Istituto Clinico Humanitas

This study tests whether giving focused radiation before surgery for large brain metastases works better than giving it after surgery. About 146 adults with solid tumors and one large brain metastasis will be randomly assigned to one of the two timing schedules. The main goal is …

This study is for people with bladder cancer that has spread to a small number of other body parts (up to 3 spots). It compares standard treatment (chemotherapy or immunotherapy) alone versus standard treatment plus a precise, high-dose radiation therapy called SBRT. The goal is …

This study looks at using a high-dose, targeted radiation therapy (SBRT) to treat kidney cancer in people who are too frail or at high risk for surgery. About 53 participants will receive this non-invasive treatment, which does not require anesthesia or a hospital stay. The goal …

This study tests whether a rapid lab test can help doctors choose the right antibiotic sooner for patients with bloodstream infections. About 400 adults with positive blood cultures will be randomly assigned to either the rapid test or standard testing. The goal is to see if the …

This study looks at how the right side of the heart copes after major lung surgery. Researchers will compare minimally invasive methods (VATS and robotic surgery) with traditional open surgery in 100 patients with heart or lung problems. The goal is to see which approach puts les…

Some head and neck cancer patients experience a tumor return in an area already treated with radiation. Surgery may not be an option, and standard radiation risks harming healthy tissue. This study tests proton therapy, which delivers radiation more precisely to the tumor while s…

This observational study looks at 30 adults with acute respiratory failure on mechanical ventilation. Researchers want to see if a bedside device called electrical impedance tomography (EIT) can reliably guide ventilator pressure settings, compared to the current gold standard (C…

This study investigates whether serious muscle weakness, known to affect ICU patients, also occurs in people hospitalized outside the ICU. Researchers will follow about 600 adults in Italian hospitals, half with organ failure and half without, to see how often weakness develops a…

This study looks at whether a precise type of radiation called SBRT can help people with breast cancer that has spread to only a few spots in the body (oligometastatic). Researchers will review medical records from 300 patients to see if SBRT improves how long the cancer stays un…

This study reviews medical records of 150 patients with inoperable lung cancer that returned after previous radiation. Researchers want to learn if giving another round of high-precision radiation (SBRT) is safe and effective. The goal is to help doctors make better treatment dec…

This study is gathering information from 500 cancer patients treated with proton therapy, a type of radiation that may cause fewer side effects than standard radiation. Researchers want to see how well it works in everyday practice and track any side effects. The goal is to build…