Neuromuscular disease

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This study tested whether giving a booster polio vaccine (sIPV) at the same time as MMR and hepatitis A vaccines is safe and works well in toddlers. About 889 healthy children aged 18 to 22 months who had already received their first polio and MMR shots took part. Researchers che…

This study tested a new vaccine called BK1310 in 370 healthy infants to see if it safely protects against several serious diseases: Hib, diphtheria, pertussis, tetanus, and polio. The vaccine was compared to existing vaccines. The goal was to check how well the infants' immune sy…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This completed Phase 3 trial tested a new Sabin strain inactivated polio vaccine (sIPV) in 1200 healthy infants aged 2 months. The study compared the new vaccine to a standard polio vaccine to see if it was safe and triggered a strong immune response. The goal is to offer a more …

This study tested a gene transfer treatment for giant axonal neuropathy (GAN), a rare genetic disease that damages nerves and affects movement, breathing, and other functions. Fourteen people aged 3 and older received a single injection of the treatment into the fluid around the …

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving …

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This completed Phase 3 study tested TAK-771, a combination of immune globulin and hyaluronidase, in 26 Japanese adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN). The main goals were to check for side effects and see…

This study is testing the drug risdiplam in newborn babies with spinal muscular atrophy (SMA), a serious muscle-weakening disease. The goal is to see how the drug moves through the body and if it is safe for infants under 20 days old. Ten babies will take part, and researchers wi…

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This early study tested whether infusing a patient's own regulatory T cells (immune-calming cells) along with interleukin-2 injections is safe for people with ALS. Only 3 participants were enrolled, and the main goal was to check for side effects. The approach aims to slow diseas…

This early-stage trial tested a new combination therapy using a polymer called polyethylene glycol (PEG) to help fuse severed nerve endings right after injury. The goal was to see if this approach could restore nerve function faster than current methods. The study involved 45 peo…

This study tests an experimental drug called AT-007 (Govorestat) in 56 adults with SORD deficiency, a rare genetic condition that causes nerve damage and muscle weakness. The drug aims to lower high levels of sorbitol, a sugar that builds up and harms nerves. Researchers will mea…

This study tested whether people with ALS or Parkinson's disease, along with healthy volunteers, could follow the MIND diet — a mix of the Mediterranean and DASH diets thought to protect the brain. Over several weeks, 43 participants received a cookbook, educational materials, an…

This early-stage trial tested a combination of two oral drugs, tipifarnib and alpelisib, in 45 adults with recurrent or metastatic head and neck squamous cell carcinoma that has specific genetic changes (HRAS overexpression or PIK3CA mutations). The goal was to find a safe dose a…

This study tested whether a 20-minute arm cycling exercise, done twice daily for five days, could improve lung function and recovery in 60 elderly patients after colon cancer surgery. Participants also received standard physical therapy. The goal was to see if the arm exercise co…

This study tested a surgical technique to help people with a severe arm nerve injury (pan-brachial plexus injury) regain the ability to bend their fingers and grasp objects. Seventeen patients who already had some elbow movement from a prior nerve surgery received a tendon transf…

This study tested the drug patisiran in 10 adults with a rare condition called ATTR amyloidosis that causes nerve damage. Participants received an IV infusion every 21 days for 24 months. Researchers measured changes in nerve function, autonomic symptoms, and quality of life to s…

This study tested the long-term safety of an oral form of edaravone in 124 people with ALS over 96 weeks. Participants took the drug in cycles of 10 days on and 14 days off. The main goal was to see how safe and tolerable the treatment was over time.

This study looked at the safety of an oral form of edaravone for people with ALS, a nerve disease that weakens muscles. Fifteen patients who had already been in earlier edaravone studies took the drug for 10 days every two weeks. Researchers tracked side effects to see if the med…

This study looked at the long-term safety of an oral form of edaravone in 185 adults with ALS. Participants took the medication for 24 to 48 weeks, and researchers tracked any side effects. The goal was to see if taking the drug by mouth is safe over time for people with this pro…

This study tested an oral drug called AZ-3102 in 13 people with GM2 gangliosidosis (Tay-Sachs or Sandhoff disease) or Niemann-Pick type C disease. The main goal was to check safety and how the drug moves through the body over 12 weeks. It was a randomized, double-blind, placebo-c…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study looked at whether a short electrical stimulation treatment after surgery can help people with severe nerve injuries in the arm regain hand function. 136 adults with complete nerve damage were randomly assigned to receive either electrical stimulation or standard care. …

This phase 2 trial tests an experimental drug called ARGX-117 in 54 adults with multifocal motor neuropathy (MMN), a condition that causes muscle weakness. Participants receive either ARGX-117 or a placebo by IV, and researchers check if the drug can safely delay the need for sta…

This study tested whether a nerve block called stellate ganglion block can improve swallowing in people with bulbar palsy after an ischemic stroke. 124 participants were randomly assigned to receive either standard rehabilitation alone or standard rehabilitation plus the nerve bl…

This study tested whether custom silicone toe orthoses (inserts) could reduce foot pressure and prevent pre-ulcerative lesions in people with diabetic neuropathy. Sixty participants with diabetes and foot deformities wore the orthoses for six months. The goal was to see if these …

This study tested a daily ketone supplement (beta hydroxybutyrate ester) in 81 people with ALS to see if it could slow the disease. The idea is that ketones provide extra energy to cells, which may help counter the energy shortage seen in ALS. Participants took the supplement alo…

This Phase 3 trial tested a stem cell treatment called Lenzumestrocel in 123 people with ALS. The treatment uses the patient's own bone marrow stem cells and is given alongside the standard drug Riluzole. The goal was to see if it could slow the disease and improve survival and f…

This small study tested whether injecting a person's own fat-derived cells (called stromal vascular fraction) into the foot could help heal diabetic nerve damage and foot ulcers. Eight adults with diabetic peripheral neuropathy received injections around the wound and along nerve…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested a new medicine called AOC 1020 in 90 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. The goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a p…

This early-phase trial tested whether combining two drugs—abatacept and interleukin-2—is safe for people with ALS. The goal was to boost the body's regulatory T cells, which may help slow disease progression. Only 5 participants were enrolled, and the study focused on safety and …

This study looked at whether a 12-week intensive lifestyle program focused on weight loss and diabetes control could improve diabetic peripheral neuropathy, a common nerve complication. Fifty adults with diabetes and a BMI between 30 and 45 took part. The program included diet, e…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study followed 24 people with metachromatic leukodystrophy (MLD), a rare and serious brain disease, who were already receiving an experimental drug called HGT-1110. The main goal was to check for side effects and immune reactions over a long period. Researchers wanted to see…

This study tested whether neuromuscular electrical stimulation (NMES) can prevent muscle wasting in patients on mechanical ventilators in the ICU. 22 adults were split into a control group and an NMES group, receiving stimulation sessions for at least 7 days. Researchers used ult…

This study tested the drug D-cycloserine in a single patient with a rare genetic form of hereditary spastic paraplegia. The goal was to see if the drug is safe and can slow the disease by lowering certain fats (sphingolipids) in the body. The patient also took pyridoxine to help …

This phase 3 trial tested the drug patisiran in 360 people with ATTR amyloidosis with cardiomyopathy, a condition where abnormal protein builds up in the heart, making it stiff and weak. Participants received either patisiran or a placebo intravenously. The study measured how far…

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This trial tested a custom-made drug called nL-TARD-001 in one person with ALS caused by a specific genetic mutation in TARDBP. The drug is an antisense oligonucleotide designed to target the faulty gene. The study measured changes in muscle function, breathing, and thinking over…

This study tested whether adults with CIDP, a nerve disorder causing weakness and numbness, could safely switch from regular intravenous immunoglobulin (IVIg) infusions to a new injectable drug called efgartigimod PH20 SC. Twenty-three participants who were stable on IVIg were gi…

This study tested a drug called TPN-101 in 42 people with ALS or frontotemporal dementia caused by a specific gene change (C9orf72). The main goal was to check if the drug is safe and tolerable over 48 weeks. Researchers also looked at how the drug moves in the body and whether i…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study looked at a collagen wrap used during nerve surgery to help healing. 40 patients had the wrap placed around repaired nerves in their arms or legs. Early results suggest it may improve movement and feeling, but more research is needed.

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study tested an oral drug called ifetroban in 46 males aged 7 and older with Duchenne muscular dystrophy (DMD). The goal was to see if the drug is safe and can help prevent or treat heart problems, which are a leading cause of death in DMD. Participants received either ifetr…

This study tested a gene therapy called OTL-200 in 10 children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. The treatment uses the child's own blood stem cells, modified to produce a missing enzyme, and aims to slow or stop disease progres…

This study looked at whether giving a steroid called prednisone twice a week at a lower dose, along with exercise training, could help boys with Duchenne muscular dystrophy (DMD) maintain muscle strength and function. The goal was to find a treatment that works as well as daily s…

This study tested a new drug called AOC 1001 in 39 adults with myotonic dystrophy type 1, a genetic muscle disorder. Participants received either the drug or a placebo by IV infusion. The goal was to check safety and how the drug moves through the body. Results will help decide i…

This study tested the safety of a drug called ataluren (also known as Translarna) in 270 people with Duchenne muscular dystrophy caused by a specific type of genetic mistake (nonsense mutation). Participants had already taken ataluren in earlier studies. The goal was to monitor s…

This study tested a drug called ataluren in 360 boys with Duchenne muscular dystrophy caused by a specific genetic mistake (nonsense mutation). The main goal was to see if ataluren could help them walk farther over 72 weeks compared to a placebo. All participants were also taking…

This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation and scar formation, can reduce sciatica pain in people who developed spinal scar tissue after back surgery. 38 adults with persistent pain after discectomy received either the drug or a pla…

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received injections of a harmless virus carrying a working copy of the ARSA gene directly into their brains. …

This study tested whether using a computer model to adjust doses of two common drugs (sitagliptin for diabetes and duloxetine for nerve pain) works better in people with liver cirrhosis. 64 patients with cirrhosis, diabetes, and nerve pain were grouped by liver severity and given…

This study tested whether deferiprone, a drug that removes excess iron, could safely slow the progression of ALS. Researchers gave the drug to 23 adults with ALS for several months. The goal was to see if reducing iron buildup in the brain might protect nerve cells and delay wors…

This early-stage study tested a new drug called ALN-TTRSC04 in 96 healthy people to see if it is safe and how the body processes it. The drug aims to lower a harmful protein that causes transthyretin amyloidosis, a serious disease affecting nerves and the heart. Participants rece…

This early-phase study tested a new gene editing treatment called HG302 in 4 boys with Duchenne muscular dystrophy (DMD), a severe muscle-wasting disease. The therapy uses CRISPR technology to fix the genetic error and help muscles produce dystrophin, a protein essential for musc…

This early-stage trial tested a single dose of the drug PGN-EDODM1 in 24 adults with myotonic dystrophy type 1, a genetic muscle disorder. The main goal was to check safety and how the body handles the drug. The study is complete, but results are not yet available.

This early-stage trial tests NTLA-2001, a CRISPR-based gene editing therapy, in 72 adults with hereditary ATTR amyloidosis—a condition where abnormal protein builds up in nerves or the heart. The treatment aims to turn off the faulty gene to reduce protein levels. The study focus…

This study tested a drug called DNL343 in 249 people with ALS, a serious nerve disease that weakens muscles over time. The goal was to see if DNL343 could slow the disease and help people live longer. The trial used a flexible platform design to test multiple treatments at once.

This study tested a new drug, ABC008, in 272 adults with inclusion body myositis, a rare muscle-weakening disease. The goal was to see if the drug is safe and can help slow the disease's progression. Participants received either ABC008 or a placebo, and their muscle function was …

This phase 3 trial tested a one-time gene therapy called Zolgensma in 22 infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The treatment delivers a working copy of the missing SMN gene via an IV infusion. The main goals were …

This study tested a one-time gene replacement therapy in infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The main goal was to see if treated babies could sit without support for at least 10 seconds by 18 months of age. The …

This study tested a one-time gene replacement therapy in 33 infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The treatment aims to replace the missing SMN1 gene to improve muscle function. Key results showed that many babies…

This study tested a single dose of Zolgensma gene therapy in 30 infants diagnosed with spinal muscular atrophy (SMA) before symptoms appeared. The goal was to see if the treatment helps them reach motor milestones like sitting or standing alone. The therapy delivers a working cop…

This Phase 3 trial tested apitegromab, a drug that blocks a muscle-limiting protein, in 188 nonambulatory children and young adults with later-onset spinal muscular atrophy (SMA types 2 and 3). All participants were already taking standard SMA therapies (nusinersen or risdiplam).…

This study tested whether an ultrasound-guided nerve block, using a steroid and local anesthetic, could better control pain from shingles and prevent postherpetic neuralgia (long-term nerve pain). 100 adults with acute shingles and moderate to severe pain were randomly assigned t…

This early-stage trial tested a single dose of a new drug called KINE-101 in 9 adults with chronic inflammatory demyelinating polyneuropathy (CIDP) that hadn't improved with steroids. The main goal was to check if the drug is safe and tolerable. Researchers also looked at whether…

This study tested a one-time gene therapy called OAV101 (Zolgensma) in 27 children aged 2 to 18 with spinal muscular atrophy (SMA) who had previously stopped taking other SMA medications (Spinraza or Evrysdi). The goal was to see if the treatment is safe and can help maintain or …

This study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA) who had never received other SMA treatments. The therapy was given as a spinal injection and compared to a sham procedure. The goal was to see if it coul…

This study tested a drug called alpelisib combined with hormone therapy (fulvestrant or letrozole) in 383 people with advanced breast cancer that has a specific genetic change (PIK3CA mutation). The goal was to see how many patients were alive without their cancer getting worse a…

This study tested a new drug called vutrisiran in 164 people with a rare inherited disease that damages nerves and organs. Participants received either vutrisiran as a shot every 3 months or the standard treatment patisiran as an IV infusion every 3 weeks. The goal was to see if …

This Phase 3 trial tested the drug edaravone (MCI-186) in 206 people with ALS. Participants received daily intravenous infusions for 14 days, followed by a rest period, repeated over 24 weeks. The goal was to see if edaravone could slow the decline in physical function compared t…

This study tested the drug edaravone (MCI-186) in 181 people with ALS, a progressive nerve disease. Participants received either edaravone or a placebo through IV infusions over 24 weeks. The goal was to see if edaravone could slow the decline in physical function. Results sugges…

This study tested a drug called MCI-186 in 137 people with ALS, a nerve disease that weakens muscles over time. The goal was to see if the drug could slow down the disease compared to a placebo over 24 weeks. The main measure was a scale of daily function. The trial did not show …

This phase 2 trial tested a combination of two oral drugs, RMC-4630 and sotorasib, in 47 adults with advanced KRASG12C-mutant non-small cell lung cancer that had progressed after standard treatments. The goal was to see if the combination could shrink tumors. The study is now com…

This study tested a drug called MCI-186 in 25 people with advanced ALS (severity grade III) to see if it could slow the disease. Participants received either the drug or a placebo daily through an IV for 24 weeks. The main goal was to measure changes in daily function and safety,…

This study tested whether giving muscle relaxants along with sedation helps improve oxygen levels in patients with severe COVID-19 lung failure (ARDS) who need a breathing machine. Forty adults were enrolled. The goal was to see if this approach could reduce complications and imp…

This completed early trial tested a single intravenous dose of EN001 stem cells in 3 adults with Charcot-Marie-Tooth disease type 1E, a severe hereditary nerve disorder with no approved treatment. The main goal was to check safety, including infusion reactions, while also looking…

This study looked at the safety of vatiquinone in 101 people with inherited mitochondrial disease who had already taken the drug in a previous study or treatment plan. The goal was to track any side effects until the drug became commercially available or the program ended. Partic…

This early study tested whether adding a patient's own Schwann cells (nerve-supporting cells) to a nerve graft could safely improve recovery after severe peripheral nerve injury. Five adults with large nerve gaps received the cell-enhanced graft. The main goal was safety, checkin…

This completed Phase 2/3 trial tested whether deferiprone, a drug that removes excess iron from the body, can slow the progression of ALS (Lou Gehrig's disease). 372 people with early-stage ALS took either deferiprone or a placebo for 12 months. The study measured changes in phys…

This study tested a gene therapy for children with metachromatic leukodystrophy (MLD), a rare, inherited brain disease that causes severe disability and early death. The treatment uses the child's own blood stem cells, which are modified in a lab to carry a working copy of the mi…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This study tested a new PET imaging tracer to see if it can safely show signs of ALS in the body. Eight people (some healthy, some with ALS) received the tracer and were scanned. The goal was to check safety and how the tracer spreads, which could lead to earlier diagnosis and be…

This study tested whether using specialized eye-movement tests (HINTS and v-HIT) in the emergency room can help doctors correctly diagnose the cause of sudden vertigo. Researchers tracked 90 adults with acute vertigo to see if these tests reduced misdiagnosis and sped up treatmen…

This completed pilot study tested whether a computer algorithm could diagnose facioscapulohumeral muscular dystrophy (FSHMD) by analyzing video recordings of people's faces. Researchers recorded 17 participants, including patients with FSHMD, other muscle diseases, and healthy co…

This study tested a new, rapid MRI method in 102 infants with brachial plexus birth palsy (nerve damage from birth). The goal was to see if the MRI could help doctors decide earlier and more accurately whether the baby needs nerve surgery. The MRI was done without anesthesia, and…

This study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

This study tested whether a special PET/MR scan using a radioactive tracer called F-18 florbetapir can detect amyloid protein buildup in the nerves of people with amyloidosis. Eight adults with confirmed nerve amyloidosis or other nerve diseases took part. The goal was to see if …

This study compared different ways to detect early nerve damage in people with hereditary TTR amyloidosis, a condition that can cause progressive nerve problems. Researchers used blood tests, skin imaging, and standard nerve exams in 47 participants. The goal was to see which too…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested whether ultrasound can accurately diagnose mild to moderate carpal tunnel syndrome (CTS) by measuring the median nerve. Researchers compared ultrasound results with standard nerve tests and checked how they related to pain, symptoms, and quality of life in 75 pe…

This study tested a new blood test (liquid biopsy) that looks for cancer DNA in the blood of 30 women with advanced ER+/HER2- breast cancer. The goal was to see if the test can accurately find cancer mutations without needing a traditional tissue biopsy. The results will help doc…

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This study looked at whether chemicals in tears and eye surface cells can help diagnose amyotrophic lateral sclerosis (ALS) or predict how the disease will progress. Researchers collected tear samples and performed eye exams on 55 people with ALS and healthy controls. The goal wa…

This completed study looked at how well a camera test called FEES (flexible endoscopic evaluation of swallowing) can detect and track swallowing problems in people with spinal muscular atrophy (SMA). Researchers studied 79 SMA patients of different types and ages, using several s…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tested whether tadalafil, a drug often used for erectile dysfunction, can prevent nerve damage caused by docetaxel chemotherapy in men with metastatic prostate cancer. 90 participants were randomly assigned to receive either tadalafil plus standard care or standard car…

This study tested whether a polio vaccine (sIPV) is still effective when given at the same time as other routine vaccines for infants, like those for pneumonia, diphtheria, tetanus, and whooping cough. About 1,400 babies in Bangladesh and Pakistan received the polio vaccine eithe…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This completed pilot study tested whether shining a low-level laser into the blood (intravenous laser therapy) can improve sleep and reduce pain in people with chronic sciatica. Sixty-six adults with sciatica and poor sleep received either electroacupuncture alone or electroacupu…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This study tests an experimental drug called SPI-1005 (ebselen) in adults with Meniere's disease, a condition that causes vertigo, tinnitus, and hearing loss. The trial compares three doses of SPI-1005 against a placebo to see if it safely reduces these symptoms. Researchers will…

This completed pilot study tested a behavioral program called PIVOT in 33 adults with chemotherapy-induced peripheral neuropathy. Participants worked with coaches to set personal health goals using a structured goal-setting method. The study aimed to see if this approach is safe …

This study tested whether people with ALS can start using a breathing machine at home instead of in the hospital. 46 patients were randomly assigned to start either at home with remote monitoring or in the hospital. The goal was to see if home initiation works just as well, measu…

This study tested two non-invasive treatments—high-intensity laser therapy and shock wave therapy—for people with cubital tunnel syndrome after an arm burn. 75 adults with healed burns and confirmed ulnar nerve problems received either laser or shock wave therapy plus nerve glidi…

This study followed 53 adults with non-dystrophic myotonic disorders who were taking Namuscla (mexiletine) to manage muscle stiffness. Researchers monitored side effects and how often patients needed to reduce their dose or stop treatment over up to 36 months. The goal was to see…

This study tests a device that cools and compresses the arms and legs to see if it can prevent nerve damage caused by chemotherapy. The device is first tested in healthy volunteers to find the best temperature and pressure, then in cancer patients receiving weekly paclitaxel. The…

This pilot study tested whether adding a vibrating chest vest to a standard cough-assist machine could reduce lung infections and hospital stays in people with ALS who use breathing support. Fourteen patients were randomly assigned to use either the vest plus cough assist or the …

This study tested whether a TENS device, which sends mild electrical pulses through the skin, can reduce leg pain in people with Charcot-Marie-Tooth disease. Ten adults with chronic pain participated. The goal was to see if pain scores dropped by at least 30%.

This study tested whether teaching good sleep habits could help people with painful diabetic nerve damage sleep better and feel better overall. Twenty-four patients were split into two groups: one received a booklet and face-to-face sleep training from a nurse, while the other co…

This completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This study looked at how common nerve pain is in cancer patients getting chemotherapy and tested if a simple exercise program could help. 282 patients took part, and those who did supervised exercises for 21 days reported less nerve pain than those who got usual care. The results…

This study tested two ultrasound-guided injections for carpal tunnel syndrome: one using a sugar-water solution (hydrodissection) and the other using a steroid. 53 adults with moderate carpal tunnel took part. The goal was to see which treatment better reduces symptoms and improv…

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested whether a new type of brain stimulation, called controlled transcranial magnetic stimulation (cTMS), can reduce pain and improve daily function in people with painful diabetic neuropathy. Twenty adults with the condition received either real or sham cTMS over fi…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested a 12-week online peer support programme for family caregivers of people with motor neurone disease who are becoming dependent on breathing or feeding technology. The programme included private messaging, weekly chats, a discussion forum, and resources. Researche…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested two numbing methods for carpal tunnel surgery in 100 adults. One method uses lidocaine with epinephrine and no tourniquet (WALANT), while the other uses lidocaine alone with a tourniquet. The main goal was to see which method causes less pain during the operatio…

This study tested an experimental drug called NMD670 in 52 adults with type 3 spinal muscular atrophy who can still walk. The goal was to see if the drug helps them walk farther in 6 minutes and improves muscle strength compared to a placebo. The trial is now complete, and result…

This study tested whether hypnosis sessions led by a nurse over video call are practical for people with long-term nerve pain. Thirty adults with peripheral neuropathic pain for over a year took part. The goal was to see if patients would complete five sessions and if it helped w…

This study tested whether roasted nux vomica capsules can help with nerve pain caused by the chemotherapy drug bortezomib in multiple myeloma patients. Twenty-two participants took the capsules for six weeks while continuing their regular chemo. Researchers measured changes in ne…

This study looked at whether hypnosis or a placebo pill (given honestly, without deception) can reduce chronic nerve pain and improve how the brain handles pain. Seventy-two adults with long-term nerve pain were randomly assigned to hypnosis, open-label placebo, or usual care. Th…

This small pilot study tested whether a 4-week course of repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain and improve quality of life in 18 adults with diabetic neuropathy. Participants received rTMS and were monitored using questionnaires, nerve tests, a…

This study tested whether a spinal cord stimulation device can reduce chronic leg pain caused by diabetic neuropathy. Twenty-eight people with diabetes received the implant and reported their pain relief and overall improvement over 12 months. The goal was to see if this device c…

This study tested three different balance exercise programs in 45 adults with dizziness from a chronic inner ear condition. One group did standard head and eye exercises, another watched 2D moving patterns, and a third used 3D virtual reality. All groups practiced for 6 weeks, an…

This study tested whether adding shockwave therapy to standard treatment (kinesio taping and physical therapy) helps relieve pain and numbness in women with mild-to-moderate carpal tunnel syndrome. One hundred female physical therapists participated. The goal was to see if the co…

This study tested a portable knee training device in 13 children aged 6-12 with spinal muscular atrophy (SMA). The goal was to see if regular exercise with the device could improve leg muscle strength and function. Researchers measured muscle size, strength, and nerve activity ov…

This study looked at whether a type of electrical stimulation called Russian current can help people regain hand grip strength and function after carpal tunnel release surgery. Fifty-two adults aged 30 to 50 with hand weakness after surgery took part. Researchers measured grip st…

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This study looked at two types of nerve blocks—fascia iliaca block and femoral nerve block—to see which one works better for pain control in people having hip fracture surgery. 80 adults were randomly assigned to receive one of the two blocks before spinal anesthesia. The main go…

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This study tested two non-invasive treatments—low-level laser and transcutaneous vagus nerve stimulation—in 30 adults with diabetic neuropathy. The goal was to see which better improves blood flow and reduces nerve pain. Participants had diabetes for over 5 years and stable blood…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study tested whether an ultrasound-guided injection of sugar water around the sciatic nerve could safely reduce sciatica pain in the emergency department. Researchers enrolled 69 adults with acute sciatica and followed up 72 hours later. The goal was to see if the procedure …

This early-stage study tested a new drug called 4ET1103 in 40 healthy volunteers to see if it is safe and how the body processes it. Each person received a single dose of either the drug or a placebo. The goal was to check for side effects and measure drug levels, not to treat pa…

This study tested whether playing WiiFit games is more effective than standard balance exercises for people with dizziness and balance problems caused by inner ear issues. 42 adults aged 18-65 took part in a 4-week program. The goal was to see if the fun, interactive nature of Wi…

This study tested two types of eye exercises—gaze stabilization and optokinetic training—in 32 adults aged 35-55 with chronic dizziness from inner ear problems. The goal was to see which better improves dizziness, balance, and confidence in daily activities. Results help guide th…

This study tested whether combining balance exercises with mental tasks (like naming animals) can improve balance and mild memory problems in people with diabetic nerve damage. Fifty adults aged 50 and older with type 2 diabetes and mild cognitive issues took part in 24 sessions …

This study tested whether eye and neck exercises can reduce dizziness and uncontrolled eye movements in young adults with benign paroxysmal positional vertigo (BPPV). Fifty-six participants did either eye exercises alone or combined eye and neck exercises for six weeks. The goal …

This study tested whether adding a four-cell galvanic bath therapy to standard rehabilitation could reduce pain and improve balance in people with diabetic nerve damage. 66 adults with type 2 diabetes and diabetic neuropathy participated. Over 4 weeks, some received the bath ther…

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested whether remote monitoring through the Neurosphere app could improve pain relief and lower healthcare costs for people with chronic pain using spinal cord stimulators. Thirty-two adults were split into two groups: one had in-person clinic visits, the other used r…

