugada syndrome, a heart condition that can cause dangerous heart rhythms. Half received the real ablation, which uses heat to destroy small areas of heart tissue thought to cause the problem…

This study tested a new type of pacemaker that doesn't use wires (leads) to help both the upper and lower chambers of the heart beat in sync. It involved 464 people with slow heart rhythms who needed a pacemaker. The main goals were to see if the device was safe and worked well a…

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study tested whether using a smartphone app and phone calls to monitor patients after a heart failure hospital stay helps doctors safely increase their medications. 66 adults with chronic heart failure and low ejection fraction were split into two groups: one received usual …

This study tested a new drug called RBD4059 in 30 adults with stable coronary artery disease to see if it is safe. Participants received either the drug or a placebo and had 11-12 clinic visits over about a year. The main goal was to check for side effects and measure how the dru…

This study followed 650 low-risk patients with severe aortic valve narrowing who received a less invasive valve replacement called TAVI. Researchers tracked deaths, strokes, and return hospital visits for heart problems. The goal was to see how well TAVI works in everyday practic…

This study tested whether a drug called dexrazoxane, given through a vein, can reduce permanent heart muscle damage in people having a severe heart attack (STEMI). Fifty adults received either the drug or a placebo during their standard stent procedure. The goal was to see if the…

This study tested a mobile app designed to help people with heart failure monitor their blood pressure, weight, and heart rate daily. The app also tracks symptoms and medications, sharing the data with doctors to guide treatment. Researchers wanted to see if using the app leads t…

This study tested the drug patisiran in 10 adults with a rare condition called ATTR amyloidosis that causes nerve damage. Participants received an IV infusion every 21 days for 24 months. Researchers measured changes in nerve function, autonomic symptoms, and quality of life to s…

This study tested whether empagliflozin (Jardiance), a diabetes drug, can help the heart recover after aortic valve replacement. 206 patients took either the drug or a placebo for six months. The goal was to see if the drug reduces heart muscle thickness and improves symptoms.

This study tested a new way to give extra oxygen to the heart after a heart attack. Twenty patients received a special oxygen treatment for one hour through a thin tube placed in the heart artery. The main goal was to see if the procedure was safe and could be done without proble…

This study tested a new drug called JTT-861 in 314 adults with chronic heart failure and reduced pumping ability. Participants took either the drug or a placebo once daily for 12 weeks, alongside their usual heart medications. The goal was to see if the drug improves heart functi…

This study tested whether using a CT scan before heart ablation can make the procedure faster and safer for people with ventricular tachycardia, a fast heart rhythm that can be life-threatening. 119 adults who had a prior heart attack and an implanted defibrillator were randomly …

This study looked at 108 people whose heart stents had narrowed again after being placed. Doctors tested three different devices: two types of drug-coated balloons and one new stent. The goal was to see which one works best to keep the artery open and prevent future heart problem…

This study tested whether the drug sacubitril/valsartan can improve heart function in people with heart failure who are on chronic hemodialysis. 52 patients were split into two groups: one received the drug, the other standard care. Researchers measured changes in heart ultrasoun…

This study looked at whether giving a drug called protamine to all patients after a minimally invasive heart valve replacement (TAVI) reduces bleeding complications compared to giving it only when needed. The trial involved 1000 adults with aortic valve stenosis. The goal was to …

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested whether giving low doses of two steroids (hydrocortisone and fludrocortisone) helps adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. 380 participants received either the steroids or a placebo. The main goal was…

This study tested a new type of pacemaker that doesn't need wires (leads) to connect to the heart. It was implanted directly into the heart in over 1,200 people with slow heart rhythms. The goal was to see if it is safe and works well. The study found that most patients had no se…

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested whether using a 3D electroanatomic mapping system (FARAVIEW) during pulsed field ablation helps create more precise lesions in the pulmonary veins of people with atrial fibrillation. Thirty-two participants were randomly assigned to receive ablation with or with…

This study tested whether a smartphone app that reminds patients to take their medication can improve how consistently people with atrial fibrillation take their blood thinner (rivaroxaban). Over 600 adults with AF and other health issues like high blood pressure or diabetes used…

This study tested whether a slow-release form of the beta-blocker carvedilol can improve heart function in people with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff. 63 adults with high blood pressure and signs…

This study tested whether eating yam gruel daily for 12 weeks could improve cholesterol levels in 72 people who had a heart stent placed. Participants either received standard care alone or standard care plus yam gruel as a partial dinner replacement. Researchers measured cholest…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study looked at how safe and effective Vyndaqel is for people with a rare heart condition called transthyretin amyloid cardiomyopathy. Over 1,200 patients in Japan were followed while taking the drug in regular medical practice. The main goal was to track side effects and su…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This early study tested a new device called the FieldForce™ Ablation System in 34 people with ventricular arrhythmias (dangerous heart rhythms). The device uses pulsed electric fields to destroy the small areas of heart tissue causing the problem. The main goal was to see if the …

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. 292 adults with drug-resistant AF took part. The goal was to see if the new method is faster, safer, and more effectiv…

This study tested whether using a smartphone app to alert nearby volunteers (called 'heart runners') to bring an automated external defibrillator (AED) to a suspected cardiac arrest can improve survival. Over 2,000 emergency calls were randomly assigned to either activate these v…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested a special balloon coated with the drug everolimus in 51 people whose previously placed heart stents had become blocked again. The balloon is inflated inside the artery to deliver the drug directly to the blockage, aiming to keep the artery open. The main goals w…

This study tested whether giving heart failure patients with fluid in their lungs a lower oxygen target (90% oxygen saturation) or a higher one (96%) leads to better outcomes. 122 patients were randomly assigned to one of the two groups in the emergency department. The goal was t…

This study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …

This study compared two medications, levosimendan and adrenaline, given during heart bypass surgery to patients with weak hearts (ejection fraction 30-40%). Sixty adults aged 18-65 having elective surgery were included. The goal was to see which drug better supports heart functio…

