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New MRI study aims to solve MS's 'Clinical-Radiological Paradox'

NCT ID NCT04220814

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 94 people with relapsing-remitting multiple sclerosis to better understand why standard MRI scans often don't match a person's actual walking ability. Researchers used advanced MRI to measure damage in brain and spinal cord pathways important for movement and sensation. The goal was to improve how we predict disability in MS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

94 people

The number who actually took part.

Started

Nov 2020

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients : * More than 18 years old * relapsing-remitting multiple sclerosis according to Mac Donald criteria (2010) * EDSS score at the inclusion from 0 to 4 * With at least 1 symptom of pyramidal injury during clinical exam * Written informed consent * Affiliated to a Health Care system Healthy Volunteers: * More than 18 years old * Written informed consent * Affiliated to a Health Care system Exclusion Criteria: Patients * progressive MS ; * Corticoids during the last 60 days before inclusion ; * Other neurological disease or Other progressive systemic disease * adults subject to legal protection or persons deprived of liberty * Contraindications to MRI * Contraindications to motor evoked potentials * Current pregnancy or breast-feeding Healthy volunteers: * History of disease affecting central nervous system * Familial history of MS * History of medullar injury * Spinal osteoarthritis which can lead to a spinal hypersignal ; * adults subject to legal protection or persons deprived of liberty * Contraindications to MRI * Contraindications to motor evoked potentials * Current pregnancy or breast-feeding

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis, relapsing-remitting

Contacts and locations

Locations

  • AP-HM Timone

    Marseille, France

  • CHU Rennes

    Rennes, France

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