Rennes University Hospital

This trial tests whether providing nursing home residents with meals rich in omega-3 fatty acids (ALA, EPA, DHA) can slow the loss of independence over two years. About 315 residents will receive either the omega-3-enriched diet or their usual meals. The study measures changes in…

This study looked at 144 people with aggressive relapsing multiple sclerosis to compare two treatment plans over three years: monthly natalizumab infusions versus a six-month course of mitoxantrone followed by another immune-modulating drug. Researchers measured cost-effectivenes…

This study tested two ways of using a breathing machine during heart surgery in 441 high-risk patients. One method used higher air pressure and periodic deep breaths (recruitment maneuvers), while the other used lower pressure. The goal was to see which approach better prevents s…

This study tested whether a simple mouth rinse could help diagnose Pneumocystis pneumonia, a serious lung infection in people with weakened immune systems. Researchers used a PCR test on the rinse sample to look for the fungus, aiming to find a threshold that indicates active inf…

This study tested a short questionnaire called SEFI that asks children about their food intake to see if it can reliably identify those at risk for malnutrition in the hospital. Researchers compared SEFI results to standard growth measurements in 368 children aged 10-17. The goal…

This study tests whether wearing a virtual reality headset during oocyte (egg) retrieval under local anesthesia can lower pain and anxiety. About 90 women undergoing IVF or egg donation who choose local anesthesia will be randomly assigned to use the VR headset or not. The goal i…

This study tested whether an apomorphine pump can improve quality of life for people in the early stages of Parkinson's disease who have just started experiencing motor complications. 134 adults aged 65 or younger with mild Parkinson's used either the pump plus standard care or s…

This study tested a mobile robot designed to help people who have had a stroke regain their ability to walk. 37 stroke survivors used the robot for 16 sessions along with their usual physical therapy. The goal was to see if the robot improved their balance and walking more than s…

This study tested a new device that uses gentle vibrations to treat breathing pauses (apnea) in premature babies. The device automatically detects when a baby stops breathing and delivers a mild vibration to stimulate breathing. The goal was to reduce the need for manual stimulat…

This study tested whether mindfulness meditation training can improve quality of life and brain activity in people with refractory epilepsy (seizures that don't respond to drugs). 37 participants (patients and healthy volunteers) took part in meditation sessions. The main goal wa…

This completed observational study from France aimed to identify the best educational and organizational features that help self-management education programs succeed in multi-professional health centres. Researchers surveyed health agencies and interviewed staff from selected ce…

This study tested how willing healthy seniors aged 80 and older are to use connected health devices like scales, activity trackers, and blood pressure monitors at home. 34 participants used the devices while researchers measured their comfort and acceptance through questionnaires…

This study looked at why some people have trouble balancing while sitting after a stroke. Researchers used a special pressure-sensing pad and motion trackers to measure how 32 stroke survivors shifted their weight and moved their head and trunk. The goal was to better understand …

This study collects heart rate, breathing, movement, and sound data from premature babies in hospital. The goal is to build a database that will help researchers develop new, non-invasive monitoring tools. These tools could one day reduce the need for wires and sensors, making ca…

This study tested a prediction tool (nomogram) to see if it could forecast how patients with metastatic clear cell renal cell carcinoma respond to the targeted therapy sunitinib. Researchers looked at 45 patients who had their kidney removed and were treated with sunitinib as the…

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study looked at how the brain's emotional centers work in people with Parkinson's disease who had just received a deep brain stimulator implant. Researchers measured brain activity while patients listened to sounds or saw images with emotional meaning. The goal was to better…

This study used brain scans (fMRI) to look at how people process emotions and make decisions, comparing those who have attempted suicide, those with past suicidal thoughts, depressed patients without suicidal history, and healthy controls. The goal was to find brain activity patt…

This study followed 115 people with relapsing-remitting multiple sclerosis for up to 5 years to see if early damage to the spinal cord could predict later walking difficulties. Researchers used MRI scans and walking tests to track changes. The goal was to better understand how ea…

This study tested three different ways to teach oral hygiene to 90 teenagers with braces. One group got standard advice, another had hands-on brushing practice, and the third watched a video and took a quiz. The goal was to see which method best reduced plaque and gum inflammatio…

This study tested whether an electronic conductivity device can reduce the amount of X-ray radiation needed during spine surgery. 32 adults having spine surgery were randomly assigned to receive either the standard tool or the new device. The goal was to see if the new device cou…

This study looked at whether a non-invasive heart ultrasound method (E/e') can accurately estimate left ventricular filling pressure, compared to the standard invasive catheter test. 85 adults who were already getting an ultrasound took part. The goal was to see if the ultrasound…

This study looked at 37 critically ill COVID-19 patients who were moved by train from overcrowded ICUs in Paris to less busy ICUs in western France. Researchers tracked how many died, got infections, needed breathing machines, and how long they stayed in the hospital. The goal wa…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looks at patients with a condition called posterior pelvic static disorder, which can cause problems with bowel control. Researchers want to see if having surgery for this condition leads to more cases of fecal incontinence compared to treating it with medicine alone. …

