New gel promises better nerve repair after severe arm injuries
NCT ID NCT06616025
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 5 times
Summary
This Phase 3 trial tests a product called NTX-001, a set of three solutions applied during surgery to help reconnect severed nerves in the arm. About 98 adults with severe nerve cuts will be randomly assigned to receive either standard nerve stitching plus NTX-001 or standard stitching alone. The main goal is to see if NTX-001 improves hand function and reduces pain 24 weeks after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NTX-001 (PEG-Fusion) - a set of three solutions applied to the nerve repair site during surgery
- What this could lead to
- If it works, this could lead to better recovery of hand function and less pain after severe nerve injuries in the arm.
- What could go wrong
- This is a Phase 3 trial, but it's still relatively small (98 people). The improvement over standard surgery may be modest, and results may not apply to all nerve types or injuries.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Allegheny Health Network
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Barnes-Jewish Hospital 1 Barnes Jewish Hospital Plaza St.
RECRUITINGSt Louis, Missouri, 63110, United States
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Baylor, Scott and White Health
RECRUITINGDallas, Texas, 75246, United States
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Cedars Sinai Medical Center
NOT_YET_RECRUITINGLos Angeles, California, 90048, United States
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Curtis National Center at MedStar Union Memorial Hospital
RECRUITINGBaltimore, Maryland, 21218, United States
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Grady Health
RECRUITINGAtlanta, Georgia, 30303, United States
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Harborview Medical Center
RECRUITINGSeattle, Washington, 98104, United States
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Louisiana State University Health Sciences Center
RECRUITINGNew Orleans, Louisiana, 70112, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29429, United States
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Missouri Orthopaedic Institute
RECRUITINGColumbia, Missouri, 65211, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10003, United States
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Orlando Health Orlando Regional Medical Center
RECRUITINGOrlando, Florida, 32806, United States
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Rothman Orthopedics - Advent Health
RECRUITINGOrlando, Florida, 32804, United States
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Texas Tech
RECRUITINGLubbock, Texas, 79415, United States
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The Cooper Health System
RECRUITINGCamden, New Jersey, 08103, United States
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The MetroHealth System
RECRUITINGCleveland, Ohio, 44109, United States
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The Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43212, United States
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UC Health
RECRUITINGCincinnati, Ohio, 45267, United States
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UVA Health
RECRUITINGCharlottesville, Virginia, 22903, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
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University of Cincinnati Health
RECRUITINGCincinnati, Ohio, 45267, United States
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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University of Pennsylvania, Department of Orthopaedic Surgery
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Utah Health
NOT_YET_RECRUITINGSalt Lake City, Utah, 84132, United States
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