This completed trial tested whether combining neurodynamic exercises with proprioceptive neuromuscular facilitation (PNF) techniques can reduce pain and improve range of motion in people with carpal tunnel syndrome. Forty-eight diagnosed patients performed the exercises for two w…

This study tested two non-drug treatments—whole-body vibration and neuromuscular electrical stimulation—in 60 ICU patients with muscle weakness. Patients received one of the therapies twice daily for two weeks, alongside standard care. Researchers measured muscle strength and thi…

This study tested two non-drug treatments for piriformis syndrome, a condition where a muscle in the buttock presses on a nerve, causing pain. Seventy adults received either low-level laser therapy or radial shockwave therapy, both combined with exercise, over four weeks. Researc…

This study tested whether virtual peer support helps family caregivers of people with neuromuscular disease feel more in control and less isolated. About 100 Canadian caregivers joined online sessions with trained peer mentors. The goal was to improve caregivers' sense of mastery…

This study looked at whether adding dexmedetomidine to standard spinal anesthesia could lower the chance of acute neuropathic pain after a leg amputation. Thirty adults having elective lower limb amputation were split into two groups: one got the standard anesthetic plus a placeb…

This study tested a non-invasive treatment called radial pressure wave therapy for people with mild to moderate carpal tunnel syndrome. 60 adults received three weekly sessions of either a constant or modulated dose of the therapy. Researchers measured pain, hand function, and ne…

This study compared two physical therapy methods—pulsed ultrasound and pulsed shortwave diathermy—in 40 adults with mild-to-moderate carpal tunnel syndrome. All participants wore a wrist splint and did exercises for three weeks, plus one of the two treatments. Researchers measure…

This study tested whether NT 201 injections can reduce pain in adults with long-term nerve pain caused by shingles or a nerve injury. 123 people received either NT 201 or a placebo shot, and researchers tracked their pain levels over 20 weeks. The goal was to see if the treatment…

This pilot study tested whether electro-acupuncture—a treatment that combines traditional acupuncture with mild electrical current—is practical and helpful for people with nerve pain and numbness from chemotherapy. Twenty cancer survivors who had completed chemotherapy at least t…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study tested a new drug called SR750 in 138 people with trigeminal neuralgia, a condition that causes sudden, severe facial pain. Participants took either SR750 or a placebo for 6 weeks and recorded their daily pain levels. The goal was to see if SR750 reduces pain better th…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This study tested whether injecting platelet-rich plasma (PRP) near nerves can reduce pain and nerve damage caused by chemotherapy. 62 cancer patients with persistent nerve pain received PRP injections guided by ultrasound. Researchers measured pain levels and nerve function to s…

This study tested whether virtual reality (using Xbox Kinect) or biofeedback training could improve motor function and balance in 24 children with neuromuscular diseases like Duchenne muscular dystrophy and spinal muscular atrophy. Participants were split into three groups: VR tr…

This study looked at whether two common drugs, memantine and dextromethorphan, can help maintain or improve pain relief after a ketamine treatment in people with long-term nerve pain. Seven adults with chronic neuropathic pain who had already responded to ketamine took part. The …

This study tested whether ethosuximide, a drug already used for epilepsy, can reduce pain in people with nerve damage. 114 adults with peripheral neuropathic pain took either the drug or a placebo for 42 days. Researchers measured pain levels and quality of life to see if the dru…

This study compared two hands-on treatments—post-facilitation stretch and active release technique—for piriformis syndrome in 40 women aged 25 to 45. Researchers measured pain, disability, quality of life, and hip movement over six weeks. The goal was to see which approach offers…

This completed trial from Harvard University tested whether an online mindfulness program and social community could improve quality of life for 100 people with ALS and their primary caregivers. Participants used a three-week e-learning program with cognitive exercises and videos…

This Phase 3 study tested whether injections of MYOBLOC (a botulinum toxin type B) into the salivary glands can safely reduce troublesome drooling in adults. 187 participants received either MYOBLOC or a placebo. The main goals were to measure changes in saliva flow and overall i…

This completed study compared two treatments for piriformis syndrome, a condition causing buttock and leg pain. Forty adults whose pain lasted at least three months were randomly assigned to receive either five sessions of focused sound wave therapy or a single steroid injection.…

This study tested whether an interactive virtual reality (VR) system could help children aged 5–10 with Duchenne muscular dystrophy (DMD) stick to their physiotherapy exercises at home. Fourteen children used the VR system for 8 weeks, and researchers measured how often and how l…

This study tested whether a rehabilitation program using a smartphone app (MORA) could help bedridden hospital patients improve their physical function. Twenty-five adults who could not walk used the app to do personalized exercises twice daily for two weeks. The goal was to see …

This study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …

This study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…

This study compared a capsaicin patch (Qutenza) to a standard nerve pain medication (amitriptyline) in 13 head and neck cancer survivors with long-term nerve pain. The goal was to see if the patch could reduce pain and improve quality of life. Participants received either the pat…

This study tested two exercise techniques—dynamic stretching and nerve gliding—in 72 adults with lumbar radiculopathy (nerve-related back pain). Both groups also received standard physiotherapy. The goal was to see which approach better reduced pain and improved daily function ov…

This study looked at whether adding manual therapy (hands-on techniques) to standard breathing exercises could improve breathing, fatigue, and trunk control in children with neuromuscular diseases. Twenty-eight children aged 7 to 18 took part. One group did only conventional phys…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested if a simpler numbing method called WALANT works as well as a standard arm block for carpal tunnel release surgery. WALANT involves injecting numbing medicine directly into the wrist area, avoiding the need for a tourniquet or sedation. The trial included 130 adu…

This study tested whether adding transcranial magnetic stimulation (TMS) to standard exercise can reduce fatigue, pain, and improve walking in people with postpolio syndrome. 26 adults who had polio earlier in life and now have new symptoms took part. Half got TMS plus exercise, …

This study tested two physical therapy techniques—nerve gliding exercises and manual muscle release—to see which better relieves sciatica pain. 48 adults with long-term sciatica took part. Researchers measured pain, leg movement, and daily function to find the most effective appr…

This study tested two types of nerve mobilization exercises—slider and tensioner—in 36 adults with chronic neck pain from cervical radiculopathy. Participants received standard care plus one of the two techniques. The goal was to see which better reduces pain, improves neck movem…

This study tested whether using the WALANT technique (numbing the hand with local anesthetic and epinephrine) along with nerve blocks at the wrist could make carpal tunnel release surgery more comfortable than using a standard tourniquet. 60 adults having endoscopic carpal tunnel…

This study looked at whether adding foot exercises to aerobic exercise helps people with type 2 diabetes and nerve damage in their legs. 74 participants were split into three groups: usual medical care, aerobic exercise only, or aerobic exercise plus foot exercises. The goal was …

This pilot study tested whether adding cognitive behavioral therapy and mindfulness meditation to ketamine infusions could make pain relief last longer for people with chronic nerve pain. Thirty adults with moderate-to-severe neuropathic pain were randomly assigned to receive ket…

This pilot study tested whether acupuncture could reduce tingling, numbness, and pain in the hands and feet caused by chemotherapy in breast cancer survivors. Fifty-seven women who had completed taxane-based chemotherapy were randomly assigned to receive acupuncture immediately o…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study looked at whether progressive relaxation exercises can help people with type 2 diabetes who have nerve pain, fatigue, and poor sleep. 88 adults took part. The goal was to see if these simple exercises could improve their symptoms and quality of life.

This study tested a minimally invasive procedure for carpal tunnel syndrome using ultrasound guidance. 40 patients who did not get better with standard treatments received the procedure. Researchers measured pain, hand function, quality of life, and how quickly patients could ret…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study looked at whether a diabetes education program plus cinnamon supplements could help adults with type 2 diabetes who have painful nerve damage in their feet. Sixty-two participants were split into two groups and followed for six months. Researchers measured changes in b…

This study tested a device that delivers pain medicine directly to the spinal cord for cancer patients with severe pain not controlled by oral opioids. Researchers compared the pump to standard medical management in 30 adults. The goal was to see if the pump reduces pain intensit…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This study looked at whether doing hip abductor strengthening exercises could help people with piriformis syndrome feel less pain and move better. 48 adults with the condition took part. The exercises focused on strengthening muscles that move the leg away from the body. The goal…

This study tested whether electrostimulation and compression can reduce nerve pain and improve quality of life in people with gastrointestinal cancer who developed peripheral neuropathy from oxaliplatin chemotherapy. 140 patients were split into four groups: control, electrostimu…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This early-stage study tested whether an experimental pill called PIPE-791 is safe and can lower pain in adults with long-term osteoarthritis knee pain or chronic low back pain. 43 participants stopped their usual pain meds, then took either the study drug or a placebo daily for …

This study tested several experimental treatments for painful diabetic peripheral neuropathy, a common complication of diabetes that causes burning or shooting pain in the feet and hands. 127 adults with this condition rated their daily pain on a 0-10 scale to see if the treatmen…

This study tested whether a daily capsule called NRD135S.E1 can safely reduce nerve pain caused by diabetes. 127 adults with painful diabetic neuropathy took either the drug or a placebo for 13 weeks. Researchers measured pain changes using a 0-10 scale and tracked any side effec…