This study looked at whether people with hereditary hemochromatosis (a condition causing too much iron in the body) have higher rates of gum disease. Researchers examined 87 adults aged 35 to 64 with the C282Y gene mutation. They measured gum pocket depth and clinical attachment …

This study followed 100 adults with genetic hemochromatosis (a condition causing too much iron in the body) for 3 years to see how their bone health changed. Researchers measured bone density and checked for fractures and joint problems. The goal was to understand if iron overloa…

This study looked at how the antibiotic metronidazole works in 171 newborns to find the best dose. Researchers used leftover blood or spinal fluid from routine tests, so no extra pokes were needed. The goal was to make sure enough babies get the right amount to fight infection wi…

This study looked at how the body processes an antibiotic called piperacillin in intensive care patients who are on a life-support machine (ECMO) compared to those who are not. Researchers wanted to see if ECMO changes antibiotic levels, which could affect how well the drug fight…

This completed registry study tracked 177 heart patients who received an intra-aortic balloon pump (IABP), a device that helps the heart pump blood. Researchers recorded how often the pump was used, why it was used, and patient survival rates. The goal was to gather real-world da…

This study looks at how to accurately measure pressure inside the bladder of newborns in intensive care. Doctors need to know the right amount of fluid to use for reliable readings, especially in very small babies. The goal is to improve early detection of abdominal compartment s…

This study looked at 98 adults with cirrhosis who were hospitalized for sudden worsening of their liver condition. Researchers measured different forms of iron in the blood to see how they relate to short-term death risk. The goal was to better understand iron's role in liver fai…

This pilot study tested a new type of brain training called neurofeedback for people with depression. Participants learned to control their own brain activity using real-time feedback from both EEG and fMRI scans. The goal was to see if combining these two methods could help impr…

This study looked at 597 women with low-risk pregnancies to see if a special midwife-led care unit (called Filière Physiologique) leads to more natural births compared to standard hospital care. The special unit offers personalized support from a midwife throughout pregnancy and …

This study followed 75 malnourished patients after they left the hospital to see what kind of care they received and how their nutrition changed. Researchers also interviewed some patients and caregivers to learn about their understanding of malnutrition. The goal is to improve s…

This study looked at hormone levels in 26 people within 48 hours of a brain bleed from a burst aneurysm. Researchers checked cortisol and thyroid hormones and did a stimulation test to see if the pituitary gland was working properly. They then tracked complications like rebleedin…

This study follows couples who gave birth in either a midwifery-led birth unit or a standard obstetric unit in France. Researchers want to see if the type of care affects parents' mental health, especially post-traumatic stress, and the child's development up to two years later. …

This study looked at whether measuring hepcidin, a hormone that controls iron levels, in the blood of 114 patients with severe sepsis or septic shock could predict who would die within 28 days. Researchers also tracked deaths at 90 days and infections acquired in the hospital. Th…

This study tests whether a tiny finger-prick blood sample can accurately measure levels of nine oral cancer drugs, compared to standard blood draws. Researchers will enroll 160 patients taking one of these drugs. If the microsampling method works, it could offer a less invasive w…

This study looked at how a single injection of erythropoietin, a hormone that boosts red blood cell production, changes levels of hepcidin — a key protein that controls iron in the body. Fourteen healthy men aged 18–30 took part. Researchers measured hepcidin in blood and urine t…

This study followed about 94 moderately premature babies (born at 30-32 weeks) from birth to age 2. Researchers tracked the types of bacteria in their guts and compared that to their thinking, movement, and social skills at age 2. The goal was to see if early gut bacteria pattern…

This study looked at how the body processes lidocaine, a common painkiller, in young (under 40) and elderly (over 70) patients during surgery. The goal was to find the best dose for older adults to manage pain safely while avoiding side effects. 67 participants were monitored to …

This study looked at how people with multiple sclerosis and their natural caregivers (like family members) feel about the quality of care they receive. Researchers surveyed over 1,000 participants to understand their expectations and experiences. The goal was to create a tool tha…

This completed study looked at why the blood thinner clopidogrel is less effective in people over 70. Researchers measured levels of the drug's active metabolite and platelet function in 37 patients aged 50 to 100. The goal was to understand how age affects drug resistance, which…

This study looked at the gut's own nervous system in 16 healthy adults to understand how it normally works. Researchers took small tissue samples from the colon during an endoscopy and measured how the rectum responds to pressure. The goal is to use this information as a healthy …

This study looked at 36 adults with spina bifida to understand why they often have bowel issues. Researchers took small tissue samples from the colon during a routine scope and measured how the rectum works. The goal was to see if nerve damage affects the gut's lining and nerves,…

This study looked at 46 people with progressive multiple sclerosis who have more weakness on one side of their body. Researchers used MRI scans to see how damage in the brain and spinal cord relates to muscle strength in each limb. The goal was to better understand what causes ph…

This study looked at 94 people with relapsing-remitting multiple sclerosis to better understand why standard MRI scans often don't match a person's actual walking ability. Researchers used advanced MRI to measure damage in brain and spinal cord pathways important for movement and…