This study tested whether catheter ablation (a procedure to fix irregular heart rhythm) is better than standard rate-control medication for people with both atrial fibrillation and heart failure. Over 400 participants were randomly assigned to either ablation or medication. The m…

This study tested whether sacubitril/valsartan (Entresto) works better than enalapril for people with heart failure caused by chronic Chagas disease. Over 900 adults with reduced heart function took part. The goal was to see if the drug could reduce heart-related deaths, hospital…

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This study tested whether the diabetes drug ertugliflozin can reduce fluid buildup in the skin and tissues of people with heart failure. 28 adults with reduced heart function took the drug or a placebo for one month each. Researchers measured skin water and sodium content to see …

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This early study tested a single injection of HM2002, a circular RNA, given directly into the heart muscle during bypass surgery. Only 3 people with heart failure took part. The main goal was to check safety, not to prove it works. The study is complete, but results are not yet a…

This study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…

This study tested a new drug called AC01 in 58 adults with heart failure and reduced pumping ability. The goal was to check safety and how the body processes the drug. Participants received either AC01 or a placebo in increasing doses. The study is complete, but results are not y…

This study looked at whether short-term diet changes can improve heart health in people who have had a first heart attack. 24 adults were assigned to either a standard heart-healthy diet, a plant-based (vegan) diet, or no special diet for 3 months. Researchers measured weight, bo…

This early-phase study tested a new drug called ABX1100 in 46 people, including healthy volunteers and patients with late-onset Pompe disease. The main goal was to check safety and how the drug moves through the body. Researchers gave single or multiple doses to find the right am…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested a new device called the Volt PFA System, which uses pulsed field ablation to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 392 people with symptomatic AF that didn't respond to medication. The goal was to see if the procedur…

This study tested a new way to replace a narrowed heart valve without open-heart surgery. It involved 782 people with severe aortic stenosis who were considered too high-risk for traditional surgery. The procedure, called TAVI, uses a thin tube to place a new valve inside the hea…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This pilot study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve. 24 adults with mild-to-moderate aortic stenosis were randomly assigned to take colchicine or a placebo for 6 months. The study measured changes in valve cal…

This study tested the drug mepolizumab in 16 children aged 6 to 17 with hypereosinophilic syndrome (HES), a rare condition causing too many eosinophils (a type of white blood cell). The goal was to see if mepolizumab could reduce disease flares and lower the need for steroids ove…

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether a breathing muscle training device could improve blood flow in the hearts of people with coronary artery disease. Forty participants used the device daily for six weeks. Researchers compared high-intensity versus low-intensity training to see if it incre…

This study tested whether evolocumab (Repatha), a drug that lowers LDL cholesterol, can reduce inflammation and improve heart function in people who recently had a mild heart attack (NSTEMI). Sixty participants received either evolocumab or a placebo within 24 hours of admission.…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and at…

This study looked at whether a 12-week course of glecaprevir/pibrentasivir can safely cure hepatitis C in heart transplant patients who got the virus from infected donors. Fifty adults on the transplant waitlist were enrolled, and those who received a hepatitis C-positive heart w…

This study tested whether taking a probiotic called Lactobacillus plantarum 299v for 12 weeks could improve exercise ability and blood vessel function in people with heart failure. Ten participants took either the probiotic or a placebo. The goal was to see if the probiotic could…

This study looked at 200 people with both heart failure and permanent atrial fibrillation. Participants received either a standard defibrillator (ICD) or one that also paces both lower heart chambers (CRT/ICD). The goal was to see if the extra pacing reduces heart size and improv…

This study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…

This completed study looked at over 3000 people with coronary artery disease to compare two types of drug-eluting stents: everolimus-eluting (Xience/Promus) and sirolimus-eluting (Cypher). The goal was to see which one better prevents major heart problems like heart attacks or th…

This study tested whether a small wearable sensor, combined with a smart computer program, could detect early signs of worsening heart failure and alert doctors to adjust treatment before a hospital stay is needed. Researchers enrolled 176 veterans with heart failure and randomly…

This study looked at over 3,400 people with acute coronary syndrome (a heart attack or unstable angina) who received a stent to open blocked arteries. Researchers compared two types of stents (biostable vs. biodegradable polymer) and two doses of the blood thinner prasugrel (5 mg…

This study looked at over 5,500 heart patients in Korea who had a drug-coated stent and took two blood thinners for about a year. After that, they were given either clopidogrel or aspirin alone for up to two more years. The goal was to see which drug better prevents heart attacks…

This study looked at whether a diabetes drug called empagliflozin, combined with a breathing machine (CPAP), can improve sleep and heart function in 70 adults with both heart failure and obstructive sleep apnea. Participants were randomly assigned to take empagliflozin or not, an…

This early study tested a new, less invasive procedure to treat functional mitral regurgitation, a condition where a leaky heart valve causes heart failure symptoms like shortness of breath and fatigue. Nineteen adults with this condition received a permanently implanted device t…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tests an artificial intelligence platform called Willem that analyzes electrocardiograms (ECGs) to detect heart attacks. Researchers will compare how fast and accurately the AI spots heart attack patterns versus human doctors. The study involves 500 adults who have had…

This study tested whether wearing a small heart monitor (MEMO Patch PLUS) for 8 to 14 days finds more cases of hidden atrial fibrillation than wearing it for just 1 day. About 1,000 adults aged 75 or older (or with other stroke risk factors) wore the patch. The goal was to see if…

This study tested whether a special smartwatch (Watch HOP) can help detect heart failure by measuring heart rate, movement, skin temperature, and voice patterns. Researchers compared 56 people with and without heart failure during physical tasks and daily life. The goal is to fin…

This study tested whether a special heart scan (SPECT) can predict how well patients with ischemic cardiomyopathy will recover after heart surgery. 120 patients underwent imaging at rest and during stress to measure heart function and blood flow. The goal was to find patterns tha…

This study tested a new one-hour diagnostic algorithm using a protein called FABP to quickly confirm or rule out a type of heart attack called NSTEMI. It involved 20 male patients who arrived at the hospital within 4 hours of chest pain. The goal was to see if measuring FABP leve…

