New drug combo targets genetic weaknesses in head and neck cancer
NCT ID NCT04997902
First seen Jan 11, 2026 · Last updated May 06, 2026 · Updated 19 times
Summary
This study tested a combination of two drugs, tipifarnib and alpelisib, in 45 adults with advanced head and neck cancer that had spread or come back. The drugs target specific genetic changes in the tumor (HRAS overexpression or PIK3CA mutations/amplification). The main goals were to check safety and find the best dose, while also seeing if the combination could shrink tumors.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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Dana-Farber Cancer Institute (Head and Neck Cancer Treatment Center)
Boston, Massachusetts, 02215, United States
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Johns Hopkins University School of Medicine (Sidney Kimmel Comprehensive Cancer Center)
Baltimore, Maryland, 21231, United States
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Lake Nona DDU (Florida Cancer Specialists)
Orlando, Florida, 32827, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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UT Southwestern Medical Center (Harold C. Simmons Comprehensive Cancer Center)
Dallas, Texas, 75390, United States
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University of Maryland School of Medicine (Marlene and Stewart Greenebaum Comprehensive Cancer Center)
Baltimore, Maryland, 21201, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792, United States
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Washington University, School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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