Could your own nerve cells help heal severe injuries?

NCT ID NCT03999424

Completed Disease control Sponsor: W. Dalton Dietrich Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tested whether adding a patient's own Schwann cells (nerve-supporting cells) to a nerve graft could safely improve recovery after severe peripheral nerve injury. Five adults with large nerve gaps received the cell-enhanced graft. The main goal was safety, checking for side effects and signs of nerve regrowth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: autologous human Schwann cells
What this could lead to: If it works, this could point toward a treatment that improves nerve regrowth and function after severe injuries.
What could go wrong: This is a very early Phase 1 safety trial with only 5 people. It is too small to prove effectiveness, and the approach may not work or could cause side effects like pain or nerve changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Peripheral Nerve Injuries traumatic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL NERVE INJURIES

Contacts and locations

Locations

University of Miami

Miami, Florida, 33136, United States

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