This study tested two ways to give steroid injections for mild-to-moderate carpal tunnel syndrome: one guided by ultrasound into the wrist, and one into the buttock muscle. 63 adults with symptoms like numbness and pain were followed to see which method improved pain, hand functi…

This study tested a minimally invasive procedure called pulsed radiofrequency on a nerve bundle in the face (the sphenopalatine ganglion) to see if it could reduce pain in 55 people with chronic headaches or facial pain who hadn't gotten relief from medication. The procedure uses…

This small pilot study tested whether a temporary spinal cord stimulator (like a pacemaker for the spine) could help people with spinal muscular atrophy types 3 and 4 move their legs better. Three adults who could stand independently received the implant for up to 29 days. The go…

This study tested two different doses of lidocaine given through an IV to women who had nerve pain after mastectomy for breast cancer. Thirty women took part, and researchers measured how the pain felt (like burning or stinging) using a special scale. The goal was to see if lidoc…

This study tested whether a non-invasive magnetic brain stimulation technique called rTMS can reduce chronic low back pain. Thirty adults with long-lasting pain received multiple sessions of rTMS over the brain's motor cortex. Researchers measured pain changes using a standard pa…

This study looked at 48 adults with peroneal neuropathy, a condition that causes foot drop and muscle weakness. Researchers compared two treatments: strength training plus taping alone, versus the same plus a special stretching technique called PNF. The goal was to see if adding …

This study tested whether a set of foot and ankle exercises could reduce pain and improve quality of life in 100 people with painful diabetic neuropathy. Participants performed exercises like ankle circles, toe spreads, and rolling a warm bottle under the foot. Researchers measur…

This study compared two physical therapy techniques—neurodynamic mobilization and Mulligan SNAGs—for people with chronic sciatica caused by a disc problem. 66 participants completed the trial at Cairo University. Researchers measured pain intensity, pressure pain threshold, and l…

This study tested whether Pilates or Gyrotonic exercises can ease nerve pain and reduce fall risk in 100 cancer survivors who have nerve damage from chemotherapy. Participants did one of the two exercise programs. The goal was to see if these exercises improve symptoms like numbn…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This completed study tested whether an injection of 5% dextrose (a sugar solution) works as well as a steroid (betamethasone) to relieve pain and symptoms in people with mild-to-moderate carpal tunnel syndrome. Thirty participants received one of the two ultrasound-guided injecti…

This study tested whether acupuncture can help prevent or reduce nerve pain, numbness, and tingling caused by chemotherapy in people with early-stage breast cancer. 89 participants were split into two groups: one received acupuncture, the other watched nature videos and did relax…

This small pilot study looked at whether osteopathic manipulative therapy (OMT) can reduce stiffness in the median nerve and improve symptoms in people with mild to moderate carpal tunnel syndrome. Ten participants received OMT along with standard care. Researchers measured nerve…

This study tested whether a web-based exercise program could reduce nerve pain and improve quality of life in breast cancer patients receiving chemotherapy. 90 patients with stage II-III breast cancer and neuropathy symptoms took part. The program was guided by a physiotherapist …

This study looked at whether adding mud therapy (peloidotherapy) to standard care (wrist splint and exercises) can further reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. 70 adults took part, with half receiving mud therapy plus stand…

This study tested whether adding pulsed electromagnetic field (PEMF) therapy to standard physical therapy could reduce nerve pain and disability in people with a slipped disc in the lower back. Forty-six patients completed the trial, receiving either real or fake PEMF alongside u…

This study tested whether low-level laser therapy (using Nd:YAG or diode lasers) can help repair nerve damage in the lower jaw after dental procedures like wisdom tooth removal or implant placement. Thirty adults with numbness or tingling in their lower lip and chin received lase…

This study tested an experimental drug called LX9211 in 79 adults with postherpetic neuralgia, a type of nerve pain that can last for months after a shingles rash heals. The goal was to see if the drug reduces pain and helps with sleep compared to a placebo over 11 weeks. Partici…

This study tested a device called SinuSonic that combines sound vibrations with gentle pressure to help people with Eustachian tube dysfunction (ETD) and facial pain. Thirty adults used the device twice a day for six weeks. Researchers measured changes in symptoms like ear pressu…

This study looked at whether adding a muscle relaxation technique (integrated neuromuscular inhibition) to a standard set of strengthening exercises (McGill program) helps people with piriformis syndrome more than the exercises alone. Fifty-six adults with chronic buttock pain fr…

This study tested two types of laser therapy (red and infrared) to help repair damaged nerves in the face. Thirty adults with nerve injuries that had not improved for at least six months received treatment. The goal was to reduce pain and improve sensation, offering a possible al…

This study looked at whether adding low-level laser therapy or nerve mobilization (gentle stretching of the median nerve) after carpal tunnel release surgery improves nerve function more than surgery alone. Forty-five adults who had carpal tunnel surgery were split into three gro…

This study tested whether a smartphone app helps people with dizziness do their prescribed balance exercises more consistently. Thirty adults with various vestibular disorders were randomly assigned to use the app or keep a paper diary. The researchers measured how often particip…

This study tested a drug that blocks a pain-signaling protein (CGRP) in 26 adults with trigeminal or glossopharyngeal nerve pain caused by small fiber neuropathy or fibromyalgia. The goal was to see if it reduces pain and the need for other pain medications, while checking for si…

This study tested a single injection of 5% dextrose (sugar water) guided by ultrasound to separate the median nerve from surrounding tissues in 37 people with mild-to-moderate carpal tunnel syndrome. Participants were followed for 3 months to see if pain and hand function improve…

This study tested whether wearing prism goggles during pointing exercises can reduce pain in people with Complex Regional Pain Syndrome (CRPS) type I. Fifty-four patients with CRPS after a wrist fracture or surgery were split into two groups: one used real prism goggles, the othe…

This study looked at whether a moderate-intensity breathing exercise program is safe and doable for people with ALS. Nine adults with ALS did four 3-week cycles of respiratory muscle training at home, with weekly check-ins via video call. The main goal was to see if participants …

This study tested whether low-level laser therapy, combined with a self-care program, could help people with jaw joint pain (TMJ disorders). 66 adults with recent jaw muscle pain received the treatment. Researchers measured pain levels, jaw movement, and tender spots to see if th…

This study tested a new automatic setting (Auto-EPAP) on a ventilator to see if it could better manage airway blockages during sleep compared to the standard manual setting. It involved 23 adults with conditions like sleep apnea, COPD, or obesity-related breathing problems who al…

This study looked at 113 adults with carpal tunnel syndrome to see if there is a difference in pain and hand function shortly after surgery. One group had endoscopic surgery (small incisions) and the other had open surgery (larger incision). Researchers measured pain and function…

This study tested whether adding shockwave therapy to simple hand exercises helps people with carpal tunnel syndrome feel less pain and use their hands better. Twenty-six adults with mild to moderate symptoms received either shockwave plus exercises or physical therapy plus exerc…

This study tested whether adding sensory integration exercises (like brushing and textured balls on the feet) to standard exercises could improve body awareness and balance in people with diabetic nerve damage. Thirty participants with moderate nerve damage were split into two gr…

This study tested a topical cannabidiol (CBD) cream against a placebo cream to see if it could reduce nerve pain, numbness, and tingling in the hands and feet caused by chemotherapy. Forty adults with moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) applied th…

This small study tested whether combining mirror therapy (watching the healthy hand move in a mirror) with electrical stimulation could help people with recent nerve injuries in the forearm regain hand movement and feeling. Seven participants did hand exercises with or without th…

This study looked at whether virtual reality exercises and whole-body vibration can improve muscle strength and balance in children with Duchenne muscular dystrophy (DMD). Fifty children aged 6 to 10 years who could still walk took part. The goal was to see if these fun, non-drug…

This study tested two different modes of transcutaneous electrical nerve stimulation (TENS) to relieve chronic pelvic pain in 60 men who had prostate surgery. Participants received TENS sessions three times a week for three months. The goal was to see which mode works better for …

This study tested whether adding nerve mobilization exercises to standard ultrasound therapy helps people with mild-to-moderate carpal tunnel syndrome. 86 adults aged 20-55 took part. Researchers measured pain, hand strength, and nerve size before and after three weeks of treatme…

This study tested whether nursing interventions based on the Levine Conservation Model could help colorectal cancer patients cope with fatigue, nerve damage, and anxiety caused by chemotherapy. 68 patients receiving the FOLFOX regimen were taught to use sensory balls, progressive…

This study tested whether adding a painless magnetic stimulation treatment to standard manual therapy (like massage and stretching) helps people with sciatica caused by a herniated disc. Forty adults were split into two groups: one got manual therapy alone, the other got manual t…

This study tested a combined laser and ultrasound treatment for people with type 2 diabetes who have early nerve damage in their feet. Sixty participants received either the real treatment or a placebo over 24 sessions. The results showed that the treatment helped reduce pain, bu…

This completed study tested whether botulinum toxin type-A injections relieve pain from myofascial pain syndrome better than a standard local anesthetic (prilocaine). Thirty-eight adults with long-term muscle pain were randomly assigned to receive either botulinum toxin or priloc…

