Heart disorder

This early study tests a new catheter technique called VINTAGE for people with ventricular arrhythmia that hasn't improved with standard treatment. The procedure uses special catheters to reach and destroy heart tissue causing the abnormal rhythm. Thirty adults will be enrolled a…

This study tests an experimental drug called CAEL-101 in 125 people with a rare disease called AL amyloidosis, where abnormal proteins build up in organs like the heart and kidneys. The drug is designed to remove those protein deposits. The goal is to see if it helps people live …

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…

This study tests a device called Barostim that stimulates nerves in the neck to help the heart work better. It involves 2,500 adults with moderate heart failure who still have symptoms despite standard treatments. The goal is to see if the device reduces deaths and hospital stays…

This study looks at whether giving people a heart-lung machine (ECPR) right where they collapse from a cardiac arrest can help more of them survive to leave the hospital. Researchers will compare people who get this extra treatment with those who get standard CPR and care. The st…

This study tests whether combining two procedures—closing the left atrial appendage and using pulsed field ablation to correct heart rhythm—works better than closing the appendage alone in people with persistent atrial fibrillation and high stroke risk. Fifty participants will be…

This study tests a behavioral program called Individualized Developmental Care (NIDCAP) for newborns with complex congenital heart disease. The program aims to reduce stress from the hospital environment by supporting parent involvement, creating a soothing setting, and adjusting…

This study tests whether hearts from donors who died from circulatory death (DCD) are as safe for transplant as hearts from brain-dead donors (DBD). About 40 adult heart transplant recipients will receive either a DCD or DBD heart. The goal is to see if using DCD hearts can safel…

This study tests whether a procedure called pulsed field ablation (PFA) is safer and more effective than anti-arrhythmic drugs as a first treatment for people with persistent atrial fibrillation, a type of irregular heartbeat. About 484 participants will be randomly assigned to r…

This study looks at how safe and effective a new treatment called FARAPULSE pulsed field ablation is for people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 228 participants will be followed for up to 12 months to see if the procedure stops the …

This study tests the long-term safety and effectiveness of an experimental drug called VX-670 in adults with myotonic dystrophy type 1 (DM1). Participants who completed a previous VX-670 study can join. The drug is given through a vein, and researchers will monitor side effects a…

This study tests a device that electrically stimulates the vagus nerve to help manage heart failure. About 118 patients with moderate-to-severe heart failure received the implant. The goal is to see if this stimulation can improve heart function and exercise capacity over six mon…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart fu…

This early study tests a new stent system designed to treat blockages at artery branch points in the heart. It involves 13 people with heart disease who need a procedure to open these blockages. The main goal is to see if the stent can be safely placed and work as intended.

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This study tests whether benralizumab can improve lung structure and function in people with severe eosinophilic asthma who still have symptoms despite standard treatments. About 75 adults aged 18-70 will receive either the drug or a placebo for 48 weeks, followed by a 4-week che…

This phase 3 study tests Coagadex, a human clotting factor X, in 15 adults with acquired factor X deficiency caused by AL amyloidosis. The goal is to see if it safely stops active bleeding and helps manage bleeding during surgery. Participants receive the drug on demand for bleed…

This trial tests two types of drug-coated balloon catheters to treat small, newly blocked heart arteries. About 180 adults with stable or unstable angina will be randomly assigned to receive one of the two devices during a standard angioplasty procedure. The goal is to see which …

This study tests a new system that combines a leadless pacemaker with a subcutaneous defibrillator to treat dangerously fast heart rhythms. The devices communicate wirelessly to deliver pacing therapy without wires inside the heart. About 300 people at risk for ventricular tachyc…

This phase 3 trial is testing a drug called aficamten in 36 Japanese adults with symptomatic obstructive hypertrophic cardiomyopathy, a condition where the heart muscle thickens and makes it hard to pump blood. The drug aims to reduce over-contraction of the heart muscle. Researc…

This study tests a new device called the DurAVR™ THV System, a replacement heart valve placed through a small tube in an artery, for people with severe aortic stenosis (a narrowed heart valve). The trial involves 150 participants and aims to see if the device is safe and works we…

This early study tests a new device called the DurAVR™ heart valve in 15 people aged 65 and older with severe aortic stenosis, a condition where the heart's aortic valve becomes narrowed. The valve is implanted through a catheter (TAVR) without open-heart surgery. The main goals …

This study compares two ways to fix a leaky mitral valve in people aged 60 and older: a less invasive procedure using a clip (TEER) versus traditional open-heart surgery. About 450 participants will be randomly assigned to one of the two treatments. The goal is to see if the clip…

This study follows 16 infants aged 6 months or younger with infantile-onset Pompe disease, a rare genetic disorder that weakens muscles and breathing. All receive alglucosidase alfa (Myozyme) as part of their routine care. Researchers track how many survive without needing a brea…

This study compares two surgical techniques to fix a leaky mitral valve caused by degenerative disease. One method replaces the tiny chords that support the valve, while the other moves existing chords to a better position. The trial will follow 64 adults for one year after surge…

This pilot study tests whether a new pacing method called LOT-CRT, which paces two areas of the heart at once, works better than standard pacing alone in people with heart failure. Ten patients will each receive a special pacemaker and try both pacing settings for 6 months each. …

This study tests whether inclisiran, a drug given as a shot every 6 months, can reduce plaque buildup in the heart's arteries when added to standard statin therapy. About 608 adults with mild artery blockages (less than 50%) and no prior heart events will be randomly assigned to …

This study is tracking over 1,100 people with atrial fibrillation who are treated with the FARAPULSE system, a device that uses electrical pulses to destroy tiny areas of heart tissue causing the irregular rhythm. The goal is to see how well it works and how safe it is in everyda…

This study looks at how well Onyx drug-eluting stents work in everyday medical practice for people with coronary artery disease. Researchers will track 4,500 patients to see if these stents are safe and effective compared to other stents. The main focus is on preventing stent-rel…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This phase 3 trial tests whether the drug troriluzole can slow the progression of spinocerebellar ataxia, a rare genetic disorder that affects coordination and balance. About 300 adults with different types of SCA are randomly assigned to take either troriluzole or a placebo dail…

This large study compared two treatments for severe aortic stenosis (a narrowed heart valve) in 1,746 patients at intermediate risk for surgery. One group got a less invasive procedure called TAVI (a new valve inserted through a tube in the artery), and the other had open-heart s…

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This registry tracks 550 people with atrial fibrillation who are treated with the FARAPULSE pulsed field ablation system, using a special catheter and mapping technology. The goal is to see how safe and effective the procedure is in real-world settings over one year. Researchers …

This early study tested a new device called the Millipede ring, which is delivered through a catheter to tighten the mitral valve in people with functional mitral regurgitation (a leaky valve). Only 4 participants were enrolled to see if the procedure is safe and technically poss…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This study looks at children with congenital heart disease who take the blood thinner rivaroxaban after a Fontan procedure. The goal is to see how often serious or minor bleeding happens. Researchers will collect data from regular doctor visits for up to 2 years. No extra tests o…

This study tests a special balloon coated with a drug to treat heart arteries that have narrowed again after a stent was placed. About 600 adults with this condition will be randomly assigned to receive either the drug-coated balloon or a standard balloon procedure. The goal is t…

This study monitors the safety of the intravenous drug Samtasu (tolvaptan sodium phosphate) in people with heart failure who have fluid overload. Researchers will track side effects, including serious events and off-label use, in about 1,600 patients. The goal is to confirm the d…

This study looks at whether taking penicillin twice a day by mouth works as well as getting a penicillin shot every month to stop latent rheumatic heart disease from getting worse. About 1,000 children aged 5 to 17 with early signs of the disease are taking part. The goal is to f…

This study tests a new device called Tendyne, which is a replacement heart valve placed through a tube in the blood vessels, avoiding open-heart surgery. It is for people with a leaky mitral valve (mitral regurgitation) who are too high-risk for traditional surgery. The trial com…

This study follows 200 adults with persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year) who are treated with the Sphere-9 catheter and Affera ablation system. The goal is to see how safe the procedure is and how well it prev…

This study tests a special balloon coated with the drug paclitaxel to treat in-stent restenosis, where a previously placed stent in a heart artery narrows again. Twenty adults who have this condition will receive the balloon treatment or standard care. Researchers will check if t…

This phase 3 trial tests whether CAEL-101, an antibody that removes abnormal protein deposits from organs, can help people with AL amyloidosis live longer and avoid heart-related hospital stays. About 281 participants who have not yet received treatment for their plasma cell diso…

