Frozen nerves to fight surgery pain? trial pulled before it began

NCT ID NCT05255146

Terminated Symptom relief Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to see if freezing certain nerves during minimally invasive heart surgery could lower pain afterward. It planned to enroll adults having mitral valve or atrial septal defect repair. However, the trial was withdrawn before any participants were enrolled, so no data was collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nitrous oxide cryoprobe (device that freezes nerves to block pain)
What this could lead to: If it worked, this could offer a way to reduce chronic pain after minimally invasive heart surgery.
What could go wrong: The trial was withdrawn before starting, so no results are available. The approach is still experimental and may not prove effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia atrial septal defect mitral valve disorder Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRYOTHERAPY EFFECT POST OPERATIVE PAIN

More trials for these conditions

Other studies related to the condition(s) this trial covers.