This study tested a new way to treat carpal tunnel syndrome using ultrasound guidance to perform the release procedure right in the doctor's office. 149 adults with carpal tunnel syndrome who had not improved with other treatments took part. The goal was to see if this office-bas…

This study tested an online insomnia treatment program for adult survivors of childhood cancer. Over 1,500 survivors participated, using a web-based program that teaches healthy sleep habits and cognitive behavioral techniques. The goal was to see if improving sleep could also bo…

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sha…

This study tested whether adding thymoquinone, a compound from black seed oil, to the standard pain drug pregabalin could better relieve nerve pain in people with diabetes. Fifty adults with diabetic peripheral neuropathy took both treatments daily for two months. Researchers mea…

This study looked at whether supervised exercise training is better than unsupervised exercise for improving balance and quality of life in people with diabetic nerve damage in their feet and legs. 32 adults aged 55-70 with type 2 diabetes for at least 10 years took part. The goa…

This study tested a steroid injection into a trapped nerve in the lower back to see if it reduces pain and improves daily activities. 41 adults with low back pain from superior cluneal nerve entrapment received the injection. The goal was to measure pain levels and disability bef…

This study tested whether doing nerve-gliding exercises on both hands (bilateral) is better than only the affected hand (unilateral) for people with carpal tunnel syndrome. 28 adults completed the trial. The goal was to see which approach reduces symptoms like pain and numbness m…

This study tested a dietary supplement containing ingredients like palmitoylethanolamide, alpha lipoic acid, and several B vitamins to see if it could reduce nerve pain in cancer patients receiving chemotherapy. 71 newly diagnosed patients who had not yet started treatment took e…

This study tested whether a combination of nucleotides and B vitamins (Nucleo CMP and Neurorubine) could provide better and longer-lasting pain relief than the standard drug carbamazepine for people with trigeminal neuralgia, a severe facial pain condition. 38 adults with classic…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help adults with persistent post-concussion symptoms like headaches, fatigue, and memory problems. Twenty participants with mild traumatic brain injury received either real tr…

This study tested whether the drug fisetin, found naturally in fruits, can safely reduce symptoms of mild to moderate carpal tunnel syndrome. Forty adults took fisetin capsules for two days, then again a month later. Researchers measured changes in symptom severity and hand funct…

This study looked at whether adding extra sensory feedback to physical therapy could improve balance and reduce fall risk in women with nerve damage from cancer treatment. Forty women who had recovered from breast cancer took part. The group that received the extra sensory feedba…

This study looked at whether specific hand and wrist exercises could help people with mild to moderate carpal tunnel syndrome. 91 participants did either nerve gliding exercises or strengthening exercises daily for three weeks. The results suggest these exercises may reduce stiff…

This study tested an experimental drug called MT-8554 in 61 adults with painful diabetic peripheral neuropathy, a common complication of diabetes causing nerve pain. The goal was to see if the drug could safely reduce pain compared to a placebo. Participants took the drug or plac…

This study tested a drug called MT-8554 (Elismetrep) in 156 adults with painful diabetic peripheral neuropathy. The goal was to see if it reduces pain better than a placebo over 12 weeks. Participants took either the drug or a placebo capsule, and pain was measured using a 0-10 s…

This study looked at whether exercise or nutrition education can reduce nerve pain caused by chemotherapy in women with breast cancer. 80 women took part in a phase 2 trial comparing the two approaches. The goal was to see if these lifestyle changes could help manage symptoms and…

This study tested a non-invasive brain stimulation method called tDCS to see if it can reduce chronic nerve pain. Researchers compared real stimulation to a placebo in 24 healthy volunteers and patients with long-term nerve pain. The goal was to measure changes in pain levels and…

This study looked at whether adding a special self-stretching technique to standard physical therapy can better reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. 36 adults with stage I or II carpal tunnel took part. One group did the se…

This study tested surgery to treat Complex Regional Pain Syndrome (CRPS) in the upper limb. 74 adults with CRPS who had not improved with other treatments received either nerve decompression or correction of a specific structural problem. Pain levels were measured before surgery,…

This study looked at whether a targeted ultrasound-guided nerve block (SPSIPB) can reduce pain in people with postherpetic neuralgia, a chronic pain condition that can linger after shingles. Researchers reviewed records of 34 adults who received this injection and measured pain l…

This study tested whether a physiotherapy technique called median nerve neural mobilization reduces pain in people with carpal tunnel syndrome better than ibuprofen or no treatment. 117 adults with confirmed carpal tunnel syndrome took part. Researchers measured pain using a stan…

This study tested if people with painful diabetic neuropathy can safely use a new electrical stimulation device at home. 40 adults who had not gotten enough relief from standard pain medicines used the device for 10 days. The goal was to see if the device is easy to use and has s…

This study looked at whether adding a specific hand and arm therapy technique (called median nerve neural mobilization) to the pain medication gabapentin could reduce pain more than gabapentin alone in people with carpal tunnel syndrome. 72 adults with confirmed carpal tunnel syn…

This study tested two common treatments for carpal tunnel syndrome: over-the-counter ibuprofen pills and a nerve exercise called neural mobilization. 123 adults with carpal tunnel took part. The goal was to see if these treatments reduce pain and improve hand and arm function bet…

This study tested two local anesthesia methods for hand, wrist, or elbow surgery. One used lidocaine alone, the other added ropivacaine for longer pain relief. 91 adults participated. Researchers measured pain and recovery quality 48 hours after surgery to see if the combination …

This study tested whether gabapentin pills or a simple physiotherapy hand stretch (nerve mobilization) can reduce pain and improve hand function in people with carpal tunnel syndrome. 126 adults with confirmed carpal tunnel took part. The goal was to see if either treatment works…

This study tested whether physiotherapy, ibuprofen arginine, or gabapentin reduces pain and improves hand function in people with carpal tunnel syndrome. 196 participants were assigned to one of these treatments or no treatment at all. The goal was to see which approach offers th…

This completed study tested whether combining a hand therapy technique (nerve mobilization) with two pain medications (gabapentin and ibuprofen arginine) reduces pain better than ibuprofen alone in people with carpal tunnel syndrome. 129 adults with confirmed carpal tunnel took p…

This study tested whether a specific physical therapy technique called median nerve neural mobilization can reduce pain in people with carpal tunnel syndrome. 74 participants were randomly assigned to receive the therapy or no treatment. The main goal was to measure pain reductio…

This study looked at 76 people with carpal tunnel syndrome to see if adding a simple hand therapy technique (nerve mobilization) to an ibuprofen pain reliever reduces pain more than the pain reliever alone. Participants were treated and their pain levels were measured using a sta…

This pilot study tested whether a structured foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life, compared to walking or standard care. Over 12 weeks, 108 participants either did foot-ankle exercises, walked regularly,…

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This study follows about 74 adults with ALS who have already decided to take the drug Edaravone (Radicava). Researchers collect blood and urine samples over 24 weeks to measure various biomarkers—molecules that might show how the drug affects oxidative stress, inflammation, and n…

This study is testing whether a smartphone app can reliably track speech and swallowing problems in people with ALS. Participants will record their voice and swallowing sounds at home each week using the app. The goal is to see if this remote monitoring is feasible and accurate c…

This study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…

This study explores whether digital tools on a tablet can measure changes in speech and handwriting in people with motor neuron diseases like ALS. Participants complete a single session of speaking and tracing tasks. Researchers compare results between patients and healthy contro…

This study tests whether digital tools like smartphone apps, wearable sensors, and home spirometers can reliably track symptoms of neuromuscular diseases. Researchers will compare data collected at home with in-clinic measurements from 40 participants aged 12–60. The goal is to d…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This completed study examined muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury that affects arm nerves. Researchers took small muscle samples during planned shoulder surgery to see if the cells can repair themselves. The goal was to understand w…

This study looks at whether a French version of the SMAFRS questionnaire gives reliable results when used twice in adults with spinal muscular atrophy (SMA). About 60 participants will fill out the questionnaire during a routine visit and again 15 days later. No treatment is give…

This completed study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 patients about their pain, its location, intensity, and whether it was chronic. The goal was to highlight an often-overlooked issue and encourage better pain care f…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study from the University of Oxford aims to understand how specific physiotherapy exercises (neurodynamic exercises) work for carpal tunnel syndrome. Researchers will compare these exercises to standard steroid injections and simple advice in 78 patients with mild to moderat…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This study tested whether a brain-computer interface (BCI) device is ready for commercial use to help people with minimal movement communicate. Researchers worked with 8 device users, plus speech therapists and support staff, to evaluate how well the device worked at home. The go…

This study looked at 144 adults who had carpal tunnel surgery to see if the thickness of a wrist ligament (the flexor retinaculum) is linked to developing heel pain afterward. Researchers measured the ligament during surgery and compared patients who got heel pain with those who …

This completed study in Russia checked how many people with carpal tunnel syndrome also have a rare inherited nerve condition called hereditary transthyretin amyloidosis. Researchers reviewed medical records of 721 patients and will test some for the genetic mutation. The goal is…

This study looks at how ALS (Lou Gehrig's disease) affects social thinking, like recognizing emotions in faces and voices. Researchers will compare 74 ALS patients to healthy volunteers using video-based tests. The goal is to better understand these challenges, which can impact d…

