Oxford scientists probe why nerve exercises ease carpal tunnel pain

NCT ID NCT05859412

Completed Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study from the University of Oxford aims to understand how specific physiotherapy exercises (neurodynamic exercises) work for carpal tunnel syndrome. Researchers will compare these exercises to standard steroid injections and simple advice in 78 patients with mild to moderate carpal tunnel syndrome, plus 30 healthy volunteers. Using advanced MRI scans, nerve tests, and blood samples, they hope to uncover the biological mechanisms behind the exercises' effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neurodynamic exercises (nerve and tendon gliding exercises) and steroid injection (Depomedrone 40mg)
What this could lead to: If successful, this could help doctors better target physiotherapy exercises to patients who will benefit most, potentially reducing the need for surgery.
What could go wrong: This is a small, early-stage mechanistic study focused on understanding how treatments work, not on proving they are effective. Results may not change clinical practice directly.

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARPAL TUNNEL SYNDROME DIFFUSION MRI MECHANISTIC TRIAL NERVE MOBILISATION NEURODYNAMIC TREATMENT PHYSIOTHERAPY

Contacts and locations

Locations

Nuffield Department of Clinical Neurosciences, University of Oxford

Oxford, Oxfordshire, OX3 9DU, United Kingdom

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