New algorithm could take guesswork out of heart valve surgery

NCT ID NCT03292497

Ongoing Disease control Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using a specific set of measurements (an algorithm) to decide between repairing or replacing a leaky mitral valve leads to better outcomes than letting the surgeon choose. About 110 patients with severe ischemic mitral regurgitation will be randomly assigned to either the algorithm-guided approach or standard surgeon preference. Researchers will compare changes in heart size and function over 12 months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Treatment algorithm for mitral valve surgery
What this could lead to: If successful, this could provide a clear, evidence-based way to choose between valve repair or replacement, potentially improving heart function and reducing complications.
What could go wrong: This is a relatively small, early-stage study (110 patients) comparing two surgical approaches. The algorithm may not prove superior to surgeon preference, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mitral valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MITRAL REGURGITATION

Contacts and locations

Locations

University of Ottawa Heart Institute

Ottawa, Ontario, K1Y4W7, Canada

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