This study tests a new way to help people with heart failure in Uganda manage their condition. It combines a standard care program with a mobile app that tracks symptoms and gives advice. The goal is to see if this approach improves self-care and reduces deaths or hospital stays.…

This study tests whether switching to avalglucosidase alfa is safe and more effective for people with late-onset Pompe disease whose condition has worsened on the standard treatment, alglucosidase alfa. Participants receive biweekly infusions of the new drug and are monitored for…

This early study tests a new procedure called TRAIPTA for people with severe tricuspid valve regurgitation, a condition where a heart valve leaks and causes breathlessness and fluid buildup. The procedure uses a catheter to place a belt-like device around the heart from inside, t…

This study tests a drug called selatogrel, which people inject themselves at the first sign of a heart attack. The goal is to see if it can prevent death or reduce heart damage. The trial involves 25,000 people who recently had a heart attack and have other risk factors. Particip…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests whether a personalized catheter ablation approach, guided by mapping low-voltage areas in the heart, works better than standard ablation for people with persistent atrial fibrillation (AFib). About 510 adults with persistent AFib will be randomly assigned to rece…

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This study tests a new device that uses shock waves to break up calcium deposits in heart arteries before placing a stent. About 335 adults with coronary artery disease will receive this treatment at up to 55 US sites. The goal is to see if the device helps stents work better and…

This study tests if a new growth hormone medicine (somapacitan) given once a week works as well as the standard daily growth hormone (Norditropin) for children who are very short due to being born small, or having Turner syndrome, Noonan syndrome, or unknown causes. About 412 chi…

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This study tests whether giving a drug that blocks a key inflammatory protein (TNF-alpha) within 6 hours after a cardiac arrest can help more people survive. The trial includes 208 adults who remain unconscious after their heartbeat is restored. The goal is to see if the drug imp…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This early-stage study tests a gene therapy called AT845 for adults with late-onset Pompe disease, a condition that weakens muscles. The treatment aims to deliver a working copy of the GAA gene to muscle cells. Eleven participants who have been on standard enzyme replacement ther…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow the buildup of artery plaque in people with a high genetic risk for heart disease. Researchers will use CT scans to measure changes in plaque over one year. The trial invo…

This trial tests whether a new device called OmniHeart 4.0 can safely support the heart during high-risk angioplasty, compared to the standard ECMO machine. About 254 patients will be randomly assigned to receive either the OmniHeart or ECMO. Researchers will track major heart an…

This early-stage trial tests a combination of three drugs—venetoclax, ixazomib, and dexamethasone—in 24 patients with light chain amyloidosis that has returned or not responded to prior treatment. The study focuses on finding the safest dose and checking side effects. All partici…

This study tests an investigational drug called COR-1167 in 300 people hospitalized with worsening heart failure. Participants receive either the drug or a placebo for 28 days. Researchers measure how well the body removes fluid, changes in weight, heart function, and symptoms. T…

This study tests whether a daily pill called dapagliflozin can help adults with Fontan circulation, a heart condition from birth. Researchers want to see if it lowers pressure in the veins and improves exercise ability. About 29 adults will take the drug for 4 weeks and have chec…

This study tests a drug called eplontersen in Chinese adults with a heart condition caused by abnormal protein buildup. The goal is to see if the drug lowers that protein and is safe over time. Participants will be randomly assigned to receive the drug or a placebo for 24 weeks, …

This study tests a next-generation heart valve (Navitor) in 333 people with severe aortic stenosis who are too high-risk for open-heart surgery. The goal is to see if the valve is safe and works well at 30 days, focusing on survival and reducing leaks around the valve. The valve …

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests a device called the Edwards APTURE shunt, which is implanted in the heart to create a small opening that lowers pressure. The goal is to see if it can improve symptoms and quality of life for 100 people with a certain type of heart failure. Half of the participan…

This study looks at how well a special catheter (THERMOCOOL SMARTTOUCH SF) and software (Ablation Index) work to treat paroxysmal atrial fibrillation, a type of irregular heartbeat. Researchers will track 150 adults who get this procedure to see if they stay free of heart rhythm …

This study compares a new oral blood thinner, milvexian, to the standard apixaban in about 20,000 adults with atrial fibrillation (an irregular heartbeat). The goal is to see if milvexian is at least as good at preventing strokes and blood clots, while also checking for major ble…

This study tests whether a ketone ester supplement, taken three times a day for 12 weeks, can improve heart function in people with heart failure. Fifty participants will be randomly assigned to receive the supplement or a placebo. Heart function will be measured using cardiac MR…

This study tests whether the drug tafamidis can safely stop the progression of ATTR amyloidosis in people who have already received a heart transplant. About 25 stable patients will take tafamidis daily for 12 months. Researchers will measure changes in blood protein levels, nerv…

This phase 2 trial tests a drug combination including daratumumab for people with AL amyloidosis, a rare disease where abnormal proteins damage organs, especially the heart. The study has two groups: one gets the full combo right away, the other starts some drugs later. Researche…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This early study tests a device that closes a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who cannot take blood thinners. The goal is to lower the risk of stroke without needing lifelong medication. About 58 participants will be followe…

This study looks at how well the Harmony Transcatheter Pulmonary Valve (TPV) works when used by doctors in everyday practice. It involves 174 people with congenital heart disease who need a new pulmonary valve. The main goal is to see if the valve works properly without needing a…

This study tests whether intravenous immunoglobulin (IVIG) can reduce symptoms of autonomic dysfunction—such as dizziness, rapid heartbeat, and fatigue—in people with long COVID. Two hundred participants will receive either IVIG or a placebo (saline) for 9 months, plus coordinate…

This study tests a small sensor implanted in the lung artery that sends daily pressure readings to doctors. It involves 81 adults with advanced heart failure (NYHA Class III). The goal is to see if the device is safe and accurate, helping patients avoid hospital stays by catching…

This early-phase trial tests whether giving stem cells (from a donor) during heart-lung bypass surgery is safe for infants under 6 months with certain congenital heart defects. Seventeen infants will receive the cells while undergoing heart repair. The main goal is to check for s…

This study tests a device called AccuCinch that is placed around the heart to help it pump more effectively. It is for people with heart failure and a weakened heart muscle. The goal is to see if the device improves quality of life, exercise ability, and reduces serious heart eve…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study tests a smartphone app called Medly that helps heart failure patients monitor their health after a hospital stay. The app reminds patients to check their weight and symptoms, and sends the information to their care team. The goal is to see if using the app improves pat…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests a new device that creates a small passage in the heart to relieve pressure, without leaving a permanent implant. It is for 350 people with heart failure and reduced pumping ability. The goal is to see if it reduces deaths, need for a heart pump or transplant, and…

This study compares a new, less invasive shockwave device to standard surgery for treating severe calcium buildup in the main leg artery. The shockwave uses sound waves to break up the calcium, while surgery involves physically removing the blockage. Researchers want to see if th…

This study tests a device called Amulet 2 that is implanted in the heart to seal off a small pouch (the left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. About 4…

This study tests whether the antibiotic doxycycline can prevent or slow the enlargement of heart arteries in children with Kawasaki disease. About 26 children with already enlarged coronary arteries will receive doxycycline for three weeks. The goal is to see if the drug blocks a…

This study compares two types of TAVR devices (self-expanding vs. balloon-expandable) in over 1,100 people with severe aortic stenosis and a small aortic annulus. The goal is to see which device leads to fewer deaths, strokes, or hospitalizations, and which performs better over t…

This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined app…

This study tested a small sensor placed in the lung artery to help doctors monitor heart failure patients remotely. 738 people with advanced (NYHA Class III) heart failure took part. The goal was to see if using the sensor could reduce hospitalizations and deaths compared to a ta…

This study tests if adding a tiny shunt (a small passage) between the upper chambers of the heart can lower pressure after a standard valve repair procedure called MitraClip. Ten people with heart failure and a leaky mitral valve will receive the shunt right after their MitraClip…

This study tests whether adding a nerve-calming kidney procedure (renal denervation) to standard heart ablation (pulsed-field ablation) can better prevent atrial fibrillation from coming back. About 86 adults with persistent AFib will be randomly assigned to get either the combin…

This study tests whether a combination of high-dose statins, blood pressure medications (ACE inhibitors or ARBs), and low-dose aspirin can reduce the risk of death, heart attack, stroke, or hospitalization in women who have chest pain or shortness of breath but no major blockages…

This study tests whether inclisiran, a newer cholesterol-lowering drug, works better than standard treatments for Chinese patients with coronary heart disease. About 1,590 adults whose cholesterol is still high despite statins will receive either inclisiran or usual care. The mai…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study is tracking 100 adults who receive an EluPro antibiotic-eluting envelope during implantation of a heart device (like a pacemaker). The envelope slowly releases antibiotics to prevent infection. Researchers are monitoring complication rates in real-world use to see how …