This study tested whether a special PET scan using 68Ga-DOTATOC can detect inflammation in the heart muscle of people with myocarditis. 33 adults with suspected acute myocarditis and normal angiograms received the scan. The goal was to see if this method is as good as or better t…

This study tested whether a special heart scan (SPECT) can predict which people with severe chronic heart failure will improve after getting a cardiac resynchronization therapy device. The scan uses a radioactive tracer to measure nerve activity in the heart. Researchers enrolled…

This study compares a new ultra-high-resolution CT scanner (UHR-CT) to the standard invasive coronary angiography for detecting significant blockages in the heart's arteries. It focuses on patients with severe calcium buildup or stents, where regular CT scans often fall short. Th…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

This completed study tested a structured heart failure screening pathway for adults aged 65 and older during routine general practice visits. The screening involved a questionnaire, a blood test (NT-proBNP), and an echocardiogram. Researchers aimed to see how many patients would …

Heart failure is a serious condition with high death and rehospitalization rates. This study tested whether using a blood marker called ST2 to guide treatment could reduce hospital readmissions within one month. Researchers compared standard care with a strategy that adjusts medi…

This study tested a new type of CT scanner (photon-counting detector CT) to see if it gives clearer images of heart arteries and blood flow compared to standard CT and nuclear stress tests. Researchers enrolled 276 adults with suspected coronary artery disease. The goal was to se…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested whether a special PET-CT scan using a radioactive tracer (18F-FDG) can improve diagnosis of infectious endocarditis on natural heart valves. Researchers scanned 31 adults with suspected endocarditis within 5 days of starting care. The goal was to see how well th…

This completed Phase 3 study tested whether a radioactive tracer called [18F]Florbetaben, used in PET scans, can accurately diagnose cardiac AL amyloidosis—a condition where abnormal proteins build up in the heart. 244 adults with suspected cardiac amyloidosis received a single P…

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This study tested whether two wearable devices—the Apple Watch and the Skylab CART-I ring—can accurately detect atrial fibrillation and other irregular heart rhythms compared to the standard 12-lead ECG. Researchers recruited 500 adults from UK cardiology clinics. Each participan…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study looked at whether a high-sensitivity blood test for troponin I can accurately determine the stage of a heart attack. Researchers analyzed data from 312 patients across multiple hospitals. The goal is to provide a faster, simpler way to classify heart attack severity wi…

This study tested a non-invasive mapping system (Cardioinsight®) to help doctors treat heart rhythm disorders. It included 492 patients who needed ablation, pacemaker implantation, or risk assessment for sudden death. The goal was to see if the mapping system improves outcomes co…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This completed trial tested whether an artificial intelligence (AI) tool could help doctors decide which low-risk patients with suspected heart disease should get a safer, non-invasive CT scan instead of an invasive angiogram. The study involved 251 adults referred for non-urgent…

This completed study looked at 313 children to see if blood tests and advanced heart scans could help detect congenital heart disease earlier and predict which children might need surgery. Researchers compared children with heart defects to healthy controls using blood biomarkers…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study tested whether a computerized stethoscope that uses artificial intelligence (AI) can accurately detect two common heart valve conditions: aortic stenosis and mitral regurgitation. Researchers at Mayo Clinic recorded heart sounds from 400 adults and compared the AI's an…

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This study tested whether giving mannitol, a substance that reduces brain swelling, could prevent delirium in older adults hospitalized for a heart attack. Fifty patients aged 65 and older with high inflammation levels were included. The goal was to see if mannitol could lower th…

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This large observational study followed over 135,000 Chinese women aged 40-70 to see if eating soy food reduces the risk of heart attacks and fatal heart disease. Researchers tracked participants' soy intake and heart health over time. The study aims to provide clues about diet a…

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study tests whether watching an augmented reality (AR) educational video on a tablet can lower anxiety in people about to undergo cardiac catheterization, a common heart procedure. Participants in the experimental group view the AR video in addition to receiving standard pap…

This study compares two types of nerve blocks (ESPB and SPSIPB) to manage pain after heart bypass surgery. About 60 adults aged 18-80 having planned bypass surgery will take part. The goal is to see which block reduces the need for painkillers and improves comfort after surgery.

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This study tested whether regular phone calls from a nurse after coronary artery bypass surgery could help patients manage symptoms and take better care of themselves at home. 72 patients were split into two groups: one received standard care, and the other got scheduled phone co…

This study tested a modified pacemaker in 34 people with heart failure (NYHA class II or III). The device delivers special pacing signals to reduce overactive sympathetic nerve activity, which can strain the heart. Researchers measured changes in arterial elastance, a sign of rel…

This study tests whether wearing virtual reality glasses during femoral sheath removal — a routine step after a heart catheterization — can lower pain, anxiety, and changes in vital signs. About 60 adults undergoing this procedure will be randomly assigned to either use VR glasse…

This study tests whether starting cardiopulmonary rehabilitation (exercise and breathing training) early in the hospital helps people with acute decompensated heart failure recover faster. About 40 adults who are stable enough will take part. The goal is to see if early rehab imp…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested a computer algorithm called CartoFinder to help doctors better identify and treat complex heart rhythm problems (arrhythmias). 70 adults with persistent atrial fibrillation (a type of irregular heartbeat) took part. The goal was to see if the algorithm could imp…

This study tested whether using a device that electrically stimulates the thigh muscles at home, for 4 weeks after a hospital stay, could help people with heart failure walk farther and feel stronger. Only 8 people took part, so the results are very early. The goal is to find a s…

This study tested whether metformin, a standard diabetes drug, could help older adults with a specific type of heart failure (HFpEF) feel better and move more easily. Over 20 weeks, 86 participants took either metformin or a placebo. Researchers measured exercise capacity, qualit…

This study tested whether an 8-week cardiac rehabilitation program using a stationary bike could improve cardiorespiratory fitness in 20 adults with atrial fibrillation. Participants exercised for 6 minutes, three times a week. The goal was to see if exercise capacity could incre…

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method …

This study looked at 50 adults having heart bypass surgery to see if one sedative (dexmedetomidine) causes less confusion after surgery than another (midazolam). The goal was to find a way to reduce postoperative delirium, a common problem after heart surgery. Researchers checked…

This study tested a phone-based system that helps people with heart failure monitor their symptoms and get coaching on how to manage them at home. 50 patients used the system after being discharged from the hospital. The goal was to see if the system could help patients better ca…

This study tested whether a nasal spray containing vasopressin, a natural hormone, can improve social functioning in children with autism. 157 children aged 6 to 17 took part. Researchers measured changes in social responsiveness and overall symptoms over 8 weeks.