This study looked at whether vitamin D levels in the blood are linked to how fast ALS (Lou Gehrig's disease) gets worse. Researchers measured vitamin D in 127 people with ALS and tracked their motor decline, breathing, and weight loss. No treatment was given—the goal was simply t…

This completed study looked at how nerve damage from the chemotherapy drug oxaliplatin affects hand function, grip strength, and quality of life in 103 colorectal cancer patients. Researchers measured hand and finger strength, dexterity, and daily living abilities using standard …

This study tested a new way to monitor vision during brain surgery near the optic nerve. Researchers used special goggles and anesthesia to track brain signals (visual evoked potentials) in 40 patients. The goal was to see if this method could help surgeons avoid damaging eyesigh…

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This small study tested whether adding exercise (stationary biking) to standard sensory training could improve sensation and reduce pain after nerve injuries in the arm or hand. Seven adults who had a nerve injury between 2010 and 2025 took part. The goal was to see if this appro…

This early-stage study looked at how a single dose of oral edaravone moves through the bodies of 9 Japanese adults with ALS. The main goal was to measure drug levels in the blood and urine, not to test if it helps symptoms. Researchers also tracked any side effects. The study is …

This early-stage study looked at how the body handles a single dose of oral edaravone in 6 Japanese ALS patients who have a feeding tube (gastrostomy). The goal was to measure drug levels in the blood and urine, not to test if it works. No treatment benefit was evaluated.

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study tested whether a new device called KForce Sens can reliably measure how well people with mild to moderate carpal tunnel syndrome sense their wrist position. Researchers compared it to a standard tool (Baseline electrogoniometer) in 70 adults. The goal was to see if the…

This study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…

This study looked at how the way words sound (phonotactic probability) and how they are spelled (orthography) affect vocabulary learning in 23 children with low oral language skills (DLD). All children took part in the same 12-week program, which used real words to improve vocabu…

This study tested whether doctors can accurately assess physical function and quality of life in children with Duchenne muscular dystrophy (DMD) through video calls. Twenty ambulatory patients aged 5-18 completed timed tests and questionnaires remotely. The goal was to see if tel…

This study examined 47 female football players to see if those with Morton toe (a longer second toe) have different muscle and jumping abilities compared to those with normal feet. Researchers measured muscle contraction speed and reactive strength during jumps. The goal was to u…

This completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study looked at whether advanced MRI scans and a nerve test called MUNIX can detect the earliest signs of nerve damage in people who carry a gene mutation for familial amyloid neuropathy. Researchers studied 60 adults with the TTR mutation, comparing those with and without s…

This study involved 156 people with Charcot-Marie-Tooth disease type 1A (CMT1A), a rare nerve condition that slowly gets worse. Researchers took blood and skin samples over two years to find biological markers that could show how the disease progresses. The goal was to develop mo…

This completed study of 500 people with ALS (Lou Gehrig's disease) aimed to find biological signs, or biomarkers, that can predict how the disease will progress. Researchers collected clinical, imaging, and lab data to better understand different forms of ALS. The goal is to help…

This study looked at how 8 children aged 4 to 17 with moderate foot drop walk when using different supports: barefoot, a Lycra sock, a rigid ankle-foot orthosis (AFO), and a new OrthoPed splint. The goal was to see if the OrthoPed splint allows more natural ankle movement while s…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This completed study tested three different intensities of gentle neck movements designed to stimulate the vagus nerve in 128 healthy adults. Researchers measured changes in heart rate, balance, pain sensitivity, and digestion (via stool samples). The goal was to find the best 'd…

This completed study looked at how muscle oxygen levels change during exercise in people with various neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee-extension exercise while a device measured muscle oxygen. The goal was to understand diff…

This study looked at how the drug tuvusertib is absorbed, broken down, and removed from the body in 12 people with advanced solid tumors. Participants received a tiny radioactive tracer to track the drug. The main goal was to understand the drug's path in the body, not to treat t…

This study examined whether pseudoexfoliation syndrome (an eye condition) is related to carpal tunnel syndrome (a wrist nerve problem). Researchers measured blood markers in 159 adults aged 50-80. The goal was to see if these conditions share a common cause, not to test a treatme…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This study used ultrasound to measure the thickness of certain hip muscles in 60 adults with hip pain on one side (Greater Trochanteric Pain Syndrome) and compared them to healthy people. The goal was to see if muscle thickness differs between the groups and to check for related …

This study looked at how neck pain changes the way people walk and control their movements. Researchers tested 60 adults—some with chronic neck pain and some without—while they performed walking tasks. The goal was to understand how neck problems affect balance and coordination d…

This study looked at 110 people who needed surgery for a broken wrist. Some had an extra procedure to release the carpal tunnel at the same time, while others waited to see if carpal tunnel symptoms developed later. The goal was to see which approach led to fewer repeat surgeries…

This study used a special ultrasound technique to measure stiffness in pelvic floor muscles of 94 women — some healthy and some with pudendal neuralgia, a chronic nerve pain condition. Researchers compared the muscle stiffness between the two groups to see if differences exist. T…

This study looked at 52 adults with dizziness and balance problems from a one-sided inner ear disorder. Researchers measured how well people functioned before and after a standard balance therapy program. The goal was to see if things like dizziness severity or personal factors c…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This completed observational study looked at 84 people to understand how diabetic polyneuropathy (nerve damage from diabetes) changes the median nerve in patients with carpal tunnel syndrome. Researchers used advanced ultrasound techniques, including shear wave elastography and m…

This study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…

This completed study looked at how different levels of carpal tunnel syndrome affect people's ability to do daily activities and participate in life. Researchers measured quality of life, hand function, and symptoms in 156 adults with carpal tunnel in their dominant hand. The goa…

This study tested whether ultrasound can measure how tendons and nerves move inside the wrist in people with and without carpal tunnel syndrome. Researchers used sound waves to create images of the wrist in 257 participants. The goal was to better understand the condition, not to…

This study looked at whether certain blood markers of inflammation and vitamin B12 levels are linked to carpal tunnel syndrome. Researchers compared 70 people with and without the condition. The goal was to see if these markers could help explain why some cases are more severe.

This study tested whether ChatGPT-4o could correctly diagnose polyneuropathies (nerve diseases) in 100 real patients. Researchers compared the AI's answers to those of nerve specialists and general neurologists. The goal was to see if AI can help non-specialist doctors make bette…

This pilot study examined whether inflammation, measured by cytokines in the blood, plays a role in type 1 facioscapulohumeral muscular dystrophy (FSHD1). Researchers compared 20 FSHD1 patients with healthy controls to see if certain inflammatory markers are higher in the disease…

This study analyzed medical records of 213 children with spinal muscular atrophy (SMA) in the Czech and Slovak Republics. Researchers looked at what treatments were used and how the children's motor skills, breathing, and feeding changed over time. The goal was to understand real…

This early study tested whether a special ultrasound technique could safely open the blood-brain barrier in the motor area of the brain in 4 people with ALS. The goal was to see if the procedure was safe and possible, not to treat the disease. Researchers measured side effects an…

This study tested an online tool designed to help doctors decide which patients with chronic pain are good candidates for spinal cord stimulation. About 80 adults with conditions like failed back surgery syndrome or complex regional pain syndrome took part. The tool's recommendat…

This study looked at 77 adults with long-term nerve pain after shingles (postherpetic neuralgia) to see if a spinal nerve stimulation device works better for certain types of pain. Researchers grouped patients by their pain features and measured pain levels, quality of life, and …

This study looked at 537 people with myotonic dystrophy type 1 to understand their risk of serious heart rhythm problems, including sudden cardiac arrest. Researchers tracked participants for two years to see how often these events happened and what factors might predict them. Th…

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study involved 50 people with gastrointestinal cancer who had nerve pain from the chemotherapy drug oxaliplatin. Researchers interviewed patients to understand their symptoms and how the pain affected their daily life. The goal was to use this information to design a medical…

This completed study enrolled 150 people with Duchenne muscular dystrophy to create a video database of their movement abilities. Caregivers recorded children doing specific tasks at home using a secure app. The goal was to help validate a new tool called the Duchenne Video Asses…

This study looked at 98 adults with severe-to-profound hearing loss to see if they also have balance problems. Since the inner ear controls both hearing and balance, researchers used special tests to measure how well the balance system works. The goal was to understand if hearing…

This study looked at 30 adults in rehabilitation who needed a walking aid for the first time. Researchers checked their hand and wrist health before and after using the aid, using questionnaires and nerve tests. The goal was to see if using canes or walkers might lead to carpal t…

This study looked at 40 adults who had to wear a splint or cast on their dominant hand for 6 weeks after an injury. The goal was to see if being forced to use the non-dominant hand actually improves its function. Researchers measured hand skills and disability levels to understan…

This study used ultrasound to measure the thickness of the piriformis muscle and sciatic nerve in 19 people with piriformis syndrome, comparing the painful side to the pain-free side. The goal was to see if ultrasound can help tell whether the pain comes more from muscle or nerve…