This study is testing a device called the Tendyne mitral valve system in 200 people with mitral regurgitation, a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The valve is implanted through a tube in an artery, avoiding open-hear…

This study tests a new device that combines two heart therapies: one to strengthen heartbeats and another to stop dangerous rhythms. About 300 adults with heart failure and a weak heart pump will get the device. Researchers will check if it safely converts life-threatening heart …

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests a new device called the Occlutech Flex II PFO Occluder, which is used to close a small hole in the heart (PFO) that can cause strokes. The trial involves 450 people who have had a stroke with no clear cause and a PFO. Researchers want to see if the new device wor…

This study tracks how well the MITRIS RESILIA mitral valve works in real-world patients who need a new mitral valve due to narrowing or leakage. About 504 adults having valve replacement surgery will be followed for safety and performance, including valve function and major heart…

This study tests whether a minimally invasive procedure to repair a leaky tricuspid valve can help people with right-sided heart failure. About 360 participants will either receive the valve repair plus standard medications or medications alone. The goal is to see if the repair r…

This study looks at a procedure called cryoablation that uses a freezing balloon to destroy tiny areas of heart tissue causing an irregular heartbeat (persistent atrial fibrillation). About 400 adults with this condition will be followed for up to 3 years to see how well the trea…

This study looks at whether doing a heart procedure called cryoablation right away in the emergency room can help people with recent atrial fibrillation (AFib). About 350 adults with AFib that started within the past year will be randomly assigned to get either immediate ablation…

This study is testing a device that uses sound waves (intravascular lithotripsy) to break up hard calcium deposits in the heart arteries of women with coronary artery disease. The goal is to make it easier to place stents and improve outcomes. About 400 women are being followed t…

This registry is following 10,000 people with atrial fibrillation who are getting a procedure called pulsed field ablation using the Farapulse system. The goal is to see how well it stops irregular heart rhythms and how safe it is in everyday medical practice. Researchers will tr…

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This study tests whether a less invasive heart valve replacement (TAVR) is safe and effective for people with moderate aortic stenosis, a condition where the heart's aortic valve is partially blocked. About 650 participants will receive the TAVR device and be monitored for compli…

This Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…

This study tests whether a wearable sensor that measures lung fluid can help doctors better treat fluid buildup in patients hospitalized for acute heart failure. About 216 adults will be randomly assigned to either standard care or care guided by the sensor. The goal is to see if…

This study compares two procedures for severe aortic valve stenosis: transcatheter aortic valve implantation (TAVI), a less invasive approach, and standard open-heart surgery. It will follow 4,000 high-risk patients for up to 24 months to see which method leads to fewer deaths, h…

This study tests a new device called the Acolyte Catheter System in people with completely blocked heart arteries (chronic total occlusions) who still have symptoms despite medication. The goal is to see if the catheter can safely help doctors guide wires through the blockage to …

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This study compares a less invasive procedure (TEER) to standard open-heart surgery for people with severe mitral regurgitation, a condition where a heart valve doesn't close properly. About 600 adults will be randomly assigned to one of the two treatments. The main goal is to se…

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This study looks at whether measuring blood pressure inside the heart's left upper chamber during a procedure for atrial fibrillation (an irregular heartbeat) can spot patients with hidden heart failure. If the pressure is high, patients get a heart failure checkup and medication…

This study compares two ways to place stents in the left main coronary artery when there is a blockage at the opening of a branch. One method places a stent only in the blocked branch, while the other extends a stent from the main artery into the branch. Researchers will track 10…

This study is tracking 511 patients with severe tricuspid regurgitation who are treated with the Abbott TriClip device in real-world settings. The main goal is to see if the device can successfully reduce the valve leak by at least one grade at discharge. Researchers are also mon…

This study tests whether using a special imaging tool called OCT during stent placement leads to fewer heart problems over two years compared to standard methods. About 1,200 adults with blocked heart arteries that need complex stenting are taking part. The goal is to see if OCT …

This study tests a new device that uses special electrical pulses to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. About 150 adults aged 18-75 who have not responded well to medication will receive the treatment. The goal is to see if the de…

This large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…

This study looks at whether doing a preventive heart ablation (a procedure to destroy small areas of heart tissue causing irregular rhythms) before LVAD surgery can reduce serious problems like dangerous heart rhythms, death, blood clots, or heart failure in the first 30 days aft…

This study tests a small device called the BLOOM Micro-Occluder to close a common heart hole (PDA) in premature babies. About 55 babies weighing between 600 and 2500 grams will be enrolled. The goal is to see if the device is safe and works well over 6 months.

This study tests a new drug called DAY101 (tovorafenib) against standard chemotherapy for children and young adults with a type of brain tumor called low-grade glioma that has a specific gene change (RAF alteration). The goal is to see if the new drug works better at shrinking tu…

This study tests if a newer pacing method called left bundle branch pacing (LBBP) is better than standard right ventricular pacing (RVP) at preserving heart function in 683 adults with atrioventricular block (a type of heart block). Participants will be randomly assigned to one o…

This study tests whether a special heart pacing technique (left bundle branch pacing) combined with standard heart failure drugs can improve heart function better than drugs alone. It includes 50 adults with non-ischemic heart failure and a specific heart block. The main goal is …

This early study tests a new device called the FieldForce Ablation System in 35 people with atrial fibrillation (AFib). The device uses short electrical pulses to destroy tiny areas of heart tissue causing the irregular rhythm. The main goals are to see if it is safe and if it ca…

This study compares two ways to replace a narrowed heart valve in people with severe aortic stenosis who are at intermediate risk for surgery. About 1,400 participants will be randomly assigned to get either a less invasive TAVI procedure or open-heart surgery (SAVR). The main go…

This phase 3 trial tests two things at once in 2312 people with coronary artery disease: a new drug-coated stent (Angiolite) versus a standard stent, and a shorter course of blood thinners versus the usual longer course. The goal is to see if the new stent works as well and if sh…

This study tests whether propranolol, a drug often used for high blood pressure, can safely treat chylothorax—a buildup of lymphatic fluid—in children after open heart surgery. About 50 children aged 7 days to 18 years with congenital heart disease will receive either propranolol…

This study tests if a device called MitraClip, which fixes a leaky mitral valve without open-heart surgery, works as well as traditional surgery. About 500 people with severe mitral regurgitation who are at moderate risk for surgery will take part. The goal is to see if the devic…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This Canadian study tests whether remote monitoring of implantable defibrillators can replace regular in-clinic checkups. Over 1,100 participants will either use a home transmission system or receive usual care. The goal is to see if remote monitoring can detect heart issues fast…

This study planned to test a new device called the Cardiovalve for people with severe tricuspid regurgitation (a leaky heart valve). The goal was to see if the device could safely replace the valve and reduce leakage. However, the study was withdrawn before any participants were …

This study is tracking 500 heart failure patients in Germany who receive a small device called the InterAtrial Shunt. The device is implanted to create a tiny passage between the heart's upper chambers, which may help lower pressure and improve breathing and quality of life. Rese…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This study looks at whether actively treating a heart condition called patent ductus arteriosus (PDA) in premature babies is better than simply monitoring it. About 482 infants born between 22 and 28 weeks of pregnancy will be followed to see which approach reduces the risk of de…

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost tec…

This study tests whether using the Impella 5.5 heart pump during and after heart surgery improves outcomes for 100 patients with severely weakened hearts. The pump supports blood flow, aiming to reduce death, stroke, kidney failure, and heart failure after surgery. Participants m…

This study tests a new device called the Cardiovalve TR system for people with a leaky tricuspid heart valve (tricuspid regurgitation). The goal is to see if the device is safe and can reduce the leak. The study involves 157 participants with moderate to severe symptoms. Research…

This study is a large registry that will follow 5,000 people with heart failure who have received a Barostim implant. The goal is to see how well the device works in everyday medical practice to improve symptoms and quality of life. Participants are already implanted and will be …

This trial aimed to test whether umbilical cord stem cells, delivered through a catheter into heart arteries, could safely improve heart function in people with severe heart damage after a major heart attack. It was designed for patients with very weak hearts (ejection fraction b…

This study tests whether a less invasive procedure called TAVR (replacing the aortic valve through a tube in an artery) is as safe and effective as open-heart surgery for people with severe aortic stenosis who are otherwise healthy enough for surgery. About 2,200 participants wil…