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study tested whether adding leg compression to standard diuretic treatment helps people hospitalized with heart failure and severe fluid buildup. 106 adults received either diuretics alone or diuretics plus leg compression for up to 72 hours. Researchers measured changes in …

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study tested whether acupressure, a technique that applies pressure to specific points on the body, can reduce anxiety and improve vital signs like blood pressure and heart rate in people hospitalized with acute coronary syndrome (ACS). Sixty-eight adults with a first-time A…

This study tested whether using virtual reality glasses during physical therapy can reduce pain, improve blood oxygen levels, and help children walk farther after open heart surgery. Forty children aged 6 to 12 took part. One group used VR glasses during their cardiac rehab exerc…

This study tested a 24-week sleep program delivered partly through WhatsApp for people with heart failure and poor sleep. The program included education, daily tips, and smartwatch sleep tracking. Researchers measured sleep quality, sleep habits, and quality of life in 28 partici…

This study tested two types of nerve blocks (SAP and PECS II) to see if they could reduce pain after coronary artery bypass grafting. 243 adults received one of the blocks or standard care. Researchers measured pain scores, opioid use, and recovery times. The goal was to find a b…

This phase 2 trial tested a drug called BX1514M in 38 people with hypertrophic cardiomyopathy, a genetic heart condition that can cause shortness of breath, chest pain, and dizziness. The drug aims to improve blood flow by tightening veins, which may reduce blockages in the heart…

This study tested a nasal spray called etripamil for people with a condition that causes sudden rapid heartbeats (PSVT). Participants, who had been in earlier studies, used the spray themselves at home to stop an episode. The main goal was to see if it was safe and easy to use ou…

This study tested a program called ADAPT HF, which uses a lay coach or self-guided materials to help Black adults with advanced heart failure manage pain. Ten participants completed weekly sessions covering pain education, relaxation, social support, and coping. The goal was to s…

This study looked at whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific body points, can reduce pain, pain-related beliefs, and anxiety in people recovering from coronary artery bypass graft (CABG) surgery. Researchers enrolled 66 adults and me…

This study tested whether a 12-week home-based walking program could help heart failure patients with depression, frailty, and quality of life. 68 patients were split into two groups: one got standard health education, the other added a walking routine of 3,000 extra steps per se…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested problem-solving therapy (PST) for adults with type 2 diabetes or heart disease who also have poor mental well-being. PST is a structured talk therapy where patients list their problems, weigh solutions, and take action. The trial involved 147 patients in general…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This study tested whether watching a short video before coronary bypass surgery could reduce confusion (delirium) in the ICU and speed up recovery. 220 adults were randomly assigned to either watch the video or receive standard care. The video explained the surgery, ICU environme…

This study tested whether a nurse-led program, including education and an animated video, could reduce anxiety in 60 adults scheduled for coronary artery bypass graft surgery. Participants were split into two groups: one received the extra program, the other standard care. Resear…

This study tested whether a home-based exercise program is practical for people with chronic heart failure who have just been hospitalized. Thirty patients were taught exercises by a physiotherapist and did them at home for 12 weeks. The goal was to see how many completed the pro…

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested a simple, non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The procedure involves inflating a blood pressure cuff on the affected leg to briefly stop blood flow, then releasing it, repeated several times. Researchers measured …

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study looked at whether high-intensity interval training (short bursts of hard exercise) is better than moderate continuous exercise for people with heart failure. Researchers measured nerve activity, blood vessel function, and muscle health in 35 participants. The goal was …

This study looked at whether different types of exercise training can help adults with congenital heart disease exercise more easily. 47 participants were split into three groups: interval training, moderate continuous training, or usual care (no training). The main goal was to s…

This study tested whether light exercise or a technique called remote ischaemic preconditioning (rIPC) — using a blood pressure cuff to briefly restrict blood flow to the arm — could protect the heart during dialysis. 33 adults on hemodialysis took part in three sessions: one wit…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study tested whether an internet-based support program helps caregivers of people with heart failure feel more prepared and supported. About 202 caregivers from four healthcare regions took part. The program provided education and a chance to share experiences. Results showe…

This study looks at medical records from France to see how doctors prescribe blood thinners to people with atrial fibrillation (an irregular heartbeat) who also have a high risk of stomach bleeding. The goal is to understand which treatments are used and how often serious bleedin…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This pilot study looked at whether it's possible to run a larger trial comparing two types of exercise—moderate steady exercise and high-intensity interval training—on symptoms of atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 25 men and women with …

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study follows 340 people with atrial fibrillation who are having their first ablation procedure. Researchers will track heart rhythm using remote monitoring, along with imaging and blood tests, to find which factors—like patient health, heart structure, or electrical signals…

This study tests a guidance algorithm that tracks the position of an ultrasound probe in real time to help non-specialists capture standard heart images. Researchers will compare the probe positions suggested by the algorithm with those chosen by experts. The goal is to make echo…

This study looked at 179 heart failure patients who used remote monitoring after a hospital stay. Researchers tracked how long patients kept using the system and interviewed some who stopped to understand why. The goal is to learn what helps or hinders sticking with remote monito…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This completed study looked at blood samples from 47 patients in France (part of a larger European study) to find biological markers linked to diastolic heart failure in people with metabolic syndrome. The goal was to confirm earlier findings about these markers. Participants had…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study looked at 70 people aged 75 and older with atrial fibrillation who were taking a Xaban blood thinner (dabigatran, rivaroxaban, or apixaban) during an unplanned hospital stay. Researchers wanted to see if certain clinical or lab factors were linked to higher drug levels…

