Rennes University Hospital

This study tests whether giving extra albumin (a protein in the blood) after a liver transplant can prevent acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only g…

This phase 3 trial tests whether rituximab, a less expensive drug, works as well as ocrelizumab for people with relapsing-remitting multiple sclerosis. About 386 participants will receive either drug and be followed for 2 years. The main goal is to see if rituximab can keep the d…

This early-phase trial is testing whether repeated injections of stem cells from donated fat tissue are safe for people with primary progressive multiple sclerosis (MS). Ten participants will receive the cells directly into the spinal canal. The main goal is to check for serious …

This study compares two types of minimally invasive surgery for early-stage endometrial cancer: robot-assisted laparoscopy and conventional laparoscopy. About 1,680 patients will be randomly assigned to one of the two procedures. The goal is to see which approach offers better va…

This study tests whether the blood thinner rivaroxaban can prevent strokes, heart attacks, and death in people with hypertrophic cardiomyopathy (HCM) who have early signs of atrial damage but normal heart rhythm. About 532 adults aged 40-80 with HCM and reduced left atrial strain…

This study tests a type of hypnotherapy called E2R for people with chronic insomnia. It compares E2R to usual care (like sleep medications) to see if it reduces insomnia severity. About 136 adults with chronic insomnia will take part, and the goal is to find a safer, non-drug opt…

This study tests whether using EEG neurofeedback — a way to train brain activity — can improve arm movement in people who recently had a stroke. Forty adults with a stroke within the past three weeks will either get real or fake (sham) neurofeedback, plus standard rehab. The goal…

This study tests whether a set of simple decision rules, adapted from the Canadian C-Spine Rule, can help emergency responders decide when a neck collar and hospital imaging are truly needed. Researchers will enroll 840 stable, conscious adults with recent neck trauma treated by …

This study looks at whether a special training program helps healthcare students work better together in primary care clinics. About 96 students will take part, with some receiving the training and others not. Researchers will measure teamwork skills before and after the placemen…

This study collects small tissue samples (biopsies) from people undergoing routine endoscopy and grows them into mini-organs called organoids in the lab. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goa…

This study tests a new, non-invasive MRI technique to detect early brain changes linked to Alzheimer's disease. Researchers will compare brain scans from 50 people with mild memory concerns to healthy volunteers. The goal is to find a simple, affordable way to identify those at r…

This study tests whether temporarily blinding the team leader during simulated medical emergencies improves how the team works together. Fifty-four experienced medical professionals will be randomly assigned to have their leader wear a visual deprivation mask or not. Team perform…

This study looks at whether patients who take antiplatelet drugs (blood thinners) and have a minor head injury, but no other signs of brain bleeding, still need a CT scan. Current guidelines recommend a scan for these patients, but the evidence is weak. The study will follow 3,20…

This study is testing whether a new, low-cost type of brain scan can find early signs of Alzheimer's and Parkinson's disease. Researchers will compare brain scans from 120 people, including those at risk for Alzheimer's, those with Parkinson's, and healthy volunteers. The goal is…

This study looks at why 20% of children with B-cell acute lymphoblastic leukemia (B-ALL) relapse after treatment. Researchers will collect bone and blood samples from 50 newly diagnosed children at three key points during therapy. They will study how a protein called CD9 is regul…

This study is testing whether certain substances in urine (called biomarkers) can predict kidney damage in people with spina bifida. Researchers will measure these biomarkers in 50 patients and compare them to a standard risk score. The goal is to find a non-invasive way to monit…