This study tests a new stenting technique called double kissing nano-culotte for people with complex blockages in heart arteries. The procedure uses two stents with minimal overlap to keep arteries open. Researchers will track 12 patients for heart attacks, repeat procedures, or …

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study looks at 3,500 people with severe tricuspid regurgitation, a common heart valve problem in older adults. It compares medical therapy (diuretics), surgery, and a less invasive transcatheter procedure to see which works best and when to treat. The goal is to improve surv…

This study compares three catheter ablation techniques for people with persistent atrial fibrillation (AF), a heart rhythm disorder. About 617 adults having their first ablation will be randomly assigned to one of three groups: isolating the pulmonary veins alone, adding ablation…

This study planned to test a new device called the Cardiovalve, which is threaded through a leg vein to replace a leaky mitral valve in people too sick for open-heart surgery. The trial was withdrawn before any participants were enrolled, so no results are available. The approach…

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

This study tests a new catheter that uses two types of energy (radiofrequency and pulsed field) to destroy the tiny areas of heart tissue causing ventricular tachycardia, a fast and dangerous heart rhythm. Thirty patients with recurrent episodes will undergo the procedure. The go…

This study is testing a custom-made artificial heart valve, called TRICENTO, in 15 people with carcinoid heart disease who have severe leakage of the tricuspid valve and cannot have surgery. The valve is delivered through a catheter, avoiding open-heart surgery. The goal is to se…

This study is testing a device called the Edwards Cardioband FIT, which is used to repair the tricuspid valve in people with tricuspid regurgitation (a leaky heart valve). The device is delivered through a catheter, avoiding open-heart surgery. The trial includes 75 participants …

This study is testing a new device called the Edwards EVOQUE system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. The trial includes 228 people with moderate or severe tricuspid regurgitation who still have symptoms despite medica…

This pilot study tests whether using advanced imaging (ECGI, MRI, and PET scans) to identify abnormal heart tissue and electrical circuits can improve catheter ablation for persistent atrial fibrillation. Fifty-two adults with persistent AF who have not had prior ablation will re…

This study is for people with systemic amyloidosis, a disease where abnormal proteins build up in organs. It tests the long-term safety of an experimental drug called AT-02. About 120 adults will receive the drug and be monitored for side effects and how the drug behaves in the b…

This study tests a device that creates a small opening between the heart's upper chambers to relieve pressure in people with chronic heart failure. Unlike other shunts, this one leaves no permanent implant behind. The trial will compare the device to a sham procedure in 700 patie…

This study tests whether showing people their own coronary CT scans can motivate them to lower their LDL cholesterol and reduce side effects from statins. 273 adults with non-obstructive coronary artery disease will be followed for 12 months. The goal is to see if visual feedback…

This study tested a new device called the ACURATE neo2, which replaces a narrowed heart valve without open-heart surgery. About 1,900 people with severe aortic stenosis received either the new device or a standard one. The goal was to see if the new device is safe and works as we…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This study is testing a less invasive procedure called TAVR to replace the aortic valve in 150 people who have a bicuspid aortic valve (a valve with two flaps instead of three) and severe narrowing. The goal is to see if it is safe and works well for people who are at low risk fo…

This study tests whether a drug called anakinra, which reduces inflammation, can help prevent heart failure in people who have just had a heart attack. About 84 participants will receive daily injections of anakinra or a placebo for up to 14 days. The goal is to see if blocking i…

This study tests a minimally invasive heart bypass surgery for people with blockages in multiple coronary arteries. Instead of opening the chest fully, surgeons work through a small incision on the left side. The goal is to see if this approach is safe and effective, with fewer c…

This study tests a new device system that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm problem. About 300 people with symptomatic, recurrent atrial fibrillation will receive the procedure. The goal is to see if it safely and effectively restores…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study is testing whether a special pacemaker (cardiac resynchronization therapy, or CRT) can improve heart function and symptoms in people with mild heart failure and a specific type of heart block called left bundle-branch block. About 21 participants will receive a CRT dev…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study tests a new laser-based device that breaks up calcium deposits in the heart's arteries before placing a stent. About 426 adults with coronary artery disease will receive the treatment. The goal is to see if the device safely improves stent delivery and reduces complica…

This study compares two catheter ablation techniques for atrial fibrillation (AF), a condition where the heart beats irregularly. One method uses a standard approach with a drug called adenosine to find missed spots, while the other adds an extra ring of ablation without the drug…

This study tests whether adding the weight-loss drug liraglutide and a lifestyle program to standard catheter ablation can reduce fat around the heart and improve outcomes for people with atrial fibrillation (AF). About 60 adults with AF and a BMI of 27 or higher will take liragl…

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assi…

This study tests whether using a specific set of measurements (an algorithm) to decide between repairing or replacing a leaky mitral valve leads to better outcomes than letting the surgeon choose. About 110 patients with severe ischemic mitral regurgitation will be randomly assig…

This study looks at two treatment options for people who have both a leaky heart valve (ischemic mitral regurgitation) and blocked heart arteries. One option is open-heart surgery to fix the valve and bypass the blockages at the same time. The other is a less invasive procedure t…

This study looks at a procedure done before birth to help babies with a severe heart defect called hypoplastic left heart syndrome (HLHS). The goal is to improve blood flow through the heart so that the baby may have a better chance at a two-sided heart repair after birth. The st…

This study compares a newer pacing method called left bundle branch area pacing (LBBAP) with standard right ventricular pacing in 100 adults who need a pacemaker but have normal heart function. The goal is to see if LBBAP better prevents the decline in heart pumping ability that …

This study tests a smartphone app called MED-AD that sends reminders and tracks medication use for people with heart disease, high blood pressure, or high cholesterol. About 1,000 adults in Oman will be randomly assigned to use the app, receive daily text reminders, or get usual …

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This study follows 2000 people who have or will get the OmniaSecure defibrillation lead, a wire that helps control dangerous heart rhythms. Researchers will track how often the lead causes problems over 5 years. The goal is to make sure the lead is safe and works as expected in e…

This study tests whether a newer pacing method (conduction system pacing) is as good as or better than standard biventricular pacing in heart failure patients with atrial fibrillation who need a heart ablation. About 82 participants will be randomly assigned to one of the two pac…

This study tests whether a new leadless pacemaker (Micra AV) is better than a traditional wired pacemaker for people aged 75 and older with heart block. The goal is to see if the leadless device improves quality of life, patient acceptance, and exercise ability. Eighty participan…

This study is testing the Carmat Total Artificial Heart in 104 people with severe, irreversible heart failure who are waiting for a heart transplant. The device is designed to replace both heart chambers and keep patients alive until a donor heart becomes available. Researchers a…

This study is testing a new surgical heart valve (Model 400) in over 1,300 people with aortic valve disease. The valve is designed to replace the damaged aortic valve and improve blood flow. Researchers are checking how safe the valve is and how well it works over one year, looki…

This study tests a new drug-coated heart stent (VIVO ISAR) against a standard one (XIENCE Skypoint) in 40 people with coronary artery disease. Each patient receives both stents in different blocked arteries, and doctors use a special camera to check healing after one month. The g…

This trial aimed to test an experimental drug called CM-336 for people with AL amyloidosis that has returned, not responded to treatment, or only partially responded after initial therapy. The drug works by helping the immune system attack and destroy harmful cells. However, the …

This study compares two ways of programming implantable defibrillators (ICDs) in 398 Japanese patients. One group uses early, multiple bursts of rapid pacing (ATP) to stop dangerous heart rhythms, while the other uses a longer detection time before pacing. The goal is to see whic…

This study tests the drug mavacamten in 50 adults in India who have a condition where the heart muscle is too thick and blocks blood flow, causing symptoms like shortness of breath and chest pain. The goal is to see if the drug is safe and works well. Participants will take the d…

This study looks at how safe and effective the Avalus Ultra artificial heart valve is for people with aortic valve disease. About 190 participants will be followed for one year after surgery to check for problems like blood clots or valve failure, and to see how well the valve wo…

This study looks at two ways to treat a type of irregular heartbeat called non-paroxysmal atrial fibrillation (AFib) that doesn't go away on its own. Both methods use a new technique called pulsed-field ablation to destroy tiny areas of heart tissue causing the problem. One group…

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study looks at a procedure called hybrid convergent ablation for people with a long-lasting type of irregular heartbeat (atrial fibrillation) that hasn't improved with medication. The procedure uses heat energy to destroy heart tissue causing the problem, combining a small c…

This phase 3 study is testing the long-term safety and effectiveness of an experimental drug called AOC 1001 (del-desiran) for people with myotonic dystrophy type 1 (DM1), a genetic muscle disorder. The trial enrolls 230 adults who have completed a prior AOC 1001 study and will r…

