Can a blood filter tame the inflammatory storm after pediatric heart surgery?

NCT ID NCT07771491

NEW Not yet recruiting Disease control Sponsor: Norfaniza Zabidi Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This trial tests whether adding a blood-filtering device, called hemoadsorption, to the heart-lung machine can reduce harmful inflammation in children undergoing complex open-heart surgery. The device is designed to remove inflammatory proteins, known as cytokines, from the blood during the procedure. Researchers will compare children who receive this therapy plus standard care against those receiving standard care alone, measuring inflammation levels and recovery outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hemoadsorption therapy using a Jafron HA-60 or HA380 cartridge, which filters inflammatory proteins (cytokines) from the blood during cardiopulmonary bypass.
What this could lead to: If effective, this could reduce post-surgical complications, shorten ICU stays, and improve recovery for children undergoing major heart surgery.
What could go wrong: This is a single-center trial, and the outcome is still uncertain. The device may not significantly reduce inflammation or improve outcomes, and there are potential risks like bleeding or device-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital heart disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOPULMONARY BYPASS CONGENITAL HEART DISEASE CYANOTIC HEART DISEASE ENDOCARDITIS ACUTE AND SUBACUTE OPEN HEART SURGERY

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