This study observed over 1,600 adults in French emergency rooms to understand how patients are managed in the resuscitation area and whether being admitted directly to that area versus later affects their need for intensive care within 24 hours. Researchers recorded patient detai…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study examined how being obese (BMI over 30) affects hospital outcomes after coronary artery bypass grafting (CABG) in 500 patients with chronic ischemic heart disease. Researchers tracked death rates, neurological injury, kidney injury, breathing machine time, and need for …

This study tested two different methods of closing the main leg artery after a minimally invasive heart valve replacement (TAVR). One method used two small stitch-like devices, the other used one stitch device plus a plug. The goal was to see which approach caused fewer bleeding …

This study looked at two ways to improve CPR during cardiac arrest: changing how often rescuers switch (every 2 vs. 4 minutes) and using a device called CPRmeter that gives real-time feedback on chest compressions. Researchers measured the quality of compressions in 51 patients. …

This study tested whether a newer type of MRI called 4D flow can more accurately measure leakage in the pulmonary valve and heart chamber size in people born with tetralogy of Fallot who had corrective surgery. Researchers compared 4D flow MRI with standard 2D MRI in 21 patients …

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This study tested whether giving personalized nutrition training to mothers of children with congenital heart disease helps their kids grow better after heart surgery. The training covered feeding from birth to age 3, including breastfeeding and starting solid foods. Researchers …

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This study tests whether special low-energy MRI settings can make it safe to use guidewires during heart catheterization. Guidewires help position catheters but can heat up in standard MRI. Researchers will enroll 22 adults who need a right heart catheterization to see if this ap…

This study follows 200 adults who have elective coronary bypass or heart valve surgery to see how their physical abilities, lung function, and muscle strength change after the operation. Researchers measure walking speed, balance, handgrip strength, and breathing tests before and…

This small, completed study tested whether special pacing signals from a pacemaker could help control blood pressure in people with slow heartbeats. Five adults who needed a pacemaker or similar device took part. Researchers measured blood pressure and heart function during brief…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This study looked at 130 adults who survived a cardiac arrest outside the hospital and were treated with cooling therapy. Researchers measured two simple tests—a blood protein level and a motor response score—to see if they could predict brain function 6 months later. The goal is…

This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the foc…

This study tested a mobile health program called Heart2Heart for teens aged 12-18 with congenital heart disease. The goal was to see if teens liked the program and found it easy to use. Seventeen teens completed surveys, used the app, and gave feedback in interviews.

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study looked at whether using a very low flow of the anesthesia gas sevoflurane during heart surgery is safe and reduces environmental impact. 92 adults having planned heart surgery were randomly assigned to receive either ultra-low-flow or normal-flow anesthesia. Researcher…

This study reviewed records of 630 adults who survived a cardiac arrest and were treated in an ICU in Italy over 14 years. Researchers compared outcomes across three time periods when different official treatment guidelines were in use. The goal was to see if newer guidelines led…

This completed study looked at whether four easy-to-use nutrition scoring tools (GNRI, MNA-SF, PNI, and NAF) can predict serious lung complications after heart surgery in 217 patients aged 60 and older. Researchers tracked problems like pneumonia, blood clots in the lungs, and ne…

This study looked at 250 adults with stable coronary artery disease to see if feeling empowered and having a sense of purpose (called 'ikigai' in Japanese) are connected. Researchers used surveys to measure these feelings and how they relate to each other. The goal is to help nur…

This study looked at a new way of managing chronic heart failure using nurse-led consultations. Researchers reviewed the records of 138 patients to understand how these consultations helped with adjusting medications and monitoring health. The goal was to see if this approach can…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study reviewed information from 683 adults with obstructive hypertrophic cardiomyopathy who took mavacamten through a support program in Canada. Researchers looked at patient characteristics and how long they stayed on the medication. The goal was to understand real-world us…

This study looked at whether a quick bedside test (Hemochron Jr) gives the same results as standard lab tests for measuring blood clotting in people having planned heart bypass surgery. Twenty patients were tested before and after being placed on a heart-lung machine. The goal wa…

This study tested a new X-ray-based imaging tool called 3DStent against the standard IVUS method to measure calcium buildup in heart arteries. Thirty adults with coronary lesions were enrolled. The goal was to see if 3DStent can accurately identify and measure calcium deposits, w…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study tested a new tool called a linear cognitive aid to help emergency medical teams treat children during critical situations like cardiac arrest. The tool gives simple, step-by-step instructions based on the child's age and emergency type. Researchers compared teams using…

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study looked at whether it's safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD). The test involves purposely triggering a dangerous heart rhythm to make sure the device can stop it. About 965 people took part. T…

This study tested if using the lower leg to push on the chest during CPR works as well as the standard hand method. About 99 paramedic and nursing students performed two minutes of chest compressions on a manikin, either with their hands or their dominant foot. The goal was to se…

This study tested whether specially designed educational videos, sent through a mobile messaging app, could help people with coronary heart disease improve their fitness and heart health knowledge during a 12-week home-based cardiac rehabilitation program. Twenty-one participants…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looks at people with end-stage heart failure who have a mechanical heart pump (LVAD). It checks whether the pump's flow rate, adjusted for body size, is linked to liver and kidney function and the chance of being readmitted to the hospital. The goal is to see if this m…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested whether individually adjusting the timing (atrioventricular delay) of a pacemaker improves heart function in 39 adults with conduction system pacing. Researchers used echocardiography to optimize settings and measured changes in heart strain, pumping ability, an…

This study looked at damage to the protective lining of blood vessels during heart bypass surgery. Researchers measured a substance called syndecan-1 in the blood of 147 patients to see when and why this damage happens. The goal was to understand how surgery affects the body and …

