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Could cheap steroids help hearts in shock?

NCT ID NCT03773822

Completed Disease control Sponsor: CMC Ambroise Paré Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving low doses of two steroids (hydrocortisone and fludrocortisone) helps adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. 380 participants received either the steroids or a placebo. The main goal was to see if the steroids increased the number of days patients could go without blood pressure support medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
hydrocortisone and fludrocortisone (low-dose steroids)
What this could lead to
If it works, this could offer a simple, low-cost way to help people in cardiogenic shock recover faster and need less intensive support.
What could go wrong
This is a completed phase 3 trial, but results may not apply to all patients. Steroids can have side effects, and the benefit may be modest or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adrenocortical insufficiency cardiogenic shock Shock, Cardiogenic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOGENIC SHOCK

Contacts and locations

Locations

  • CH Intercommunal de Villeneuve Saint Georges

    Villeneuve-Saint-Georges, Villeneuve Saint Georges, 94190, France

  • CH Pontoise

    Pontoise, 95300, France

  • CH de Marne la Vallée - Site Jossigny

    Jossigny, Jossigny, 77600, France

  • CHRU Hôpitaux de Tours

    Tours, 37000, France

  • CHU Lille - Institut Cœur Poumon

    Lille, 59000, France

  • CHU de Nîmes

    Nîmes, 30029, France

  • CHU de Strasbourg

    Strasbourg, Strasbourg, 67000, France

  • CMC Ambroise Paré

    Neuilly-sur-Seine, 92200, France

  • Centre Hospitalier Saint Joseph Saint Luc

    Lyon, 69007, France

  • Centre cardiologique du nord saint denis

    Saint-Denis, 93200, France

  • Groupe Hospitalier Paris Saint Joseph

    Paris, 75014, France

  • Hopital Rangueil

    Toulouse, 31400, France

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, Boulogne-Billancourt, 92100, France

  • Hôpital Arnaud-de-Villeneuve

    Montpellier, 34090, France

  • Hôpital Bichat

    Paris, 75018, France

  • Hôpital Cochin

    Paris, 75014, France

  • Hôpital Henri Mondor

    Paris, Île-de-France Region, France

  • Hôpital Parly II

    Le Chesnay, Le Chasnay, 78150, France

  • Hôpital Privé Jacques Cartier

    Massy, Massy, 91300, France

  • Hôpital européen Georges-Pompidou

    Paris, 75015, France

  • Hôpitaux Universitaires Pitié Salpêtrière

    Paris, 75013, France

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