This study followed 10 people with late onset Tay-Sachs disease to see how their symptoms and body chemistry changed over six months. Researchers measured balance, coordination, and brain chemicals. The goal was to gather information that will help design better clinical trials f…

This completed study looked at 125 patients of different ages to find out how much ciprofol (an anesthetic drug) they needed to lose consciousness. Researchers measured the dose and brain activity (bispectral index) during anesthesia induction. The goal is to help doctors tailor …

This study tested a new method to evaluate the strength and function of face and mouth muscles in people with facioscapulohumeral muscular dystrophy (FSHD). Twenty-two adults with a genetic diagnosis of FSHD took part. The goal was to see if this new assessment tool can reliably …

This study involved 116 people with Limb Girdle Muscular Dystrophy (LGMD), a group of rare muscle-weakening disorders. Researchers measured how well participants could walk, move their arms, and breathe, and asked about their daily activities and overall health. The goal was to i…

This study measured calf muscle thickness and length in 26 children with Duchenne muscular dystrophy (ages 6-12) who could still walk. Researchers used ultrasound and motion analysis to see how muscle structure relates to walking and other movements. The goal was to better unders…

This study looked at 67 adults with spinal muscular atrophy (SMA) types 2 and 3 to see if special electrical tests (MUNE and CMAP) can track nerve loss over time. The goal was to find better ways to measure how the disease changes, not to test a treatment. Participants had geneti…

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study followed 316 people with Duchenne muscular dystrophy who were taking Translarna (ataluren) as part of their normal medical care. The goal was to monitor side effects and see how well the drug works in everyday use. Researchers also checked if doctors and patients follo…

This study looked at 18 adults with spinal muscular atrophy (SMA) who had taken the oral medication risdiplam for at least one year. Researchers measured how well nerves and muscles communicate by using electrical stimulation tests. The goal was to see if risdiplam improves these…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study looked at 20 adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN) who were starting intravenous immunoglobulin (IVIg) treatment. Researchers measured changes in IgG levels in the blood after the first dose to…

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study investigates how obesity affects the way the body processes intravenous immune globulin (IVIG), a treatment for immune deficiencies. Researchers measured body composition and blood levels of IVIG in 40 obese and normal-weight patients to find the best dosing strategy. …

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study tested whether a mobile app (myFSHD) can help doctors monitor patients with facioscapulohumeral muscular dystrophy (FSHD) remotely. 70 adults with FSHD used the app at home for 12 months, completing questionnaires and video-recorded exercises. The goal was to see if pa…

This study looked at 150 patients who had surgery for trigeminal neuralgia, a condition causing severe facial pain. Surgeons used a Teflon implant to cushion a blood vessel pressing on a nerve. The study compared two ways of placing the Teflon—either directly against the nerve or…

This study followed 52 people with limb-girdle muscular dystrophy 2I (LGMD2I) for up to two years to learn more about how the disease changes over time. Researchers measured walking ability, muscle strength, heart function, and daily activities. The goal was to better understand …

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This early-stage trial tested a single dose of the study drug GRT6019 in 18 healthy men to check its safety and how the body processes it. The study also looked at whether food changes drug absorption. Results will guide future research for Duchenne muscular dystrophy, but this t…

This study analyzed health records of nearly 5,000 people with spinal muscular atrophy (SMA) to see how well three approved treatments work in everyday medical practice. Researchers looked at complications, medical equipment use, and hospital visits before and after starting each…

This completed study used ultrasound to examine the structure of nerves in the neck (the brachial plexus) in 200 adults scheduled for elective surgery. Researchers recorded how many nerve bundles were visible at different nerve roots. The goal was to better understand normal anat…

This study looked at 39 people having lower back surgery for a herniated disc or spinal stenosis. Researchers checked for nerve pain before surgery and again 1, 3, 6, and 12 months after using a simple questionnaire. The goal was to see how common nerve pain is after surgery and …

This study analyzed insurance claims from over 4,000 people with spinal muscular atrophy to see how three approved treatments (Zolgensma, Spinraza, and Evrysdi) are actually used in daily practice and what they cost over time. Researchers looked at dosing patterns, yearly drug co…

This study tested whether advanced MRI scans can find new biomarkers for amyotrophic lateral sclerosis (ALS), a fast-progressing nerve disease. Researchers used high-field and very-high-field MRI to look at the brain, spinal cord, and muscles of 22 ALS patients over six months. T…

This study tested whether brief smartphone surveys can help detect early signs of fall risk in people receiving chemotherapy that can cause nerve damage. Twelve cancer patients used a mobile app to report symptoms like numbness or tingling in their legs. The goal was to see if pa…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study reviewed medical records of 60 adults who had radiofrequency treatment for intercostal neuralgia, a type of nerve pain in the chest wall. The goal was to find out which patient or clinical factors are linked to better pain relief after the procedure. Researchers measur…

This study followed 30 adults with myotonic dystrophy type 1 (Steinert disease) and 30 healthy volunteers over three years to see how muscle strength and function change naturally over time. Researchers measured things like muscle power, walking ability, and nerve responses to fi…

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study checked whether hot air balloon pilots, who are exposed to burner noise and air pressure changes, have more hearing, eustachian tube, or balance problems than other adults. About 105 pilots and non-pilots took part in safe, non-invasive hearing and balance tests. The g…

This completed Phase 4 trial looked at how two common anesthetics—desflurane and propofol—affect the optic nerve sheath diameter (a measure of pressure around the eye) in 146 adults undergoing laparoscopic gallbladder removal. The goal was simply to observe differences between th…

This study looked at how nerves in the spine work in people recently diagnosed with ALS compared to healthy volunteers. The goal was to find specific electrical signals that could help doctors understand the disease better and track its progress. 101 participants took part in tes…

This study tested whether ultrasound can detect early facial muscle changes in people with facioscapulohumeral muscular dystrophy (FSHD), a rare muscle disease. Researchers compared 20 FSHD patients with 19 healthy adults, measuring muscle thickness and echo intensity in key faci…

This study looked at how different shoe fit guidelines affect pressure inside the shoe for people with diabetes and nerve damage. Researchers measured foot pressure while 26 participants walked in standardized shoes with different toe gap sizes. The goal was to see which fit guid…

This study looked at whether giving expectant fathers online training about basic newborn care helps them feel more capable and makes their pregnant partners feel more supported. Researchers enrolled 70 couples where the father was over 18, the pregnancy was in the third trimeste…

This completed study looked at how metabolism differs in people with ALS. Researchers took blood and skin samples from 9 patients to analyze molecules and genes. The goal was to better understand the disease, not to test a treatment.

This study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…

This study looked at 120 women with early-stage breast cancer to see if having low muscle mass (sarcopenia) before treatment raises the risk of nerve damage from the chemotherapy drug paclitaxel. Researchers measured muscle mass on CT scans and checked for nerve symptoms using qu…

This study looked at how common nerve damage is in adults who had vincristine chemotherapy for childhood leukemia. 467 survivors were assessed using a questionnaire about nerve symptoms. The goal was to understand how often and how severe this side effect is long after treatment …

This study aimed to find biological markers (biomarkers) in muscle, blood, and cells to help diagnose amyotrophic lateral sclerosis (ALS) earlier and understand the disease better. Researchers analyzed samples from 37 adults with ALS using advanced techniques to look at molecules…

This completed study compared 72 adults with cervicogenic headache (headache from the neck) to healthy volunteers. Researchers used questionnaires to measure central sensitization (overactive pain signaling) and neuropathic pain (nerve pain). The goal was to see if these pain mec…

This study looked back at 80 children with spinal muscular atrophy (SMA) types II and III to see how using braces (orthoses) helped them sit, stand, and walk. Researchers recorded when and how often children achieved these milestones and what types of braces they used. The goal w…

This completed survey study asked 131 people with or at risk for Huntington disease about their feelings, attitudes, and beliefs toward clinical research. The goal is to help researchers design better studies that are more aware of participants' needs. No treatment or drug was te…

This completed study surveyed 250 adults with vestibular disorders (like vertigo) across Belgium, France, and the US. Participants filled out questionnaires about dizziness, anxiety, and thinking problems, while doctors provided routine test results. The goal is to link symptoms …

This study looked at whether showing health warning messages in a mobile app where people buy alcohol affects their purchasing. Over 11,700 adults in Sweden took part. One group saw rotating health warnings, while the other saw standard messages. The researchers tracked purchases…

This study tested how different lower-limb prostheses and orthoses affect movement during daily life. Twenty participants with lower-limb amputation or drop foot wore each device for a period while sensors tracked their walking. The goal was to compare devices and improve how we …

This completed Phase 1 trial tested the safety and how the body absorbs VRG50635 in 22 healthy adults aged 19 to 55. Participants received either the drug or a placebo. The study focused on side effects and drug levels in the blood, not on treating any disease.

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at two types of plasmapheresis (blood filtering) in 8 people with CIDP, a rare nerve disorder causing weakness. The goal was to see how each method affects immune cells in the blood. It is a very early, small study focused on understanding how these treatments w…

This study looked at how two types of nerve diseases—inherited and acquired—affect walking and balance. Researchers used motion analysis and simple tests like the Timed Up and Go test in 67 participants. The goal was to find clear differences that could help doctors tell the two …