Could a single dose of radiation rejuvenate failing hearts?
NCT ID NCT07770230
First seen Aug 18, 2026 · Last updated Aug 18, 2026
Summary
This trial explores whether a single, low-dose radiation treatment to the heart can improve pumping function in people with advanced or end-stage heart failure. The study includes 20 adults with severe heart failure who are not eligible for a transplant or mechanical heart pump. Participants receive one 5 Gy radiation session, and researchers measure changes in heart function using MRI over six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Low-dose cardiac radiation therapy (5 Gy)
- What this could lead to
- If it works, this could offer a new, non-surgical way to improve heart function in people with advanced heart failure who cannot have a transplant or heart pump.
- What could go wrong
- This is a small, early proof-of-concept study, so results may not be conclusive or apply broadly. Radiation to the heart carries risks, and the benefit is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rennes University Hospital
Rennes, 35000, France