This study tests a new method to preserve hearts from donors after circulatory death. The hearts are kept cool and oxygenated using a special machine during transport. The goal is to see if this helps more people get heart transplants and survive. The study involves 20 adults alr…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This study tests whether advanced CT imaging can help doctors plan better coronary bypass surgery for 200 people with heart disease. Participants get a CT scan before and after surgery to measure blood flow changes. The goal is to improve surgical decisions and reduce chest pain,…

This study aimed to compare a new type of heart stent that slowly dissolves over time (MeRes100) with standard permanent metal stents in people with coronary artery disease. The trial was planned to include about 2,000 participants worldwide, but it was withdrawn before enrolling…

This early study tests a new device called the NORM™ system in 25 adults with heart failure. The device is placed inside a large vein near the heart to send health information to doctors. The goal is to see if the implant is safe and can reliably transmit data, which may help man…

This study was designed to test an experimental drug called OPC-131461 in people hospitalized for worsening heart failure who still had fluid buildup after standard treatment. The goal was to see if the drug could improve a key blood marker of heart strain over 30 days. However, …

This study is checking the long-term safety of a drug called eplontersen in people with ATTR-CM, a heart condition caused by abnormal protein buildup. About 1400 adults who completed earlier studies will receive eplontersen injections. Researchers will monitor side effects, kidne…

This study compares two surgical techniques—flexible band and rigid ring—to repair a leaky tricuspid heart valve. About 300 adults with tricuspid regurgitation will be followed to see which method better prevents the need for repeat surgery, worsening of the leak, or death. The g…

This study tests a device called the Farapulse system, which uses electrical pulses to treat atrial fibrillation (AFib), a common heart rhythm problem. Researchers will enroll 275 adults with AFib who are already scheduled for a catheter ablation procedure. The goal is to see if …

This study is testing a newer version of a heart valve device, called the SAPIEN 3 Ultra, in 200 people with severe aortic stenosis (a narrowed heart valve). The valve is implanted through a tube in an artery, avoiding open-heart surgery. Researchers are checking how well the val…

This study planned to test whether cooling the body before and after opening a blocked artery could help people having a heart attack. It was designed to include 80 patients at up to 15 hospitals. However, the trial was withdrawn before anyone was enrolled, so we have no informat…

This phase 2 trial tests whether empagliflozin (Jardiance), a diabetes drug, can reduce the 'no-reflow' phenomenon—when blood flow fails to fully restore after angioplasty—in 162 heart attack patients. Participants receive a loading dose before the procedure and daily doses for 3…

This study tests a temporary heart pump called Impella ECP in 100 adults undergoing high-risk angioplasty. The pump helps maintain blood flow during the procedure. Researchers are checking if the device is safe and works as intended, with follow-up for 30 days after the procedure…

This study tests a new device called the Edwards EVOQUE eos mitral valve replacement system. It is for people with a leaky mitral valve who are too high-risk for open-heart surgery. The study will check if the device is safe and works well by looking at complications, heart funct…

This early-phase trial tests a radioactive imaging agent called 18F-mFBG to see how well it can show the nerves in the heart. Researchers will give the agent to 10 adults—some with heart disease and some without—and take PET scans over time. The goal is to measure how the agent m…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests a device called Infrasensor that may help doctors quickly identify people with severe heart artery blockages. About 350 adults with chest pain will use the device for 5 minutes, and results will be compared to standard heart catheterization. If accurate, it could…

This study tests a smartphone app called ausculto™ that records and analyzes heart sounds to detect congenital heart disease. Researchers will record heart sounds from 220 people aged 6 and older who have had recent echocardiograms. The goal is to see if the app can accurately te…

This study tests whether combining an AI-enhanced electrocardiogram (ECG) with a focused heart ultrasound can better detect structural heart disease in people without symptoms. About 2,705 adults with no known heart problems will get an AI-ECG, and if it flags a concern, they'll …

This study looks at whether certain blood markers can identify people without significant coronary artery disease, avoiding the need for more invasive tests. Researchers will enroll 1000 adults referred for a CT scan of the heart. The goal is to see if these biomarkers can accura…

This study compares a new AI-based method of analyzing CT scans of the heart to standard care for people with symptoms that might be coronary artery disease. The goal is to see if the AI approach helps doctors diagnose the condition more accurately, control risk factors like chol…

This study looks at people with Long COVID who have new chest pain but no blocked arteries. It tests whether a special heart function test can guide treatment to improve symptoms and quality of life. 108 participants will be randomly assigned to either treatment guided by the tes…

This study looks at CT scans of the heart from 22,000 people who had chest pain. Researchers want to see if certain features of plaque (fatty deposits) in the heart arteries can help predict who will later have a heart attack, stroke, or die from heart disease. The goal is to imp…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study is developing an artificial intelligence system to analyze CT scans of the heart. The goal is to automatically detect and measure dangerous plaque that can cause heart attacks. Researchers will compare the AI's findings with detailed imaging tests and track patient out…

This study looks at two new methods to tell apart blockages in large versus tiny heart arteries. About 68 adults with known or suspected coronary artery disease will get a PET scan and a heart catheterization. Researchers will compare the new measurements with standard tests to s…

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This study looks at whether existing blood markers can accurately identify the underlying cause of heart failure in 511 patients. Researchers aim to improve diagnosis and potentially reduce healthcare costs by avoiding unnecessary tests. Participants were recently diagnosed with …

This study looks at whether adding just 3 minutes to a cardiac MRI can help doctors find heart inflammation (myocarditis) early in cancer patients on immunotherapy. Myocarditis is a rare but often deadly side effect of these drugs. The researchers will scan 200 patients who alrea…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This study tests a new, non-invasive ultrasound method called electromechanical wave imaging (EWI) to see if it can more accurately locate and diagnose heart rhythm problems compared to standard tests. About 322 adults already scheduled for a heart procedure will get an EWI scan …

This large UK study (EVAREST) aims to improve how doctors interpret stress echocardiograms for diagnosing coronary artery disease. Researchers will collect blood samples and analyze echocardiogram images from up to 23,000 patients to find new biomarkers that make diagnosis more a…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study explores whether a community-based cooking program can help African-American adults at risk for heart disease cook and eat healthier. About 43 participants from Washington, D.C. will take surveys, attend cooking classes led by a chef, and track their eating habits. The…

This study tests whether using a special heart CT scan to guide intensive treatment can reduce major heart problems like heart attacks and strokes compared to standard care. About 15,000 high-risk adults aged 40-75 in rural China will take part. The goal is to see if this persona…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This study tests whether adding N-Acetylcysteine (NAC) to the standard drug amiodarone can better prevent atrial fibrillation (a type of irregular heartbeat) in people at high risk after major chest surgery. About 184 adults having lung or esophagus surgery will be randomly assig…

This study looks at the long-term safety and effectiveness of odevixibat in 70 people with Alagille syndrome, a rare genetic condition that affects the liver and other organs. The drug aims to reduce severe itching and improve bile flow. Participants who completed a prior 24-week…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This study tests a program called UPHOLDS to improve quality of life for 64 older adults with advanced heart failure. Participants receive different combinations of coaching, financial help, and a palliative care consultation. The goal is to see which parts of the program are mos…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, exercise ability, and quality of life in 150 adults with a type of heart failure called HFpEF who also have iron deficiency. Participants will receive either the iron infusion …

This study tests a new exercise program for people with coronary artery disease who have had heart surgery or a stent. The program combines high-intensity interval training with Nordic walking (walking with poles). Researchers want to see if it is safe, enjoyable, and better at i…

This pilot study looks at whether following the DASH diet (a heart-healthy eating plan) can improve the health of people with heart failure. Researchers will track diet, blood pressure, and heart failure markers in 26 adults over time. The goal is to see if medical nutrition coun…

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medi…

This study tests a single dose of an experimental drug called REGN7544 in 82 people with Postural Orthostatic Tachycardia Syndrome (POTS). The goal is to see if the drug safely reduces the rapid heart rate that happens when standing up. Researchers will also check for side effect…

This study tests whether an 8-week mindfulness meditation program (MBSR) can reduce anxiety and depression in heart patients who have completed cardiac rehab. About 74 participants will either take the meditation course or continue with standard rehab. Researchers will measure ch…

This study tests a simpler deep-sedation method for people having a heart procedure called pulsed-field ablation to treat atrial fibrillation (an irregular heartbeat). The goal is to see if the new sedation approach is safe and makes patients more comfortable. About 40 adults wil…

This study tests whether a probiotic supplement called Neuralli® MP can help adults aged 18 to 50 who have autistic traits. Participants take two capsules daily and set their own personal goals to track progress. The trial is small and open-label, meaning everyone knows they are …