This completed study looked at 26,000 adults with chronic heart failure in France who used a web app for remote monitoring. Researchers compared those who were digitally literate with those who were not, tracking hospitalizations and death rates. The goal was to understand whethe…

This study looked at whether giving heart attack patients personalized diet advice during early cardiac rehab helps them eat better. Fifty adults who recently had a heart attack took part. Some got standard rehab, while others also received one-on-one counseling from a dietitian.…

This study tested whether long-term digital education, like online lessons or app-based guidance, helps people who had a heart attack lower their LDL (bad) cholesterol more than standard care. Researchers followed 121 patients in the Czech Republic for 12 months. The goal was to …

This study looked at how common cardiac cachexia (unintentional weight loss) is in people with advanced heart failure and how it affects their outcomes. Researchers followed about 200 patients for one year to compare survival and hospitalizations between those with and without th…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study enrolled 91 people with atrial fibrillation to see if computer simulations can identify the main electrical problem causing their irregular heartbeat. Participants had heart imaging, mapping, and symptom tracking before and after a standard ablation procedure. The goal…

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study looked at 40 children with congenital heart disease who had heart surgery. During surgery, doctors used a special filtering technique called SBUF-SMUF to remove inflammatory substances from the blood. The goal was to see how this affected inflammation and recovery. The…

This study tested whether using a pulse oximeter (a small sensor on the foot or hand) to measure oxygen levels in all seemingly healthy newborns can help find hidden, life-threatening heart defects early. Over 44,000 babies took part. The goal was to see if this screening reduces…

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This study looked at how blood vessel function relates to heart blockage in people with a genetic heart condition called hypertrophic cardiomyopathy. Researchers measured blood flow and vessel flexibility in 40 adults. The goal was to understand the connection, not to test a trea…

This study looked at 150 patients who had a heart attack 12 to 36 hours earlier. Researchers wanted to see if opening the blocked artery right away was better than waiting a few days. They used MRI scans to measure heart muscle damage and function.

This study looked at whether DNA can be taken from heart muscle cells to help diagnose arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare heart condition. Researchers collected cells from 34 people during a routine heart procedure. The goal was to see if the DNA from …

This completed study looked at inherited disorders common in Amish and Mennonite populations. Researchers collected medical histories, blood or cheek swab samples from 157 participants to find the genes behind these conditions. They also built a computer database of family trees …

This study tested whether a special heart ultrasound (speckle tracking echocardiography) can predict which patients need an implantable defibrillator (ICD) after a large heart attack. Researchers followed 200 patients for 90 days to see whose heart function stayed low enough to q…

This study checked how often nerve damage (neuropathy) occurs in people with a rare heart condition called wild-type TTR cardiac amyloidosis. Researchers examined 65 patients using interviews, physical exams, and nerve tests (electromyograms). The goal was to find out if nerve pr…

This study tested whether a nurse-led education program helps people with heart failure improve their self-care, medication and diet compliance, and confidence in managing their condition. Researchers enrolled 66 adults with stable heart failure and provided a 30-minute training …

This study looked at whether electrically stimulating scarred heart muscle after a heart attack could improve how well the heart contracts. Ten patients undergoing a standard procedure for abnormal heart rhythms had their heart function measured before and after stimulation of th…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study tested whether a CT scan before a heart procedure could help doctors better target the source of a dangerous heart rhythm called ventricular tachycardia. 23 people who had a prior heart attack and needed catheter ablation took part. The approach aimed to see if using C…

This study looked for genetic causes of congenital heart disease (heart problems present at birth) in families from Uganda and Nigeria. Over 1,200 people took part, including affected children and their parents. Researchers used advanced DNA testing to find gene changes linked to…

This study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs (using the whole body or just one leg) could improve fitness. The study involved 93 adults aged 60…

This study looked at new ways to test blood clotting in 200 children with congenital heart disease undergoing surgery. The goal was to see if newer technologies like TEG, ROTEM, and T2MR could help doctors manage bleeding more precisely and reduce the need for blood transfusions.…

This study looked at 636 older Italian patients with a type of irregular heartbeat called non-valvular atrial fibrillation (NVAF). Researchers wanted to understand why some patients start taking blood thinners and others do not, and how long they stay on their treatment. The goal…

This study looks at 250 people with atrial fibrillation who are having a hybrid ablation procedure. Researchers want to find out which factors—like clinical history, blood markers, and genetics—are linked to the procedure failing. The goal is to create a risk profile that helps d…

This study looked at how well two types of stents (small mesh tubes) placed in heart arteries after a heart attack become covered by the body's own cells. 22 people who had a heart attack were randomly assigned to get either a SYNERGY stent or a bioresorbable scaffold. Doctors us…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study tested a new catheter designed to measure the heart's electrical signals in people with irregular heartbeats (atrial fibrillation, ventricular fibrillation, or junctional tachycardia). Researchers enrolled 42 adults to see if the device could better identify abnormal e…

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This completed study looked at 1000 people who had a coronary stent placed to see if a score based on insulin resistance could predict whether the stent would narrow again (restenosis). Researchers measured insulin resistance using routine blood tests and checked for restenosis w…

This study looked at two different heart stents (tiny mesh tubes used to open blocked arteries) to see which one works better in routine hospital care. Over 1,000 patients who needed a stent took part. The goal was to compare costs, procedure time, and how many extra devices were…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study collected medical and social information from 111 patients having their first ablation for atrial fibrillation, a common heart rhythm problem. Researchers wanted to understand how factors like income, education, location, and ethnicity might affect who receives this tr…

This early-stage trial tested the safety and tolerability of a new drug called SHR-6934 in 88 healthy adults. Participants received either the drug or a placebo as a single or multiple injections under the skin. The goal was not to treat any disease, but to gather important safet…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study looked at how a sedative called dexmedetomidine affects heart function during off-pump coronary artery bypass surgery. Researchers used ultrasound to measure heart pumping ability in 36 patients with coronary artery disease. The goal was to see if this medication helps…

