Can a drug melt away painful scar tissue after back surgery?
NCT ID NCT00385086
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation and scar formation, can reduce sciatica pain in people who developed spinal scar tissue after back surgery. 38 adults with persistent pain after discectomy received either the drug or a placebo. The main goal was to see if pain levels improved.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TNF-alpha blocker
What this could lead to
If it works, this could provide a new treatment option for chronic sciatica caused by scar tissue after back surgery.
What could go wrong
This is a small, completed trial with only 38 participants, so results may not apply to everyone. TNF blockers also carry risks like increased infection.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hopital Cochin
Paris, Paris, 75014, France