New nerve graft could spare patients a second surgery

NCT ID NCT07657182

Recruiting now Disease control Sponsor: Axogen Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a processed nerve graft from a donor (Avance Nerve Graft) works as well as using a piece of the patient's own leg nerve to repair damaged nerves in the arm. About 178 adults with upper arm nerve injuries will be randomly assigned to receive either the donor graft or their own nerve. The main goal is to see how well motor and sensory function recovers over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Avance Nerve Graft (a processed human nerve scaffold)
What this could lead to: If successful, this could offer a safe and effective alternative to using a patient's own nerve for repair, avoiding the need for a second surgery and loss of function at the donor site.
What could go wrong: This is a relatively early-phase study with 178 participants, so results may not apply to all nerve injuries. The Avance graft may not perform as well as the patient's own nerve in restoring full function.

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Conditions

The condition(s) this trial relates to.

Peripheral Nerve Injuries traumatic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIXED PERIPHERAL NERVE INJURY MOTOR PERIPHERAL NERVE INJURY PERIPHERAL NERVE DISCONTINUITY PERIPHERAL NERVE INJURY UPPER EXTREMITY NERVE INJURY

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

OrthoIndy
RECRUITING

Indianapolis, Indiana, 46260, United States

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