Can a new drug strengthen hearts weakened by genetic disease?

NCT ID NCT07771465

NEW Not yet recruiting Disease control Sponsor: Kardigan, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This study tests the long-term safety and effectiveness of an investigational drug called danicamtiv in adults with symptomatic genetic or familial dilated cardiomyopathy (DCM), a condition where the heart muscle weakens and enlarges. Participants who completed a prior 24-week study will receive danicamtiv twice daily for up to 5 years. The goal is to see if the drug can improve heart function and reduce disease-related events, while monitoring for side effects. There are currently no approved medicines specifically for this type of DCM.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: danicamtiv
What this could lead to: If successful, danicamtiv could become the first approved treatment specifically for genetic or familial dilated cardiomyopathy, potentially improving heart function and quality of life.
What could go wrong: This is an extension study, so it builds on earlier data but still may not prove long-term benefit. Side effects and tolerability over up to 5 years are unknown, and the drug is not yet approved.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dilated cardiomyopathy familial dilated cardiomyopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYMPTOMATIC GENETIC DILATED CARDIOMYOPATHY (DCM)

Contacts and locations

Locations

AP-HP Hopital Europeen Georges Pompidou

Paris, 75015, France
AP-HP Hopital Pitie-Salpetriere

Paris, 75013, France
ASST Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
AZORG - Campus Moorselbaan

Aalst, 9300, Belgium
Aarhus University Hospital

Aarhus, 8200, Denmark
Amsterdam UMC - Locatie AMC

Amsterdam, 1105-AZ, Netherlands
Azienda Ospedale - Università Padova

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Consorziale - Policlinico Bari

Bari, 70124, Italy
Azienda Ospedaliero-Universitaria Careggi

Florence, 50314, Italy
Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) - Ospedale di Cattinara

Trieste, 34100, Italy
Baylor College of Medicine

Houston, Texas, 77030, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CHRU de Tours - Hopital Trousseau

Chambray-lès-Tours, 37170, France
CHU Rennes - Hopital Pontchaillou

Rennes, 35033, France
CHU de Lille - Institut Coeur Poumon

Lille, 59037, France
Cardiovascular Clinical Research Facility (CCRF)

Oxford, OX3 9DU, United Kingdom
Cedars Sinai

Los Angeles, California, 90048, United States
Centro Cardiologico Monzino

Milan, 20138, Italy
Columbia University Medical Center/ New York Presbyterian Hospital

New York, New York, 10027, United States
Danderyds sjukhus

Stockholm, 182 88, Sweden
Duke University Medical Center

Durham, North Carolina, 27708, United States
Erasmus MC

Rotterdam, 3015 GD, Netherlands
Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy
Glenfield hospital

Leicester, LE3 9QP, United Kingdom
Hammersmith Hospital, Imperial College of London

London, W12 0HS, United Kingdom
Henry Ford Health System

Detroit, Michigan, 48202, United States
Hospital Clinico Universitario Virgen de la Arrixaca

Murcia, 30120, Spain
Hospital Universitari de Bellvitge

Barcelona, 08907, Spain
Hospital Universitario Puerta de Hierro, Majadahonda, Madrid 20222

Madrid, 20222, Spain
Hospital Universitario Son Llatzer, Palma De Mallorca,

Palma de Mallorca, 7198, Spain
Hospital Universitario Vall d'Hebron, Horta-Guinardó

Barcelona, 08035, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29001, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital Universitario de A Coruña

A Coruña, 15006, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
Istituto Clinico Humanitas

Rozzano, 20089, Italy
Jessa Ziekenhuis

Hasselt, 3500, Belgium
Johns Hopkins Medicine

Baltimore, Maryland, 21218, United States
Krakowski Szpital Specjalistyczny im. sw. Jana Pawla II

Krakow, 31-202, Poland
Louisiana State University (LSU) Health Sciences Center

New Orleans, Louisiana, 70112, United States
Maastricht University Medical Center

Maastricht, 6229 HX, Netherlands
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
NHS Greater Glasgow and Clyde

Glasgow, G12 0YN, United Kingdom
NYU Langone Health

New York, New York, 10016, United States
Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy w Warszawie

Warsaw, 04-628, Poland
Northwestern University

Chicago, Illinois, 60611, United States
Odense University Hospital - Odense

Odense, 5000, Denmark
Oregon Health & Science University (OHSU)

Portland, Oregon, 97239, United States
Ospedale Policlinico Casilino

Roma, 00169, Italy
Rigshospitalet

Copenhagen, 1050, Denmark
Royal Brompton Hospital

London, SW3 6NP, United Kingdom
Saint Luke's Mid America Heart Institute

Kansas City, Missouri, 64111, United States
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

Lodz, 92-213, Poland
Semmelweis Egyetem - Varosmajori Sziv es Ergyogyaszati Klinika

Budapest, 1122, Hungary
Sodersjukhuset AB

Stockholm, 11883, Sweden
St George's Hospital

London, SW17 0QT, United Kingdom
St. Bartholomew's Hospital

London, EC1A, United Kingdom
Stanford University Medical Center

Stanford, California, 94305, United States
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, 6724, Hungary
The Lindner Center for Research and Education at The Christ Hospital

Cincinnati, Ohio, 45219, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
UZ Leuven

Leuven, 3000, Belgium
Universitair Ziekenhuis Antwerpen (UZA)

Edegem, 2650, Belgium
Universite Libre de Bruxelles (ULB) - Hopital Erasme

Brussels, 1070, Belgium
University Hospitals Bristol NHS Foundation Trust

Bristol, BS1 3NU, United Kingdom
University of Alabama Birmingham

Birmingham, Alabama, 35233, United States
University of California, Los Angeles (UCLA) - David Geffen School of Medicine

Los Angeles, California, 90095, United States
University of California, San Diego (UCSD) - Medical Center

San Diego, California, 92037, United States
University of California, San Francisco (UCSF)

San Francisco, California, 94158, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68106, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Uniwersyteckie Centrum Kliniczne, Gdansk

Gdansk, 80-952, Poland
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States