Heart surgery lung risk: which ventilation method wins?

NCT ID NCT04408495

Completed Disease control Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two ways of using a breathing machine during heart surgery in 441 high-risk patients. One method used higher air pressure and periodic deep breaths (recruitment maneuvers), while the other used lower pressure. The goal was to see which approach better prevents serious lung complications and death after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mechanical ventilation with high PEEP and recruitment maneuvers
What this could lead to: If successful, this could establish a safer ventilation method during heart surgery, reducing lung complications and deaths in high-risk patients.
What could go wrong: This is a completed trial, but results may not apply to all patients. The intervention could cause temporary drops in blood pressure.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PULMONARY COMPLICATIONS

Contacts and locations

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Locations

CHRU Brest

Brest, France
CHRU Tours

Tours, France
CHU Amiens-Picardie

Amiens, France
CHU Nantes

Saint-Herblain, France
CHU Poitiers

Poitiers, France
CHU Rennes

Rennes, France
CHU de Dijon

Dijon, France
CHU de Nancy

Nancy, France
CHU de Rouen

Rouen, France
CHU de Toulouse

Toulouse, France

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