Traumatic neuropathy

This Phase 3 trial tests a product called NTX-001, a set of three solutions applied during surgery to help reconnect severed nerves in the arm. About 98 adults with severe nerve cuts will be randomly assigned to receive either standard nerve stitching plus NTX-001 or standard sti…

This trial tests a product called NTX-001, which is applied during surgery to repair completely severed nerves in the arm or face. The product combines three solutions and a device, and is given only once. The study includes people with fresh nerve injuries (within 48 hours) that…

This study tests a new device called the NeuroSpan Bridge for repairing damaged nerves in the arms or legs. It is compared to two standard treatments: a nerve guide and a nerve graft from another part of the body. The trial will enroll 80 people with nerve injuries and measure ho…

This study tests whether a processed nerve graft from a donor (Avance Nerve Graft) works as well as using a piece of the patient's own leg nerve to repair damaged nerves in the arm. About 178 adults with upper arm nerve injuries will be randomly assigned to receive either the don…

This study tests whether functional electrical stimulation (FES) can improve arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove device to stimulate muscles during short therapy sessions. The goal is to see if this appr…

This study tests a temporary electrical stimulation system that delivers a single, one-hour therapy to help heal acutely injured peripheral nerves. Researchers will enroll 110 people with recent nerve injuries to see if the treatment is safe and improves sensory recovery. The app…

This study tests whether a substance called polyethylene glycol (PEG) can help reconnect severed nerves in the arm more effectively than standard surgery. About 40 adults with a recent, complete nerve injury from trauma will receive either PEG plus standard repair or standard rep…

This study is testing whether a robotic surgical system called Symani can safely and effectively repair damaged nerves in the hand. One hundred adults with a finger nerve injury will be randomly assigned to receive either robotic-assisted or traditional manual surgery. The main g…

This study tests whether giving a 10-minute electrical stimulation to a repaired finger nerve during surgery can speed up healing and improve sensation. Sixty adults aged 18-80 with a cut digital nerve will receive either standard surgical repair alone or with added electrical st…

This phase 2 trial tests whether tesamorelin, a daily self-injected drug, can speed nerve regrowth and reduce muscle loss after surgical repair of injured nerves in the arm. 36 adults with a cut ulnar nerve at the wrist will be randomly assigned to receive tesamorelin or no addit…

This early-stage trial tests whether injecting a person's own Schwann cells (taken from a leg nerve) into a damaged major nerve is safe. The study enrolls 30 adults with severe sciatic, brachial plexus, or other major nerve injuries. The goal is to see if the cells can be used wi…

This study tests a device called Walkasins, worn on the lower legs, that vibrates to give sensory feedback about foot pressure. The goal is to see if using it daily for six months improves balance and walking in 200 adults aged 55+ with peripheral neuropathy. Participants will do…

This study is tracking 1,000 people who have received or will receive the Allay Hydrogel Cap, a gel device placed during nerve surgery to protect the nerve ending. Researchers are collecting real-world data on pain levels, medication use, and complications to see how safe and hel…

This study tests whether combining spinal cord stimulation with a rehabilitation program can reduce chronic nerve pain in the legs and improve physical function. Ten adults aged 18-60 with nerve pain lasting over 6 months will receive the treatment bundle. The goal is to see if t…

This early study tests a small device that sends gentle electrical pulses to nerves to relieve severe, long-lasting knee, elbow, or shoulder pain. About 30 adults with chronic pain will first try a temporary implant for up to 8 hours. If it works well, they can get a permanent ve…

This study tests whether wrapping a stitched finger nerve with MatriDerm, a collagen-elastin matrix normally used for skin healing, improves sensation recovery. Seventy people with traumatic finger nerve cuts will be randomly assigned to receive either standard nerve stitching al…

This study tests whether a non-invasive magnetic stimulation device (AtMS) can reduce nerve pain caused by injury or surgery in veterans and active-duty military. 180 participants will receive either active, fixed, or sham stimulation over 16 weeks. Researchers will measure pain,…

This study tests whether 4-aminopyridine (4-AP) can help men recover faster from nerve damage caused during prostate cancer surgery. About 70 men aged 45-75 with early-stage prostate cancer will take the drug or a placebo after their operation. The goal is to see if it improves b…

This study tests whether ankle braces made with 3D scanning and printing work as well as those made the old-fashioned way with plaster casts. About 50 people aged 8 and older with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury will try both types …

This study follows 100 adults who had surgery for traumatic nerve injuries in the hand or arm. Researchers will measure hand function, strength, and quality of life over time to better understand long-term recovery. The goal is to gather information, not to test a new treatment.

This study follows 100 adults who had a chest tube placed after breaking their ribs. The goal is to learn how many develop long-term nerve pain (intercostal neuralgia) and how it affects their quality of life. Researchers will track pain levels and daily function over time to bet…

This study looks at whether a common heart procedure (using the wrist artery) can damage nerves in the hand. Researchers will check 400 patients for signs of carpal tunnel syndrome or other nerve problems. The goal is to understand the risks better, not to test a new treatment.

This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for…

This study is collecting information from 4,000 adults with peripheral neuropathy (nerve damage) to better understand the condition. Researchers will combine standard tests with nerve ultrasound to see if it helps diagnose and track the disease. No new treatments are being tested…

This study looks at the best way to treat nerve injuries in the fingers. It compares surgery with wearing a cast. About 166 adults with a cut nerve in one finger will be randomly assigned to one of the two treatments. The main goal is to see how well feeling returns after one yea…

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …