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AI takes on nerve disease diagnosis: ChatGPT matches specialists?

NCT ID NCT07493681

Knowledge-focused Sponsor: Istituto Clinico Humanitas Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether ChatGPT-4o could correctly diagnose polyneuropathies (nerve diseases) in 100 real patients. Researchers compared the AI's answers to those of nerve specialists and general neurologists. The goal was to see if AI can help non-specialist doctors make better diagnoses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Jun 2023

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Cases will be identified from patients with a confirmed diagnosis of polyneuropathy consecutively attending the polyneuropathy outpatient clinics of the two participating institutions. Demographic, clinical, and diagnostic data will be extracted from medical records at two time points: the initial neurological consultation and the first follow-up visit after completion of standard screening investigations, including laboratory tests and nerve conduction studies.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Confirmed diagnosis of polyneuropathy of any etiology * Final etiological diagnosis confirmed after at least 12 months of clinical follow-up * Availability of sufficient clinical, electrophysiological, and laboratory information in the medical record to allow preparation of a standardized case summary Exclusion Criteria \- Absence of a confirmed etiological diagnosis (idiopathic neuropathy)

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Conditions

The condition(s) this trial relates to.

polyneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polyneuropathies

Contacts and locations

Locations

  • Humanitas Research Hospital

    Milan, MI, 20089, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.