This study tested a new way to predict dangerous heart rhythm problems after a common heart valve procedure called TAVR. Researchers combined ECG results with CT scan measurements and implant depth to see if they could safely identify low-risk patients. The study looked back at 2…

This study looked at 200 adults having a cardiac arrest outside the hospital to see how long it takes paramedics to get a working IV or IO line. The goal was to find out what causes delays or failures when trying to start an IV first and then switching to an IO if needed. The res…

This study looked at whether a special mapping tool called vMap can help doctors perform heart ablations more efficiently for people with irregular heartbeats (arrhythmias). Researchers tracked 112 patients to see if using vMap reduced procedure time and improved success rates. T…

This study examines how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people (20 survivors and 20 relatives) within a week of the event and again at 3 months using standard questionnaires…

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study collected information from over 15,000 people hospitalized with cardiomyopathy, a heart muscle disease. Researchers looked at how much these hospital stays cost and what the money was spent on. The goal was to understand the real-world financial impact and help manage …

This completed study looked at whether stomach emptying is slower during a heart attack, which could delay the absorption of crucial antiplatelet drugs. Researchers measured paracetamol levels in the blood every 15 minutes in 23 participants to track stomach emptying. The goal wa…

This study looked at how often cardiac amyloidosis occurs in older Tunisian patients with a type of heart failure called HFpEF. Researchers used heart scans and imaging to find cases and identify early warning signs. The goal is to make diagnosis easier and faster for this seriou…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This pilot study looked at whether adding genetic risk information to standard heart disease counseling or health coaching helps people make healthier choices. 31 adults at risk for heart disease participated. The goal was to see if this approach is practical and can improve diet…

This study looked at how certain natural chemicals in the body affect recovery after heart surgery. Researchers followed 287 adults having open-heart surgery to see if these chemicals are linked to problems like confusion after the operation. The goal was to better understand the…

This study looked at how well a new heart monitor (Assert-IQ) detects atrial fibrillation (an irregular heartbeat) in people who have had a heart ablation procedure. 151 participants wore the monitor as part of their normal care. Researchers compared the monitor's readings to a s…

This pilot study tested whether drinking beet juice twice daily for two weeks could improve blood vessel function and breathing muscle strength in older adults with coronary artery disease. Eight participants were randomly assigned to receive either nitrate-rich beet juice or a p…

This study looked at 81 patients who had coronary artery bypass surgery to find out what factors affect how long they need a breathing tube afterward. Researchers checked things that happened before, during, and after surgery. The goal was to better understand what influences rec…

This study tracked 300 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVI) to see how long they stayed in the hospital and why some stayed longer than 3 days. The goal was to find out what factors, like needing a blood transfusion or a…

This study looked at whether CT scans can help doctors choose the right size for the Perceval sutureless heart valve. The valve is used to replace a leaky aortic valve. Researchers studied 50 patients to see if CT-based sizing leads to good early results after surgery, like prope…

This completed study involved 250 adults with AL amyloidosis, a rare disease where abnormal proteins damage organs. Researchers analyzed patient samples and data to find biological markers that predict how well someone will respond to initial treatments. The goal is to help docto…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study used computer simulations to compare three types of radiation (photons, protons, and carbon ions) for treating a dangerous heart rhythm called ventricular tachycardia. Researchers created treatment plans for 23 patients who were already scheduled for standard catheter …

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked at 502 people with heart failure who were getting an implantable defibrillator (ICD) to prevent sudden cardiac arrest. Researchers used a special MRI to see if heart scarring patterns could predict who would later need a shock from the device. The goal was to le…

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to better understand …

This study looked at 1,811 patients aged 60-70 who had heart valve replacement surgery. Researchers compared different types of artificial valves to see if the valve type was linked to developing depression, anxiety, or sleep disorders later. The goal was to understand if the cho…

This study gathered information from routine medical care for 198 adults with atrial fibrillation who had a prior procedure to close a small heart pouch (left atrial appendage occlusion) and later needed a heart ablation. Researchers looked at patient details, procedure steps, bl…

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is…

This completed study looked at 76 people having heart bypass surgery. It tested two different ways of managing the pressure in the breathing tube during the procedure to see if it affected swelling in the airway. The goal was to find a safer pressure level to reduce complications…

This study looked at how high-intensity interval training (HIIT) changes heart cells in people with heart failure. Forty stable patients were split into two groups: one did 36 sessions of HIIT plus standard medication, the other took medication only. Researchers measured fitness,…

This completed study followed over 7,200 heart patients in Tunisia to see how well they stick to their heart medications after a heart attack or procedure. Researchers simply observed and recorded data without giving any new treatment. The goal is to understand real-world medicat…

This study tested whether a special MRI scan (31P-MRS) can detect early signs of damage to heart and muscle cells caused by chemotherapy drugs like doxorubicin. Twelve cancer patients scheduled for chemo underwent three scans over time. The goal was to see if the scan could measu…

This study observed 49 adults hospitalized with acute heart failure to learn how fluid congestion behaves during treatment. Researchers tracked clinical signs, lab tests, and ultrasound measures, then followed patients for a year to see who was readmitted or died. The goal is to …

This study looked at 11 people with a repaired heart condition called tetralogy of Fallot who needed a new pulmonary valve. Researchers used MRI scans to measure heart muscle stiffness (fibrosis) and how well the heart pumped during rest and exercise. The goal was to see if these…

This study aimed to create a new questionnaire that measures how atrial fibrillation (AF) affects a person's quality of life. Researchers worked with 206 adults who have AF to develop and test this tool. The goal was to better understand the real-world impact of AF beyond just me…

This completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…

This study looked at 468 Italian adults who take blood thinners (anticoagulants) to understand their health knowledge, quality of life, and confidence in managing their condition. Researchers used questionnaires to measure these factors and see how they relate to age, education, …

This study looked at how well a procedure called catheter ablation works for treating fast heart rhythms in people with congenital heart disease. Researchers treated 40 patients and followed them for one year to see if the abnormal heart rhythm came back. The goal was to understa…

