New shot could replace IV drips for nerve disease patients

NCT ID NCT06637072

Completed Disease control Sponsor: argenx Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether adults with CIDP, a nerve disorder causing weakness and numbness, could safely switch from regular intravenous immunoglobulin (IVIg) infusions to a new injectable drug called efgartigimod PH20 SC. Twenty-three participants who were stable on IVIg were given the new drug as a shot under the skin for 12 weeks. The main goal was to see how many could stay on the new treatment without needing to go back to IVIg.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: efgartigimod PH20 SC (a biologic drug given as a shot under the skin)
What this could lead to: If this works, it could offer people with CIDP a more convenient treatment option that requires fewer clinic visits than regular IV infusions.
What could go wrong: This is a small, early-phase study with only 23 participants and no comparison group. Results may not apply to everyone with CIDP, and side effects or lack of effectiveness could limit its use.

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Conditions

The condition(s) this trial relates to.

chronic inflammatory demyelinating polyradiculoneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

Contacts and locations

Locations

Cedar Health Research - Dallas

Dallas, Texas, 75251, United States
Erlanger Neuroscience Institute

Chattanooga, Tennessee, 37403, United States
Horizon Clinical Research: Gill Neuroscience

Cypress, Texas, 21216, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
National Neuromuscular Research Institute

Austin, Texas, 78759, United States
Neurology Associates PA

Maitland, Florida, 32751, United States
Northwest Houston Neurology - Cypress

Cypress, Texas, 77429, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
SRI International - ClinEdge

Plymouth, Michigan, 48170, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Velocity Clinical Research

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research

Raleigh, North Carolina, 27607, United States
Visionary Investigators Network

Miami, Florida, 33180, United States

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