This study tests whether peer health coaching—support from someone with similar experiences—can help young adults (ages 18-26) with congenital heart disease better manage their condition. Participants receive coaching via secure phone calls and texts over 6 months. The goal is to…

This study tests a culturally tailored counseling and support program for Chinese and Korean American caregivers of relatives with dementia. The program includes family counseling sessions and online peer support groups. Researchers will measure whether it reduces stress, depress…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This early study tests a device that creates a small, temporary opening in the wall of the heart to relieve pressure and improve symptoms in people with advanced heart failure. The main goal is to see if the procedure is safe. About 20 participants who have not responded well to …

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study compares two types of heart bypass surgery for people with blocked arteries: a minimally invasive approach using small incisions between the ribs versus the traditional method that opens the breastbone. Researchers want to see if the less invasive surgery leads to bett…

This study tests a simple, non-invasive device that gently stimulates a nerve in the ear (tVNS) to see if it can improve cognitive function in people over 60 with atrial fibrillation. For 6 months, 60 participants will use the device daily after exercise. Researchers will measure…

This study aimed to see if freezing certain nerves during minimally invasive heart surgery could lower pain afterward. It planned to enroll adults having mitral valve or atrial septal defect repair. However, the trial was withdrawn before any participants were enrolled, so no dat…

This study tests whether increasing the backup pacing rate from 75 to 100 beats per minute improves blood flow in adults with cardiogenic shock who already have a permanent pacemaker. Twenty-five participants in the cardiac ICU will be exposed to both rates in random order, with …

This study tests whether a ketone drink can improve exercise ability in people with heart failure. Researchers will give 25 participants either the drink or a placebo before exercise tests. The goal is to see if the drink helps them exercise longer and with less shortness of brea…

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests whether exercise delivered through immersive virtual reality can improve physical performance, muscle strength, fatigue, and quality of life in 32 adults with idiopathic pulmonary arterial hypertension. Participants will do virtual reality exercises and be measur…

This study planned to compare two versions of the water pill torsemide (immediate release vs extended release) in people with stable heart failure. The goal was to see which form helps the body get rid of extra salt more effectively after a salty meal. However, the trial was with…

This study tests whether adding blood flow restriction (BFR) to standard resistance training helps heart rehab patients get stronger and healthier. Twenty adults with stable heart disease will do exercises with and without a special cuff that limits blood flow to the arms and leg…

This pilot study tests whether a simple 'Talk Test' can safely and effectively prescribe exercise for heart patients recovering at home after bypass surgery or stent placement. Forty participants will be randomly assigned to get exercise instructions based on either the Talk Test…

This study will collect blood, urine, stool, and DNA samples from 2000 adults with heart failure to better understand how the disease progresses. Researchers will analyze proteins and other factors linked to declining heart function. Participants will be followed for up to 5 year…

This study looks at a new way to analyze electrical signals in the heart to help doctors find exactly where to burn during atrial fibrillation treatment. Researchers will review data from 336 patients who had the procedure, comparing those who stayed free of AFib for a year with …

This study looks at how different levels of pressure from a breathing machine (called PEEP) affect the heart's pumping ability in 28 adults having heart surgery. Doctors will use special imaging and monitors to measure heart function at four different pressure settings. The goal …

This observational study looks back at 22,000 adults in Sweden diagnosed with infective endocarditis, a serious heart valve infection, since 1997. By linking national health records, researchers aim to understand which patients benefit most from valve surgery and what factors aff…

This study follows 2,000 people in China who received the SYNERGY stent to open blocked heart arteries. Researchers are collecting real-world data on safety and major heart events after the procedure. The goal is to see how well the stent performs in everyday medical practice.

This study follows 250 male endurance athletes who were part of an earlier study to see how their heart arteries have changed over time. Researchers will use CT scans and AI to examine plaque buildup and determine if it is stable and harmless or likely to cause heart attacks. The…

This study collects blood and other samples from people with sickle cell disease and healthy volunteers to help researchers understand how inflammation affects blood vessels. Up to 2,000 adults aged 18 and older will take part. The samples will be used in lab tests to support fut…

This study looks at whether bosentan, a drug that blocks a natural vessel-constricting substance, can improve blood flow in the tiny heart vessels of people with angina who have no major blockages. About 45 participants will get bosentan for 4 weeks and have MRI scans before and …

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study is gathering health information from 4,600 people in rural areas of Alabama, Kentucky, Louisiana, and Mississippi. Researchers will look for risk factors that lead to heart and lung disease. No treatments or drugs are being tested. The goal is to learn more about what …

This study follows over 3,400 adults who have had a heart stent procedure to understand how continuity of care, health literacy, and medication adherence influence their long-term health. Researchers will track hospital readmissions, medication use, and patient-reported outcomes …

This study looks at how inflammation and oxidation (chemical reactions in the body) might damage the heart and lead to heart failure. Researchers are tracking over 1,200 healthy adults aged 40+ (or 18+ with a family history of heart failure) to see if waste products in blood or u…

This study compares six different ECG patches that people wear for a week to monitor heart rhythms. Researchers want to see which patches give the clearest and most useful recordings. The study involves 150 adults aged 65 and older who already need heart monitoring as part of the…

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

This study is building a large gene bank by collecting blood samples and health information from nearly 10,000 people who have had heart catheterization or cardiac CT scans. The goal is to identify genetic and other factors that contribute to coronary artery disease. Participants…

This study explores whether artificial intelligence can predict which children with a type of heart hole (perimembranous ventricular septal defect) will later develop complications like valve problems or blockages. Researchers will analyze past echocardiogram reports and medical …

This study uses two advanced MRI techniques to measure muscle health in heart failure patients with and without sarcopenia (age-related muscle loss). Researchers will scan 70 participants to compare muscle composition and energy recovery. The goal is to find better ways to detect…

This study was designed to compare electrical and mechanical activation of the right ventricle in adults who had surgery for Tetralogy of Fallot, a congenital heart condition. Researchers planned to use 3D mapping and imaging to see if electrical signals match the heart's physica…

This registry is collecting data from over 500 patients with atrial fibrillation who are treated with the FARAPULSE ablation system in routine care. The goal is to identify which pre-procedure, procedure, and follow-up steps work best for different types of patients. Researchers …

This study tests a wearable device that continuously measures lactate levels in the fluid just under the skin. Researchers want to see if it matches standard blood tests in patients recovering from heart bypass or valve surgery. If it works, the device could make recovery more co…

This study tests whether a special CT scan (CCTA) of the heart can predict if atrial fibrillation will come back after a standard ablation procedure. Researchers will scan patients before their first ablation and then follow them for a year. The goal is to see if heart structure …

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study looks at people with persistent atrial fibrillation (an irregular heartbeat) and moderate-to-severe functional mitral regurgitation (a leaky heart valve). Researchers want to see if a procedure called catheter ablation—which zaps abnormal heart tissue to restore normal…

This study follows 280 people with mitral valve prolapse over 3 years to see if heart MRI scans and blood tests can predict who will develop dangerous heart rhythms or heart muscle changes. Participants undergo MRI, blood draws, and heart monitoring. The goal is to find early war…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study looks at tiny pieces of RNA in the blood of people with congestive heart failure. Researchers want to see if these RNA levels change with treatment and if they can predict heart health or future heart problems. About 400 adults with heart failure will be followed durin…

This study tests a machine-learning tool built into electronic health records to help emergency doctors quickly assess risk in adults with acute heart failure. The tool predicts which patients are at high risk of complications and likely need hospital admission, and which low-ris…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study tracks 130 people with chronic heart failure to understand how taking multiple medications (polypharmacy) affects their safety, adherence, and health outcomes. Researchers will look for patterns of over- or under-prescribing and factors linked to low medication adheren…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study compares a new X-ray system (Azurion R4.0) to an older version during heart procedures like angiography. The goal is to see if the new system lowers the radiation dose patients receive while still allowing doctors to work effectively. About 824 adults from several coun…

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study follows about 35 people with dilated cardiomyopathy caused by a BAG3 gene mutation, a condition that weakens the heart muscle. Over three years, researchers will monitor heart function, symptoms, and quality of life using tests like imaging and blood work. The goal is …

This study uses healthcare claims data from nearly 24,000 people to see if it can reproduce the results of the EMPEROR-Reduced trial, which tested the diabetes drug empagliflozin against sitagliptin in heart failure patients. The goal is not to test a new treatment, but to learn …