This study looked at 300 women undergoing frozen embryo transfer as part of IVF treatment. Researchers measured progesterone levels in the blood to understand how the body processes the hormone. The goal was to find out if low progesterone on transfer day leads to higher failure …

This study looked at whether certain cells and substances in the blood can help predict if a person who has had a heart attack or unstable angina will have another heart problem within a year. Researchers took blood samples from 180 patients and tracked their health for one year.…

This completed study looked at 262 people with dilated cardiomyopathy, a condition where the heart muscle is weakened and enlarged. Researchers used a special MRI technique (T1 mapping) to measure scarring (fibrosis) in the heart. They wanted to see if the amount of scarring coul…

This study aimed to make heart rate monitors more accurate for people with heart conditions. Researchers collected data from 138 participants, including cardiac patients and athletes, using Fitbit and Polar devices over 13 weeks. The goal was to remove false readings and develop …

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study looked at how men and women's brains and hearts react to mental stress. Researchers used special brain and heart scans on 64 healthy adults aged 50-75. The goal was to understand if stress affects heart health differently based on sex. No treatment was given; this was …

This study measured levels of an inflammatory protein called HMGB1 in 74 children with congenital heart disease and pulmonary hypertension. Researchers compared these levels to those in children with heart disease alone and healthy controls. The goal was to see if inflammation pl…

This study compared two common sedation drugs, propofol and dexmedetomidine, in 65 older adults undergoing a less invasive heart valve replacement called TAVR. The goal was to see which drug leads to better kidney function, less confusion, and fewer complications after the proced…

This study looked at 155 people with early-onset atrial fibrillation to see if genetic testing can help doctors choose better treatments. Participants had heart imaging and ECG tests to find hidden heart muscle or rhythm disorders. The goal is to learn how genetics influence the …

This study examined how the Impella heart pump changes platelet function in 30 patients with cardiogenic shock or cardiac arrest. Researchers measured markers of platelet activation and aggregation before and during pump support. The goal was to understand why some patients devel…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at 140 adults having mitral valve surgery to see if a special heart ultrasound measure (called global longitudinal strain) could predict a serious complication called low cardiac output syndrome. Researchers checked ultrasound images taken during surgery and tra…

This study tested whether a small, band-aid-like heart monitor (Zio patch) can be worn by children for up to 14 days. It involved 36 kids aged 1 to 17 years. The goal was to see if the patch sticks well and gives clear heart signals. The study did not test any treatment, only the…

This study looked at 30 people who had a heart attack and were treated with a procedure to open blocked arteries. Researchers used a special heart scan soon after treatment to see how much heart muscle was saved. They then checked if that scan could predict how well the heart wou…

This study tracked 1,826 people who received a small implantable heart monitor (Confirm Rx) to check for irregular heartbeats. Over 12 months, researchers recorded how often the device caused serious problems and how well it worked in daily life. The goal was to see if the monito…

This study looked at how common vitamin D deficiency is in people with chronic heart failure and whether giving vitamin D supplements improves their health. 91 adults with heart failure were divided into groups based on their vitamin D levels. Those with severe deficiency were ra…

This study looked at 321 people with pacemakers or heart monitors who had short, symptomless episodes of atrial fibrillation (silent AF). Researchers measured certain proteins in the blood to see if they could predict who might later have a stroke or other heart problems. The goa…

This study tested a computer alert that pops up in doctors' electronic health records to remind them to prescribe recommended heart failure medications. Over 1,100 patients with a specific type of heart failure (reduced ejection fraction) took part across four health systems. The…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study tested how easy and acceptable the P-STEP mobile app is for people with chronic conditions like asthma, COPD, heart disease, or diabetes. 178 adults in Leicester, UK used the app for 12 weeks to track their walking and get air quality updates. The main goal was to meas…

This study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study tested whether simple nudges—like an alert in a doctor's daily task list or an email comparing their prescribing habits to peers—could increase the use of two types of heart failure medications (SGLT2 inhibitors and MRAs) that are proven to save lives but are often und…

This study looked at whether being physically active over a lifetime is linked to developing a rare heart disease called wild-type transthyretin amyloid cardiomyopathy. Researchers compared the exercise histories of 180 people over age 60, including those with the disease, those …

This study looked at 200 people with atrial fibrillation to see if treatments like catheter ablation or exercise training change levels of a brain chemical called BDNF. Researchers also checked if these changes relate to mood and quality of life. The goal was to gather knowledge,…

This completed study tested whether sotagliflozin, a dual SGLT1/2 inhibitor, reduces blood clot formation better than empagliflozin, a standard SGLT2 inhibitor. Seventeen healthy volunteers took each drug for one month in a crossover design. Researchers measured clot size and pla…

This completed study tested whether a telehealth program, including a heart monitor and regular phone check-ins, could reduce symptoms and improve self-care and quality of life in 160 adults who had coronary artery bypass surgery. Participants were randomly assigned to either the…

This study looked at data from 100 patients who had heart artery imaging and pressure measurements. Researchers developed a new computer algorithm to analyze ultrasound images of the arteries and estimate how much they block blood flow. The goal was to see if the algorithm could …

This study looked at whether giving extra oxygen to pregnant mothers carrying babies with congenital heart disease (CHD) could increase oxygen levels in the fetal brain. Researchers used ultrasound and MRI to measure changes in 53 fetuses with different types of CHD. The goal was…

This study tested a 12-week virtual education program for primary care providers in North Carolina to improve how they manage atrial fibrillation (AFib). 70 providers joined online sessions to learn about AFib care and EKG interpretation. Researchers measured changes in provider …

This study tested whether a special pacing technique in the heart's right ventricle can more accurately predict where certain rapid heartbeats originate, compared to standard ECG criteria. Researchers enrolled about 200 patients undergoing catheter ablation for ventricular arrhyt…

This completed Phase 4 trial looked at how evolocumab (Repatha), a cholesterol-lowering drug, affects markers of inflammation and blood clotting in 41 people with type 2 diabetes and heart disease. Participants received either evolocumab or a placebo injection every 4 weeks for 1…