Could your own cells heal a severed nerve?

NCT ID NCT05541250

Recruiting now Disease control Sponsor: W. Dalton Dietrich Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This early-stage trial tests whether injecting a person's own Schwann cells (taken from a leg nerve) into a damaged major nerve is safe. The study enrolls 30 adults with severe sciatic, brachial plexus, or other major nerve injuries. The goal is to see if the cells can be used without causing harm, with a future hope of improving motor and sensory recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Autologous human Schwann cells (one's own nerve-support cells)
What this could lead to: If it works, this could point toward a new way to improve recovery after severe nerve damage, potentially restoring more movement and feeling.
What could go wrong: This is a very early Phase 1 safety trial with only 30 people. It is not yet known if the cells actually help recovery, and there may be unknown side effects from the injection or nerve harvest.

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Conditions

The condition(s) this trial relates to.

Peripheral Nerve Injuries traumatic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL NERVE INJURY

Contacts and locations

Locations

University of Miami
RECRUITING

Miami, Florida, 33136, United States

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