This study looks at whether using a cardiac MRI (CMR) instead of the usual ultrasound helps doctors make better decisions about heart valve surgery for people with severe mitral regurgitation (a leaky heart valve). About 260 adults with no symptoms but severe leakage will be foll…

This study looks at whether telling people they have a high genetic risk for heart disease helps them make healthier choices. About 200 adults without heart disease will be followed for one year. Researchers will compare heart health scores between those who learn their genetic r…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study tests a questionnaire called NECPAL to see if it can spot patients with serious long-term illnesses like cancer, heart failure, or kidney disease who might benefit from palliative care. Researchers will check 200 adults in the hospital or day clinic to see how many are…

This study tests whether artificial intelligence can help doctors see heart valve structures more clearly during a minimally invasive repair procedure called TEER. Researchers will use data from 1,500 patients who have already had the procedure to train and test the AI. The goal …

This study reviewed medical records of 1000 people who received a special balloon treatment (drug-coated balloon angioplasty) for blocked heart arteries between 2009 and 2015. Researchers tracked major heart problems like death, heart attacks, or need for repeat procedures for up…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study looks at whether the amount of carbon dioxide a person breathes out during CPR can help predict if they will survive a cardiac arrest that happens outside a hospital. Researchers are reviewing records from 3,500 adults who had a cardiac arrest and were treated by emerg…

This study looks at how SGLT2 inhibitors, a type of diabetes drug also used for heart failure, affect the body's metabolism. About 40 adults with mild to moderate heart failure will have blood tests, walking tests, and calf MRIs before and after starting the medication. The goal …

This study uses advanced CT scans to look for fat and scar tissue inside the heart. Researchers want to see if these findings can help predict who is at risk for dangerous heart rhythms. About 110 adults with heart disease who already have a defibrillator or need one will get a C…

This study is enrolling 15,000 adults who are already scheduled for a coronary CT angiography (CCTA) scan. Researchers will analyze the scan images along with participants' health outcomes over time. The goal is to see if detailed information from the scans can help doctors more …

This study analyzes data from over 377,000 people who had a heart attack and were prescribed blood thinners (clopidogrel, ticagrelor, or prasugrel) in Germany and the United States between 2011 and 2024. Researchers aim to describe how often each drug is used and how much it cost…

This study followed children and young adults with genetic liver diseases that cause bile buildup. The goal was to track how these diseases progress over time, including the need for liver transplants or other complications. No treatments were tested; the aim was simply to learn …

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will fo…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study looks at whether adding a stress CT scan that checks blood flow to the heart muscle helps doctors decide the best treatment for people with known or suspected heart disease. About 2000 adults will be followed to see if this extra test reduces the need for more tests an…

This study looks at medical records from over 600 Indian adults with chronic heart failure who were prescribed vericiguat between 2022 and 2023. Researchers want to see how the drug is used in routine care, how well it works, and what side effects occur. No new tests or visits ar…

This study tests a redesigned clinical decision support tool for heart failure patients during virtual visits. The tool gives doctors medication recommendations and tips for patients to upload their vitals at home. Researchers will compare it to the usual tool in a small pilot wi…

This study compares three ways of delivering genetic counseling to adults with inherited heart conditions. Some participants get counseling before testing, others get it after, with or without a required phone call. The goal is to see which approach is most efficient and empoweri…

This study is testing an implantable heart monitor (LUX-Dx ICM) in 525 people with heart failure. The goal is to collect sensor data to better understand when heart failure events happen. Participants have moderate heart failure (NYHA class II or III) and certain heart structure …

This study tests a new computer tool that gives doctors personalized reminders when prescribing heart failure medications. The goal is to help doctors follow treatment guidelines more closely. About 764 doctors from cardiology and primary care clinics are taking part.

This study looks at whether training nurses with realistic simulations helps them perform CPR and use defibrillators better during cardiac arrest. About 134 experienced nurses will take part. The goal is to improve patient survival by boosting nurses' skills.

This study follows 1000 Chinese patients with myotonic dystrophy type 1 (DM1) to understand how the disease affects multiple body systems and leads to disability. Researchers will collect health data and blood samples every 3 to 6 months for several years. The goal is to identify…

This study gathers 35-50 international critical care experts to agree on how to classify and manage septic shock using point-of-care ultrasound. The goal is to create consensus statements that could help personalize treatment. No patients are enrolled; instead, experts complete s…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at 320 people with complex coronary artery disease who need a stent. It compares using a special camera (OCT) versus standard X-ray (angiography) to guide the stent placement. The goal is to see which method leads to better blood flow after the procedure.

This study will collect and analyze genetic data from 1000 people with suspected inherited metabolic diseases, including conditions like epilepsy and mitochondrial disorders. Researchers at Karolinska University Hospital aim to improve diagnosis by using advanced genetic testing …

This registry follows 545 people with arrhythmia who received a heart ablation using the DiamondTemp system. Researchers will track how many stay free of their heart rhythm problem and how many have serious side effects over 12 months. The goal is to see how well the device works…

This pilot study looks at whether a simple, non-invasive eye scan (OCT-A) can detect early signs of memory decline in people with atrial fibrillation, a common heart rhythm disorder. Researchers will compare retinal blood vessel patterns in 40 patients with and without mild cogni…

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study examines whether a low pulse pressure (the difference between top and bottom blood pressure numbers) in the first hours after a cardiac arrest is linked to early death. Researchers will analyze data from 3500 patients who had a cardiac arrest outside the hospital and a…

This study was designed to see if early mobilization and a simple bottle-based breathing device (Bottle-P.E.P.) could improve breathing and physical function in people recovering from heart valve surgery. The trial was withdrawn before enrolling any participants, so no results ar…

This study looks at whether diabetes or blood sugar problems can worsen thinking and memory issues in people with myotonic dystrophy type 1. Researchers will use MRI brain scans and thinking tests over 4 years to track changes. The goal is to understand why some patients have mor…

This study looks at whether a special heart MRI, done within a week of a heart attack, can help doctors better predict a patient's future health. Researchers will follow 2,000 adults for years to track serious heart events like another attack or heart failure. The goal is to lear…

This study uses anonymous health insurance records from Germany to learn more about a rare heart condition called ATTR-CM, where abnormal protein builds up in the heart. Researchers will look at survival rates, hospital visits, and how common the disease is. No new treatments are…

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…

Over two million people in the UK have a chronic condition like diabetes or heart disease without knowing it. This study will use information from 4.5 million hospital patients to build a digital platform that spots those at risk. The goal is to help doctors diagnose these condit…

This study tests whether a wearable sensor can accurately estimate the heart's pumping ability (LVEF) compared to standard ultrasound. Researchers will enroll 500 adults already scheduled for an echocardiogram. The goal is to develop a simpler, more accessible way to monitor hear…

This study follows over 3,400 people who have already received the Aveir VR leadless pacemaker, a small device placed directly in the heart to treat slow heart rhythms. Researchers are using real-world medical records to check for complications up to 10 years after implantation. …

This study follows 100 ICU patients who developed new atrial fibrillation (AF) during their stay. Using a chest-worn heart monitor, researchers track whether AF returns after leaving the ICU and up to 3 months after hospital discharge. The goal is to understand who might need lon…

This study is looking at whether an artificial intelligence tool can help doctors decide which heart surgery patients might benefit from a drug called ulinastatin. Ulinastatin is used to reduce inflammation after surgery, but it doesn't work for everyone. Researchers will analyze…

This study looks at whether a new computer algorithm can predict if atrial fibrillation (an irregular heartbeat) will come back after a common treatment called pulmonary vein isolation. Researchers will review medical records from 300 patients who had this procedure. The goal is …

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study looks at whether giving a personalized dose of a radioactive tracer (rubidium-82) based on a patient's weight can improve the quality of PET heart scans. Researchers will enroll 48 adults with known or suspected heart disease and divide them into four weight groups. Th…

This study follows nearly 20,000 patients who had major non-cardiac surgery to see how often heart injury occurs and what happens a year later. Researchers are looking at death rates and major heart complications. The goal is to better understand who is at risk and how to improve…

This study aims to make genetic testing for inherited heart muscle disease available directly in heart failure clinics, instead of requiring a separate referral to a genetics specialist that can take years. Researchers will train heart doctors to order a simple blood or saliva te…

This study is testing a mobile app called CHAMP that lets parents of children with complex congenital heart disease enter health data and upload photos or videos from home. The goal is to see if the app helps doctors monitor the child's condition remotely and improve communicatio…

This study analyzes data from over 4,200 heart failure patients to create a tool that uses biomarkers to guide diuretic dosing. Researchers aim to develop a machine-learning algorithm that could personalize treatment and improve outcomes. The study is observational and does not t…

This study looks at two methods for treating atrial fibrillation (an irregular heartbeat) using a special balloon catheter. The goal is to see if using a 3D mapping system (CARTO) makes the procedure faster and safer than using X-ray guidance alone. About 60 adults with paroxysma…

This study looks at how a common heart valve procedure called TAVI changes the gut microbiome in older adults with aortic stenosis. Researchers will collect blood and stool samples before and three months after TAVI to measure bacterial byproducts and diversity. The goal is to se…

This study will enroll 210 adults aged 65 and older with early aortic stenosis (a heart valve narrowing) to see if an artificial intelligence tool can better predict how fast the disease worsens. Participants will have standard echocardiograms, and researchers will compare the AI…

This study follows 319 people under 21 who developed heart inflammation (myocarditis or pericarditis) within 21 days of receiving the Comirnaty (Pfizer) COVID-19 vaccine. Researchers will monitor their heart function with imaging tests for up to 5 years to see if there are lastin…

This study aimed to validate several blood biomarkers (like NT-proBNP and IL-6) to help doctors assess atrial fibrillation burden and track treatment effectiveness. Researchers planned to analyze samples from 266 patients before and after treatment. However, the study was withdra…

This study looks at 50 adults hospitalized with acute decompensated heart failure who need intravenous diuretics (water pills). Researchers want to see if a non-invasive monitor called the Starling System can accurately measure changes in heart function as fluid is removed. The g…

This study looks at whether measuring salt levels in the kidneys using a special MRI can help doctors predict which heart failure patients will not respond well to water pills (diuretics). About 50 adults with heart failure and kidney disease will be scanned to compare salt conte…

This study follows 331 adults with hypertrophic cardiomyopathy (HCM) to see how they are treated in everyday medical practice, especially with the drug mavacamten. Researchers will collect data on diagnosis, symptoms, treatments, and outcomes over time. The goal is to understand …

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This study looks at whether a new screening system can help doctors find heart complications early in high-risk patients after noncardiac surgery. Researchers will track 900 patients to see how well the screening works in practice and what it costs. The goal is to gather informat…

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This large trial tests whether a coordinated community approach can improve survival and brain function after cardiac arrest. The plan includes faster 911 dispatch, CPR instructions over the phone, public CPR and AED training, and better first responder performance. About 20,000 …

This international registry is collecting information from 2000 people who have had spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks. Researchers will track participants' health over time to better understand the condition and develop best practices fo…

This study looks at whether a pre-surgery test called FFR can predict how well arterial bypass grafts work six months after coronary artery bypass grafting (CABG). About 120 patients with multi-vessel heart disease will have an FFR test during their diagnostic angiogram. Six mont…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study watches 40 adults who need a leadless pacemaker to see if where the device sits inside the heart changes heart rhythm or pumping strength. Researchers will use CT scans and ECGs to check heart function and valve leakage. The goal is to find the best spot for the pacema…

This study tests whether adding automatic reminders to echocardiogram (heart ultrasound) reports can increase the number of patients with heart valve disease who see a cardiologist within six months. Researchers will randomly assign 300 patients' reports to receive no prompt, a p…

This study looks at blood samples from 682 adults who survived a cardiac arrest outside the hospital. Researchers are analyzing proteins to find new markers that could help predict recovery and understand the body's response after the heart stops. The goal is to discover potentia…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…

This study checks if insulin resistance (when your body doesn't use insulin well) can predict whether a heart procedure called pulsed field ablation will work for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their first ablation…

This study aimed to compare two versions of the water pill torsemide (extended release vs immediate release) in adults with stable heart failure. Participants would have taken each version for a week, then had their sodium excretion measured after a single dose and a salty lunch.…

This study looks at 224 adults who had surgery as children for a heart defect called tetralogy of Fallot. Researchers are using MRI scans and blood tests to measure scarring in the heart muscle. They want to see if this scarring is linked to serious heart problems like arrhythmia…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study looks at real-world data from 6,000 heart failure patients to compare a newer pacing method (conduction system pacing) with the standard method (biventricular pacing). The goal is to see if the newer approach is just as safe and effective at reducing heart failure hosp…

This study looks at whether giving doctors early results from heart biomarker tests (NT-proBNP and hs-cTnT) along with a structured interpretation note can improve outcomes for patients admitted with rapid breathing (tachypnea). About 574 adults will be randomly assigned to recei…

This study looks at 600 adults with non-compaction cardiomyopathy, a rare heart muscle condition that can lead to heart failure, stroke, or dangerous heart rhythms. Researchers will use heart scans, genetic tests, and health records to find better ways to predict who is at highes…

This study looks at whether mepolizumab, a drug already used to reduce asthma attacks, can also improve physical activity and exercise tolerance in people with severe asthma. Researchers will track daily steps and activity levels in 62 adults over six months. The goal is to see i…

This study looks at 2,000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict future heart failure, another heart attack, or bleeding. Researchers will track participants for several years to identify which measur…

This study looks at whether a specific type of heart stent (zotarolimus-eluting) can be expanded more than usual to treat tricky blockages. Researchers will use a special camera (OCT) to check the stent's size and safety in 30 adults with coronary artery disease. The goal is to s…

This study looks at 57 people who received a COVID-19 vaccine to understand why some develop heart injury or myocarditis. Researchers use advanced heart scans (PET/MRI) and blood tests to find early warning signs. The goal is to better identify those at risk and improve follow-up…

This study tests a web-based platform called 'My Voice' that helps heart failure patients learn about their illness, decide on end-of-life care goals, and share those wishes with doctors and caregivers. About 244 patients in Singapore will use the tool to see if it increases adva…

This study uses advanced heart MRI scans to look for the earliest signs of dilated cardiomyopathy (a weakened heart muscle) in close relatives of people already diagnosed. Researchers will follow 650 family members over time to see how genetic factors relate to heart changes. The…

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This study looks at 40 people who recently had a heart attack and had one blockage treated. Researchers will use special pressure wires and optical imaging to examine other blockages that were not treated. The goal is to see how many of these leftover blockages are actually dange…

This study looks at whether a smartwatch ECG can predict heart muscle disease (cardiomyopathy) in adult survivors of childhood cancer as well as a standard clinic ECG does. About 1,300 survivors will have both a standard 12-lead ECG and a 30-second Apple Smartwatch ECG. The goal …

This study looks at whether a special heart scan (CTCA) can help find hidden heart disease in people who come to the hospital with chest pain but are not having a heart attack. About 3,170 adults with slightly elevated troponin levels (a sign of heart stress) will get the scan to…

This study involves 100 adults who have a cardiac arrest outside the hospital. Doctors will use portable ultrasound, blood tests, and a digital checklist to quickly find reversible causes, like a blocked artery or drug overdose. The goal is to see how often these causes are found…

This study follows over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to under…

This study looks at how doctors treat people having a severe heart attack complicated by cardiogenic shock, where the heart can't pump enough blood. Researchers will track 124 patients at 20 U.S. hospitals to see how decisions about using mechanical heart support devices affect s…

This trial aimed to see if an AI program could help doctors choose better heart failure treatments for each patient. It planned to compare standard care with AI-generated treatment advice. However, the study was withdrawn before enrolling any participants, so no results are avail…

This study tracks 40 people with nasal polyps and severe asthma who are taking mepolizumab, a drug that reduces inflammation. Researchers collect nose, blood, and sputum samples before treatment and at 3, 6, and 12 months to see how the drug affects symptoms, nose bacteria, and g…

This study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare 60 adults with and without HFpEF using tests like MRI, exercise testin…

This study involves 3,600 people who have had a heart stent placed. Researchers want to see if a special cholesterol test (VAP) can help predict when the artery narrows again. Participants provide a blood sample from routine care, and no extra blood draws are needed. The goal is …

This study looks at how certain blood components and heart imaging patterns might help predict the worsening of aortic stenosis, a common heart valve condition in older adults. Researchers will study 65 people with mild or moderate aortic stenosis and compare them to healthy cont…

This study looks at whether a new type of heart medication, called a cardiac myosin inhibitor, can improve blood flow in the small blood vessels of the heart in people with hypertrophic cardiomyopathy (HCM). Researchers will use special ultrasound imaging to measure blood flow be…

This small pilot study is testing whether a gentle, non-invasive electrical stimulation on the ear (auricular vagus nerve stimulation) can change how the heart's electrical system works. Ten people who are already scheduled for a heart procedure will receive the stimulation while…

This study collects tissue and blood samples from 200 people with advanced heart failure who are getting a heart pump or transplant. Researchers will use these samples to learn more about the disease. No new treatments are being tested, and the study does not change how patients …

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …